G Burnstock

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Unresolved issues and controversies in purinergic signalling
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    J Physiol 586:3307-12. 2008
  2. doi Purinergic signalling and disorders of the central nervous system
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Nat Rev Drug Discov 7:575-90. 2008
  3. doi Purinergic signalling in the reproductive system in health and disease
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London, NW3 2PF, UK
    Purinergic Signal 10:157-87. 2014
  4. doi Purinergic signalling in endocrine organs
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London, NW3 2PF, UK
    Purinergic Signal 10:189-231. 2014
  5. doi Purinergic signalling in the liver in health and disease
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London, NW3 2PF, UK
    Purinergic Signal 10:51-70. 2014
  6. doi Purinergic signalling in the gastrointestinal tract and related organs in health and disease
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London, NW3 2PF, UK
    Purinergic Signal 10:3-50. 2014
  7. doi Purinergic signalling in the urinary tract in health and disease
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London, NW3 2PF, UK
    Purinergic Signal 10:103-55. 2014
  8. doi Purinergic signalling in the kidney in health and disease
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London, NW3 2PF, UK
    Purinergic Signal 10:71-101. 2014
  9. doi Purinergic signalling: from discovery to current developments
    Geoffrey Burnstock
    G Burnstock University College Medical School, Autonomic Neuroscience Centre, Rowland Hill Street, London NW3 2PF, UK and Department of Pharmacology, The University of Melbourne, Australia
    Exp Physiol 99:16-34. 2014
  10. doi Purinergic signaling and blood vessels in health and disease
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London NW3 2PF, UK and Department of Pharmacology, The University of Melbourne, Australia
    Pharmacol Rev 66:102-92. 2014

Collaborators

Detail Information

Publications175 found, 100 shown here

  1. pmc Unresolved issues and controversies in purinergic signalling
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    J Physiol 586:3307-12. 2008
    ....
  2. doi Purinergic signalling and disorders of the central nervous system
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Nat Rev Drug Discov 7:575-90. 2008
    ....
  3. doi Purinergic signalling in the reproductive system in health and disease
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London, NW3 2PF, UK
    Purinergic Signal 10:157-87. 2014
    ..Changes in purinoceptor expression occur in pathophysiological conditions, including pre-eclampsia, cancer and pain. ..
  4. doi Purinergic signalling in endocrine organs
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London, NW3 2PF, UK
    Purinergic Signal 10:189-231. 2014
    ..Adipocytes have been recognised recently to have endocrine function involving purinoceptors. ..
  5. doi Purinergic signalling in the liver in health and disease
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London, NW3 2PF, UK
    Purinergic Signal 10:51-70. 2014
    ..Purinergic therapeutic strategies for the treatment of these pathologies are being explored. ..
  6. doi Purinergic signalling in the gastrointestinal tract and related organs in health and disease
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London, NW3 2PF, UK
    Purinergic Signal 10:3-50. 2014
    ..Purinergic signalling is also involved in salivary gland and bile duct secretion. ..
  7. doi Purinergic signalling in the urinary tract in health and disease
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London, NW3 2PF, UK
    Purinergic Signal 10:103-55. 2014
    ..Purinergic therapeutic strategies are being explored that hopefully will be developed and bring benefit and relief to many patients with urinary tract disorders. ..
  8. doi Purinergic signalling in the kidney in health and disease
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London, NW3 2PF, UK
    Purinergic Signal 10:71-101. 2014
    ....
  9. doi Purinergic signalling: from discovery to current developments
    Geoffrey Burnstock
    G Burnstock University College Medical School, Autonomic Neuroscience Centre, Rowland Hill Street, London NW3 2PF, UK and Department of Pharmacology, The University of Melbourne, Australia
    Exp Physiol 99:16-34. 2014
    ..The physiology and pathophysiology of purinergic signalling is discussed...
  10. doi Purinergic signaling and blood vessels in health and disease
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London NW3 2PF, UK and Department of Pharmacology, The University of Melbourne, Australia
    Pharmacol Rev 66:102-92. 2014
    ..The pathophysiology of blood vessels and therapeutic potential of purinergic agents in diseases, including hypertension, atherosclerosis, ischemia, thrombosis and stroke, diabetes, and migraine, is discussed. ..
  11. pmc Purinergic signalling in the musculoskeletal system
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London, NW3 2PF, UK
    Purinergic Signal 9:541-72. 2013
    ..Strategies for future musculoskeletal therapies might involve modulation of purinergic receptor function or of the ecto-nucleotidases responsible for ATP breakdown or ATP transport inhibitors. ..
  12. doi Purinergic mechanisms and pain--an update
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London NW3 2PF, United Kingdom Electronic address
    Eur J Pharmacol 716:24-40. 2013
    ..Current developments of compounds for the therapeutic treatment of both visceral and neuropathic pain are discussed...
  13. doi Cotransmission in the autonomic nervous system
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, London, UK and Department of Pharmacology, University of Melbourne, Australia Electronic address
    Handb Clin Neurol 117:23-35. 2013
    ..For example, ATP appears to become a more prominent cotransmitter in inflammatory and stress conditions. ..
  14. pmc Purinergic signalling and diabetes
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London, NW3 2PF, UK
    Purinergic Signal 9:307-24. 2013
    ..This integrated picture will aid our understanding of the challenges of the potential and currently used drugs targeted to specific organ/cells or disorders associated with diabetes...
  15. doi Purinergic signalling in the lower urinary tract
    G Burnstock
    Autonomic Neuroscience Centre, University College Medical School, London, UK
    Acta Physiol (Oxf) 207:40-52. 2013
    ..Acupuncture is widely used for the treatment of urinary disorders, and a purinergic hypothesis is discussed for the underlying mechanism...
  16. pmc Discovery of purinergic signalling, the initial resistance and current explosion of interest
    G Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London, UK
    Br J Pharmacol 167:238-55. 2012
    ..Medicinal chemists are starting to develop small molecule purinergic drugs that are orally bioavailable and stable in vivo...
  17. doi Purinergic signaling in the airways
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, Royal Free Campus, London, UK
    Pharmacol Rev 64:834-68. 2012
    ....
  18. doi Introduction to purinergic signalling in the brain
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, Royal Free Campus, Rowland Hill Street, NW3 2PF, London, UK
    Adv Exp Med Biol 986:1-12. 2013
    ....
  19. doi Purinergic signalling in the pancreas in health and disease
    G Burnstock
    University College Medical School, Autonomic Neuroscience Centre, Rowland Hill Street, London NW3 2PF, UK
    J Endocrinol 213:123-41. 2012
    ..There is upcoming evidence for the role of purinergic signalling in the pathophysiology of the pancreas, and the new challenge is to understand how it is integrated with other pathological processes...
  20. doi Purinergic signaling in healthy and diseased skin
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, London, UK
    J Invest Dermatol 132:526-46. 2012
    ..Purinergic signaling is involved in skin pathology, including inflammation, wound healing, pain, psoriasis, scleroderma, warts, and skin cancer...
  21. doi Targeting the visceral purinergic system for pain control
    G Burnstock
    Autonomic Neuroscience Centre, University College Medical School, London NW3 2PF, United Kingdom
    Curr Opin Pharmacol 12:80-6. 2012
    ....
  22. doi Purinergic signalling: Its unpopular beginning, its acceptance and its exciting future
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, London, UK
    Bioessays 34:218-25. 2012
    ..Purinergic therapeutic strategies are being developed for treatment of gut, kidney, bladder, lung, skeletal and reproductive system disorders, pain and cancer...
  23. pmc Purinergic receptors are part of a signalling system for proliferation and differentiation in distinct cell lineages in human anagen hair follicles
    Aina V H Greig
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London, NW3 2PF, UK
    Purinergic Signal 4:331-8. 2008
    ..The therapeutic potential of purinergic agonists and antagonists for controlling hair growth is discussed...
  24. pmc ATP release from the human ureter on distension and P2X(3) receptor expression on suburothelial sensory nerves
    R C Calvert
    Department of Urology, Royal Free and University College Medical School, Rowland Hill Street, London, UK
    Purinergic Signal 4:377-81. 2008
    ..These findings are consistent with the hypothesis that purinergic signalling is involved in human ureteric mechanosensory transduction, leading to nociception...
  25. pmc P2 receptors in cardiovascular regulation and disease
    David Erlinge
    Department of Cardiology, Lund University Hospital, 22185, Lund, Sweden
    Purinergic Signal 4:1-20. 2008
    ..The extracellular nucleotides and their cardiovascular P2 receptors are now entering the phase of clinical development...
  26. doi Vas deferens--a model used to establish sympathetic cotransmission
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Trends Pharmacol Sci 31:131-9. 2010
    ..It has also been used to study sympathetic reinnervation following vasectomy and castration, as well as the deleterious effects of diabetes, hypertension and chronic alcohol...
  27. pmc Purinergic mechanosensory transduction and visceral pain
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Mol Pain 5:69. 2009
    ....
  28. ncbi Purinergic signalling: past, present and future
    G Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, London, UK
    Braz J Med Biol Res 42:3-8. 2009
    ....
  29. ncbi Interstitial cells of Cajal and purinergic signalling
    G Burnstock
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, London, UK
    Auton Neurosci 97:68-72. 2002
    ..It is speculated that release of ATP from enteric nerves, enteric glial cells or from contracting smooth muscle may provide a feedback mechanism for pacemaker activity in the intestine...
  30. ncbi Purinergic signaling and vascular cell proliferation and death
    Geoffrey Burnstock
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, London, UK
    Arterioscler Thromb Vasc Biol 22:364-73. 2002
    ..Thus, the involvement of ATP and its breakdown product, adenosine, is implicated; it is hoped that with the development of selective P1 (A2) and P2Y receptor agonists and antagonists, new therapeutic strategies will be explored...
  31. doi Purinergic signaling in embryonic and stem cell development
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, Royal Free Campus, Rowland Hill Street, London, UK
    Cell Mol Life Sci 68:1369-94. 2011
    ..Since normal development is disturbed by dysfunction of purinergic signaling in animal models, further studies are needed to elucidate the functions of purinoceptor subtypes in developmental processes...
  32. doi Therapeutic potential of purinergic signalling for diseases of the urinary tract
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, London, UK
    BJU Int 107:192-204. 2011
    ..A purinergic hypothesis is discussed for the mechanism underlying acupuncture, widely used for the treatment of urinary disorders...
  33. doi Evolutionary origins of the purinergic signalling system
    G Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, London, UK
    Acta Physiol (Oxf) 195:415-47. 2009
    ..g. in some insects, roundworms (Caenorhabditis elegans) and the plant Arabidopsis] in contrast to the potent pharmacological actions of nucleotides in the same species, suggests that novel receptors are still to be discovered...
  34. ncbi Potential therapeutic targets in the rapidly expanding field of purinergic signalling
    G Burnstock
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, London
    Clin Med 2:45-53. 2002
    ....
  35. doi The birth and postnatal development of purinergic signalling
    G Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, London, UK
    Acta Physiol (Oxf) 199:93-147. 2010
    ..We summarize the current knowledge on purinoceptors, their distribution and role in signal transduction in various tissues in physiological and pathophysiological conditions...
  36. doi Acupuncture: a novel hypothesis for the involvement of purinergic signalling
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Med Hypotheses 73:470-2. 2009
    ....
  37. ncbi Purinergic receptors and pain
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London, UK
    Curr Pharm Des 15:1717-35. 2009
    ..Current developments of compounds for the therapeutic treatment of both visceral and neuropathic pain are discussed...
  38. doi Autonomic neurotransmission: 60 years since sir Henry Dale
    Geoffrey Burnstock
    Autonomic Neuroscience Center, Royal Free and University College Medical School, London NW3 2PF, United Kingdom
    Annu Rev Pharmacol Toxicol 49:1-30. 2009
    ..In this way, autonomic neurotransmission is matched to ongoing changes in demands and can sometimes be compensatory in pathophysiological situations...
  39. doi Purinergic cotransmission
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Exp Physiol 94:20-4. 2009
    ..In recent years, studies have shown that ATP is released with ACh, noradrenaline, glutamate, gamma-aminobutyric acid, 5-hyroxytryptamine and dopamine in different subpopulations of neurons in the central nervous system...
  40. pmc Purinergic signalling
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF
    Br J Pharmacol 147:S172-81. 2006
    ....
  41. ncbi 50 years of passionate commitment
    G Burnstock
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, Rowland Hill Steet, NW3 2PF, London, United Kingdom
    Cell Mol Life Sci 61:1693-6. 2004
  42. ncbi Historical review: ATP as a neurotransmitter
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Trends Pharmacol Sci 27:166-76. 2006
    ..I also discuss the current status of the field, including recent interest in the pathophysiology of purinergic signalling and its therapeutic potential...
  43. ncbi Introduction: P2 receptors
    Geoffrey Burnstock
    Autonomic Neuroscience Institute, Royal Free and University College, Rowland Hill Street, London NW3 2PF, UK
    Curr Top Med Chem 4:793-803. 2004
    ..Lastly, there are some speculations about future developments in the purinergic signalling field...
  44. ncbi Cotransmission
    Geoffrey Burnstock
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Curr Opin Pharmacol 4:47-52. 2004
    ..In the past two years, interest has focused on the mechanisms underlying cotransmission, plasticity and differential control of cotransmitter expression...
  45. ncbi Purine and pyrimidine receptors
    G Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, London, UK
    Cell Mol Life Sci 64:1471-83. 2007
    ..P2Y receptors are G protein-coupled receptors, and eight subtypes have been cloned and characterised to date...
  46. ncbi Physiology and pathophysiology of purinergic neurotransmission
    Geoffrey Burnstock
    Autonomic Neurscience Centre, Royal Free and University College Medical School, London, UK
    Physiol Rev 87:659-797. 2007
    ..Finally, the pathophysiology of purinergic neurotransmission in both peripheral and central nervous systems is reviewed, and speculations are made about future developments...
  47. ncbi Non-synaptic transmission at autonomic neuroeffector junctions
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College School of Medicine, Rowland Hill Street, London NW3 2PF, United Kingdom
    Neurochem Int 52:14-25. 2008
    ..It is suggested that autonomic neural control of immune, epithelial and endothelial cells also involves non-synaptic transmission...
  48. ncbi Dual control of vascular tone and remodelling by ATP released from nerves and endothelial cells
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London, UK
    Pharmacol Rep 60:12-20. 2008
    ..The involvement of these regulatory mechanisms in pathological conditions, including hypertension, atherosclerosis, restenosis, diabetes and vascular pain, are discussed...
  49. doi The journey to establish purinergic signalling in the gut
    G Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, London, UK
    Neurogastroenterol Motil 20:8-19. 2008
    ....
  50. ncbi Involvement of purinergic signaling in cardiovascular diseases
    Vera Ralevic
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, United Kingdom
    Drug News Perspect 16:133-40. 2003
    ..This will open up new avenues for research into the physiological roles of purine receptors and their therapeutic potential...
  51. ncbi Pathophysiology and therapeutic potential of purinergic signaling
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, London NW3 2PF, UK
    Pharmacol Rev 58:58-86. 2006
    ..Recent advances in therapies using purinergic-related drugs in a wide range of pathological conditions will be addressed with speculation on future developments in the field...
  52. doi Purinergic receptors as future targets for treatment of functional GI disorders
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Gut 57:1193-4. 2008
  53. ncbi Purinergic P2 receptors as targets for novel analgesics
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Pharmacol Ther 110:433-54. 2006
    ..The involvement of purinergic signaling in long-term neuropathic pain and inflammation as well as acute pain is discussed as well as the development of P2 receptor antagonists as novel analgesics...
  54. pmc Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death
    G Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, London, UK
    Cell Death Dis 1:e9. 2010
    ..In this article, we focus on the latter in the immune/defence system, in stratified epithelia in visceral organs and skin, embryological development, bone formation and resorption, as well as in cancer...
  55. pmc Control of vascular tone by purines and pyrimidines
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, Royal Free Campus, London, UK
    Br J Pharmacol 161:527-9. 2010
    ..are considered and put into the wider context of the mechanisms of control of vascular tone by purinergic signalling via receptors located on both smooth muscle and endothelial cells...
  56. ncbi Purinergic receptors: their role in nociception and primary afferent neurotransmission
    G Burnstock
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Curr Opin Neurobiol 6:526-32. 1996
    ....
  57. ncbi Purine-mediated signalling in pain and visceral perception
    G Burnstock
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, Rowland Hill Street, NW3 2PF, London, UK
    Trends Pharmacol Sci 22:182-8. 2001
    ....
  58. doi Purinergic signalling: from normal behaviour to pathological brain function
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Prog Neurobiol 95:229-74. 2011
    ..Finally, the role of purinergic signalling in neuropsychiatric diseases (including schizophrenia), epilepsy, migraine, cognitive impairment and neuropathic pain will be considered...
  59. pmc Release of vasoactive substances from endothelial cells by shear stress and purinergic mechanosensory transduction
    G Burnstock
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, London, UK
    J Anat 194:335-42. 1999
    ....
  60. ncbi Introductory overview of purinergic signalling
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, London, UK
    Front Biosci (Elite Ed) 3:896-900. 2011
    ....
  61. ncbi Adenosine and ATP receptors in the brain
    Geoffrey Burnstock
    Autonomic Neuroscience Centre, University College Medical School, London, Rowland Hill Street, London NW3 2PF, UK
    Curr Top Med Chem 11:973-1011. 2011
    ..Examples of the roles of purinoceptors in neuropathology involve: A(2A) receptors in Parkinson's disease and epilepsy, P2 receptors in trauma, ischaemia. Neuroinflammatory and neuropsychiatric disorders, and neuropathic pain...
  62. pmc Inhibitory action of PPADS on relaxant responses to adenine nucleotides or electrical field stimulation in guinea-pig taenia coli and rat duodenum
    U Windscheif
    Department of Anatomy and Developmental Biology, University College London
    Br J Pharmacol 115:1509-17. 1995
    ..Furthermore, we conclude that in addition to the classical P2y-subtype, which is largely PPADS-resistant,the guinea-pig taenia coli may be endowed with a distinct relaxation-mediating P2-purinoceptor subtype which is sensitive to PPADS...
  63. ncbi Coexpression of P2X(3) and P2X(2) receptor subunits in varying amounts generates heterogeneous populations of P2X receptors that evoke a spectrum of agonist responses comparable to that seen in sensory neurons
    M Liu
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, Royal Free Campus, Hampstead, London, United Kingdom
    J Pharmacol Exp Ther 296:1043-50. 2001
    ..This spectrum may explain the variability of agonist responses in small sensory neurons that also express P2X(2) and P2X(3) subunits in different amounts...
  64. ncbi Coexpression of rat P2X2 and P2X6 subunits in Xenopus oocytes
    B F King
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, Royal Free Campus, Hampstead, London NW3 2PF, United Kingdom
    J Neurosci 20:4871-7. 2000
    ..Although homomeric P2X(6) receptors function poorly, the P2X(6) subunit can contribute to functional heteromeric P2X channels and may influence the phenotype of native P2X receptors in those cells in which it is expressed...
  65. pmc Diinosine pentaphosphate: an antagonist which discriminates between recombinant P2X(3) and P2X(2/3) receptors and between two P2X receptors in rat sensory neurones
    P M Dunn
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, London
    Br J Pharmacol 130:1378-84. 2000
    ..6. In conclusion, Ip(5)I is a potent antagonist at homomeric P2X(3) receptors but not at heteromeric P2X(2/3) receptors, and therefore should be a useful tool for elucidating the subunit composition of native P2X receptors...
  66. ncbi Effects of long-term laxative treatment on rat mesenteric resistance vessel responses in vitro
    V Ralevic
    Department of Anatomy and Developmental Biology, University College London, England
    Gastroenterology 99:1352-7. 1990
    ....
  67. pmc Impaired sensory-motor nerve function in the isolated mesenteric arterial bed of streptozotocin-diabetic and ganglioside-treated streptozotocin-diabetic rats
    V Ralevic
    Department of Anatomy and Developmental Biology, University College London
    Br J Pharmacol 110:1105-11. 1993
    ..Ganglioside treatment did not modify any aspect of vascular function of mesenteric beds from streptozotocin-diabetic or control rats...
  68. pmc Selective antagonism by PPADS at P2X-purinoceptors in rabbit isolated blood vessels
    A U Ziganshin
    Department of Anatomy and Developmental Biology, University College London
    Br J Pharmacol 111:923-9. 1994
    ..5. In conclusion, these results support the evidence that PPADS is a selective antagonist of P2X-purinoceptor-mediated responses...
  69. ncbi Neural endothelin in hypertension: increased expression in ganglia and nerves to cerebral arteries of the spontaneously hypertensive rat
    P Milner
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, London, UK
    J Vasc Res 37:39-49. 2000
    ..An increased neural source of endothelin in the SHR may contribute to the development of hypertension or may be a consequence of selective degenerative change...
  70. ncbi Abnormalities in neuromuscular junction structure and skeletal muscle function in mice lacking the P2X2 nucleotide receptor
    M Ryten
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Neuroscience 148:700-11. 2007
    ..These findings demonstrate a role for P2X2 receptor-mediated signaling in NMJ formation and suggest that purinergic signaling may play an as yet largely unrecognized part in synapse formation...
  71. pmc Effects of vitamin E deficiency on autonomic neuroeffector mechanisms in the rat caecum, vas deferens and urinary bladder
    C H Hoyle
    Department of Anatomy and Developmental Biology, University College London, UK
    J Physiol 487:773-86. 1995
    ....
  72. pmc Multiple P2X receptors on guinea-pig pelvic ganglion neurons exhibit novel pharmacological properties
    Y Zhong
    Autonomic Neuroscience Institute, Department of Anatomy and Developmental Biology, Royal Free and University College Medical School, Rowland Hill Street, London, NW3 2PF
    Br J Pharmacol 132:221-33. 2001
    ..However, some of the novel pharmacological properties observed suggest that the guinea-pig P2X receptor subtypes may differ from their rat orthologues...
  73. ncbi Use of reserpine and 6-hydroxydopamine supports evidence for purinergic cotransmission in the rabbit ear artery
    V L Saville
    Department of Anatomy and Developmental Biology, University College London, U K
    Eur J Pharmacol 155:271-7. 1988
    ..This study provides supporting evidence for the involvement of noradrenaline and ATP in sympathetic cotransmission in the rabbit central ear artery...
  74. ncbi Alterations in serotonin and neuropeptide Y content of cerebrovascular sympathetic nerves following experimental subarachnoid hemorrhage
    A Jackowski
    Department of Anatomy and Developmental Biology, University College London, U K
    J Cereb Blood Flow Metab 9:271-9. 1989
    ..This pattern of change was not observed in either sham-operated or saline-injected controls...
  75. ncbi A novel G protein-coupled P2 purinoceptor (P2Y3) activated preferentially by nucleoside diphosphates
    T E Webb
    Molecular Neurobiology Unit, Royal Free Hospital School of Medicine, London, UK
    Mol Pharmacol 50:258-65. 1996
    ..The results indicated that P2Y3 is a previously unknown P2 purinoceptor subtype with a preference for nucleoside diphosphates...
  76. pmc Guinea-pig sympathetic neurons express varying proportions of two distinct P2X receptors
    Y Zhong
    Autonomic Neuroscience Institute, Department of Anatomy and Developmental Biology, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    J Physiol 523:391-402. 2000
    ..7. We conclude that varying proportions of two distinct P2X receptors coexist on the cell bodies of individual guinea-pig SCG neurons, which may correspond to homomeric P2X2 and heteromeric P2X2/3 receptors...
  77. ncbi Pharmacological comparison of P2X receptors on rat coeliac, mouse coeliac and mouse pelvic ganglion neurons
    Y Zhong
    Autonomic Neuroscience Institute, Department of Anatomy and Developmental Biology, Royal Free and University College Medical School, London, UK
    Neuropharmacology 39:172-80. 2000
    ..e. they are homomeric P2X2 receptors, or heteromultimers with P2X2 being the dominant subunit...
  78. ncbi Characterization of P2 receptors modulating neural activity in rat rostral ventrolateral medulla
    V Ralevic
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, London, UK
    Neuroscience 94:867-78. 1999
    ..The data suggest that both P2X and P2Y receptors are involved, and that the functional expression of these receptors within the rostral ventrolateral medulla is not uniform...
  79. pmc Possible role of diadenosine polyphosphates as modulators of cardiac sensory-motor neurotransmission in guinea-pigs
    A Rubino
    Department of Anatomy and Developmental Biology, University College London, UK
    J Physiol 495:515-23. 1996
    ..A postjunctional negative inotropism was also shown, mediated by myocardial A1 adenosine receptors...
  80. ncbi Calcitonin gene-related peptide (CGRP)-evoked inotropism during hyper- and hypo-sensory-motor innervation in rat atria
    A Rubino
    Department of Anatomy and Developmental Biology, University College London, UK
    J Auton Pharmacol 17:121-7. 1997
    ..Down-regulation of CGRP receptors or altered post-receptor signalling may be involved in the reduced responsiveness to CGRP...
  81. ncbi Selective expression of purinoceptor cP2Y1 suggests a role for nucleotide signalling in development of the chick embryo
    M P Meyer
    Department of Anatomy and Developmental Biology, University College London, England
    Dev Dyn 214:152-8. 1999
    ....
  82. pmc Effects of nitric oxide synthase inhibitors, L-NG-nitroarginine and L-NG-nitroarginine methyl ester, on responses to vasodilators of the guinea-pig coronary vasculature
    A Vials
    Department of Anatomy and Developmental Biology, University College London
    Br J Pharmacol 107:604-9. 1992
    ..L-NAME was a more effective agent than L-NOARG in inhibiting the vasodilator actions of 5-HT and ATP in this preparation...
  83. ncbi Effects of long-term laxative treatment on neuropeptides in rat mesenteric vessels and caecum
    P Milner
    Department of Anatomy and Developmental Biology, University College London, UK
    J Pharm Pharmacol 44:777-9. 1992
    ..In the caecum, VIP-, SP- and CGRP-immunoreactivity and catecholamine-fluorescence were unchanged by the laxative treatments...
  84. ncbi Marked increases in calcitonin gene-related peptide-containing nerves in the developing rat following long-term sympathectomy with guanethidine
    J Aberdeen
    Department of Anatomy and Developmental Biology, University College London, U K
    Neuroscience 35:175-84. 1990
    ..The possibility that nerve growth factor is involved in the mechanism of hyperinnervation by calcitonin gene-related peptide-containing sensory nerves following long-term sympathectomy is discussed...
  85. ncbi Evidence that release of adenosine triphosphate from endothelial cells during increased shear stress is vesicular
    P Bodin
    Autonomic Neuroscience Institute, Department of Anatomy and Developmental Biology, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF
    J Cardiovasc Pharmacol 38:900-8. 2001
    ..We suggest, therefore, that the release of ATP from vascular endothelial cells, like that of nerve cells, is probably by vesicular exocytosis...
  86. ncbi Cloning and functional expression of a brain G-protein-coupled ATP receptor
    T E Webb
    Molecular Neurobiology Unit, Royal Free Hospital School of Medicine, London, UK
    FEBS Lett 324:219-25. 1993
    ..When expressed as a complementary RNA (cRNA) in Xenopus oocytes a slowly-developing inward current was observed in response to application of ATP. The pharmacology of this expressed protein defines it as a P2Y purinoceptor...
  87. ncbi P2X3 knock-out mice reveal a major sensory role for urothelially released ATP
    M Vlaskovska
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, London NW3 2PF, United Kingdom
    J Neurosci 21:5670-7. 2001
    ..These data strongly suggest a major sensory role for urothelially released ATP acting via P2X(3) receptors on a subpopulation of pelvic afferent fibers...
  88. ncbi A P2X purinoceptor cDNA conferring a novel pharmacological profile
    X Bo
    Department of Anatomy and Developmental Biology, University College London, UK
    FEBS Lett 375:129-33. 1995
    ..Due to lack of any known antagonist for P2X4 it is unlikely that native P2X4 has previously been recognized as a P2X purinoceptor...
  89. ncbi Expression of P2X purinoceptors during rat brain development and their inhibitory role on motor axon outgrowth in neural tube explant cultures
    K K Cheung
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Neuroscience 133:937-45. 2005
    ..It is speculated that P2X7 receptors may be involved in programmed cell death during embryogenesis and that P2X4, P2X(5) and P2X6 receptors might be involved in postnatal neurogenesis...
  90. ncbi A P2X purinoceptor expressed by a subset of sensory neurons
    C C Chen
    Department of Anatomy, University College, London, UK
    Nature 377:428-31. 1995
    ..The remarkable selectivity of expression of the channel coupled with its sensory neuron-like pharmacology suggests that this channel may transduce ATP-evoked nociceptor activation...
  91. ncbi Enteric neuropeptides in streptozotocin-diabetic rats; effects of insulin and aldose reductase inhibition
    A Belai
    Department of Anatomy and Developmental Biology, University College London, UK
    J Auton Nerv Syst 58:163-9. 1996
    ..The dissimilarity of the effect of the two treatments on CGRP expression may imply a neurotrophic effect of insulin, although there are certainly consequences of hyperglycaemia other than exaggerated flux through the polyol pathway...
  92. ncbi Selective agonism of group I P2X receptors by dinucleotides dependent on a single adenine moiety
    O Cinkilic
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, London, United Kingdom
    J Pharmacol Exp Ther 299:131-6. 2001
    ..The data suggest that naturally occurring Ap(n)As and Ap(n)Gs may play an important physiological role in different human tissues and systems by activating group I P2X receptors...
  93. ncbi The extracellular ATP receptor, cP2Y(1), inhibits cartilage formation in micromass cultures of chick limb mesenchyme
    M P Meyer
    Department of Anatomy and Developmental Biology, University College London, London, United Kingdom
    Dev Dyn 222:494-505. 2001
    ....
  94. pmc Molecular cloning and characterization of rat P2Y4 nucleotide receptor
    Y D Bogdanov
    Department of Anatomy and Developmental Biology, University College London
    Br J Pharmacol 124:428-30. 1998
    ..Thus, rP2Y4 and the P2Y2 subtype appear to be structurally distinct forms of the P2U receptor (where ATP and UTP are equi-active) but can be distinguished as suramin-insensitive and suramin-sensitive P2U receptors, respectively...
  95. pmc A2-purinoceptor-mediated relaxation in the guinea-pig coronary vasculature: a role for nitric oxide
    A Vials
    Department of Anatomy and Developmental Biology, University College London
    Br J Pharmacol 109:424-9. 1993
    ....
  96. ncbi Roles of P2-purinoceptors in the cardiovascular system
    V Ralevic
    University College, London, UK
    Circulation 84:1-14. 1991
    ..The development of selective and potent antagonists to P2X- and P2Y-purinoceptors has so far remained elusive, and their therapeutic potential can only be guessed...
  97. ncbi Identification of P1 and P2 purinoceptors in the aorta of the lizard (Agama sp.)
    G E Knight
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, Rowland Hill Street, NW3 2PF, London, UK
    Comp Biochem Physiol C Toxicol Pharmacol 128:413-23. 2001
    ..However, in contrast to mammalian aorta, P2Y receptors on endothelial cells mediating vasodilatation via nitric oxide do not appear to be present...
  98. ncbi ATP and UTP at low concentrations strongly inhibit bone formation by osteoblasts: a novel role for the P2Y2 receptor in bone remodeling
    Astrid Hoebertz
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Cell Biochem 86:413-9. 2002
    ..These findings suggest that extracellular nucleotides could function locally as important negative modulators of bone metabolism, perhaps contributing to bone loss in a number of pathological states...
  99. pmc Blockade by glibenclamide of the flow-evoked endothelial release of ATP that contributes to vasodilatation in the pulmonary vascular bed of the rat
    H Hassessian
    Department of Anatomy and Developmental Biology, University College London
    Br J Pharmacol 109:466-72. 1993
    ..10).6. It is concluded that flow-induced ATP release is mediated by a glibenclamide-sensitive K+ channel,and that the release of ATP from endothelial cells probably functions to vasodilate the pulmonary vascular bed of the rat...
  100. ncbi Early expression of a novel nucleotide receptor in the neural plate of Xenopus embryos
    Y D Bogdanov
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Biol Chem 272:12583-90. 1997
    ..This restricted pattern of expression and novel pharmacological features confer unique properties to XlP2Y, which may play a key role in the early development of neural tissue...
  101. ncbi Upregulation of heat shock proteins rescues motoneurones from axotomy-induced cell death in neonatal rats
    B Kalmar
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
    Exp Neurol 176:87-97. 2002
    ..In addition, treatment with BRX-220 resulted in a significant increase in the expression of hsp70 and hsp90 in glia and neurones. Thus, treatment with BRX-220, a co-inducer of hsps, protects motoneurones from axotomy-induced cell death...