Affiliation: University of Manchester
- Tandem-pore K+ channels mediate inhibition of orexin neurons by glucoseDenis Burdakov
Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom
Neuron 50:711-22. 2006..These results reveal an unexpected energy-sensing pathway in neurons that regulate states of consciousness and energy balance...
- Biophysical re-equilibration of Ca2+ fluxes as a simple biologically plausible explanation for complex intracellular Ca2+ release patternsDenis Burdakov
Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
FEBS Lett 580:463-8. 2006....
- Low-voltage-activated A-current controls the firing dynamics of mouse hypothalamic orexin neuronsDenis Burdakov
Laboratory of Physiology, University of Oxford, Oxford, United Kingdom
Eur J Neurosci 20:3281-5. 2004..These results identify an important determinant of the firing dynamics of orexin neurons, and support the idea that the A-current can control neuronal gain...
- Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situDenis Burdakov
Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
J Neurosci 25:2429-33. 2005..We propose that these direct actions of glucose on the arousal- and metabolism-regulating LH neurons play a key role in the translation of normal variations in body energy resources into appropriate changes in arousal and metabolism...
- Metabolic state signalling through central hypocretin/orexin neuronsDenis Burdakov
Faculty of Life Sciences, University of Manchester, UK
J Cell Mol Med 9:795-803. 2005..Hypocretin/orexin neurons may thus directly translate rises and falls in body energy levels into different states of consciousness...
- Glucose-sensing neurons of the hypothalamusDenis Burdakov
The University of Manchester Faculty of Life Sciences 1 124 Stopford Building, Oxford Road, Manchester M13 9PT, UK
Philos Trans R Soc Lond B Biol Sci 360:2227-35. 2005..These results stress the fundamental importance of hypothalamic glucose-sensing neurons in orchestrating sleep-wake cycles, energy expenditure and feeding behaviour...
- Control of hypothalamic orexin neurons by acid and CO2Rhiannan H Williams
Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, England
Proc Natl Acad Sci U S A 104:10685-90. 2007..The effects of pHe involve acid-induced closure of leak-like K+ channels in the orexin cell membrane. These results suggest a new mechanism of how orexin/hypocretin networks generate homeostatically appropriate firing patterns...
- Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium--calcium exchangerDenis Burdakov
University Laboratory of Physiology, Oxford, OX1 3PT, United Kingdom
J Neurosci 23:4951-7. 2003..Because GABA is a potent stimulus for feeding, in both the ARC and its main projection site, these results suggest a mechanism for how orexin may control appetite...
- Cholecystokinin tunes firing of an electrically distinct subset of arcuate nucleus neurons by activating A-Type potassium channelsDenis Burdakov
University Laboratory of Physiology, Oxford, OX1 3PT, United Kingdom
J Neurosci 22:6380-7. 2002..Our study thus identifies several fundamental biophysical mechanisms underlying the physiological activity of ARC neurons and suggests a novel mechanism by which endogenous CCK may control appetite...
- Electrical signaling in central orexin/hypocretin circuits: tuning arousal and appetite to fit the environmentDenis Burdakov
University Laboratory of Physiology, University of Oxford, UK
Neuroscientist 10:286-91. 2004..Electrical signaling in orexin circuits thereby couples arousal to the environment and synchronizes foraging with states of high alertness...
- Intraluminal calcium as a primary regulator of endoplasmic reticulum functionDenis Burdakov
Faculty of Life Sciences, The University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester M13 9PT, UK
Cell Calcium 38:303-10. 2005..Direct monitoring of [Ca2+](ER) under conditions where the cytosolic [Ca2+] is known may also help to capture elusive biophysical information about the ER, such as the potential difference across the ER membrane...
- Gain control by concerted changes in I(A) and I(H) conductancesDenis Burdakov
Neurosciences Division, Biological Sciences, University of Manchester, Manchester, UK
Neural Comput 17:991-995. 2005..Concerted changes in I(A) and I(H) can thus control neuronal gain while preserving intrinsic activity...
- Acute suppressive and long-term phase modulation actions of orexin on the mammalian circadian clockMino D C Belle
Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom and King s College London and MRC National Institute for Medical Research, London NW7 1AA, United Kingdom
J Neurosci 34:3607-21. 2014....
- Convergent inputs from electrically and topographically distinct orexin cells to locus coeruleus and ventral tegmental areaJ Antonio González
Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
Eur J Neurosci 35:1426-32. 2012..Contrary to previous predictions, our data suggest that medial and lateral orx/hcrt cells, and the different electrical and morphological subclasses of orx/hcrt cells identified to date, send projections to both LC and VTA...
- K+ channels stimulated by glucose: a new energy-sensing pathwayDenis Burdakov
Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, UK
Pflugers Arch 454:19-27. 2007..A hypothesis is outlined whereby the stimulation of brain K+ channels by sugar could relieve stress and enhance reward, although probably at a cost of increased sleepiness...
- Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesityLeona Plum
Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne and Center of Molecular Medicine Cologne CMMC, Cologne, Germany
J Clin Invest 116:1886-901. 2006..Moreover, icv administration of tolbutamide abolished hyperphagia in PPKO mice. These data indicate that PIP3-mediated signals are critical regulators of the melanocortin system via modulation of KATP channels...
- Adaptive sugar sensors in hypothalamic feeding circuitsRhiannan H Williams
Department of Pharmacology, University of Cambridge, Cambridge C82 1PD, United Kingdom
Proc Natl Acad Sci U S A 105:11975-80. 2008..These data provide insights into how vital behavioral orchestrators sense key features of the internal environment while sustaining a basic activity tone required for the stability of consciousness...
- Hypothalamic orexins/hypocretins as regulators of breathingRhiannan H Williams
Department of Pharmacology, University of Cambridge, Cambridge, UK
Expert Rev Mol Med 10:e28. 2008..Overall, these findings suggest that orexins are important for the regulation of breathing and may potentially play a role in the pathophysiology and medical treatment of respiratory disorders...
- Electrical inhibition of identified anorexigenic POMC neurons by orexin/hypocretinXiaosong Ma
University Laboratory of Physiology, Oxford OX1 3PT, United Kingdom
J Neurosci 27:1529-33. 2007..Our results suggest a reduction in the electrical activity of ARC POMC neurons, which is mediated by changes in presynaptic inputs, contributes to the appetite-enhancing action of orexins...
- Unraveling electrical signaling strategies in hypothalamic feeding circuitsDenis Burdakov
Trends Endocrinol Metab 16:202-3. 2005