Research Topics
| Emma J BurtonSummaryAffiliation: University of Newcastle Country: UK Publications
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Detail Information
Publications
Quantitative neurodegenerative pathology does not explain the degree of hippocampal atrophy on MRI in degenerative dementiaE J Burton
Institute for Ageing and Health, Newcastle University, UK
Int J Geriatr Psychiatry 27:1267-74. 2012..The purpose of this study was to investigate the neuropathological substrates underlying in vivo hippocampal atrophy on magnetic resonance imaging (MRI) in autopsy confirmed neurodegenerative dementia cases...- Neuropathological correlates of volumetric MRI in autopsy-confirmed Lewy body dementiaEmma J Burton
Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
Neurobiol Aging 33:1228-36. 2012.... 
Brain atrophy rates in Parkinson's disease with and without dementia using serial magnetic resonance imagingEmma J Burton
Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
Mov Disord 20:1571-6. 2005..Serial MRI may be a useful tool for monitoring disease progression in PDD and further studies should investigate its utility for early diagnosis...- Patterns of cerebral atrophy in dementia with Lewy bodies using voxel-based morphometryE J Burton
Institute for Ageing and Health, University of Newcastle upon Tyne, United Kingdom
Neuroimage 17:618-30. 2002..Comparison of dementia groups showed preservation of the medial temporal lobe, hippocampus, and amygdala in DLB relative to AD. Significant gray matter loss was also observed in the thalamus of AD patients compared to DLB... - Medial temporal lobe atrophy on MRI differentiates Alzheimer's disease from dementia with Lewy bodies and vascular cognitive impairment: a prospective study with pathological verification of diagnosisE J Burton
Wolfson Research Centre, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
Brain 132:195-203. 2009..Pathologically, it is more strongly related to tangle rather than plaque or Lewy body pathology in the temporal lobe. It may have utility as a means for stratifying samples in vivo on the basis of putative differences in pathology... - Cerebral atrophy in Parkinson's disease with and without dementia: a comparison with Alzheimer's disease, dementia with Lewy bodies and controlsEmma J Burton
The Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle General Hospital, Newcastle, UK
Brain 127:791-800. 2004..This provides important information about the pattern of cerebral atrophy in Parkinson's disease and PDD... - High resolution imaging of the medial temporal lobe in Alzheimer's disease and dementia with Lewy bodiesMichael J Firbank
Institute for Ageing and Health, Newcastle University, Newcastle, UK
J Alzheimers Dis 21:1129-40. 2010..Future studies should investigate whether subiculum thickness or the hypointense line could be a diagnostic feature to help discriminate AD from DLB... - Validation of a fully automated hippocampal segmentation method on patients with dementiaMichael J Firbank
Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Westgate Road, Newcastle upon Tyne NE4 6BE, United Kingdom
Hum Brain Mapp 29:1442-9. 2008..Linear regression between manual and automated volume gave V(auto) = V(manual) x 0.83 + 401 ml. The method provides an acceptable automated alternative to manual segmentation which may be of value in large studies... - Progression of white matter hyperintensities in Alzheimer disease, dementia with lewy bodies, and Parkinson disease dementia: a comparison with normal agingEmma J Burton
Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
Am J Geriatr Psychiatry 14:842-9. 2006..CONCLUSIONS: Significant WMH progression occurs in degenerative dementias with rates influenced by severity of lesions at baseline rather than dementia type or cognitive decline... 
Neuroimaging predictors of death and dementia in a cohort of older stroke survivorsMichael J Firbank
Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
J Neurol Neurosurg Psychiatry 83:263-7. 2012..Subjects had a cognitive assessment at 3 months post stroke to exclude dementia, and had an MRI scan (n=106) at that time. Subjects were then followed longitudinally for incident dementia and/or death...- Brain atrophy and white matter hyperintensity change in older adults and relationship to blood pressure. Brain atrophy, WMH change and blood pressureMichael J Firbank
Institute for Ageing and Health, Wolfson Research Centre, Newcastle upon Tyne, NE4 6BE, UK
J Neurol 254:713-21. 2007..These changes are independent. Successful hypertension treatment was associated with reduced risk of WMH progression and possibly brain atrophy... - A volumetric magnetic resonance imaging study of entorhinal cortex volume in dementia with lewy bodies. A comparison with Alzheimer's disease and Parkinson's disease with and without dementiaEva R Kenny
Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
Dement Geriatr Cogn Disord 26:218-25. 2008.... - Does posterior cortical atrophy on MRI discriminate between Alzheimer's disease, dementia with Lewy bodies, and normal aging?James O'Donovan
Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
Int Psychogeriatr 25:111-9. 2013..Therefore, we assessed whether visual rating scales for assessing posterior atrophy (PA), medial temporal lobe atrophy (MTA), and ventricular enlargement (VEn) aid in the discrimination between AD, DLB, and normal aging... - Cognitive associations of subcortical white matter lesions in older peopleJohn T O'Brien
Institute for Ageing and Health, Wolfson Research Centre, University of Newcastle upon Tyne, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
Ann N Y Acad Sci 977:436-44. 2002.... - The application of serial MRI analysis techniques to the study of cerebral atrophy in late-onset dementiaS M Paling
Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
Med Image Anal 8:69-79. 2004..001) compared to controls. In general the analysis technique is shown to be a robust, accurate and transferable tool of potential value for future studies of dementia and related neuro-degenerative disorders... - Atrophy of the putamen in dementia with Lewy bodies but not Alzheimer's disease: an MRI studyD A Cousins
Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
Neurology 61:1191-5. 2003..This may be important in understanding the etiology of parkinsonian features seen in DLB, though in this study, no direct correlation was found between degree of volume loss and severity of parkinsonism... - Medial temporal atrophy rather than white matter hyperintensities predict cognitive decline in stroke survivorsMichael J Firbank
Institute for Ageing and Health, University of Newcastle, Wolfson Research Centre, Newcastle upon Tyne NE4 6BE, UK
Neurobiol Aging 28:1664-9. 2007..The association of MTA but not WMH with subsequent cognitive decline and increasing brain atrophy suggests a greater role for Alzheimer type than vascular pathology in delayed cognitive impairment after stroke... - Dementia with Lewy bodies and AD are not associated with occipital lobe atrophy on MRIH A Middelkoop
Institute for Ageing and Health, University of Newcastle upon Tyne, UK
Neurology 57:2117-20. 2001..There were no significant differences between groups in occipital lobe volume. The authors conclude gross structural changes in the occipital lobe do not occur in patients with mild to moderate DLB or AD... - High resolution imaging of the medial temporal lobe in Alzheimer's disease and dementia with lewy bodiesMichael J Firbank
Institute for Ageing and Health, Newcastle University, Newcastle, UK
J Alzheimers Dis 21:1129-40. 2010..Future studies should investigate whether subiculum thickness or the hypointense line could be a diagnostic feature to help discriminate AD from DLB... - Hippocampal atrophy, whole brain volume, and white matter lesions in older hypertensive subjectsR M Wiseman
Institute for Aging and Health, University of Newcastle upon Tyne, UK
Neurology 63:1892-7. 2004..CONCLUSIONS: Moderate hypertension in non-impaired older subjects is associated with smaller whole brain volume and an increased burden of subcortical and periventricular white matter lesions... - White matter hyperintensities are associated with impairment of memory, attention, and global cognitive performance in older stroke patientsEmma J Burton
Institute for Ageing and Health, Newcastle General Hospital, Newcastle, UK
Stroke 35:1270-5. 2004.... - Comparing gray matter loss profiles between dementia with Lewy bodies and Alzheimer's disease using cortical pattern matching: diagnosis and gender effectsMartina Ballmaier
Laboratory of Neuroimaging, Department of Neurology, David Geffen UCLA School of Medicine, Los Angeles, CA 90095-1769, USA
Neuroimage 23:325-35. 2004..Further investigation of the influence of gender might provide a more comprehensive understanding of the pathophysiological differences underlying the two forms of dementia... - MRI study of caudate nucleus volume in Parkinson's disease with and without dementia with Lewy bodies and Alzheimer's diseaseOsvaldo P Almeida
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Nedlands, Australia
Dement Geriatr Cogn Disord 16:57-63. 2003..Results indicate that the executive and attentional dysfunctions associated with PD and DLB are unlikely to be a direct and specific consequence of caudate atrophy as assessed on MRI...