Denis Burdakov

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose
    Denis Burdakov
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom
    Neuron 50:711-22. 2006
  2. ncbi Metabolic state signalling through central hypocretin/orexin neurons
    Denis Burdakov
    Faculty of Life Sciences, University of Manchester, UK
    J Cell Mol Med 9:795-803. 2005
  3. ncbi Low-voltage-activated A-current controls the firing dynamics of mouse hypothalamic orexin neurons
    Denis Burdakov
    Laboratory of Physiology, University of Oxford, Oxford, United Kingdom
    Eur J Neurosci 20:3281-5. 2004
  4. ncbi Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ
    Denis Burdakov
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 25:2429-33. 2005
  5. ncbi Biophysical re-equilibration of Ca2+ fluxes as a simple biologically plausible explanation for complex intracellular Ca2+ release patterns
    Denis Burdakov
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    FEBS Lett 580:463-8. 2006
  6. ncbi Glucose-sensing neurons of the hypothalamus
    Denis Burdakov
    The University of Manchester Faculty of Life Sciences 1 124 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Philos Trans R Soc Lond B Biol Sci 360:2227-35. 2005
  7. ncbi Control of hypothalamic orexin neurons by acid and CO2
    Rhiannan H Williams
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, England
    Proc Natl Acad Sci U S A 104:10685-90. 2007
  8. ncbi Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium--calcium exchanger
    Denis Burdakov
    University Laboratory of Physiology, Oxford, OX1 3PT, United Kingdom
    J Neurosci 23:4951-7. 2003
  9. ncbi Cholecystokinin tunes firing of an electrically distinct subset of arcuate nucleus neurons by activating A-Type potassium channels
    Denis Burdakov
    University Laboratory of Physiology, Oxford, OX1 3PT, United Kingdom
    J Neurosci 22:6380-7. 2002
  10. ncbi Electrical signaling in central orexin/hypocretin circuits: tuning arousal and appetite to fit the environment
    Denis Burdakov
    University Laboratory of Physiology, University of Oxford, UK
    Neuroscientist 10:286-91. 2004

Collaborators

Detail Information

Publications19

  1. ncbi Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose
    Denis Burdakov
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom
    Neuron 50:711-22. 2006
    ..These results reveal an unexpected energy-sensing pathway in neurons that regulate states of consciousness and energy balance...
  2. ncbi Metabolic state signalling through central hypocretin/orexin neurons
    Denis Burdakov
    Faculty of Life Sciences, University of Manchester, UK
    J Cell Mol Med 9:795-803. 2005
    ..Hypocretin/orexin neurons may thus directly translate rises and falls in body energy levels into different states of consciousness...
  3. ncbi Low-voltage-activated A-current controls the firing dynamics of mouse hypothalamic orexin neurons
    Denis Burdakov
    Laboratory of Physiology, University of Oxford, Oxford, United Kingdom
    Eur J Neurosci 20:3281-5. 2004
    ..These results identify an important determinant of the firing dynamics of orexin neurons, and support the idea that the A-current can control neuronal gain...
  4. ncbi Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ
    Denis Burdakov
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 25:2429-33. 2005
    ..We propose that these direct actions of glucose on the arousal- and metabolism-regulating LH neurons play a key role in the translation of normal variations in body energy resources into appropriate changes in arousal and metabolism...
  5. ncbi Biophysical re-equilibration of Ca2+ fluxes as a simple biologically plausible explanation for complex intracellular Ca2+ release patterns
    Denis Burdakov
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    FEBS Lett 580:463-8. 2006
    ....
  6. ncbi Glucose-sensing neurons of the hypothalamus
    Denis Burdakov
    The University of Manchester Faculty of Life Sciences 1 124 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Philos Trans R Soc Lond B Biol Sci 360:2227-35. 2005
    ..These results stress the fundamental importance of hypothalamic glucose-sensing neurons in orchestrating sleep-wake cycles, energy expenditure and feeding behaviour...
  7. ncbi Control of hypothalamic orexin neurons by acid and CO2
    Rhiannan H Williams
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, England
    Proc Natl Acad Sci U S A 104:10685-90. 2007
    ..The effects of pHe involve acid-induced closure of leak-like K+ channels in the orexin cell membrane. These results suggest a new mechanism of how orexin/hypocretin networks generate homeostatically appropriate firing patterns...
  8. ncbi Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium--calcium exchanger
    Denis Burdakov
    University Laboratory of Physiology, Oxford, OX1 3PT, United Kingdom
    J Neurosci 23:4951-7. 2003
    ..Because GABA is a potent stimulus for feeding, in both the ARC and its main projection site, these results suggest a mechanism for how orexin may control appetite...
  9. ncbi Cholecystokinin tunes firing of an electrically distinct subset of arcuate nucleus neurons by activating A-Type potassium channels
    Denis Burdakov
    University Laboratory of Physiology, Oxford, OX1 3PT, United Kingdom
    J Neurosci 22:6380-7. 2002
    ..Our study thus identifies several fundamental biophysical mechanisms underlying the physiological activity of ARC neurons and suggests a novel mechanism by which endogenous CCK may control appetite...
  10. ncbi Electrical signaling in central orexin/hypocretin circuits: tuning arousal and appetite to fit the environment
    Denis Burdakov
    University Laboratory of Physiology, University of Oxford, UK
    Neuroscientist 10:286-91. 2004
    ..Electrical signaling in orexin circuits thereby couples arousal to the environment and synchronizes foraging with states of high alertness...
  11. ncbi Intraluminal calcium as a primary regulator of endoplasmic reticulum function
    Denis Burdakov
    Faculty of Life Sciences, The University of Manchester, 1.124 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Cell Calcium 38:303-10. 2005
    ..Direct monitoring of [Ca2+](ER) under conditions where the cytosolic [Ca2+] is known may also help to capture elusive biophysical information about the ER, such as the potential difference across the ER membrane...
  12. ncbi Gain control by concerted changes in I(A) and I(H) conductances
    Denis Burdakov
    Neurosciences Division, Biological Sciences, University of Manchester, Manchester, UK
    Neural Comput 17:991-995. 2005
    ..Concerted changes in I(A) and I(H) can thus control neuronal gain while preserving intrinsic activity...
  13. ncbi Convergent inputs from electrically and topographically distinct orexin cells to locus coeruleus and ventral tegmental area
    J Antonio González
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Eur J Neurosci 35:1426-32. 2012
    ..Contrary to previous predictions, our data suggest that medial and lateral orx/hcrt cells, and the different electrical and morphological subclasses of orx/hcrt cells identified to date, send projections to both LC and VTA...
  14. ncbi K+ channels stimulated by glucose: a new energy-sensing pathway
    Denis Burdakov
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, UK
    Pflugers Arch 454:19-27. 2007
    ..A hypothesis is outlined whereby the stimulation of brain K+ channels by sugar could relieve stress and enhance reward, although probably at a cost of increased sleepiness...
  15. ncbi Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity
    Leona Plum
    Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne and Center of Molecular Medicine Cologne CMMC, Cologne, Germany
    J Clin Invest 116:1886-901. 2006
    ..Moreover, icv administration of tolbutamide abolished hyperphagia in PPKO mice. These data indicate that PIP3-mediated signals are critical regulators of the melanocortin system via modulation of KATP channels...
  16. ncbi Adaptive sugar sensors in hypothalamic feeding circuits
    Rhiannan H Williams
    Department of Pharmacology, University of Cambridge, Cambridge C82 1PD, United Kingdom
    Proc Natl Acad Sci U S A 105:11975-80. 2008
    ..These data provide insights into how vital behavioral orchestrators sense key features of the internal environment while sustaining a basic activity tone required for the stability of consciousness...
  17. ncbi Hypothalamic orexins/hypocretins as regulators of breathing
    Rhiannan H Williams
    Department of Pharmacology, University of Cambridge, Cambridge, UK
    Expert Rev Mol Med 10:e28. 2008
    ..Overall, these findings suggest that orexins are important for the regulation of breathing and may potentially play a role in the pathophysiology and medical treatment of respiratory disorders...
  18. ncbi Electrical inhibition of identified anorexigenic POMC neurons by orexin/hypocretin
    Xiaosong Ma
    University Laboratory of Physiology, Oxford OX1 3PT, United Kingdom
    J Neurosci 27:1529-33. 2007
    ..Our results suggest a reduction in the electrical activity of ARC POMC neurons, which is mediated by changes in presynaptic inputs, contributes to the appetite-enhancing action of orexins...
  19. ncbi Unraveling electrical signaling strategies in hypothalamic feeding circuits
    Denis Burdakov
    Trends Endocrinol Metab 16:202-3. 2005