D J Burn

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. pmc Multiple system atrophy: cellular and molecular pathology
    D J Burn
    Regional Neurosciences Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Mol Pathol 54:419-26. 2001
  2. ncbi request reprint Depression in Parkinson's disease
    D J Burn
    Regional Neurosciences Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Eur J Neurol 9:44-54. 2002
  3. ncbi request reprint Movement Disorders Society Scientific Issues Committee report: SIC Task Force appraisal of clinical diagnostic criteria for Parkinsonian disorders
    Irene Litvan
    Movement Disorder Program, University of Louisville, KY 40205, USA
    Mov Disord 18:467-86. 2003
  4. pmc Frequency of orthostatic hypotension in a community based cohort of patients with Parkinson's disease
    L M Allcock
    Parkinson s Disease Research Unit, Department of Neurology, Sunderland Royal Hospital and Institute for Ageing and Health, University of Newcastle, Sunderland, UK
    J Neurol Neurosurg Psychiatry 75:1470-1. 2004
  5. ncbi request reprint Cholinergic systems in progressive supranuclear palsy
    N M Warren
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Brain 128:239-49. 2005
  6. pmc The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA
    BMC Med 6:32. 2008
  7. ncbi request reprint Neuropsychiatric complications of medical and surgical therapies for Parkinson's disease
    David J Burn
    Department of Neurology, Regional Neurosciences Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE
    J Geriatr Psychiatry Neurol 17:172-80. 2004
  8. ncbi request reprint Cortical Lewy body disease and Parkinson's disease dementia
    David J Burn
    Institute for Aging and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle, UK
    Curr Opin Neurol 19:572-9. 2006
  9. ncbi request reprint Commentary on: Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson's syndrome and PSP-parkinsonism, by D. Williams, R. de Silva, D. Paviour, et al. (Brain-2004-01045.R1)
    David J Burn
    Regional Neurosciences Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Brain 128:1235-6. 2005
  10. ncbi request reprint Toward future therapies in progressive supranuclear palsy
    David J Burn
    Department of Neurology, Regional Neurosciences Centre, Newcastle General Hospital and Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Mov Disord 20:S92-8. 2005

Collaborators

Detail Information

Publications84

  1. pmc Multiple system atrophy: cellular and molecular pathology
    D J Burn
    Regional Neurosciences Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Mol Pathol 54:419-26. 2001
    ..Further research into this devastating condition is urgently needed to improve our understanding of the pathogenesis, and also to produce new treatment approaches...
  2. ncbi request reprint Depression in Parkinson's disease
    D J Burn
    Regional Neurosciences Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Eur J Neurol 9:44-54. 2002
    ..Depression in the PD patient may be associated with a more rapid deterioration in cognitive and motor functions...
  3. ncbi request reprint Movement Disorders Society Scientific Issues Committee report: SIC Task Force appraisal of clinical diagnostic criteria for Parkinsonian disorders
    Irene Litvan
    Movement Disorder Program, University of Louisville, KY 40205, USA
    Mov Disord 18:467-86. 2003
    ..In each of these areas, diagnosis continues to rest on clinical findings and the judicious use of ancillary studies...
  4. pmc Frequency of orthostatic hypotension in a community based cohort of patients with Parkinson's disease
    L M Allcock
    Parkinson s Disease Research Unit, Department of Neurology, Sunderland Royal Hospital and Institute for Ageing and Health, University of Newcastle, Sunderland, UK
    J Neurol Neurosurg Psychiatry 75:1470-1. 2004
    ..Forty two (47%) of patients met the criteria for OH. Subjects with OH were older than those without OH, but there was no difference in PD disease duration or severity, MMSE or depression rating between the groups...
  5. ncbi request reprint Cholinergic systems in progressive supranuclear palsy
    N M Warren
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Brain 128:239-49. 2005
    ..Cholinergic deficits based on clinical and neurochemical parameters are then discussed, before concluding with suggested future directions for cholinergic treatments...
  6. pmc The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA
    BMC Med 6:32. 2008
    ..Studies of the penetrance of LRRK2 mutations have produced a wide range of estimates, possibly due to differences in study design and recruitment, including in particular differences between samples of familial PD versus sporadic PD...
  7. ncbi request reprint Neuropsychiatric complications of medical and surgical therapies for Parkinson's disease
    David J Burn
    Department of Neurology, Regional Neurosciences Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE
    J Geriatr Psychiatry Neurol 17:172-80. 2004
    ..The optimal management approach for surgically related neuropsychiatric problems is unknown at present. Prospective multicenter studies would contribute significantly to resolving this therapeutic uncertainty...
  8. ncbi request reprint Cortical Lewy body disease and Parkinson's disease dementia
    David J Burn
    Institute for Aging and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle, UK
    Curr Opin Neurol 19:572-9. 2006
    ....
  9. ncbi request reprint Commentary on: Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson's syndrome and PSP-parkinsonism, by D. Williams, R. de Silva, D. Paviour, et al. (Brain-2004-01045.R1)
    David J Burn
    Regional Neurosciences Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Brain 128:1235-6. 2005
  10. ncbi request reprint Toward future therapies in progressive supranuclear palsy
    David J Burn
    Department of Neurology, Regional Neurosciences Centre, Newcastle General Hospital and Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Mov Disord 20:S92-8. 2005
    ..We review progress to date in this area and briefly consider future potential therapeutic strategies...
  11. pmc Motor subtype and cognitive decline in Parkinson's disease, Parkinson's disease with dementia, and dementia with Lewy bodies
    D J Burn
    Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, NE4 6BE, UK
    J Neurol Neurosurg Psychiatry 77:585-9. 2006
    ....
  12. ncbi request reprint Use of functional imaging in Parkinsonism and dementia
    David J Burn
    Department of Neurology, Regional Neurosciences Centre, Newcastle General Hospital, United Kingdom
    Mov Disord 18:S88-95. 2003
    ..Longitudinal studies with clinicopathological correlation represent the "gold standard" for fully evaluating functional imaging techniques...
  13. ncbi request reprint Current treatment of dementia with Lewy bodies and dementia associated with Parkinson's disease
    David J Burn
    Department of Neurology, Regional Neurosciences Centre, Newcastle General Hospital, United Kingdom
    Mov Disord 18:S72-9. 2003
    ..Early identification of PD patients at greatest risk of developing dementia would permit early use of disease modifying treatments which represent the "golden fleece" management approach to these groups...
  14. ncbi request reprint Update on dementia with Lewy bodies
    David J Burn
    Regional Neurosciences Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, United Kingdom
    Curr Neurol Neurosci Rep 5:339-44. 2005
    ..Emphasis is given to clinical topics, including the clinical phenomenology, differential diagnosis, and the treatment of core features of the disease...
  15. ncbi request reprint Effects of rivastigmine in patients with and without visual hallucinations in dementia associated with Parkinson's disease
    David Burn
    Regional Neuroscience Center, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Mov Disord 21:1899-907. 2006
    ..Visual hallucinations appear to predict more rapid decline and possibly greater therapeutic benefit from rivastigmine treatment in PDD...
  16. ncbi request reprint Progressive supranuclear palsy: where are we now?
    David J Burn
    University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Lancet Neurol 1:359-69. 2002
    ..No drug treatment significantly and consistently benefits patients, and novel therapies are urgently required...
  17. ncbi request reprint Allelic variation of a functional polymorphism in the serotonin transporter gene and depression in Parkinson's disease
    David J Burn
    Department of Neurology, University of Newcastle upon Tyne, UK
    Parkinsonism Relat Disord 12:139-41. 2006
    ..Using a logistic regression model we found no evidence for an association between 5-HTTLPR genotypes, or the presence of the S allele, and depression...
  18. ncbi request reprint Beyond the iron mask: towards better recognition and treatment of depression associated with Parkinson's disease
    David J Burn
    Neurology, Regional Neurosciences Centre, Newcastle General Hospital, and University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Mov Disord 17:445-54. 2002
    ..Several studies have suggested that depression in the PD patient is associated with a more rapid deterioration in cognitive and motor functions, perhaps as a surrogate marker for more extensive brainstem cell loss...
  19. doi request reprint The treatment of cognitive impairment associated with Parkinson's disease
    David J Burn
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Brain Pathol 20:672-8. 2010
    ..Limited benefit may, however, be possible through exercise programmes and so-called "medical foods", although randomised trials are required to confirm largely anecdotal observations...
  20. doi request reprint Poor attentional function predicts cognitive decline in patients with non-demented Parkinson's disease independent of motor phenotype
    J P Taylor
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    J Neurol Neurosurg Psychiatry 79:1318-23. 2008
    ..People with PD display attentional deficits; however, it is not clear whether attentional deficits in patients with non-demented PD are associated with (i) PIGD phenotype and/or (ii) subsequent cognitive decline...
  21. pmc Effect of levodopa on cognitive function in Parkinson's disease with and without dementia and dementia with Lewy bodies
    S A Molloy
    Institute of Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    J Neurol Neurosurg Psychiatry 77:1323-8. 2006
    ..Therefore, the effect of L-dopa on the cognitive profile of dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD) is unclear...
  22. doi request reprint Impaired attention predicts falling in Parkinson's disease
    L M Allcock
    Institute for Ageing and Health, Newcastle University, UK
    Parkinsonism Relat Disord 15:110-5. 2009
    ..Our objective was to determine whether measures of attention were associated with falls in a large cohort of subjects with PD studied prospectively...
  23. pmc Longitudinal change in 99mTcHMPAO cerebral perfusion SPECT in Parkinson's disease over one year
    M J Firbank
    Institute for Ageing and Health, University of Newcastle upon Tyne, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK
    J Neurol Neurosurg Psychiatry 76:1448-51. 2005
    ..Brain perfusion deficits have been reported previously in subjects with Parkinson's disease in comparison with healthy controls...
  24. ncbi request reprint The prevalence of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) in the UK
    U Nath
    Department of Neurology and Department of Epidemiology and Public Health, School of Health Sciences, University of Newcastle upon Tyne, UK
    Brain 124:1438-49. 2001
    ..The study also confirms the importance of active and detailed case ascertainment in ensuring reliable prevalence estimates...
  25. pmc The role of levodopa in the management of dementia with Lewy bodies
    S Molloy
    Regional Neurosciences Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    J Neurol Neurosurg Psychiatry 76:1200-3. 2005
    ..Levodopa is currently the gold standard oral therapy for Parkinson's disease (PD), but its use in DLB has been tempered by concerns of exacerbating neuropsychiatric symptoms...
  26. pmc The basal ganglia cholinergic neurochemistry of progressive supranuclear palsy and other neurodegenerative diseases
    N M Warren
    Institute for Ageing and Health, Newcastle University, New Castle upon Tyne, UK
    J Neurol Neurosurg Psychiatry 78:571-5. 2007
    ..This relates, in part, to a lack of knowledge of the underlying neurochemical abnormalities, including cholinergic receptor status in the basal ganglia...
  27. ncbi request reprint Visual perception in Parkinson disease dementia and dementia with Lewy bodies
    U P Mosimann
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK
    Neurology 63:2091-6. 2004
    ..To quantify visual discrimination, space-motion, and object-form perception in patients with Parkinson disease dementia (PDD), dementia with Lewy bodies (DLB), and Alzheimer disease (AD)...
  28. doi request reprint Frequency, prevalence, incidence and risk factors associated with visual hallucinations in a sample of patients with Parkinson's disease: a longitudinal 4-year study
    G Gibson
    Institute of Health and Society, Newcastle University, Newcastle, UK
    Int J Geriatr Psychiatry 28:626-31. 2013
    ..To examine the prevalence, incidence and risk factors associated with visual hallucinations (VHs) amongst people suffering from Parkinson's disease (PD)...
  29. ncbi request reprint POLG1 in idiopathic Parkinson disease
    W Tiangyou
    Department of Neurology, University of Newcastle upon Tyne, UK
    Neurology 67:1698-700. 2006
    ..Our observations do not support a role for common POLG1 genetic variants in PD and indicate that dominant POLG1 mutations are a rare cause of parkinsonism in the general population...
  30. doi request reprint Swallowing problems in Parkinson disease: frequency and clinical correlates
    N Miller
    Institute of Health and Society, Speech and Language Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, UK
    J Neurol Neurosurg Psychiatry 80:1047-9. 2009
    ..The aim of this study was to establish the frequency of impaired swallowing in people with PD and the relationship between swallowing performance and indicators of disease progression...
  31. ncbi request reprint Regional cerebral blood flow in Parkinson's disease with and without dementia
    M J Firbank
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Neuroimage 20:1309-19. 2003
    ..The perfusion deficits in PDD are similar those in DLB, and in a location associated with visual processing, and may be associated with the visuospatial perception deficits which are present in persons with DLB and PDD...
  32. ncbi request reprint Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium
    I G McKeith
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Neurology 65:1863-72. 2005
    ....
  33. doi request reprint Targeting dopa-sensitive and dopa-resistant gait dysfunction in Parkinson's disease: selective responses to internal and external cues
    Lynn Rochester
    Clinical Ageing Research Unit, Newcastle University, Newcastle upon Tyne, United Kingdom
    Mov Disord 26:430-5. 2011
    ..We explored the effect of two different cue strategies on gait characteristics in relation to their response to dopaminergic medications...
  34. ncbi request reprint More severe functional impairment in dementia with lewy bodies than Alzheimer disease is related to extrapyramidal motor dysfunction
    Ian G McKeith
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Am J Geriatr Psychiatry 14:582-8. 2006
    ..The objective of this study was to compare functional impairments in dementia with Lewy bodies (DLB) and Alzheimer disease (AD) and their relationship with motor and neuropsychiatric symptoms...
  35. doi request reprint Factors predicting discharge of Huntington's disease patients from a neuropsychiatry unit
    Akshya Vasudev
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Int Psychogeriatr 22:489-92. 2010
    ..We explored phenotypic parameters of people with Huntington's disease who had been admitted to a psychiatric unit and then discharged, with a view to determining prognostic factors for discharge to higher levels of care...
  36. doi request reprint Executive dysfunction and attention contribute to gait interference in 'off' state Parkinson's Disease
    Sue Lord
    Department of Medicine, University of Otago Wellington, New Zealand
    Gait Posture 31:169-74. 2010
    ..Whilst both contribute to functional gait, they are used selectively to optimise performance for different conditions and to meet complex task requirements...
  37. ncbi request reprint Systematic review and meta-analysis show that dementia with Lewy bodies is a visual-perceptual and attentional-executive dementia
    Daniel Collerton
    Bensham Hospital, Gateshead, UK
    Dement Geriatr Cogn Disord 16:229-37. 2003
    ..These findings need to be confirmed in prospective, longitudinal, clinicopathological studies...
  38. ncbi request reprint Dementia with Lewy bodies
    Ian McKeith
    Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, UK
    Lancet Neurol 3:19-28. 2004
    ..Clear guidance on the management of DLB is urgently needed. Virtually unrecognised 20 years ago, DLB could within this decade be one of the most treatable neurodegenerative disorders of late life...
  39. ncbi request reprint Hard to swallow: dysphagia in Parkinson's disease
    Nick Miller
    Speech Language Sciences, George VI Building, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Age Ageing 35:614-8. 2006
    ..Little empirical evidence exists concerning the individual's own perception of changes, the impact these have on their life and coping strategies to deal with them...
  40. ncbi request reprint Effects of donepezil on central processing speed and attentional measures in Parkinson's disease with dementia and dementia with Lewy bodies
    Elise Rowan
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 23:161-7. 2007
    ..We examined attention-enhancing effects of the cholinesterase inhibitor donepezil in Dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD) by means of open label study...
  41. ncbi request reprint Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with Lewy bodies
    John T O'Brien
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, England
    Arch Neurol 61:919-25. 2004
    ..Dementia with Lewy bodies (DLB) is a common form of late-life dementia that can be difficult to differentiate from other disorders, especially Alzheimer disease (AD), during life. At autopsy the striatal dopaminergic transporter is reduced...
  42. ncbi request reprint Life with communication changes in Parkinson's disease
    Nick Miller
    Speech Language Sciences, George VI Building, University of Newcastle, Newcastle upon Tyne GB NE1 7RU, UK
    Age Ageing 35:235-9. 2006
    ..Little empirical evidence exists concerning the individual's own perception of changes, the impact these have on their life and coping strategies to deal with them...
  43. doi request reprint Parkinson's disease is overdiagnosed clinically at baseline in diagnostically uncertain cases: a 3-year European multicenter study with repeat [123I]FP-CIT SPECT
    Vicky L Marshall
    Department of Neurology, Southern General Hospital, 1345 Govan Road, Glasgow, Scotland G51 4TF, United Kingdom
    Mov Disord 24:500-8. 2009
    ..The corresponding baseline [123I]FP-CIT SPECT results showed a mean sensitivity of 78% and a specificity of 97%. Inter-reader agreement for rating scans as normal or abnormal was high (Cohen's kappa = 0.94-0.97)...
  44. doi request reprint Retinal thickness in Parkinson's disease
    N K Archibald
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Parkinsonism Relat Disord 17:431-6. 2011
    ..Our aim was to examine the retinal thickness of a cohort of Parkinson's disease subjects (and age-matched controls) to establish the practical utility of optical coherence tomography in a representative older Parkinson's disease group...
  45. ncbi request reprint Clinical features and natural history of progressive supranuclear palsy: a clinical cohort study
    U Nath
    Department of Neurology, School of Health Sciences, University of Newcastle upon Tyne, UK
    Neurology 60:910-6. 2003
    ..To describe clinical features and identify prognostic predictors in progressive supranuclear palsy (PSP)...
  46. ncbi request reprint Progressive supranuclear palsy
    Naomi M Warren
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Pract Neurol 7:16-23. 2007
  47. ncbi request reprint Clinical diagnostic criteria for dementia associated with Parkinson's disease
    Murat Emre
    Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Mov Disord 22:1689-707; quiz 1837. 2007
    ..Based on the characteristic features associated with this condition, clinical diagnostic criteria for probable and possible PD-D are proposed...
  48. ncbi request reprint Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease
    An Goris
    Department of Clinical Neurosciences Neurology Unit, University of Cambridge, Cambridge, United Kingdom
    Ann Neurol 62:145-53. 2007
    ..We investigated the genetic basis of susceptibility to and cognitive heterogeneity of this disease...
  49. ncbi request reprint Rotigotine transdermal patch in early Parkinson's disease: a randomized, double-blind, controlled study versus placebo and ropinirole
    Nir Giladi
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Mov Disord 22:2398-404. 2007
    ..Application-site reactions were predominantly mild or moderate in intensity. In conclusion, the rotigotine transdermal patch represents an effective and safe option for the treatment of patients with early Parkinson's disease...
  50. ncbi request reprint How do I sound to me? Perceived changes in communication in Parkinson's disease
    Nick Miller
    Institute of Health and Society, Speech Language Sciences, University of Newcastle, Newcastle upon Tyne, UK
    Clin Rehabil 22:14-22. 2008
    ..To examine self and carer perceived changes in communication associated with Parkinson's disease and relate these to speech intelligibility, gender, age and other disease measures...
  51. doi request reprint Intact coupling of M1 receptors and preserved M2 and M4 receptors in the cortex in progressive supranuclear palsy: contrast with other dementias
    Naomi M Warren
    Wolfson Research Centre, Newcastle University Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
    J Chem Neuroanat 35:268-74. 2008
    ..We conclude from this first systematic study of cortical muscarinic receptors in PSP that functioning cortical muscarinic receptors are preserved. A further, larger trial of cholinergic therapy, such as an M1 agonist, may be warranted...
  52. ncbi request reprint The application of statistical parametric mapping to 123I-FP-CIT SPECT in dementia with Lewy bodies, Alzheimer's disease and Parkinson's disease
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neuroimage 23:956-66. 2004
    ....
  53. ncbi request reprint Brain atrophy rates in Parkinson's disease with and without dementia using serial magnetic resonance imaging
    Emma J Burton
    Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Mov Disord 20:1571-6. 2005
    ..Serial MRI may be a useful tool for monitoring disease progression in PDD and further studies should investigate its utility for early diagnosis...
  54. pmc Replication of association between ELAVL4 and Parkinson disease: the GenePD study
    Anita L Destefano
    Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Crosstown Center, 3rd Floor, Boston, MA 02118, USA
    Hum Genet 124:95-9. 2008
    ..This replication of association with rs967582 in a third cohort further implicates ELAVL4 as a PD susceptibility gene...
  55. ncbi request reprint Increased Alzheimer pathology in Parkinson's disease related to antimuscarinic drugs
    Elaine K Perry
    MRC Building, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Ann Neurol 54:235-8. 2003
    ..02 and 0.05, respectively). The findings, if replicated, have potential implications for the use of anticholinergic medication in elderly Parkinson's disease patients...
  56. ncbi request reprint Rapidly progressive behavioral changes and parkinsonism in a 68-year-old man
    Galit Kleiner-Fisman
    Department of Medicine, Division of Neurology, Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 19:534-43. 2004
  57. ncbi request reprint Cerebral atrophy in Parkinson's disease with and without dementia: a comparison with Alzheimer's disease, dementia with Lewy bodies and controls
    Emma J Burton
    The Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle General Hospital, Newcastle, UK
    Brain 127:791-800. 2004
    ..This provides important information about the pattern of cerebral atrophy in Parkinson's disease and PDD...
  58. ncbi request reprint Extrapyramidal features in Parkinson's disease with and without dementia and dementia with Lewy bodies: A cross-sectional comparative study
    David J Burn
    Department of Neurology, Regional Neurosciences Centre, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Mov Disord 18:884-9. 2003
    ..Neurodegeneration within the cholinergic system is likely to mediate many of these motor problems, as well as playing a significant role in determining the neuropsychiatric symptomatology of both PDD and DLB...
  59. ncbi request reprint Dementia with Lewy bodies
    Ian G McKeith
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle, UK
    Semin Clin Neuropsychiatry 8:46-57. 2003
    ..Dementia developing late in the course of PD shares many of the same clinical and pathological characteristics...
  60. ncbi request reprint Late-onset axial jerky dystonia due to the DYT1 deletion
    Patrick F Chinnery
    Department of Neurology, The University of Newcastle upon Tyne, United Kingdom
    Mov Disord 17:196-8. 2002
    ..She recalled that her symptoms began 62 years prior to study and remained unchanged for 40 years, illustrating the broad phenotype of DYT1 idiopathic torsion dystonia...
  61. ncbi request reprint Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies
    Urs P Mosimann
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Brain 128:1267-76. 2005
    ..The similarities in saccade performance in PDD and DLB underline the overlap between these conditions and underscore differences from Alzheimer's disease and Parkinson's disease...
  62. pmc Prevalence and pattern of perceived intelligibility changes in Parkinson's disease
    Nick Miller
    Institute of Health and Society, Speech and Language Sciences, George VI Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK
    J Neurol Neurosurg Psychiatry 78:1188-90. 2007
    ..Changes to spoken communication are inevitable in Parkinson's disease (PD). It remains unclear what consequences changes have for intelligibility of speech...
  63. ncbi request reprint Longitudinal study of cerebral blood flow SPECT in Parkinson's disease with dementia, and dementia with Lewy bodies
    Michael J Firbank
    The Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 20:776-82. 2005
    ..Whilst perfusion studies have shown parieto-occipital hypoperfusion in DLB and PDD relative to controls, there have not been any longitudinal studies of perfusion changes in PDD and DLB...
  64. ncbi request reprint In vivo SPECT imaging of muscarinic acetylcholine receptors using (R,R) 123I-QNB in dementia with Lewy bodies and Parkinson's disease dementia
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neuroimage 33:423-9. 2006
    ..123I-QNB binding was also compared to the corresponding cerebral perfusion changes in the same subjects...
  65. ncbi request reprint A comparison of the efficacy of donepezil in Parkinson's disease with dementia and dementia with Lewy bodies
    Alan J Thomas
    Institute for Ageing and Health, University of Newcastle upon Tyne, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 20:938-44. 2005
    ..Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB) overlap in phenomenology and neurochemical deficits. We hypothesised they would not differ in their response to the cholinesterase inhibitor donepezil...
  66. ncbi request reprint Progression of white matter hyperintensities in Alzheimer disease, dementia with lewy bodies, and Parkinson disease dementia: a comparison with normal aging
    Emma J Burton
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Am J Geriatr Psychiatry 14:842-9. 2006
    ..The objective of this study was to investigate cross-sectional and longitudinal white matter hyperintensity (WMH) changes in older subjects with clinically diagnosed dementia...
  67. ncbi request reprint Prevalence and severity of gait disorders in Alzheimer's and non-Alzheimer's dementias
    Louise M Allan
    Institute for Aging and Health, University of Newcastle upon Tyne, United Kingdom
    J Am Geriatr Soc 53:1681-7. 2005
    ....
  68. ncbi request reprint Subjectively reported sleep quality and excessive daytime somnolence in Parkinson's disease with and without dementia, dementia with Lewy bodies and Alzheimer's disease
    Frauke Boddy
    Institute for Ageing and Health, University of Newcastle, UK
    Int J Geriatr Psychiatry 22:529-35. 2007
    ..We investigated whether sleep dysfunction and EDS associate with motor phenotype in PD, PDD and DLB...
  69. ncbi request reprint Change in perfusion, hallucinations and fluctuations in consciousness in dementia with Lewy bodies
    John T O'Brien
    Institute for Ageing and Health, University of Newcastle upon Tyne, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Psychiatry Res 139:79-88. 2005
    ..We have identified important neural correlates of key clinical features in Lewy body dementia and postulate that the associations can be understood through the influence of the cholinergic system on attention...
  70. ncbi request reprint Characterizing behavioral and cognitive dysexecutive changes in progressive supranuclear palsy
    David Millar
    Clinical Psychology, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Mov Disord 21:199-207. 2006
    ..The results show the potential utility of this instrument in characterizing behavioral and emotional changes associated with frontal lobe dysfunction in neurodegenerative disease...
  71. ncbi request reprint Progression of dopaminergic degeneration in dementia with Lewy bodies and Parkinson's disease with and without dementia assessed using 123I-FP-CIT SPECT
    Sean J Colloby
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle University, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Eur J Nucl Med Mol Imaging 32:1176-85. 2005
    ....
  72. ncbi request reprint Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD
    Angela Pyle
    Mitochondrial Research Group, The University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Ann Neurol 57:564-7. 2005
    ....
  73. ncbi request reprint Orthostatic hypotension in Parkinson's disease: association with cognitive decline?
    Liesl M Allcock
    Parkinson s Disease Research Unit, Department of Neurology, Sunderland Royal Hospital, Sunderland, UK
    Int J Geriatr Psychiatry 21:778-83. 2006
    ..We therefore hypothesize that PD patients with orthostatic hypotension (OH) have a different cognitive profile compared to PD patients without OH...
  74. ncbi request reprint Predicting the cost of Parkinson's disease
    Paul McCrone
    King s College London, Centre for the Economics of Mental Health, Health Services Research Department, Institute of Psychiatry, London, United Kingdom
    Mov Disord 22:804-12. 2007
    ..The regression model explained 42% of total follow-up costs and significant predictors included gender (with men having higher costs), disability, and depression...
  75. ncbi request reprint Cholinesterase inhibitors in advanced Dementia with Lewy bodies: increase or stop?
    Sanjeet Pakrasi
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 21:719-21. 2006
    ..There is little data on stopping cholinesterase inhibitors in Dementia with Lewy bodies (DLB). Equally, it is not known if increasing the dose of cholinesterase inhibitors may help neuropsychiatric symptoms in advanced DLB...
  76. ncbi request reprint Characteristics of visual hallucinations in Parkinson disease dementia and dementia with lewy bodies
    Urs P Mosimann
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Am J Geriatr Psychiatry 14:153-60. 2006
    ..Recurrent visual hallucinations (RVH) are common in both disorders. The authors have compared details of hallucination characteristics and associated neuropsychiatric features in DLB and PDD...
  77. pmc Cholinesterase inhibitor use does not significantly influence the ability of 123I-FP-CIT imaging to distinguish Alzheimer's disease from dementia with Lewy bodies
    John Paul Taylor
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    J Neurol Neurosurg Psychiatry 78:1069-71. 2007
    ..As ChEi are frequently used in people with dementia, it is important to determine whether their use affects 123I-FP-CIT uptake in the striatum...
  78. ncbi request reprint Clinical phenotype of subjects with Parkinson's disease and orthostatic hypotension: autonomic symptom and demographic comparison
    Liesl M Allcock
    Institute of Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Mov Disord 21:1851-5. 2006
    ..Longitudinal studies of changes in autonomic reflex abnormalities, autonomic symptom profiles, and motor severity might clarify these associations...
  79. ncbi request reprint Influence of heterozygosity for parkin mutation on onset age in familial Parkinson disease: the GenePD study
    Mei Sun
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Arch Neurol 63:826-32. 2006
    ..The PARK2 gene at 6q26 encodes parkin, whose inactivation is implicated in an early-onset autosomal recessive form of Parkinson disease (PD)...
  80. ncbi request reprint Screening for Lrrk2 G2019S and clinical comparison of Tunisian and North American Caucasian Parkinson's disease families
    Lianna Ishihara
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
    Mov Disord 22:55-61. 2007
    ....
  81. pmc Sex and Parkinson's disease: a world of difference?
    David J Burn
    J Neurol Neurosurg Psychiatry 78:787. 2007
  82. ncbi request reprint Basal ganglia cholinergic and dopaminergic function in progressive supranuclear palsy
    Naomi M Warren
    Institute for Ageing and Heath, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Mov Disord 22:1594-600. 2007
    ..These results do not account for the poor response to dopaminergic and cholinergic replacement therapies in PSP, and suggest relative preservation of postsynaptic striatal projection neurones bearing D2/M1 receptors...
  83. ncbi request reprint Muscarinic receptors in the thalamus in progressive supranuclear palsy and other neurodegenerative disorders
    Naomi M Warren
    From the Institute for Ageing and Heath, Newcastle General Hospital, London, UK
    J Neuropathol Exp Neurol 66:399-404. 2007
    ..There were no significant changes in the ventrolateral nucleus (motor). Cholinergic dysfunction within the AP and MD nuclei of the thalamus may contribute to behavioral and cognitive disturbances associated with PSP...
  84. ncbi request reprint Mutation of the linker region of the polymerase gamma-1 (POLG1) gene associated with progressive external ophthalmoplegia and Parkinsonism
    Gavin Hudson
    Mitochondrial Research Group, University of Newcastle upon Tyne, United Kingdom
    Arch Neurol 64:553-7. 2007
    ..To define the molecular basis of the autosomal dominant progressive external ophthalmoplegia and parkinsonism in a large family with a dominantly transmitted multiple mitochondrial DNA deletion disorder...