John Burn

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint Chemoprevention in Lynch syndrome
    John Burn
    Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
    Fam Cancer 12:707-18. 2013
  2. pmc A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis
    John Burn
    Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
    Cancer Prev Res (Phila) 4:655-65. 2011
  3. ncbi request reprint Discovery of structure of DNA: the best is yet to come
    John Burn
    Institute of Human Genetics, Centre for Life, Newcastle upon Tyne NE1 3BZ
    BMJ 334:s9. 2007
  4. pmc Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial
    John Burn
    Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
    Lancet 378:2081-7. 2011
  5. ncbi request reprint Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome
    John Burn
    Institute of Human Genetics, Newcastle University, International Centre for Life, Central Pkwy, Newcastle upon Tyne NE1 3BZ, United Kingdom
    N Engl J Med 359:2567-78. 2008
  6. doi request reprint Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial
    John C Mathers
    Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Lancet Oncol 13:1242-9. 2012
  7. doi request reprint MLH1 Differential allelic expression in mutation carriers and controls
    Mauro Santibanez Koref
    Institute of Human Genetics, University of Newcastle, Newcastle upon Tyne, UK
    Ann Hum Genet 74:479-88. 2010
  8. doi request reprint Genetics, inheritance and strategies for prevention in populations at high risk of colorectal cancer (CRC)
    John Burn
    Institute of Genetic Medicine, Centre for Life Central Parkway, Newcastle upon Tyne, UK
    Recent Results Cancer Res 191:157-83. 2013
  9. ncbi request reprint Are there socio-economic inequalities in age of resection of colorectal cancer in people with HNPCC?
    Jean Adams
    School of Population and Health Sciences, University of Newcastle upon Tyne, UK
    Fam Cancer 2:169-73. 2003
  10. pmc EASI--enrichment of alternatively spliced isoforms
    Julian P Venables
    Institute of Human Genetics, International Centre for Life, Central Parkway, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Nucleic Acids Res 34:e103. 2006

Detail Information

Publications46

  1. ncbi request reprint Chemoprevention in Lynch syndrome
    John Burn
    Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
    Fam Cancer 12:707-18. 2013
    ..CAPP3 will involve a double blind dose non-inferiority trial comparing 100, 300 or 600 mg daily in 3,000 gene carriers. We can now recommend aspirin in people at high risk of colorectal cancer...
  2. pmc A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis
    John Burn
    Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
    Cancer Prev Res (Phila) 4:655-65. 2011
    ..This clinical trial is the largest ever conducted in the setting of FAP and found a trend of reduced polyp load (number and size) with 600 mg of aspirin daily. RS had no clinical effect on adenomas...
  3. ncbi request reprint Discovery of structure of DNA: the best is yet to come
    John Burn
    Institute of Human Genetics, Centre for Life, Newcastle upon Tyne NE1 3BZ
    BMJ 334:s9. 2007
  4. pmc Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial
    John Burn
    Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
    Lancet 378:2081-7. 2011
    ....
  5. ncbi request reprint Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome
    John Burn
    Institute of Human Genetics, Newcastle University, International Centre for Life, Central Pkwy, Newcastle upon Tyne NE1 3BZ, United Kingdom
    N Engl J Med 359:2567-78. 2008
    ..Resistant starch has been associated with an antineoplastic effect on the colon...
  6. doi request reprint Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial
    John C Mathers
    Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Lancet Oncol 13:1242-9. 2012
    ..We assessed the effect of resistant starch on the incidence of colorectal cancer...
  7. doi request reprint MLH1 Differential allelic expression in mutation carriers and controls
    Mauro Santibanez Koref
    Institute of Human Genetics, University of Newcastle, Newcastle upon Tyne, UK
    Ann Hum Genet 74:479-88. 2010
    ..655G>A; p.I219V) and rs1800734 (c.-93 G>A) that are independently associated with expression. These influences are, however, small compared to the differences associated with pathological variants...
  8. doi request reprint Genetics, inheritance and strategies for prevention in populations at high risk of colorectal cancer (CRC)
    John Burn
    Institute of Genetic Medicine, Centre for Life Central Parkway, Newcastle upon Tyne, UK
    Recent Results Cancer Res 191:157-83. 2013
    ..The evidence is now sufficient to recommend aspirin to all Lynch syndrome gene carriers. CAPP3 will recruit 3000 gene carriers into a dose inferiority study to test the relative benefits of 100mg, 300 or 600mg daily doses...
  9. ncbi request reprint Are there socio-economic inequalities in age of resection of colorectal cancer in people with HNPCC?
    Jean Adams
    School of Population and Health Sciences, University of Newcastle upon Tyne, UK
    Fam Cancer 2:169-73. 2003
    ..This trend probably represents socio-economic variations in access to treatment. In addition, age based diagnostic criteria for hereditary non-polyposis colon cancer may, inadvertently, accentuate socio-economic inequalities in outcome...
  10. pmc EASI--enrichment of alternatively spliced isoforms
    Julian P Venables
    Institute of Human Genetics, International Centre for Life, Central Parkway, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Nucleic Acids Res 34:e103. 2006
    ..These contain missing exons, cryptic splice sites or include completely novel exons. EASI beads are stable for months in the fridge and can be easily combined with standard protocols to speed the cloning of novel transcripts...
  11. ncbi request reprint Clinical features and natural history of neuroferritinopathy caused by the FTL1 460InsA mutation
    Patrick F Chinnery
    Institute of Human Genetics, University of Newcastle upon Tyne, UK
    Brain 130:110-9. 2007
    ..Depressed serum ferritin is common and provides a useful screening test in routine practice, and gradient echo brain MRI will identify all symptomatic cases...
  12. ncbi request reprint Can resistant starch and/or aspirin prevent the development of colonic neoplasia? The Concerted Action Polyp Prevention (CAPP) 1 Study
    John C Mathers
    Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Proc Nutr Soc 62:51-7. 2003
    ..Biopsies of macroscopically-normal rectal mucosa are also being collected for assay of putative biomarkers of CRC risk...
  13. doi request reprint Filaggrin null mutations and childhood atopic eczema: a population-based case-control study
    Sara J Brown
    Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
    J Allergy Clin Immunol 121:940-46.e3. 2008
    ..Null mutations within the filaggrin gene (FLG) are associated with moderate-to-severe atopic eczema; their role in mild-to-moderate eczema in the general population is unknown...
  14. ncbi request reprint An investigation of folate-related genetic factors in the determination of birthweight
    Caroline L Relton
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences Child Health, Newcastle Univisersity, Newcastle upon Tyne, UK
    Paediatr Perinat Epidemiol 19:360-7. 2005
    ..However, when placed on a background of deficient maternal nutritional status, they may detrimentally affect fetal growth...
  15. pmc Neuroferritinopathy in a French family with late onset dominant dystonia
    P F Chinnery
    Department of Neurology, The University of Newcastle upon Tyne, UK
    J Med Genet 40:e69. 2003
  16. ncbi request reprint Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development
    H M Arthur
    SMIVS, School of Biochemistry and Genetics, United Kingdom
    Dev Biol 217:42-53. 2000
    ..We anticipate that heterozygous mice will ultimately serve as a useful disease model for HHT1, as some individuals have dilated and fragile blood vessels similar to vascular malformations seen in HHT patients...
  17. ncbi request reprint Developmental genetics of the heart
    J Burn
    Department of Human Genetics, University of Newcastle upon Tyne, UK john
    Curr Opin Genet Dev 6:322-5. 1996
    ..Sadly, the original insertional mutation has resulted in a complex deletion duplication which has slowed discovery of the coding sequence...
  18. pmc Autosomal dominant sacral agenesis: Currarino syndrome
    S A Lynch
    Department of Human Genetics, Newcastle upon Tyne NE2 4AA, UK
    J Med Genet 37:561-6. 2000
    ..We have also estimated risks of malformation in heterozygotes by using Weinburg's proband method on families personally known to us in order to provide accurate genetic counselling information...
  19. ncbi request reprint Nutrition in cancer prevention
    J C Mathers
    Human Nutrition Research Centre, Department of Biological and Nutritional Sciences, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Curr Opin Oncol 11:402-7. 1999
    ..Targeting initial intervention studies in those with explicit genetic predisposition to cancer may have both greater cost-effectiveness and fewer ethical difficulties than do similar studies in the general public...
  20. pmc Gene-gene interaction in folate-related genes and risk of neural tube defects in a UK population
    C L Relton
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    J Med Genet 41:256-60. 2004
    ..To investigate the contribution of polymorphic variation in genes involved in the folate-dependent homocysteine pathway in the aetiology of neural tube defects (NTD)...
  21. doi request reprint Lynch syndrome: history, causes, diagnosis, treatment and prevention (CAPP2 trial)
    John Burn
    Institute of Genetic Medicine, International Centre for Life, Newcastle University, Newcastle upon Tyne, UK
    Dig Dis 30:39-47. 2012
    ..CaPP3 will test different doses of aspirin in at least 3,000 gene carriers to determine whether low-dose aspirin is as effective...
  22. ncbi request reprint Low erythrocyte folate status and polymorphic variation in folate-related genes are associated with risk of neural tube defect pregnancy
    Caroline L Relton
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences Child Health, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne NE2 4LP, UK
    Mol Genet Metab 81:273-81. 2004
    ..001) despite assays being conducted many years after the index pregnancy (17.6+/-12.6 years). Erythrocyte folate levels were depressed in the presence of the MTHFR 677C >T variant...
  23. pmc Genetic variation in VEGF does not contribute significantly to the risk of congenital cardiovascular malformation
    Helen R Griffin
    Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS ONE 4:e4978. 2009
    ..Mutation screening of 93 TOF cases revealed no VEGF coding sequence variants and no changes at splice consensus sequences. Genetic variation in VEGF appears to play a small role, if any, in outflow tract CVM susceptibility...
  24. doi request reprint Twenty-year trends in prevalence and survival of Down syndrome
    Claire Irving
    Department of Paediatric Cardiology, Freeman Hospital, Newcastle upon Tyne, UK
    Eur J Hum Genet 16:1336-40. 2008
    ..Increasing maternal age and improved survival of children with Down syndrome have offset the effects of prenatal diagnosis followed by the termination of pregnancy and declining general birth rate...
  25. ncbi request reprint Therapeutic levels of aspirin and salicylate directly inhibit a model of angiogenesis through a Cox-independent mechanism
    Gillian M Borthwick
    Institute of Human Genetics, International Centre for Life, University of Newcastle, NE1 3BZ, UK
    FASEB J 20:2009-16. 2006
    ..We conclude that aspirin, at therapeutic concentrations, directly inhibits angiogenesis via a Cox-independent mechanism, which may significantly contribute to its neoplastic protective effects...
  26. pmc Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression
    Michael S Cunnington
    Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS Genet 6:e1000899. 2010
    ..Our study suggests that modulation of ANRIL expression mediates susceptibility to several important human diseases...
  27. ncbi request reprint A giant novel gene undergoing extensive alternative splicing is severed by a Cornelia de Lange-associated translocation breakpoint at 3q26.3
    Emma T Tonkin
    Institute of Human Genetics, International Centre for Life, University of Newcastle, NE1 3BZ, Newcastle upon Tyne, Central Parkway, UK
    Hum Genet 115:139-48. 2004
    ..Mutation screening of NAALADL2 in a panel of CdLS patient DNA samples failed to identify patient-specific mutations. We discuss the possibility that the 3q26.3 translocation could nevertheless contribute to pathogenesis...
  28. ncbi request reprint Neuroferritinopathy
    John Burn
    Institute of Human Genetics, Newcastle University, Newcastle on Tyne, UK
    Semin Pediatr Neurol 13:176-81. 2006
    ....
  29. ncbi request reprint Spectrum of movement disorders in neuroferritinopathy
    Douglas E Crompton
    Department of Neurology, Regional Neurosciences Centre, Newcastle upon Tyne, United Kingdom
    Mov Disord 20:95-9. 2005
    ..The diagnosis should therefore be considered in patients with a wide variety of different movement disorders. Characteristic neuroimaging assists in identifying affected individuals...
  30. ncbi request reprint Mouse model for hereditary hemorrhagic telangiectasia has a generalized vascular abnormality
    Evelyn Torsney
    Institute of Human Genetics, International Centre for Life, University of Newcastle upon Tyne, NE1 3BZ, UK
    Circulation 107:1653-7. 2003
    ..The reasons for the variable phenotype in hereditary hemorrhagic telangiectasia are not understood...
  31. pmc Molecular analysis of hereditary nonpolyposis colorectal cancer in the United States: high mutation detection rate among clinically selected families and characterization of an American founder genomic deletion of the MSH2 gene
    Anja Wagner
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Am J Hum Genet 72:1088-100. 2003
    ..Genealogical, molecular, and haplotype studies showed that this deletion represents a North American founder mutation that could be traced back to the 19th century...
  32. ncbi request reprint DNA repair gene polymorphisms, pre-natal factors and the frequency of somatic mutations in the glycophorin-A gene among healthy newborns
    Caroline L Relton
    Genetics Unit, Westlakes Research Institute, Moor Row, Cumbria CA24 3JY, UK
    Mutat Res 545:49-57. 2004
    ..It is concluded that the genotypic variation in DNA repair genes examined in this study has no discernable effect on the genesis of the somatic mutations observed at birth...
  33. ncbi request reprint Celecoxib for the prevention of sporadic colorectal adenomas
    Monica M Bertagnolli
    Brigham and Women s Hospital, Boston, USA
    N Engl J Med 355:873-84. 2006
    ....
  34. ncbi request reprint TGFBR1*6A may contribute to hereditary colorectal cancer
    Yansong Bian
    Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, 676 N St Clair St, Suite 880, Chicago, IL 60611, USA
    J Clin Oncol 23:3074-8. 2005
    ..To test this hypothesis, we determined whether TGFBR16A contributes to a proportion of mismatch repair (MMR) gene mutation-negative hereditary nonpolyposis colorectal cancer (HNPCC) patients...
  35. ncbi request reprint Thymidylate synthase repeat polymorphisms and risk of neural tube defects in a population from the northern United Kingdom
    Craig S Wilding
    Genetics Department, Westlakes Research Institute, Cumbria, United Kingdom
    Birth Defects Res A Clin Mol Teratol 70:483-5. 2004
    ..We investigated the association between this polymorphism and risk of NTD in families affected by NTDs and controls from the northern United Kingdom (UK)...
  36. ncbi request reprint Germ line mutations of mismatch repair genes in hereditary nonpolyposis colorectal cancer patients with small bowel cancer: International Society for Gastrointestinal Hereditary Tumours Collaborative Study
    Jae Gahb Park
    Korean Hereditary Tumor Registry, Laboratory of Cell Biology, Cancer Research Institute and Cancer Research Center, Seoul National University College of Medicine, Korea
    Clin Cancer Res 12:3389-93. 2006
    ..The aim of study was to determine the clinical characteristics and mutational profiles of the mismatch repair genes in hereditary nonpolyposis colorectal cancer (HNPCC) patients with small bowel cancer (SBC)...
  37. ncbi request reprint Polymorphisms of the DNA repair gene XRCC1 and the frequency of somatic mutations at the glycophorin A locus in newborns
    Caroline L Relton
    Genetics Unit, Westlakes Research Institute, Moor Row, Cumbria, UK
    Mutat Res 502:61-8. 2002
    ..Our results suggest that carriers of the Gln/Gln genotype are over represented in this group but the role that the genotype has in the derivation of high NN Vfs remains to be resolved...
  38. pmc Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: report by the colorectal adenoma/carcinoma prevention programme 2
    Annelie Liljegren
    The Oncology Unit of Radiumhemmet at Karolinska University Hospital, Stockholm, Sweden
    J Clin Oncol 26:3434-9. 2008
    ..These prevalences have been estimated previously in smaller studies, and the results have been found to be variable...
  39. ncbi request reprint MLH1 germline epimutations as a factor in hereditary nonpolyposis colorectal cancer
    Megan Hitchins
    Department of Medical Oncology, St Vincent s Hospital, Sydney, New South Wales, Australia
    Gastroenterology 129:1392-9. 2005
    ..In this study, we determined the frequency and role of germline epimutations of MLH1 in HNPCC...
  40. ncbi request reprint Assessing cancer risk
    John Burn
    Expert Rev Anticancer Ther 4:S13-7. 2004
  41. ncbi request reprint Molecular characterization of the spectrum of genomic deletions in the mismatch repair genes MSH2, MLH1, MSH6, and PMS2 responsible for hereditary nonpolyposis colorectal cancer (HNPCC)
    Heleen van der Klift
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Genes Chromosomes Cancer 44:123-38. 2005
    ..The characterization of these genomic rearrangements underlines the importance of genomic deletions in the etiology of HNPCC and will facilitate the development of PCR-based tests for their detection in diagnostic laboratories...
  42. ncbi request reprint Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk
    Emma Jaeger
    Molecular and Population Genetics Laboratory, Cancer Research UK, London WC2A 3PX, UK
    Nat Genet 40:26-8. 2008
    ..In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 x 10(-14))...
  43. ncbi request reprint RE: Correspondence from Wieczorek & Gillessen-Kaesbach and Hing & Parisi
    John M Opitz
    University of Utah, Salt Lake City, Utah
    Am J Med Genet A 140:2385. 2006
  44. pmc A mutation hot spot for nonspecific X-linked mental retardation in the MECP2 gene causes the PPM-X syndrome
    Sabine M Klauck
    Department of Molecular Genome Analysis, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Am J Hum Genet 70:1034-7. 2002
    ..A simple and reliable PCR approach has been developed for detection of the hot spot A140V mutation to prescreen any other unexplained cases of MR before further extensive mutation analyses...
  45. doi request reprint Patenting and licensing in genetic testing
    S Ayme
    Eur J Hum Genet 16:405-11. 2008
    ..Finally, the ESHG is calling upon all stakeholders to start the process of developing a code of conduct for partners with patents, covering ethical aspects as well as smooth licensing arrangements...
  46. pmc The CHEK2 1100delC mutation identifies families with a hereditary breast and colorectal cancer phenotype
    Hanne Meijers-Heijboer
    Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
    Am J Hum Genet 72:1308-14. 2003
    ..The unequivocal definition of the HBCC phenotype opens new avenues to search for this putative HBCC-susceptibility gene...