Graham C Burdge

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. ncbi request reprint Effect of altered dietary n-3 fatty acid intake upon plasma lipid fatty acid composition, conversion of [13C]alpha-linolenic acid to longer-chain fatty acids and partitioning towards beta-oxidation in older men
    Graham C Burdge
    Institute of Human Nutrition, University of Southampton, UK
    Br J Nutr 90:311-21. 2003
  2. ncbi request reprint Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults
    Graham C Burdge
    Institute of Human Nutrition, University of Southampton, Southampton, UK
    Reprod Nutr Dev 45:581-97. 2005
  3. ncbi request reprint Docosahexaenoic acid is selectively enriched in plasma phospholipids during pregnancy in Trinidadian women--results of a pilot study
    Graham C Burdge
    Institute of Human Nutrition, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK
    Reprod Nutr Dev 46:63-7. 2006
  4. ncbi request reprint Eicosapentaenoic and docosapentaenoic acids are the principal products of alpha-linolenic acid metabolism in young men*
    Graham C Burdge
    Institute of Human Nutrition, Level C, West Wing, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    Br J Nutr 88:355-63. 2002
  5. ncbi request reprint Maternal protein restriction with or without folic acid supplementation during pregnancy alters the hepatic transcriptome in adult male rats
    Karen A Lillycrop
    Development and Cell Biology, University of Southampton, Bassett Crescent East, Southampton, UK
    Br J Nutr 103:1711-9. 2010
  6. ncbi request reprint Lack of effect of meal fatty acid composition on postprandial lipid, glucose and insulin responses in men and women aged 50-65 years consuming their habitual diets
    Graham C Burdge
    Institute of Human Nutrition, University of Southampton, Southampton, SO16 7PX, UK
    Br J Nutr 96:489-500. 2006
  7. ncbi request reprint Peripheral blood mononuclear cell fatty acid composition and inflammatory mediator production in adult Crohn's disease
    Timothy M Trebble
    School of Medicine, Institute of Human Nutrition, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
    Clin Nutr 23:647-55. 2004
  8. pmc Progressive, transgenerational changes in offspring phenotype and epigenotype following nutritional transition
    Graham C Burdge
    Academic Unit of Human Development and Health, Faculty of Medicine, Institute of Developmental Sciences, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    PLoS ONE 6:e28282. 2011
  9. pmc The nature of the growth pattern and of the metabolic response to fasting in the rat are dependent upon the dietary protein and folic acid intakes of their pregnant dams and post-weaning fat consumption
    Graham C Burdge
    Institute of Human Nutrition, University of Southampton, Southampton, SO16 6YD, UK
    Br J Nutr 99:540-9. 2008
  10. ncbi request reprint Polyunsaturated fatty acid concentrations in young men and women consuming their habitual diets
    Lucy Bakewell
    Institute of Human Nutrition, Developmental Origins of Health and Disease Division, University of Southampton, Southampton SO16 7PX, UK
    Br J Nutr 96:93-9. 2006

Detail Information

Publications61

  1. ncbi request reprint Effect of altered dietary n-3 fatty acid intake upon plasma lipid fatty acid composition, conversion of [13C]alpha-linolenic acid to longer-chain fatty acids and partitioning towards beta-oxidation in older men
    Graham C Burdge
    Institute of Human Nutrition, University of Southampton, UK
    Br J Nutr 90:311-21. 2003
    ..This suggests regulation of ALNA conversion may limit the influence of variations in dietary n-3 fatty acid intake on plasma lipid compositions...
  2. ncbi request reprint Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults
    Graham C Burdge
    Institute of Human Nutrition, University of Southampton, Southampton, UK
    Reprod Nutr Dev 45:581-97. 2005
    ..Capacity to up-regulate alphaLNA conversion in women may be important for meeting the demands of the fetus and neonate for DHA...
  3. ncbi request reprint Docosahexaenoic acid is selectively enriched in plasma phospholipids during pregnancy in Trinidadian women--results of a pilot study
    Graham C Burdge
    Institute of Human Nutrition, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK
    Reprod Nutr Dev 46:63-7. 2006
    ..These data accord with the suggestion that the enrichment of alpha-LNA in TAG and of DHA in phospholipids reflects hepatic regulation of n-3 PUFA metabolism which potentially enhances the delivery of DHA to the placenta...
  4. ncbi request reprint Eicosapentaenoic and docosapentaenoic acids are the principal products of alpha-linolenic acid metabolism in young men*
    Graham C Burdge
    Institute of Human Nutrition, Level C, West Wing, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    Br J Nutr 88:355-63. 2002
    ..Since the capacity of adult males to convert ALNA to DHA was either very low or absent, uptake of pre-formed DHA from the diet may be critical for maintaining adequate membrane DHA concentrations in these individuals...
  5. ncbi request reprint Maternal protein restriction with or without folic acid supplementation during pregnancy alters the hepatic transcriptome in adult male rats
    Karen A Lillycrop
    Development and Cell Biology, University of Southampton, Bassett Crescent East, Southampton, UK
    Br J Nutr 103:1711-9. 2010
    ..The present findings show that the pattern of induced changes in the adult liver transcriptome were dependent on maternal protein and folic acid intakes during pregnancy...
  6. ncbi request reprint Lack of effect of meal fatty acid composition on postprandial lipid, glucose and insulin responses in men and women aged 50-65 years consuming their habitual diets
    Graham C Burdge
    Institute of Human Nutrition, University of Southampton, Southampton, SO16 7PX, UK
    Br J Nutr 96:489-500. 2006
    ..These results suggest that differences in meal fatty acid composition exert little or no effect on postprandial changes in plasma lipids, glucose and insulin concentrations...
  7. ncbi request reprint Peripheral blood mononuclear cell fatty acid composition and inflammatory mediator production in adult Crohn's disease
    Timothy M Trebble
    School of Medicine, Institute of Human Nutrition, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
    Clin Nutr 23:647-55. 2004
    ..The aim of this study is to investigate n-3 and n-6 PUFA composition and synthetic function of peripheral blood mononuclear cells (PBMC) in the basal state...
  8. pmc Progressive, transgenerational changes in offspring phenotype and epigenotype following nutritional transition
    Graham C Burdge
    Academic Unit of Human Development and Health, Faculty of Medicine, Institute of Developmental Sciences, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    PLoS ONE 6:e28282. 2011
    ..The transgenerational effects on phenotype were associated with altered DNA methylation of specific genes in a manner consistent with induction de novo of epigenetic marks in each generation...
  9. pmc The nature of the growth pattern and of the metabolic response to fasting in the rat are dependent upon the dietary protein and folic acid intakes of their pregnant dams and post-weaning fat consumption
    Graham C Burdge
    Institute of Human Nutrition, University of Southampton, Southampton, SO16 6YD, UK
    Br J Nutr 99:540-9. 2008
    ..Prevention by increased folic acid intake of an altered metabolic phenotype by maternal protein-restriction may be at the expense of somatic growth...
  10. ncbi request reprint Polyunsaturated fatty acid concentrations in young men and women consuming their habitual diets
    Lucy Bakewell
    Institute of Human Nutrition, Developmental Origins of Health and Disease Division, University of Southampton, Southampton SO16 7PX, UK
    Br J Nutr 96:93-9. 2006
    ..Overall, the present data support the suggestion that greater DHA synthesis in women than men results in a higher DHA concentration in plasma lipids...
  11. doi request reprint Non-imprinted epigenetics in fetal and postnatal development and growth
    Keith M Godfrey
    MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Southampton, UK
    Nestle Nutr Inst Workshop Ser 71:57-63. 2013
    ..Elucidation of epigenetic processes may enable early intervention strategies to improve early development and growth...
  12. pmc Effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart
    Joanne L Slater-Jefferies
    Institute of Human Nutrition, University of Southampton School of Medicine, Institute of Developmental Sciences Building, MP887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Prostaglandins Leukot Essent Fatty Acids 83:219-23. 2010
    ..These findings suggest that sex is an important factor in determining the incorporation of dietary fatty acids into cardiac lipids. This may have implications for sex differences in susceptibility to heart disease...
  13. ncbi request reprint Increasing the folic acid content of maternal or post-weaning diets induces differential changes in phosphoenolpyruvate carboxykinase mRNA expression and promoter methylation in rats
    Samuel P Hoile
    Academic Unit of Human Development and Health, Faculty of Medicine, Institute of Developmental Sciences, Southampton General Hospital, Tremona Road, Southampton, UK
    Br J Nutr 108:852-7. 2012
    ..Together, these findings show that both the period during the life course and sex influence the effect of increased exposure to folic acid on the epigenetic regulation of PEPCK and glucose homeostasis...
  14. ncbi request reprint Incorporation of cis-9, trans-11 conjugated linoleic acid and vaccenic acid (trans-11 18 : 1) into plasma and leucocyte lipids in healthy men consuming dairy products naturally enriched in these fatty acids
    Graham C Burdge
    Institute of Human Nutrition, Biomedical Sciences Building, University of Southhampton, Bassett Crescent East, Southhampton, S016 7PX, UK
    Br J Nutr 94:237-43. 2005
    ..001) and PBMC (84 %; P = 0.004). Overall, the present study shows that consumption of naturally enriched dairy products in amounts similar to habitual intakes of these foods increased the c9,t11 CLA content of plasma and cellular lipids...
  15. doi request reprint Antiretroviral therapy with or without protease inhibitors impairs postprandial TAG hydrolysis in HIV-infected men
    Lisa J Ware
    Institute of Human Nutrition, Southampton General Hospital, UK
    Br J Nutr 102:1038-46. 2009
    ..If dyslipidaemia is to be minimised in ART, the specific adverse effects of particular combinations during the fed state should be considered...
  16. doi request reprint Epigenetic mechanisms linking early nutrition to long term health
    Karen A Lillycrop
    Centre for Biological Sciences, Institute of Developmental Sciences, University of Southampton, Southampton, UK
    Best Pract Res Clin Endocrinol Metab 26:667-76. 2012
    ..This review will focus on how nutritional cues in early life can alter the epigenome, producing different phenotypes and altered disease susceptibilities...
  17. pmc Epigenetic gene promoter methylation at birth is associated with child's later adiposity
    Keith M Godfrey
    Institute of Developmental Sciences, University of Southampton, Southampton, UK
    Diabetes 60:1528-34. 2011
    ..In animal models, maternal diet alters offspring body composition, accompanied by epigenetic changes in metabolic control genes. Little is known about whether such processes operate in humans...
  18. ncbi request reprint Nutrition, epigenetics, and developmental plasticity: implications for understanding human disease
    Graham C Burdge
    Institute of Human Nutrition, University of Southampton School of Medicine, Southampton, SO16 6YD, United Kingdom
    Annu Rev Nutr 30:315-39. 2010
    ..The purpose of this review is to discuss recent advances in understanding the mechanism that underlies the early life origins of disease and to place these studies in a broader life-course context...
  19. pmc Nutrition in early life, and risk of cancer and metabolic disease: alternative endings in an epigenetic tale?
    Graham C Burdge
    Institute of Human Nutrition, Southampton General Hospital, Tremona Road, Southampton, UK
    Br J Nutr 101:619-30. 2009
    ..However, the induction of specific disease risk is dependent upon the nature of the environmental challenge and interactions between the susceptibility set by the altered epigenome and the environment throughout the life course...
  20. ncbi request reprint Inhibition of tumour necrosis factor-alpha and interleukin 6 production by mononuclear cells following dietary fish-oil supplementation in healthy men and response to antioxidant co-supplementation
    Timothy Trebble
    The Institute of Human Nutrition, School of Medicine, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
    Br J Nutr 90:405-12. 2003
    ..Thus, increased dietary n-3 PUFA consumption resulted in defined but contrasting patterns of modulation of phospholipid fatty acid composition and PBMC function, which were further influenced by antioxidant intake...
  21. pmc Epigenetic regulation of transcription: a mechanism for inducing variations in phenotype (fetal programming) by differences in nutrition during early life?
    Graham C Burdge
    DOHaD Research Division, University of Southampton, Bassett Cresent East, Southampton, UK
    Br J Nutr 97:1036-46. 2007
    ..The demonstration of altered epigenetic regulation of genes in phenotype induction suggests the possibility of interventions to modify long-term disease risk associated with unbalanced nutrition in early life...
  22. ncbi request reprint Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women
    Graham C Burdge
    Institute of Human Nutrition, University of Southampton, Southampton, UK
    Br J Nutr 88:411-20. 2002
    ..Differences in DHA status between women both in the non-pregnant state and in pregnancy may reflect variations in metabolic capacity for DHA synthesis...
  23. ncbi request reprint Effect of reduced maternal protein intake in pregnancy in the rat on the fatty acid composition of brain, liver, plasma, heart and lung phospholipids of the offspring after weaning
    Graham C Burdge
    Institute of Human Nutrition, Biomedical Sciences Building 62, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Br J Nutr 90:345-52. 2003
    ..These results suggest that restricted maternal protein intake during pregnancy results in persistent alterations to membrane fatty acid content...
  24. ncbi request reprint Incorporation of cis-9,trans-11 or trans-10,cis-12 conjugated linoleic acid into plasma and cellular lipids in healthy men
    Graham C Burdge
    Institute of Human Nutrition, University of Southampton, Southampton, SO16 7PX UK
    J Lipid Res 45:736-41. 2004
    ..These data suggest that the level of intake is a major determinant of plasma and PBMC CLA content, although PBMCs appear to incorporate both CLA isomers less readily...
  25. doi request reprint Epigenetics: are there implications for personalised nutrition?
    Graham C Burdge
    Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Tremona Road, Southampton, UK
    Curr Opin Clin Nutr Metab Care 15:442-7. 2012
    ..Findings from animal models and human cohorts are discussed in the context of whether or not epigenetics may be an important factor in the progress towards the goal of personalised nutrition...
  26. doi request reprint The effect of nutrition during early life on the epigenetic regulation of transcription and implications for human diseases
    Karen A Lillycrop
    Centre for Biological Sciences, Institute of Developmental Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, UK
    J Nutrigenet Nutrigenomics 4:248-60. 2011
    ....
  27. ncbi request reprint Acute consumption of fish oil improves postprandial VLDL profiles in healthy men aged 50-65 years
    Graham C Burdge
    Institute of Human Nutrition, Southampton General Hospital, University of Southampton, Developmental Sciences Building, Mail point 887, Tremona Road, Southampton SO16 6YD, UK
    Br J Nutr 102:160-5. 2009
    ..Increased consumption of fish oil induces acute changes in the VLDL, but not in the LDL or HDL, metabolism...
  28. pmc Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations
    Graham C Burdge
    Developmental Origins of Health and Disease Division, University of Southampton, Southampton, UK
    Br J Nutr 97:435-9. 2007
    ..This may represent a mechanism for the transmission of induced phenotypes between generations..
  29. ncbi request reprint Selective changes to phosphatidylcholine and phosphatidylethanolamine molecular species in the developing fetal guinea pig liver and plasma
    Graham C Burdge
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, UK
    Reprod Nutr Dev 44:571-82. 2004
    ..Overall, these data suggest differential regulation of hepatic PC and PE molecular species composition during development which is essentially independent of the maternal fatty acid supply...
  30. doi request reprint Developmental plasticity and developmental origins of non-communicable disease: theoretical considerations and epigenetic mechanisms
    Mark Hanson
    DOHaD Centre, University of Southampton, Southampton SO166YD, United Kingdom
    Prog Biophys Mol Biol 106:272-80. 2011
    ..Elucidation of epigenetic processes may permit perinatal identification of individuals most at risk of later NCD and enable early intervention strategies to reduce such risk...
  31. doi request reprint Gender differences in the n-3 fatty acid content of tissues
    Caroline E Childs
    School of Medicine, University of Southampton, Southampton SO16 6YD, UK
    Proc Nutr Soc 67:19-27. 2008
    ..These findings suggest that sex hormones act to modify plasma and tissue n-3 PUFA content, possibly by altering the expression of desaturase and elongase enzymes in the liver, which is currently under investigation...
  32. ncbi request reprint Prostaglandin E2 production and T cell function after fish-oil supplementation: response to antioxidant cosupplementation
    Timothy M Trebble
    Institute of Human Nutrition, School of Medicine, University of Southampton, United Kingdom
    Am J Clin Nutr 78:376-82. 2003
    ..The effects of fish oil on lymphocyte proliferation and production of IFN-gamma and IL-4 are unclear and may be influenced by the availability of antioxidants...
  33. ncbi request reprint Homocysteine: a role in fetal programming?
    Graham C Burdge
    Developmental Origins of Health and Disease Research Division, University of Southampton, Southampton
    Br J Nutr 96:415-7. 2006
  34. doi request reprint Umbilical venous-arterial plasma composition differences suggest differential incorporation of fatty acids in NEFA and cholesteryl ester pools
    Rohan M Lewis
    Institute of Developmental Sciences, Faculty of Medicine, University of Southampton, UK
    Br J Nutr 106:463-7. 2011
    ..The present study demonstrates differential enrichment across the placenta of fatty acids into specific lipid pools in the fetal circulation. Such partitioning may facilitate supply of individual fatty acids to specific fetal tissues...
  35. ncbi request reprint PGC1α Promoter Methylation in Blood at 5-7 Years Predicts Adiposity From 9 to 14 Years (EarlyBird 50)
    Rebecca Clarke-Harris
    Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, U K National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton, and University Hospital Southampton National Health Service Foundation Trust, Southampton, U K
    Diabetes 63:2528-37. 2014
    ..These findings suggest that temporally stable CpG loci measured in childhood may have utility in predicting CMD risk. ..
  36. doi request reprint Breast cancer and the importance of early life nutrition
    Karen A Lillycrop
    Centre for Biological Sciences, Institute of Developmental Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, SO16 6YD, UK
    Cancer Treat Res 159:269-85. 2014
    ....
  37. doi request reprint Folic acid supplementation in pregnancy: Are there devils in the detail?
    Graham C Burdge
    Academic Unit of Human Development and Health, Faculty of Medicine, Institute of Developmental Sciences Building MP887, Southampton General Hospital, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
    Br J Nutr 108:1924-30. 2012
    ..Nevertheless, such effects should be investigated thoroughly in order to support firm conclusions about the risk of unanticipated long-term negative effects of maternal FA supplementation in humans...
  38. doi request reprint Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression
    Kimberley D Bruce
    Institute of Developmental Sciences, University of Southampton, Southampton General Hospital, Southampton, UK
    Hepatology 50:1796-808. 2009
    ..In addition, measurement of hepatic gene expression indicated that lipogenesis, oxidative stress, and inflammatory pathways were up-regulated in the 15-week-old HF/C and HF/HF offspring...
  39. pmc Effect of sex hormones on n-3 polyunsaturated fatty acid biosynthesis in HepG2 cells and in human primary hepatocytes
    Charlene M Sibbons
    Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK
    Prostaglandins Leukot Essent Fatty Acids 90:47-54. 2014
    ..These findings show that progesterone increases n-3 PUFA biosynthesis by up-regulating the mRNA expression of genes involved in this pathway, possibly via changes in the epigenetic regulation of FADS2. ..
  40. ncbi request reprint Plasma cytokine response during the postprandial period: a potential causal process in vascular disease?
    Graham C Burdge
    Institute of Human Nutrition, Developmental Origins of Adult Health and Disease Division, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Br J Nutr 93:3-9. 2005
    ..Based on these results, we propose a model of a causal mechanism to explain how consumption of a fatty meal may impair vascular dysfunction...
  41. doi request reprint Fatty acids and epigenetics
    Graham C Burdge
    aAcademic Unit of Human Development and Health, Faculty of Medicine bCentre for Biological Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, UK
    Curr Opin Clin Nutr Metab Care 17:156-61. 2014
    ..The purpose of this review is to assess the findings of recent studies on the effects of fatty acids on epigenetic process and the role of epigenetics in regulating fatty acid metabolism...
  42. ncbi request reprint Effect of reduced dietary protein intake on hepatic and plasma essential fatty acid concentrations in the adult female rat: effect of pregnancy and consequences for accumulation of arachidonic and docosahexaenoic acids in fetal liver and brain
    Graham C Burdge
    Institute of Human Nutrition, University of Southampton, Hants, UK
    Br J Nutr 88:379-87. 2002
    ..The present results suggest that lower maternal protein intakes reduce delivery of DHA from the mother to the fetus, which may impair development and function of the fetal brain...
  43. pmc Bridging the gap between epigenetics research and nutritional public health interventions
    Graham C Burdge
    Institute of Human Nutrition, University of Southampton School of Medicine, Institute of Developmental Sciences Building MP887, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    Genome Med 2:80. 2010
    ..Despite the early stage of knowledge in this field and the intellectual, technological and financial challenges, epigenetic research has substantial potential for public health benefits...
  44. ncbi request reprint Regulation of dietary fatty acid entrapment in subcutaneous adipose tissue and skeletal muscle
    Kevin Evans
    Department of Clinical Chemistry, Staffordshire General Hospital, Stafford, UK
    Diabetes 51:2684-90. 2002
    ..Also, fatty acid trapping in skeletal muscle is fundamentally different from that in adipose tissue, in that all the fatty acids released by lipoprotein lipase in skeletal muscle are taken up by the tissue...
  45. pmc Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring
    Karen A Lillycrop
    Development and Cell Biology, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Br J Nutr 100:278-82. 2008
    ..These data show for the first time that prenatal nutrition induces differential changes to the methylation of individual CpG dinucleotides in juvenile rats which persist in adults...
  46. ncbi request reprint Selective partitioning of dietary fatty acids into the VLDL TG pool in the early postprandial period
    Richard B Heath
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, United Kingdom
    J Lipid Res 44:2065-72. 2003
    ..In summary, the contribution of dietary fatty acids to early postprandial VLDL TG is substantial. The role of DHA in VLDL TG production will require further investigation...
  47. ncbi request reprint Premenopausal advantages in postprandial lipid metabolism are lost in women with type 2 diabetes
    Michael G Masding
    Southampton University Hospitals NHS Trust, Southampton, U K
    Diabetes Care 26:3243-9. 2003
    ..Women with type 2 diabetes appear to lose the protection against cardiovascular disease afforded by estrogens. We examined the effects of menopausal status on postprandial clearance of dietary fat in healthy and diabetic women...
  48. ncbi request reprint Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy humans
    Sabine Tricon
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Whiteknights, Reading RG6 6AP, United Kingdom
    Am J Clin Nutr 80:614-20. 2004
    ..However, the effects of CLA on human health and, in particular, the effects of individual CLA isomers are unclear...
  49. ncbi request reprint The effect of dietary supplementation with linoleic acid to late gestation ewes on the fatty acid composition of maternal and fetal plasma and tissues and the synthetic capacity of the placenta for 2-series prostaglandins
    Matthew Elmes
    Reproduction and Development Group, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts, AL9 7TA, UK
    Biochim Biophys Acta 1686:139-47. 2004
    ..Variations in the extent to which the diet altered the polyunsaturated fatty acid (PUFA) content of the different tissues indicated complex interactions between nutrient availability and metabolic adaptation...
  50. ncbi request reprint Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on immune cell function in healthy humans
    Sabine Tricon
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, Reading, United Kingdom
    Am J Clin Nutr 80:1626-33. 2004
    ..However, little information on the effects of CLA on immune function is available, especially in humans. Furthermore, the effects of individual isomers of CLA have not been adequately investigated...
  51. ncbi request reprint Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring
    Karen A Lillycrop
    Development and Cell Biology, University of Southampton, UK
    J Nutr 135:1382-6. 2005
    ..Epigenetic regulation of gene transcription provides a strong candidate mechanism for fetal programming...
  52. ncbi request reprint Effects of dairy products naturally enriched with cis-9,trans-11 conjugated linoleic acid on the blood lipid profile in healthy middle-aged men
    Sabine Tricon
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences and the School of Animal and Microbial Sciences, The University of Reading, Whiteknights, Reading RG6 6AP, United Kingdom
    Am J Clin Nutr 83:744-53. 2006
    ..However, feeding regimens that enhance the CLA content of milk also increase concentrations of trans-18:1 fatty acids. The implications for human health are not yet known...
  53. ncbi request reprint Differences in maternal protein intake in pregnant rats alone alter the docosahexaenoic acid concentration in the fetal and adult offspring
    Graham C Burdge
    Metabolism 55:1429; author reply 1430. 2006
  54. ncbi request reprint Dietary fatty acids make a rapid and substantial contribution to VLDL-triacylglycerol in the fed state
    Richard B Heath
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK
    Am J Physiol Endocrinol Metab 292:E732-9. 2007
    ..We conclude that there is rapid flux of fatty acids from the diet into endogenous pools. Further study of these processes may open up new targets for intervention to reduce VLDL-TG concentrations and postprandial lipemia...
  55. ncbi request reprint Variation in [U-13C] alpha linolenic acid absorption, beta-oxidation and conversion to docosahexaenoic acid in the pre-term infant fed a DHA-enriched formula
    Clifford Mayes
    Neonatal Intensive Care Unit, Royal Maternity Hospital, Belfast, UK
    Pediatr Res 59:271-5. 2006
    ..These results show considerable variation suggesting that the worst absorption of ALNA and the greatest production of DHA occur in infants born at the earliest gestation...
  56. pmc Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and
    Karen A Lillycrop
    Development and Cell Biology, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Br J Nutr 97:1064-73. 2007
    ..These findings suggest that induction in the offspring of altered epigenetic regulation of the hepatic GR1(10) promoter, and hence metabolic phenotype, may be due to reduced Dnmt1 expression...
  57. ncbi request reprint Tissue-specific stable isotope measurements of postprandial lipid metabolism in familial combined hyperlipidaemia
    Kevin Evans
    Department of Clinical Chemistry, Staffordshire General Hospital, Stafford, UK
    Atherosclerosis 197:164-70. 2008
    ..We used stable isotope techniques combined with tissue-specific measurements in adipose tissue and forearm muscle to investigate fatty acid handling by these tissues in the fasting and postprandial states...
  58. pmc Metabolic plasticity during mammalian development is directionally dependent on early nutritional status
    Peter D Gluckman
    Liggins Institute, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand
    Proc Natl Acad Sci U S A 104:12796-800. 2007
    ....
  59. ncbi request reprint UK Food Standards Agency alpha-linolenic acid workshop report
    Peter Sanderson
    Nutrition Division, Food Standards Agency, Aviation House, 125 Kingsway, London WC2 6NH, UK
    Br J Nutr 88:573-9. 2002
    ..The workshop also highlighted the possibility of feeding livestock ALA-rich oils to provide a means of increasing the dietary intake in human consumers of EPA and DHA...
  60. ncbi request reprint The effects of conjugated linoleic acid on human health-related outcomes
    Sabine Tricon
    Hugh Sinclair Unit of Human Nutrition, School of Food Bioscienes, University of Reading, Whiteknights, UK
    Proc Nutr Soc 64:171-82. 2005
    ..These isomer-specific effects need further investigation. Until more is known, CLA supplementation in man should be considered with caution...
  61. ncbi request reprint Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease
    Keith M Godfrey
    Centre for Developmental Origins of Health and Disease, University of Southampton, UK
    Pediatr Res 61:5R-10R. 2007
    ..Future research into epigenetic processes may permit us to develop intervention strategies...