Neil G Burnet

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Clinical and Practical Considerations for the Use of Intensity-modulated Radiotherapy and Image Guidance in Neuro-oncology
    N G Burnet
    University of Cambridge Department of Oncology, Cambridge Biomedical Campus, Addenbrooke s Hospital, Cambridge, UK Cancer Research UK VoxTox Research Group, University of Cambridge Department of Oncology, Addenbrooke s Hospital, Cambridge, UK Electronic address
    Clin Oncol (R Coll Radiol) 26:395-406. 2014
  2. pmc Evaluation of poly (ADP-ribose) polymerase inhibitor ABT-888 combined with radiotherapy and temozolomide in glioblastoma
    Lara Barazzuol
    University of Surrey, Guildford, Surrey, GU2 7XH, UK
    Radiat Oncol 8:65. 2013
  3. doi request reprint Practical aspects of implementation of helical tomotherapy for intensity-modulated and image-guided radiotherapy
    N G Burnet
    University of Cambridge Department of Oncology, Oncology Centre, Addenbrooke s Hospital, Cambridge, UK
    Clin Oncol (R Coll Radiol) 22:294-312. 2010
  4. ncbi request reprint High grade glioma: imaging combined with pathological grade defines management and predicts prognosis
    Neil G Burnet
    University of Cambridge Department of Oncology, Oncology Centre, Addenbrooke s Hospital, Cambridge, UK
    Radiother Oncol 85:371-8. 2007
  5. ncbi request reprint Mathematical modelling of survival of glioblastoma patients suggests a role for radiotherapy dose escalation and predicts poorer outcome after delay to start treatment
    N G Burnet
    University of Cambridge, Department of Oncology, Oncology Centre, Addenbrooke s Hospital, UK
    Clin Oncol (R Coll Radiol) 18:93-103. 2006
  6. pmc Years of life lost (YLL) from cancer is an important measure of population burden--and should be considered when allocating research funds
    N G Burnet
    Department of Oncology, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Br J Cancer 92:241-5. 2005
  7. doi request reprint Standardized Total Average Toxicity score: a scale- and grade-independent measure of late radiotherapy toxicity to facilitate pooling of data from different studies
    Gillian C Barnett
    University of Cambridge Department of Oncology, Oncology Centre, Cambridge, UK
    Int J Radiat Oncol Biol Phys 82:1065-74. 2012
  8. doi request reprint Randomized controlled trial of forward-planned intensity modulated radiotherapy for early breast cancer: interim results at 2 years
    Gillian C Barnett
    Department of Oncology, University of Cambridge, Cambridge University Hospitals, National Health Service Foundation Trust, Cambridge, United Kingdom
    Int J Radiat Oncol Biol Phys 82:715-23. 2012
  9. pmc No association between SNPs regulating TGF-β1 secretion and late radiotherapy toxicity to the breast: results from the RAPPER study
    Gillian C Barnett
    Department of Oncology, University of Cambridge, Cambridge, UK
    Radiother Oncol 97:9-14. 2010
  10. ncbi request reprint Predicting patterns of glioma recurrence using diffusion tensor imaging
    Stephen J Price
    Academic Neurosurgery Unit, University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, Addenbrooke s Hospital, UK
    Eur Radiol 17:1675-84. 2007

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Clinical and Practical Considerations for the Use of Intensity-modulated Radiotherapy and Image Guidance in Neuro-oncology
    N G Burnet
    University of Cambridge Department of Oncology, Cambridge Biomedical Campus, Addenbrooke s Hospital, Cambridge, UK Cancer Research UK VoxTox Research Group, University of Cambridge Department of Oncology, Addenbrooke s Hospital, Cambridge, UK Electronic address
    Clin Oncol (R Coll Radiol) 26:395-406. 2014
    ..Image guidance improves the accuracy of dose delivery, which is particularly important where steep dose gradients are present. These technologies should be regarded as the state-of-the-art for our CNS patients. ..
  2. pmc Evaluation of poly (ADP-ribose) polymerase inhibitor ABT-888 combined with radiotherapy and temozolomide in glioblastoma
    Lara Barazzuol
    University of Surrey, Guildford, Surrey, GU2 7XH, UK
    Radiat Oncol 8:65. 2013
    ..The current study investigates the trimodal combination of ABT-888, a potent inhibitor of PARP1-2, ionizing radiation and temozolomide(TMZ)-based chemotherapy in glioblastoma (GBM) cells...
  3. doi request reprint Practical aspects of implementation of helical tomotherapy for intensity-modulated and image-guided radiotherapy
    N G Burnet
    University of Cambridge Department of Oncology, Oncology Centre, Addenbrooke s Hospital, Cambridge, UK
    Clin Oncol (R Coll Radiol) 22:294-312. 2010
    ..Here we report our experience of clinical implementation of daily online IGRT and IMRT using helical tomotherapy...
  4. ncbi request reprint High grade glioma: imaging combined with pathological grade defines management and predicts prognosis
    Neil G Burnet
    University of Cambridge Department of Oncology, Oncology Centre, Addenbrooke s Hospital, Cambridge, UK
    Radiother Oncol 85:371-8. 2007
    ..There is ambiguity in pathological grading of high grade gliomas within the WHO 2000 classification, especially those with predominant oligodendroglial differentiation...
  5. ncbi request reprint Mathematical modelling of survival of glioblastoma patients suggests a role for radiotherapy dose escalation and predicts poorer outcome after delay to start treatment
    N G Burnet
    University of Cambridge, Department of Oncology, Oncology Centre, Addenbrooke s Hospital, UK
    Clin Oncol (R Coll Radiol) 18:93-103. 2006
    ....
  6. pmc Years of life lost (YLL) from cancer is an important measure of population burden--and should be considered when allocating research funds
    N G Burnet
    Department of Oncology, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Br J Cancer 92:241-5. 2005
    ..As well as crude mortality, more subtle and comprehensive calculations of mortality statistics would be useful in debates on research funding and public health issues...
  7. doi request reprint Standardized Total Average Toxicity score: a scale- and grade-independent measure of late radiotherapy toxicity to facilitate pooling of data from different studies
    Gillian C Barnett
    University of Cambridge Department of Oncology, Oncology Centre, Cambridge, UK
    Int J Radiat Oncol Biol Phys 82:1065-74. 2012
    ..We propose a novel metric, the Standardized Total Average Toxicity (STAT) score, to try to overcome these difficulties...
  8. doi request reprint Randomized controlled trial of forward-planned intensity modulated radiotherapy for early breast cancer: interim results at 2 years
    Gillian C Barnett
    Department of Oncology, University of Cambridge, Cambridge University Hospitals, National Health Service Foundation Trust, Cambridge, United Kingdom
    Int J Radiat Oncol Biol Phys 82:715-23. 2012
    ..This single-center randomized trial was designed to investigate whether intensity-modulated radiotherapy (IMRT) reduces late toxicity in patients with early-stage breast cancer...
  9. pmc No association between SNPs regulating TGF-β1 secretion and late radiotherapy toxicity to the breast: results from the RAPPER study
    Gillian C Barnett
    Department of Oncology, University of Cambridge, Cambridge, UK
    Radiother Oncol 97:9-14. 2010
    ....
  10. ncbi request reprint Predicting patterns of glioma recurrence using diffusion tensor imaging
    Stephen J Price
    Academic Neurosurgery Unit, University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, Addenbrooke s Hospital, UK
    Eur Radiol 17:1675-84. 2007
    ..Diffusion tensor imaging is able to predict patterns of tumour recurrence and may allow better individualisation of tumour management and stratification for randomised controlled trials...
  11. doi request reprint Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study
    Gillian C Barnett
    University of Cambridge, Department of Oncology, Cambridge, UK
    Lancet Oncol 13:65-77. 2012
    ..Few associations have been tested in independent validation studies. This prospective study aimed to validate reported associations between genotype and radiation toxicity in a large independent dataset...
  12. ncbi request reprint Patient reported outcome measures (PROMs) following forward planned field-in field IMRT: Results from the Cambridge Breast IMRT trial
    Mukesh B Mukesh
    Oncology Centre, Cambridge University Hospitals NHS Foundation Trust, UK Department of Oncology, Colchester Hospital University NHS Foundation Trust, Essex, UK Electronic address
    Radiother Oncol 111:270-5. 2014
    ....
  13. ncbi request reprint Diffusion tensor imaging of brain tumours at 3T: a potential tool for assessing white matter tract invasion?
    S J Price
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Addenbrooke s NHS Trust and the University of Cambridge, CB2 2QQ, Cambridge, UK
    Clin Radiol 58:455-62. 2003
    ..To determine whether diffusion tensor imaging (DTI) of brain tumours can demonstrate abnormalities distal to hyperintensities on T2-weighted images, and possibly relate these to tumour grade...
  14. ncbi request reprint Detecting glioma invasion of the corpus callosum using diffusion tensor imaging
    S J Price
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Br J Neurosurg 18:391-5. 2004
    ..These abnormalities preceded the development of the tumour. We describe the technique of diffusion tissue signatures to assess tissue infiltration by tumours compared with values from normal volunteers...
  15. doi request reprint Imaging regional variation of cellular proliferation in gliomas using 3'-deoxy-3'-[18F]fluorothymidine positron-emission tomography: an image-guided biopsy study
    S J Price
    Academic Neurosurgery Unit, University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    Clin Radiol 64:52-63. 2009
    ..To compare regional variations in uptake of 3'-deoxy-3'- [(18)F]-fluorothymidine (FLT) images using positron-emission tomography (PET) with measures of cellular proliferation from biopsy specimens obtained by image-guided brain biopsies...
  16. ncbi request reprint Early radiotherapy dose response and lack of hypersensitivity effect in normal brain tissue: a sequential dynamic susceptibility imaging study of cerebral perfusion
    S J Price
    Academic Neurosurgical Unit, Cambridge University and Addenbrooke s Hospital, Cambridge, UK
    Clin Oncol (R Coll Radiol) 19:577-87. 2007
    ..To determine if magnetic resonance perfusion markers can be used as an analytical marker of subclinical normal brain injury after radiotherapy, by looking for a dose-effect relationship...
  17. ncbi request reprint Improved delineation of glioma margins and regions of infiltration with the use of diffusion tensor imaging: an image-guided biopsy study
    S J Price
    Academic Neurosurgical Unit and Wolfson Brain Imaging Centre, Department pf Radiology, University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, Addenbrooke s Hospital, Cambridge, United Kingdom
    AJNR Am J Neuroradiol 27:1969-74. 2006
    ..In this study, results of histologic examination from samples obtained from image-guided brain biopsies were correlated with diffusion tensor images...
  18. ncbi request reprint A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity
    Gillian C Barnett
    Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, UK University of Cambridge, Department of Oncology, Oncology Centre, Cambridge University Hospitals NHS Foundation Trust, UK Electronic address
    Radiother Oncol 111:178-85. 2014
    ..This study was designed to identify common single nucleotide polymorphisms (SNPs) associated with toxicity 2years after radiotherapy...
  19. ncbi request reprint Tissue signature characterisation of diffusion tensor abnormalities in cerebral gliomas
    Stephen J Price
    Department of Radiology, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Eur Radiol 14:1909-17. 2004
    ..The direction of water diffusion was grossly abnormal in these cases. Diffusion tissue signatures may be a useful method of assessing occult white matter infiltration...
  20. ncbi request reprint Diffusion tensor imaging: possible implications for radiotherapy treatment planning of patients with high-grade glioma
    R Jena
    Department of Oncology, University of Cambridge, UK
    Clin Oncol (R Coll Radiol) 17:581-90. 2005
    ..For IHV based on DTI, we use the term IHVDTI. This study assesses the value of DTI for the individualisation of radiotherapy treatment planning for patients with HGG...
  21. doi request reprint A randomised controlled trial of forward-planned radiotherapy (IMRT) for early breast cancer: baseline characteristics and dosimetry results
    Gillian C Barnett
    Department of Oncology, University of Cambridge, Cambridge, UK
    Radiother Oncol 92:34-41. 2009
    ..This paper reports baseline characteristics of trial participants and dosimetry results...
  22. ncbi request reprint Radiotherapy for glioma during pregnancy: fetal dose estimates, risk assessment and clinical management
    Y Haba
    Oncology Centre, The Addenbrooke s Hospital, Cambridge, UK
    Clin Oncol (R Coll Radiol) 16:210-4. 2004
    ..In conclusion, careful choice of linear accelerator for the treatment of a pregnant woman and the use of additional shielding is valuable, as this can dramatically affect fetal dose...
  23. pmc Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype
    Gillian C Barnett
    Department of Oncology, University of Cambridge, Oncology Centre, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Nat Rev Cancer 9:134-42. 2009
    ..Variation in sensitivity to radiation is an inherited genetic trait and recent progress in genotyping raises the possibility of genome-wide studies to characterize genetic profiles that predict patient response to radiotherapy...
  24. doi request reprint Non-pineal supratentorial primitive neuro-ectodermal tumors (sPNET) in teenagers and young adults: Time to reconsider cisplatin based chemotherapy after cranio-spinal irradiation?
    Swethajit Biswas
    Division of Oncology, Oncology Centre, Addenbrooke s Hospital, Cambridge, United Kingdom
    Pediatr Blood Cancer 52:796-803. 2009
    ..The treatment of sPNET for all age groups at our cancer center has been based on the management of medulloblastoma (MB), involving neurosurgical debulking followed by cranio-spinal irradiation (CSI) and systemic chemotherapy...
  25. doi request reprint Stent placement for management of a small parasagittal meningioma. Technical note
    Dharmendra Ganesan
    Academic Neurosurgical Unit, Department of Neurosciences, University of Cambridge, and Department of Oncology, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurosurg 108:377-81. 2008
    ..The authors describe the investigation and technical aspects of stent placement for the stenosed sinus. Good symptomatic relief in the patient was achieved...
  26. ncbi request reprint Immunohistochemical estimation of cell cycle entry and phase distribution in astrocytomas: applications in diagnostic neuropathology
    Ian S Scott
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
    Neuropathol Appl Neurobiol 31:455-66. 2005
    ..Such information may facilitate tumour grading and may enable information of prognostic value to be obtained in the routine diagnostic laboratory...
  27. doi request reprint Pattern of relapse after fractionated external beam radiotherapy for meningioma: experience from Addenbrooke's Hospital
    V Estall
    Cambridge University NHS Hospitals Trust, Cambridge, UK
    Clin Oncol (R Coll Radiol) 21:745-52. 2009
    ..Radiotherapy is an important treatment modality for meningioma. We aimed to review the clinical outcomes for meningioma patients treated with radiotherapy in the Addenbrooke's Hospital Oncology Department...
  28. ncbi request reprint Reduction of radiotherapy-induced late complications in early breast cancer: the role of intensity-modulated radiation therapy and partial breast irradiation. Part I--normal tissue complications
    C E Coles
    Oncology Centre, Box 193, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Clin Oncol (R Coll Radiol) 17:16-24. 2005
    ..Three major normal tissue side-effects will be discussed: cosmetic outcome, cardiac complications and pulmonary side-effects...
  29. ncbi request reprint Conformal rotation therapy with central axis beam block is a feasible alternative to intensity-modulated radiotherapy for chordomas of the cervical spine
    R Jena
    Oncology Centre, Addenbrooke s Hospital, Cambridge, UK
    Clin Oncol (R Coll Radiol) 16:449-56. 2004
    ..We present a simpler technique--conformal rotation therapy with a central axis beam block (CRT + BB), which can provide similar dose distributions...
  30. ncbi request reprint Reduction of radiotherapy-induced late complications in early breast cancer: the role of intensity-modulated radiation therapy and partial breast irradiation. Part II--Radiotherapy strategies to reduce radiation-induced late effects
    C E Coles
    Oncology Centre, Box 193, Addenbrookes s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Clin Oncol (R Coll Radiol) 17:98-110. 2005
    ..Accurate localisation of the tumour bed and application of appropriate clinical target volumes and planning target volumes are discussed in detail, as these concepts are fundamental for partial breast irradiation...
  31. ncbi request reprint Accuracy of a relocatable stereotactic radiotherapy head frame evaluated by use of a depth helmet
    K E Burton
    Department of Oncology, Addenbrooke s Hospital, Cambridge, UK
    Clin Oncol (R Coll Radiol) 14:31-9. 2002
    ..For fractionated stereotactic radiotherapy we use a 3 mm CTV-PTV margin. This system could assist technology transfer to centres starting stereotactic radiotherapy using the GTC frame...
  32. ncbi request reprint How much surplus capacity is required to maintain low waiting times?
    S J Thomas
    Addenbrooke s NHS Trust, Cambridge, UK
    Clin Oncol (R Coll Radiol) 13:24-8. 2001
    ..Without surplus capacity, waiting targets cannot be met. To meet the 2-week waiting target, capacity must exceed mean demand by two patient slots per week for 99% success, or by one slot per week for 90% success...
  33. ncbi request reprint Fractionated conformal radiotherapy in vestibular schwannoma: early results from a single centre
    G Horan
    Oncology Centre, Addenbrookes Hospital, Cambridge, UK
    Clin Oncol (R Coll Radiol) 19:517-22. 2007
    ..To assess the local control and cranial nerve toxicity in vestibular schwannoma patients treated with fractionated conformal radiotherapy delivered using a linear accelerator...
  34. doi request reprint Dose-volume population histogram: a new tool for evaluating plans whilst considering geometrical uncertainties
    T B Nguyen
    Medical Physics Department, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Phys Med Biol 54:935-47. 2009
    ..For OARs, the DVH obtained from DVPH with 90% confidence level is found to be different to the planning organ at risk volume (PRV) DVH recommended by ICRU 62, especially for parallel organs...
  35. doi request reprint The optimization of intensity modulated radiotherapy in cases where the planning target volume extends into the build-up region
    T B Nguyen
    Medical Physics Department, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Phys Med Biol 54:2511-25. 2009
    ..The resulting fluence maps are much simpler than those resulting from PTV optimization and will therefore be simpler to deliver. The method also permits better sparing of organs at risk such as the spinal cord...
  36. ncbi request reprint Describing patients' normal tissue reactions: concerning the possibility of individualising radiotherapy dose prescriptions based on potential predictive assays of normal tissue radiosensitivity. Steering Committee of the BioMed2 European Union Concerted
    N G Burnet
    Department of Clinical Oncology, Addenbrooke s Hospital, Cambridge, UK
    Int J Cancer 79:606-13. 1998
    ..It is hoped that the definitions and terminology proposed here will aid communication in the field of predictive testing of normal tissue radiosensitivity...
  37. ncbi request reprint Practical issues in the implementation of image-guided radiotherapy for the treatment of prostate cancer within a UK department
    Y L Rimmer
    Oncology Centre, Addenbrooke s Hospital, Cambridge, UK
    Clin Oncol (R Coll Radiol) 20:22-30. 2008
    ....
  38. ncbi request reprint High-dose radiotherapy in the management of chordoma and chondrosarcoma of the skull base and cervical spine: Part 1--Clinical outcomes
    K L Foweraker
    Neuro Oncology Unit, Oncology Centre, Addenbrooke s Hospital, Cambridge, UK
    Clin Oncol (R Coll Radiol) 19:509-16. 2007
    ..These tumours are rare and occur in difficult anatomical regions. We reviewed the local control and survival of patients treated in our centre...
  39. ncbi request reprint An audit of clinic consultation times in a cancer centre: implications for national manpower planning
    R J Benson
    Oncology Centre (Box 193, Addenbrooke's Hospital NHS Trust, Hills Road, Cambridge CB2 2QQ, UK
    Clin Oncol (R Coll Radiol) 13:138-43. 2001
    ..These results suggest that the RCR recommendations for consultant expansion substantially underestimates the true number of consultants required for the treatment of cancer patients in the UK...
  40. ncbi request reprint Primary central nervous system lymphoma: a single-centre experience of 55 unselected cases
    D J Hodson
    Department of Haematology, Addenbrooke s Hospital, Cambridge, UK
    Clin Oncol (R Coll Radiol) 17:185-91. 2005
    ..Many published studies describing this approach include a highly selected group of patients. We report a single-centre experience of unselected cases of PCNSL...
  41. ncbi request reprint A tool to measure radiotherapy complexity and workload: derivation from the basic treatment equivalent (BTE) concept
    N G Burnet
    Department of Oncology, Addenbrooke's Hospital, Cambridge, UK
    Clin Oncol (R Coll Radiol) 13:14-23. 2001
    ..1-1.5 minutes for a three- or four-field pelvic plan (i.e. 12%-13%). The models could also be used to aid planning for future linear accelerator provision and for costing radiotherapy treatment...
  42. doi request reprint Excellent local control of paraganglioma in the head and neck with fractionated radiotherapy
    S Lightowlers
    Oncology Centre, Addenbrooke s Hospital, Cambridge, UK
    Clin Oncol (R Coll Radiol) 22:382-9. 2010
    ..The aim of this study was to evaluate the outcomes of radiotherapy for paraganglioma of the head and neck region in order to inform our future practice...
  43. doi request reprint An assessment of action levels in imaging strategies in head and neck cancer using TomoTherapy. Are our margins adequate in the absence of image guidance?
    F Houghton
    Oncology Centre, Addenbrooke s Hospital, Cambridge, UK
    Clin Oncol (R Coll Radiol) 21:720-7. 2009
    ..To assess the adequacy of clinical target volume (CTV) to planning target volume (PTV) treatment planning margins when treating with intensity-modulated radiotherapy without daily image guidance...
  44. ncbi request reprint Early recurrence of benign meningioma correlates with expression of mini-chromosome maintenance-2 protein
    D P J Hunt
    Department of Pathology, University of Cambridge, UK
    Br J Neurosurg 16:10-5. 2002
    ..In conclusion, these results suggest that analysis of Mcm2 expression may facilitate identification of patients with a high risk of meningioma recurrence, for whom adjuvant radiotherapy may be of benefit...
  45. ncbi request reprint Post-partum retreatment with iridium-192 wire brachytherapy for meningioma recurring in pregnancy
    S E Old
    Department of Clinical Oncology, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Clin Oncol (R Coll Radiol) 13:114-6. 2001
    ..The various techniques of brachytherapy in the brain are highlighted. The specific advantages of 192Ir in this patient are discussed...
  46. ncbi request reprint A mathematical model of the treatment and survival of patients with high-grade brain tumours
    Norman F Kirkby
    Fluids and Systems Research Centre, School of Engineering D2, University of Surrey, Guildford, Surrey GU2 7XH, UK
    J Theor Biol 245:112-24. 2007
    ..The model may aid the design of clinical trials using radiotherapy for patients with GBM, especially in helping to estimate the size of trial required. It is also designed in a generic form, and might be applicable to other tumour types...