A Burns

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi request reprint Outcomes following hip fracture surgery: a 2-year prospective study
    Alistair Burns
    Faculty of Medical and Human Sciences, Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, England Electronic address
    Am J Geriatr Psychiatry 22:838-44. 2014
  2. pmc Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT)
    Linda Clare
    School of Psychology, Bangor University, Bangor, Gwynedd LL57 2AS, UK
    Trials 14:152. 2013
  3. pmc Individual Cognitive Stimulation Therapy for dementia (iCST): study protocol for a randomized controlled trial
    Martin Orrell
    Mental Health Sciences Unit, University College, London, UK
    Trials 13:172. 2012
  4. pmc DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT
    Rob Jones
    Section of Old Age Psychiatry, The University of Nottingham, A Floor, South Block, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Trials 10:57. 2009
  5. pmc What are the benefits of cognitive enhancers for Alzheimer's Disease: use of Population Impact Measures
    Udaya P Gammanpila
    Specialist Registrar in Psychiatry, Forest House, Royal Oldham Hospital, Rochdale Road, Oldham, OL1 2JH, UK
    BMC Geriatr 7:25. 2007
  6. doi request reprint Dimebon in Alzheimer's disease: old drug for new indication
    Alistair Burns
    Psychiatry Research Group, University of Manchester, Manchester M13 9PL, UK
    Lancet 372:179-80. 2008
  7. doi request reprint Safety and efficacy of galantamine (Reminyl) in severe Alzheimer's disease (the SERAD study): a randomised, placebo-controlled, double-blind trial
    Alistair Burns
    University of Manchester, Manchester, UK
    Lancet Neurol 8:39-47. 2009
  8. ncbi request reprint Brief psychotherapy in Alzheimer's disease: randomised controlled trial
    Alistair Burns
    Department of Psychiatry, 2nd Floor, Education and Research Centre, Wythenshawe Hospital, Southmoor Road, Manchester M23 9LT, UK
    Br J Psychiatry 187:143-7. 2005
  9. ncbi request reprint Treatment and prevention of depression after surgery for hip fracture in older people: randomized, controlled trials
    Alistair Burns
    Division of Psychiatry, University of Manchester, Manchester, UK
    J Am Geriatr Soc 55:75-80. 2007
  10. ncbi request reprint Efficacy and safety of donepezil over 3 years: an open-label, multicentre study in patients with Alzheimer's disease
    A Burns
    University of Manchster, Manchester, UK
    Int J Geriatr Psychiatry 22:806-12. 2007

Detail Information

Publications94

  1. ncbi request reprint Outcomes following hip fracture surgery: a 2-year prospective study
    Alistair Burns
    Faculty of Medical and Human Sciences, Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, England Electronic address
    Am J Geriatr Psychiatry 22:838-44. 2014
    ..To describe the health outcomes in older people following hip fracture surgery...
  2. pmc Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT)
    Linda Clare
    School of Psychology, Bangor University, Bangor, Gwynedd LL57 2AS, UK
    Trials 14:152. 2013
    ..This study aims to establish whether CR is a clinically effective and cost-effective intervention for people with early-stage dementia and their carers...
  3. pmc Individual Cognitive Stimulation Therapy for dementia (iCST): study protocol for a randomized controlled trial
    Martin Orrell
    Mental Health Sciences Unit, University College, London, UK
    Trials 13:172. 2012
    ..The aim of the current study is to develop and evaluate a home-based individual Cognitive Stimulation Therapy (iCST) programme for people with dementia which can be delivered by their family carer...
  4. pmc DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT
    Rob Jones
    Section of Old Age Psychiatry, The University of Nottingham, A Floor, South Block, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Trials 10:57. 2009
    ..The aim of this trial is to establish the most effective drug option for people with AD who are progressing from moderate to severe dementia despite treatment with donepezil...
  5. pmc What are the benefits of cognitive enhancers for Alzheimer's Disease: use of Population Impact Measures
    Udaya P Gammanpila
    Specialist Registrar in Psychiatry, Forest House, Royal Oldham Hospital, Rochdale Road, Oldham, OL1 2JH, UK
    BMC Geriatr 7:25. 2007
    ..The study aims to quantify the population impact of prescribing cholinesterase inhibitors to slow the cognitive decline in Alzheimer's disease (AD), and to compare with the benefit of treating hypertension to prevent the onset of AD...
  6. doi request reprint Dimebon in Alzheimer's disease: old drug for new indication
    Alistair Burns
    Psychiatry Research Group, University of Manchester, Manchester M13 9PL, UK
    Lancet 372:179-80. 2008
  7. doi request reprint Safety and efficacy of galantamine (Reminyl) in severe Alzheimer's disease (the SERAD study): a randomised, placebo-controlled, double-blind trial
    Alistair Burns
    University of Manchester, Manchester, UK
    Lancet Neurol 8:39-47. 2009
    ..The efficacy of galantamine has been shown in patients with mild, moderate, and advanced moderate Alzheimer's disease (AD). Here we report its efficacy in patients with severe AD...
  8. ncbi request reprint Brief psychotherapy in Alzheimer's disease: randomised controlled trial
    Alistair Burns
    Department of Psychiatry, 2nd Floor, Education and Research Centre, Wythenshawe Hospital, Southmoor Road, Manchester M23 9LT, UK
    Br J Psychiatry 187:143-7. 2005
    ..This may be important in the earlier stages of Alzheimer's disease, where insight is often preserved...
  9. ncbi request reprint Treatment and prevention of depression after surgery for hip fracture in older people: randomized, controlled trials
    Alistair Burns
    Division of Psychiatry, University of Manchester, Manchester, UK
    J Am Geriatr Soc 55:75-80. 2007
    ..To evaluate the effect of a psychiatric intervention in treating depression (treatment study) and the effect of a psychological treatment in preventing depression (prevention study) after hip fracture in older people...
  10. ncbi request reprint Efficacy and safety of donepezil over 3 years: an open-label, multicentre study in patients with Alzheimer's disease
    A Burns
    University of Manchster, Manchester, UK
    Int J Geriatr Psychiatry 22:806-12. 2007
    ....
  11. ncbi request reprint Defining treatment response to donepezil in Alzheimer's disease: responder analysis of patient-level data from randomized, placebo-controlled studies
    Alistair Burns
    University of Manchester, Wythenshawe Hospital, Manchester, UK
    Drugs Aging 25:707-14. 2008
    ..Defining treatment success in progressive diseases, such as Alzheimer's disease (AD), can be challenging...
  12. ncbi request reprint Bright light therapy for agitation in dementia: a randomized controlled trial
    Alistair Burns
    Old Age Psychiatry, University of Manchester, Manchester, UK
    Int Psychogeriatr 21:711-21. 2009
    ..Alternatives to drug treatment for agitation should be sought. The study aimed to assess the effects of bright light therapy on agitation and sleep in people with dementia...
  13. ncbi request reprint Clinical practice with anti-dementia drugs: a consensus statement from British Association for Psychopharmacology
    Alistair Burns
    University of Manchester, Manchester, UK
    J Psychopharmacol 20:732-55. 2006
    ..Patients, their carers, and clinicians deserve to be optimistic in a field which often attracts therapeutic nihilism...
  14. doi request reprint The conversational mini-mental state examination: Estimating cognitive impairment
    Alistair Burns
    The University of Manchester, Manchester Academic and Health Science Centre, UK
    Aging Ment Health 14:692-4. 2010
    ..The results underscore the need for formal cognitive assessment and the requirements for training in the administration of cognitive tests...
  15. ncbi request reprint Risperidone for the treatment of neuropsychiatric features in dementia
    Alistair Burns
    University of Manchester, Education and Research Centre, Wythenshawe Hospital, Manchester, UK
    Drugs Aging 23:887-96. 2006
    ....
  16. doi request reprint Transcultural influences in dementia care: observations from a psychosocial intervention study
    Alistair Burns
    University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    Dement Geriatr Cogn Disord 30:417-23. 2010
    ..There has been little direct comparison of cultural differences between countries and the effect any differences may exert on the outcome of caregiver interventions...
  17. doi request reprint A double-blind placebo-controlled randomized trial of Melissa officinalis oil and donepezil for the treatment of agitation in Alzheimer's disease
    Alistair Burns
    Mental Health and Neurodegeneration, Age Psychiatry, University of Manchester, Manchester, UK
    Dement Geriatr Cogn Disord 31:158-64. 2011
    ....
  18. ncbi request reprint Nurses making a diagnosis of dementia--a potential change in practice?
    S Page
    Manchester Mental Health and Social Care Trust, Wythenshawe Hospital, Manchester, UK
    Int J Geriatr Psychiatry 23:27-33. 2008
    ..To compare nurse initial diagnoses following domiciliary visits with subsequent formal multidisciplinary formulation based upon the full possession of investigations, neuropsychological tests and brain imaging...
  19. ncbi request reprint Policy, organisation and practice of specialist old age psychiatry in England
    David Challis
    University of Manchester, UK
    Int J Geriatr Psychiatry 17:1018-26. 2002
    ....
  20. doi request reprint Activities enjoyed by patients with dementia together with their spouses and psychological morbidity in carers
    R Searson
    Old Age Psychiatry, North Manchester General Hospital, Manchester Mental Health and Social Care Trust, Manchester, UK
    Aging Ment Health 12:276-82. 2008
    ..Facilitating activities that are enjoyed by both patients with dementia and spouses may be an alternative intervention strategy to reduce carer burden...
  21. ncbi request reprint Asymptomatic spontaneous cerebral emboli and cognitive decline in a cohort of older people: a prospective study
    Richard C Oude Voshaar
    University of Manchester, Division of Psychiatry, Education and Research Centre, South Manchester University Hospital, Wythenshawe, Manchester, UK
    Int J Geriatr Psychiatry 22:794-800. 2007
    ..Asymptomatic spontaneous cerebral emboli (SCE) are common in dementia and are associated with cognitive decline in dementia. The significance of their presence in older people is unknown...
  22. ncbi request reprint Older people with chronic schizophrenia
    S Karim
    University of Manchester, Manchester, UK
    Aging Ment Health 9:315-24. 2005
    ..There are shortcomings in the standard of both hospital and community care, and the cost implications of providing adequate services are high...
  23. ncbi request reprint Paradoxical embolisation and cerebral white matter lesions in dementia
    N Purandare
    University of Manchester, Division of Psychiatry, Education and Research Centre, Wythenshawe Hospital, Wythenshawe, Manchester M23 9LT, UK
    Br J Radiol 81:30-4. 2008
    ..In addition, there is a significant negative correlation between SCE and DWMH in VaD, which supports the hypothesis that VaD may be the result of ischaemic injury, predominantly reflecting embolic aetiology...
  24. ncbi request reprint Perceived mental health needs and adequacy of service provision to older people in care homes in the UK: a national survey
    Nitin Purandare
    University of Manchester, School of Psychiatry and Behavioural Sciences, 2nd Floor, Education and Research Centre, Wythenshawe Hospital, Wythenshawe, Manchester, UK
    Int J Geriatr Psychiatry 19:549-53. 2004
    ..To assess perceived need and adequacy of service provision by old age psychiatrists (OAPs) to older people living in care homes in the UK...
  25. doi request reprint Development of the Dementia Quality of Life questionnaire (D-QOL): UK version
    S Karim
    University of Manchester, Manchester, UK
    Aging Ment Health 12:144-8. 2008
    ..We conclude that the UK version of D-QOL is a reliable and valid measure of quality of life in UK population with mild to moderate dementia...
  26. ncbi request reprint Paradoxical embolization: a potential cause of cerebral damage in Alzheimer's disease?
    N Purandare
    Division of Psychiatry, Education and Research Center, Wythenshawe Hospital, Wythenshawe, Manchester, M23 9LT, UK
    Neurol Res 28:679-84. 2006
    ..We reviewed the potential role of paradoxical embolization in AD...
  27. ncbi request reprint Health of the Nation Outcome Scales for elderly people (HoNOS 65+)
    A Burns
    Department of Psychiatry, University of Manchester, Withington Hospital
    Br J Psychiatry 174:424-7. 1999
    ..Health of the Nation Outcome Scales (HoNOS) have been developed to measure of outcomes in people with mental health problems...
  28. pmc Treatment of dementia
    R Overshott
    Department of Old Age Psychiatry, Wythenshawe Hospital, Manchester M23 9LT, UK
    J Neurol Neurosurg Psychiatry 76:v53-9. 2005
  29. ncbi request reprint Asymptomatic spontaneous cerebral emboli and mood in a cohort of older people: a prospective study
    Richard C Oude Voshaar
    Division of Psychiatry, Education and Research Centre, University of Manchester, South Manchester University Hospital, Wythenshawe, Manchester, United Kingdom
    Am J Geriatr Psychiatry 15:1057-60. 2007
    ..To examine whether asymptomatic spontaneous cerebral emboli (SCE) predicts subsequent depression in older people...
  30. ncbi request reprint Clinical features of dementia associated with apolipoprotein epsilon4: discrimination with a neural network genetic algorithm
    M F Jefferson
    Department of Geriatric Medicine, University of Manchester, Clinical Sciences Building, Hope Hospital, Stott Lane, Salford, Manchester M6 8HD, UK
    Int J Geriatr Psychiatry 16:77-81. 2001
    ..83, sensitivity=0.78, specificity=0.78). CONCLUSIONS: A GANN is able to discriminate a clinically distinct group of features among dementia patients who express the epsilon4 allele...
  31. doi request reprint The balance of care: reconfiguring services for older people with mental health problems
    S Tucker
    PSSRU, University of Manchester, Manchester, UK
    Aging Ment Health 12:81-91. 2008
    ....
  32. ncbi request reprint Right-hemisphere encephalopathy in elderly subjects with schizophrenia: evidence from neuropsychological and brain imaging studies
    V S Gabrovska-Johnson
    Department of Psychiatry, Cambridgeshire and Peterborough Mental Health Partnership NHS Trust, Hinchingbrooke Hospital, Park House, Nursery Road, PE29 3RJ, Huntingdon, UK
    Psychopharmacology (Berl) 169:367-75. 2003
    ..The pattern of cognitive deficits in this age group is not yet clearly defined, although there is some evidence that it differs from that in Alzheimer's disease. There is little evidence of any underlying specific brain abnormality...
  33. ncbi request reprint Depressive symptoms in patients with Alzheimer's disease
    N Purandare
    University Department of Psychiatry, Withington Hospital, Manchester, UK
    Int J Geriatr Psychiatry 16:960-4. 2001
    ..CONCLUSION: Depressive symptoms occur in AD when co-existing depression is ruled out. Their recognition has implications for the diagnosis of major depression in these patients...
  34. ncbi request reprint Asymptomatic spontaneous cerebral emboli predict cognitive and functional decline in dementia
    Nitin Purandare
    Division of Psychiatry, University of Manchester, Manchester, UK
    Biol Psychiatry 62:339-44. 2007
    ..Spontaneous cerebral emboli (SCE) are frequent in Alzheimer's disease (AD) and vascular dementia (VaD). We investigated the effect of SCE on the rates of cognitive and functional decline in AD and VaD...
  35. ncbi request reprint Cholinesterase inhibitors for Alzheimer's disease: variations in clinical practice in the north-west of England
    Nitin Purandare
    Department of Psychiatary, University of Manchester, Manchester, UK
    Int J Geriatr Psychiatry 21:961-4. 2006
    ..The implementation of the original NICE (2001) guidance that made these drugs available in the UK was not examined in this review process, and was the objective of this study...
  36. ncbi request reprint Cerebral emboli and depressive symptoms in dementia
    Nitin Purandare
    University of Manchester, Division of Psychiatry, Education and Research Centre, South Manchester University Hospital, Manchester M23 9LT, UK
    Br J Psychiatry 189:260-3. 2006
    ..The vascular depression hypothesis and our recent findings of increased frequency of spontaneous cerebral emboli in dementia suggest that such emboli may be involved in the causation of depressive symptoms in dementia...
  37. ncbi request reprint Deletion/insertion polymorphism of the angiotensin-converting enzyme gene and white matter hyperintensities in dementia: A pilot study
    Nitin Purandare
    Division of Psychiatry, Education and Research Center, South Manchester University Hospital, Manchester, United Kingdom
    J Am Geriatr Soc 54:1395-400. 2006
    ..To examine the association between the angiotensin-converting enzyme (ACE) deletion/insertion (D/I) polymorphism and white matter hyperintensities (WMHs) in patients with dementia...
  38. ncbi request reprint Old age mental health services in England: implementing the National Service Framework for Older People
    Sue Tucker
    PSSRU, University of Manchester, Manchester, UK
    Int J Geriatr Psychiatry 22:211-7. 2007
    ..In England, the National Service Framework for Older People (NSFOP) sought to address these inconsistencies and improve care. This study describes the situation three years after its publication...
  39. doi request reprint The symptomatology of Alzheimer's disease: a cross-cultural study
    Salman Karim
    Psychiatry Research Group, University of Manchester, Manchester, UK
    Int J Geriatr Psychiatry 26:415-22. 2011
    ..This paper presents the results of a trans-cultural study looking at the possible differences in the symptomatology of Alzheimer's disease (AD) in people from Manchester, UK and Rawalpindi, Pakistan...
  40. doi request reprint Dental health of community-living older people attending secondary healthcare: a cross-sectional comparison between those with and without diagnosed mental illness
    Nitin Purandare
    Psychiatry Research Group, School of Community Based Medicine, University of Manchester and Manchester Mental Health and Social Care Trust, Old Age Psychiatry, Manchester, UK
    Int Psychogeriatr 22:417-25. 2010
    ..Mental illness and cognitive impairment are risk factors for poor dental health...
  41. doi request reprint Integrating mental health services for older people in England - from rhetoric to reality
    Sue Tucker
    PSSRU, University of Manchester, Manchester, UK
    J Interprof Care 23:341-54. 2009
    ..The implications of these findings and the challenges inherent in providing integrated care for this client group are discussed...
  42. doi request reprint Cerebral emboli in the genesis of dementia
    Nitin Purandare
    Senior Lecturer in Old Age Psychiatry, Psychiatry Research Group, The University of Manchester, Manchester, UK
    J Neurol Sci 283:17-20. 2009
    ..SCE may represent a potentially treatable target to slow and possibly prevent dementia, both AD and VaD...
  43. doi request reprint Suicide in dementia: 9-year national clinical survey in England and Wales
    Nitin Purandare
    Psychiatry Research Group, School of Community Based Medicine, University of Manchester, University Place, Oxford Road, Manchester M13 9PL, UK
    Br J Psychiatry 194:175-80. 2009
    ..Knowledge of suicide in people with dementia is limited to small case series...
  44. ncbi request reprint Donepezil for Alzheimer's disease
    Boben Benjamin
    Department of Old Age Psychiatry, Second Floor, Education and Resource Centre, Wythenshawe Hopsital, Southmoor Road, Wythenshawe, Manchester, M23 9LT, UK
    Expert Rev Neurother 7:1243-9. 2007
    ..There are a number of newer drug therapies in various stages of pharmacological development, but donepezil should continue to play a major role in the treatment of Alzheimer's disease for the next few years...
  45. ncbi request reprint Depressed mood, cognitive impairment, and survival in older people admitted to care homes in England
    Caroline Sutcliffe
    Personal Social Services Research Unit, University of Manchester, Manchester, United Kingdom
    Am J Geriatr Psychiatry 15:708-15. 2007
    ..To investigate psychiatric morbidity, cognitive impairment, dependency, and survival in residents newly admitted to care homes...
  46. ncbi request reprint Virchow-Robin space dilatation may predict resistance to antidepressant monotherapy in elderly patients with depression
    Tufail F Patankar
    Imaging Science and Biomedical Engineering, Department of Medicine, Stopford Building, University of Manchester, Oxford Rd, Manchester M13 9PT, UK
    J Affect Disord 97:265-70. 2007
    ..This study tested the hypothesis that dilation of Virchow-Robin spaces seen on Magnetic Resonance Imaging (MRI) is associated with treatment resistance in elderly depressed individuals...
  47. ncbi request reprint Knowledge of dementia among South Asian (Indian) older people in Manchester, UK
    Nitin Purandare
    School of Psychiatry and Behavioural Sciences, University of Manchester, Manchester, UK
    Int J Geriatr Psychiatry 22:777-81. 2007
    ..The aim of this study was to examine knowledge of dementia in South Asian older people, as compared with Caucasian older people...
  48. ncbi request reprint Prognosis of late life depression: a three-year cohort study of outcome and potential predictors
    Robert C Baldwin
    Old Age Psychiatry, Manchester Royal Infirmary, Manchester, UK
    Int J Geriatr Psychiatry 21:57-63. 2006
    ..Late-onset depression (LOD) has a poor prognosis which may be worsened by the presence of cerebrovascular disease. Few studies have explored prospectively the influence of vascular risk factors on longer term prognosis...
  49. ncbi request reprint Cerebral emboli and paradoxical embolisation in dementia: a pilot study
    Nitin Purandare
    University of Manchester, School of Psychiatry and Behavioural Sciences, Education and Research Centre, Wythenshawe Hospital, Wythenshawe, Manchester M23 9LT, UK
    Int J Geriatr Psychiatry 20:12-6. 2005
    ....
  50. ncbi request reprint Integrated specialist assessment of older people and predictors of care-home admission
    Paul Clarkson
    Personal Social Services Research Unit, Faculty of Medical and Human Sciences, University of Manchester, UK
    Psychol Med 36:1011-21. 2006
    ..This study examines the value of such collaboration in the assessment of older people at risk of entering care homes...
  51. pmc Cerebral emboli as a potential cause of Alzheimer's disease and vascular dementia: case-control study
    Nitin Purandare
    Department of Psychiatry, University of Manchester, Manchester
    BMJ 332:1119-24. 2006
    ..To compare the occurrence of spontaneous cerebral emboli and venous to arterial circulation shunts in patients with Alzheimer's disease or vascular dementia and controls without dementia...
  52. ncbi request reprint Efficacy of rivastigmine in subjects with moderately severe Alzheimer's disease
    A Burns
    University of Manchester, Wythenshawe Hospital, Manchester, UK
    Int J Geriatr Psychiatry 19:243-9. 2004
    ..Cholinesterase (ChE) inhibitors are primarily used in the treatment of mild to moderate Alzheimer's disease (AD), but may also be effective in more severe disease...
  53. ncbi request reprint Nonpharmacological and pharmacological interventions for symptoms in Alzheimer's disease
    Ross Overshott
    University of Manchester, School of Psychiatry and Behavioural Sciences, Wythenshawe Hospital, Manchester, UK
    Expert Rev Neurother 4:809-21. 2004
    ..In this review, the evidence and appropriateness of both types of intervention for behavioral and psychiatric symptoms in Alzheimer's disease are discussed...
  54. ncbi request reprint Alzheimer's disease
    Alistair Burns
    Department of Old Age Psychiatry, University of Manchester, Wythenshawe Hospital, Manchester, UK
    Lancet 360:163-5. 2002
  55. ncbi request reprint The use of light therapy to lower agitation in people with dementia
    Debbie Sutherland
    Wythenshawe Hospital, Manchester
    Nurs Times 100:32-4. 2004
    ..This article describes practical issues faced when implementing light therapy in a nursing home setting, and attempts to address existing perceptions about its effectiveness...
  56. ncbi request reprint Rating scales in old age psychiatry
    Alistair Burns
    Department of Old Age Psychiatry, University of Manchester, UK
    Br J Psychiatry 180:161-7. 2002
    ..There is a vast array of scales available to assess all aspects of mental and physical health in older people which may be of relevance to the work of old age psychiatrists...
  57. ncbi request reprint Apolipoprotein E epsilon4 allele frequency and age at onset of Alzheimer's disease
    Yvonne Davidson
    Clinical Neuroscience Research Group, Division of Medicine and Neuroscience, University of Manchester, Greater Manchester Neurosciences Centre, Hope Hospital, Salford, UK
    Dement Geriatr Cogn Disord 23:60-6. 2007
    ..44, was highest in the 60-69 years age class, progressively decreasing either side of this age group. APOE epsilon4 allele therefore has its maximum impact between onset ages of between 60 and 70 years...
  58. ncbi request reprint Sertraline in stroke-associated lability of mood
    A Burns
    Department of Old Age Psychiatry, Withington Hospital, Manchester, UK
    Int J Geriatr Psychiatry 14:681-5. 1999
    ..To assess whether a selective serotonin reuptake inhibitor is effective in the treatment of stroke-associated lability of mood...
  59. ncbi request reprint The use of assessment scales in Old Age Psychiatry Services in England and Northern Ireland
    S Reilly
    School of Psychiatry and Behavioural Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK
    Aging Ment Health 8:249-55. 2004
    ..These results provide key material for shaping the provision of psychiatric services for older people..
  60. doi request reprint Alzheimer disease: Perceived efficacy of antidementia drug treatment
    Kevina McAvinchey
    University of Manchester Psychiatry Research Group, University Place, Oxford Road, Manchester, UK
    Nat Rev Neurol 5:302-3. 2009
    ..The study concludes that clinicians generally consider these treatments to be beneficial, and that the provision of support to caregivers seems to further enhance the perceived benefits...
  61. ncbi request reprint The biology of psychosis in older people
    Salman Karim
    Department of Psychiatry, University of Manchester, Wythenshawe Hospital, Education and Research Centre, Manchester, United Kingdom
    J Geriatr Psychiatry Neurol 16:207-12. 2003
    ..Ample evidence suggests that biological substrates underlie many psychotic symptoms. More research will identify causal links between brain changes, symptom appearance, and the effects of psychosocial factors in their genesis...
  62. ncbi request reprint Behavioral and psychological symptoms of dementia: trial design
    Alistair Burns
    University of Manchester, Education and Research Centre, Wythenshawe Hospital, Manchester, UK
    Int Psychogeriatr 15:241-5. 2003
    ..The design of the trials in vascular dementia needs to account for these features. The specific area of BPSD in vascular dementia, their assessment, and relationship to the design of trials are considered in this article...
  63. ncbi request reprint The value of specialist clinical assessment of older people prior to entry to care homes
    David Challis
    Personal Social Services Research Unit, Faculty of Medicine, Dentistry, Nursing and Pharmacy, Dover Street Building, University of Manchester, Manchester M13 9PL, UK
    Age Ageing 33:25-34. 2004
    ..to ascertain the value of employing a specialist clinician's contribution to the assessment of older people prior to care home entry...
  64. ncbi request reprint Dental infections masquerading as skin lesions
    S W Wilson
    Department of Plastic Surgery, Withington Hospital, Manchester, UK
    Br J Plast Surg 54:358-60. 2001
    ..Recognition and treatment of the underlying dental infection is required to allow the resolution of the associated skin lesion. Two illustrative cases are presented...
  65. ncbi request reprint Relationship of deep white matter hyperintensities and cerebral blood flow in severe carotid artery stenosis
    T Patankar
    Imaging Science and Biomedical Engineering, School of Medicine, University of Manchester, Manchester, UK
    Eur J Neurol 13:10-6. 2006
    ..This suggests that microvascular abnormality is the dominant pathogenetic factor in LA even in the presence of severe stenotic/occlusive large vessel disease...
  66. ncbi request reprint The effect of anticholinesterases on personality changes in Alzheimer's disease
    N Purandare
    Wythenshawe Hospital, Nell Lane, West Didsbury, Manchester, UK
    Aging Ment Health 6:350-4. 2002
    ..Further double blind prospective studies are needed to understand natural progression of personality changes in AD and to validate the findings of this study...
  67. ncbi request reprint Is the influence of the pharmaceutical industry on prescribing, research and publication in the field of psychogeriatrics excessive? - No
    Sarmishtha Bhattacharyya
    The University of Manchester, UK
    Int Psychogeriatr 19:1010-4; discussion 1014-20. 2007
  68. ncbi request reprint 'Justifiable depression': how primary care professionals and patients view late-life depression? A qualitative study
    Heather Burroughs
    Division of Primary Care, University of Manchester, Rusholme Academic Unit, Rusholme, Manchester M14 5NP, UK
    Fam Pract 23:369-77. 2006
    ..Depression is the commonest mental health problem in elderly people and continues to be underdiagnosed and undertreated...
  69. ncbi request reprint Mild cognitive impairment in older people
    Alistair Burns
    University of Manchester, School of Psychiatry and Behavioural Sciences, Wythenshawe Hospital, Manchester, UK
    Lancet 360:1963-5. 2002
    ....
  70. ncbi request reprint Inherited frontotemporal dementia in nine British families associated with intronic mutations in the tau gene
    S M Pickering-Brown
    The School of Biological Sciences, Division of Neuroscience, University of Manchester, UK
    Brain 125:732-51. 2002
    ..All eight families with the +16 mutation seem to be part of a common extended pedigree, possibly originating from a founder member residing within the North Wales region of Great Britain...
  71. pmc Genetic associations between cathepsin D exon 2 C-->T polymorphism and Alzheimer's disease, and pathological correlations with genotype
    Y Davidson
    Clinical Neuroscience Research Group, University of Manchester, Greater Manchester Neurosciences Centre, Hope Hospital, Stott Lane, Salford M6 8HD, Manchester, UK
    J Neurol Neurosurg Psychiatry 77:515-7. 2006
    ....
  72. ncbi request reprint Does integration really make a difference? A comparison of old age psychiatry services in England and Northern Ireland
    S Reilly
    PSSRU, School of Psychiatry and Behavioural Sciences University of Manchester, Manchester, UK
    Int J Geriatr Psychiatry 18:887-93. 2003
    ..Social and health services are jointly administered and this arrangement should, in theory, promote collaborative working and interdisciplinary arrangements...
  73. ncbi request reprint Efficacy and tolerability of donepezil in vascular dementia: positive results of a 24-week, multicenter, international, randomized, placebo-controlled clinical trial
    Sandra Black
    University of Toronto, Department of Medicine Division of Neurology, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Stroke 34:2323-30. 2003
    ..Clinical observations suggest that patients with vascular dementia (VaD) may benefit from treatment with cholinesterase inhibitors. This study evaluated the efficacy and safety of donepezil for relieving symptoms of dementia in VaD...
  74. ncbi request reprint Access to diagnostic evaluation and treatment for dementia in Europe
    Gunhild Waldemar
    Memory Disorder Research Group, Department of Neurology, Neuroscience Centre, Copenhagen University Hospital Rigshospitalet, Denmark
    Int J Geriatr Psychiatry 22:47-54. 2007
    ..Culture-sensitive strategies to promote public knowledge and destigmatize dementia are essential. Policy makers and authorities should be made aware of the benefits of early access to diagnosis and treatment...
  75. ncbi request reprint Expressed emotion and attributions in the carers of patients with Alzheimer's disease: the effect on carer burden
    Nicholas Tarrier
    Academic Division of Clinical Psychology, School of Psychiatry and Behavioural Science, University of Manchester, United Kingdom
    J Abnorm Psychol 111:340-9. 2002
    ..Overinvolved carers made attributions of the patient's behavior to causes external to the patient and internal to themselves. Cortisol levels were associated with self-reports of strain and distress...
  76. ncbi request reprint Vascular cognitive impairment
    John T O'Brien
    Institute for Aging and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Lancet Neurol 2:89-98. 2003
    ..Clinical trials in vascular cognitive impairment are in their infancy but support the value of therapeutic interventions for symptomatic treatment...
  77. ncbi request reprint Fear of falling more important than pain and depression for functional recovery after surgery for hip fracture in older people
    Richard C Oude Voshaar
    Radboud University Nijmegen Medical Centre, The Netherlands
    Psychol Med 36:1635-45. 2006
    ..These variables, however, have never been studied together, nor has the timing of psychiatric assessment been taken into account...
  78. ncbi request reprint Grouping for behavioral and psychological symptoms in dementia: clinical and biological aspects. Consensus paper of the European Alzheimer disease consortium
    Philippe H Robert
    Centre Mémoire de Ressources and de Recherche, CHU, Hopital Pasteur, Universite de Nice Sophia Antipolis, 30, avenue de la Voie Romaine, 06002 Nice cedex 1, France
    Eur Psychiatry 20:490-6. 2005
    ..An individually tailored approach taking all these aspects into account is warranted as it may offer more, and better, pharmacological and non-pharmacological treatment opportunities...
  79. ncbi request reprint Alarming arbitrariness in EU prescription and reimbursement criteria for anti-dementia drugs
    Richard C Oude Voshaar
    Int J Geriatr Psychiatry 21:29-31. 2006
  80. ncbi request reprint Neurological findings in late-onset depressive disorder: comparison of individuals with and without depression
    Robert Baldwin
    Department of Old Age Psychiatry, York House, Manchester Mental Health and Social Care NHS Trust, Manchester Royal Infirmary, Oxford Rd, Manchester M13 9BX, UK
    Br J Psychiatry 186:308-13. 2005
    ..Organic factors are thought to be important in late-life depressive disorder but there have been few studies specifically of neurological signs...
  81. ncbi request reprint Predictors of incident depression after hip fracture surgery
    Richard C Oude Voshaar
    Department of Psychiatry, Nijmegen Medical Centre, Radboud University, Nijmegen, The Netherlands
    Am J Geriatr Psychiatry 15:807-14. 2007
    ..The incidence of new-onset depressive symptoms in patients initially not depressed after hip fracture surgery and their relationship with functional recovery is unknown...
  82. ncbi request reprint The impact of psychological factors in recovery following surgery for hip fracture
    Rebekah Proctor
    Manchester Mental Health and Social Care NHS Trust, UK
    Disabil Rehabil 30:716-22. 2008
    ..To increase awareness of psychological factors in recovery from hip fracture and to describe strategies that can be used to help patients in the process of recovery...
  83. ncbi request reprint Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study
    Howard H Feldman
    Division of Neurology, University of British Columbia Hospital, Vancouver, Canada
    Lancet Neurol 6:501-12. 2007
    ..To assess the effect of rivastigmine in patients with mild cognitive impairment (MCI) on the time to clinical diagnosis of Alzheimer's disease (AD) and the rate of cognitive decline...
  84. ncbi request reprint AD2000: design and conclusions
    Clive Holmes
    Lancet 364:1213-4; author reply 1216-7. 2004
  85. ncbi request reprint Apolipoprotein E epsilon4 allele frequency in vascular dementia
    Yvonne Davidson
    Clinical Neuroscience Research Group, Greater Manchester Neurosciences Centre, Hope Hospital, Salford, UK
    Dement Geriatr Cogn Disord 22:15-9. 2006
    ..The aim of the study was to investigate whether possession of the epsilon4 allelic form of the apolipoprotein E (APOE) gene increases the risk of developing vascular dementia (VaD)...
  86. ncbi request reprint Management of agitation, aggression, and psychosis associated with dementia: a pooled analysis including three randomized, placebo-controlled double-blind trials in nursing home residents treated with risperidone
    Peter Paul De Deyn
    Department of Neurology, Memory Clinic, Middelheim Hospital, ZNA, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk Antwerp, Belgium
    Clin Neurol Neurosurg 107:497-508. 2005
    ....
  87. ncbi request reprint Old age psychiatry
    Alistair Burns
    Br J Psychiatry 180:97-8. 2002
  88. ncbi request reprint Has the management of Alzheimer's disease changed over the past 100 years?
    Konrad Maurer
    Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt on Main, Frankfurt, Germany
    Lancet 368:1619-21. 2006
  89. pmc Sensory stimulation in dementia
    Alistair Burns
    BMJ 325:1312-3. 2002
  90. pmc A randomised controlled trial to test the feasibility of a collaborative care model for the management of depression in older people
    Carolyn A Chew-Graham
    Primary Care Research Group, School of Community Based Medicine, University of Manchester
    Br J Gen Pract 57:364-70. 2007
    ..Depression is the most common mental health disorder in people aged over 65 years. Late-life depression is associated with chronic illness and disability...
  91. ncbi request reprint The effects of improving hearing in dementia
    N Harry Allen
    York House, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Age Ageing 32:189-93. 2003
    ..audiological function is impaired in people with dementia and poor hearing is known to exaggerate the effects of cognitive deficits...
  92. ncbi request reprint Skill-based objectives for specialist training in old age psychiatry
    Lars Gustafson
    Departmen tof Psychogeriatrics, University Hospital Lund, Sweden
    Int J Geriatr Psychiatry 18:686-93. 2003
  93. pmc Treating depression in later life
    Carolyn Chew-Graham
    BMJ 329:181-2. 2004
  94. doi request reprint Consensus statement on genetic research in dementia
    Marcel G M Olde Rikkert
    Department of Geriatrics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    Am J Alzheimers Dis Other Demen 23:262-6. 2008
    ..The consensus statement aims to stimulate ethically acceptable research in the field of dementia and the protection of vulnerable elderly patients with dementia from application of inadequate research methods or designs...