B Burchell

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. ncbi request reprint Molecular genetic basis of Gilbert's syndrome
    B Burchell
    Department of Molecular and Cellular Pathology, Ninewells Medical School, The University, Dundee, Scotland
    J Gastroenterol Hepatol 14:960-6. 1999
  2. ncbi request reprint Drug-mediated toxicity caused by genetic deficiency of UDP-glucuronosyltransferases
    B Burchell
    Department of Molecular Pathology, Ninewells Medical School, University of Dundee, Dundee, UK
    Toxicol Lett 112:333-40. 2000
  3. ncbi request reprint Genetic variation of human UDP-glucuronosyltransferase: implications in disease and drug glucuronidation
    Brian Burchell
    Department of Molecular and Cellular Pathology, Ninewells Medical School, University of Dundee, Dundee, Scotland
    Am J Pharmacogenomics 3:37-52. 2003
  4. ncbi request reprint Gilbert's syndrome is a contributory factor in prolonged unconjugated hyperbilirubinemia of the newborn
    G Monaghan
    Departments of Molecular and Cellular Pathology, Child Health, and Obstetrics and Gynaecology, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland
    J Pediatr 134:441-6. 1999
  5. ncbi request reprint Genetic defects of the UDP-glucuronosyltransferase-1 (UGT1) gene that cause familial non-haemolytic unconjugated hyperbilirubinaemias
    D J Clarke
    Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Medical School, Scotland, UK
    Clin Chim Acta 266:63-74. 1997
  6. ncbi request reprint Almokalant glucuronidation in human liver and kidney microsomes: evidence for the involvement of UGT1A9 and 2B7
    B K Gaiser
    Department of Molecular and Cellular Pathology, Ninewells Medical School, University of Dundee DD1 9SY, UK
    Xenobiotica 33:1073-83. 2003
  7. ncbi request reprint Structure of the human UGT2B4 gene encoding a bile acid UDP-glucuronosyltransferase
    G Monaghan
    Department of Molecular and Cellular Pathology, Ninewells Hospital and Medical School, The University of Dundee, DD1 9SY, Scotland, UK
    Mamm Genome 8:692-4. 1997
  8. ncbi request reprint Characterization of the uridine diphosphate-glucuronosyltransferase-catalyzing thyroid hormone glucuronidation in man
    K A Findlay
    Department of Molecular and Cellular Pathology, Ninewells Hospital and Medical School, University of Dundee, Scotland
    J Clin Endocrinol Metab 85:2879-83. 2000
  9. ncbi request reprint In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance
    M G Soars
    Department of Molecular and Cellular Pathology, Ninewells Hospital and Medical School, Dundee, Scotland
    J Pharmacol Exp Ther 301:382-90. 2002
  10. ncbi request reprint Treatment of mammalian cells with the endoplasmic reticulum-proliferator compactin strongly induces recombinant and endogenous xenobiotic metabolizing enzymes and 3-hydroxy-3-methylglutaryl-CoA reductase in vitro
    L McLaughlin
    Biomedical Research Centre and Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
    J Cell Sci 112:515-23. 1999

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Molecular genetic basis of Gilbert's syndrome
    B Burchell
    Department of Molecular and Cellular Pathology, Ninewells Medical School, The University, Dundee, Scotland
    J Gastroenterol Hepatol 14:960-6. 1999
    ..The genetic variation described as Gilbert's syndrome may lead to pharmacological variation in drug glucuronidation and unexpected toxicity from therapeutic agents...
  2. ncbi request reprint Drug-mediated toxicity caused by genetic deficiency of UDP-glucuronosyltransferases
    B Burchell
    Department of Molecular Pathology, Ninewells Medical School, University of Dundee, Dundee, UK
    Toxicol Lett 112:333-40. 2000
    ..Recently, adverse effects of anticancer agents have been observed in Gilbert's patients due to reduced drug or bilirubin glucuronidation...
  3. ncbi request reprint Genetic variation of human UDP-glucuronosyltransferase: implications in disease and drug glucuronidation
    Brian Burchell
    Department of Molecular and Cellular Pathology, Ninewells Medical School, University of Dundee, Dundee, Scotland
    Am J Pharmacogenomics 3:37-52. 2003
    ..Additional novel polymorphisms in this gene family are yet to be revealed and studied, but will have a profound effect on the development of new drugs and therapies...
  4. ncbi request reprint Gilbert's syndrome is a contributory factor in prolonged unconjugated hyperbilirubinemia of the newborn
    G Monaghan
    Departments of Molecular and Cellular Pathology, Child Health, and Obstetrics and Gynaecology, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland
    J Pediatr 134:441-6. 1999
    ..CONCLUSIONS: A genetic predisposition to develop prolonged neonatal hyperbilirubinemia in breast-fed infants is associated with TATA box polymorphism of the UGT1A1 gene and will be recognized as Gilbert's syndrome in adulthood...
  5. ncbi request reprint Genetic defects of the UDP-glucuronosyltransferase-1 (UGT1) gene that cause familial non-haemolytic unconjugated hyperbilirubinaemias
    D J Clarke
    Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Medical School, Scotland, UK
    Clin Chim Acta 266:63-74. 1997
    ..Current methods used for the diagnosis and treatment of these diseases are discussed...
  6. ncbi request reprint Almokalant glucuronidation in human liver and kidney microsomes: evidence for the involvement of UGT1A9 and 2B7
    B K Gaiser
    Department of Molecular and Cellular Pathology, Ninewells Medical School, University of Dundee DD1 9SY, UK
    Xenobiotica 33:1073-83. 2003
    ..68 and 1.06 mM almost identical to the 1A9. 4. The results suggest a significant role for UGT1A9 and 2B7 in the catalysis of almokalant glucuronidation...
  7. ncbi request reprint Structure of the human UGT2B4 gene encoding a bile acid UDP-glucuronosyltransferase
    G Monaghan
    Department of Molecular and Cellular Pathology, Ninewells Hospital and Medical School, The University of Dundee, DD1 9SY, Scotland, UK
    Mamm Genome 8:692-4. 1997
  8. ncbi request reprint Characterization of the uridine diphosphate-glucuronosyltransferase-catalyzing thyroid hormone glucuronidation in man
    K A Findlay
    Department of Molecular and Cellular Pathology, Ninewells Hospital and Medical School, University of Dundee, Scotland
    J Clin Endocrinol Metab 85:2879-83. 2000
    ..Bioactive T3 is not significantly glucuronidated by these isoforms and other UGTs, and sulfotransferases may be involved...
  9. ncbi request reprint In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance
    M G Soars
    Department of Molecular and Cellular Pathology, Ninewells Hospital and Medical School, Dundee, Scotland
    J Pharmacol Exp Ther 301:382-90. 2002
    ..The use of cryopreserved hepatocytes as an in vitro tool to predict in vivo metabolism was also assessed with an excellent correlation obtained for a number of extensively glucuronidated drugs (R(2) = 0.80, p < 0.001)...
  10. ncbi request reprint Treatment of mammalian cells with the endoplasmic reticulum-proliferator compactin strongly induces recombinant and endogenous xenobiotic metabolizing enzymes and 3-hydroxy-3-methylglutaryl-CoA reductase in vitro
    L McLaughlin
    Biomedical Research Centre and Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
    J Cell Sci 112:515-23. 1999
    ..Since this effect extends to heterologously expressed enzymes, it also provides an efficient means by which to increase the levels of recombinant ER proteins...
  11. ncbi request reprint Drug glucuronidation by human renal UDP-glucuronosyltransferases
    K A McGurk
    Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, Scotland, UK
    Biochem Pharmacol 55:1005-12. 1998
    ..The human kidney was capable of conjugating various structurally diverse drugs and xenobiotics...
  12. pmc Genetic and environmental factors associated with variation of human xenobiotic glucuronidation and sulfation
    B Burchell
    Department of Biochemical Medicine, Ninewells Medical School, University, Dundee, Scotland, UK
    Environ Health Perspect 105:739-47. 1997
    ..This will leed to the better prediction of variation of xenobiotic glucuronidation and sulfation in man...
  13. ncbi request reprint Evaluation of the marmoset as a model species for drug glucuronidation
    M G Soars
    Department of Molecular and Cellular Pathology, Ninewells Hospital and Medical School, Dundee, UK
    Xenobiotica 31:849-60. 2001
    ....
  14. ncbi request reprint Cloning and characterization of a canine UDP-glucuronosyltransferase
    M G Soars
    Department of Molecular and Cellular Pathology, Ninewells Hospital and Medical School, Dundee, DD1 9SY, Scotland, UK
    Arch Biochem Biophys 391:218-24. 2001
    ..07 nmol/min/mg protein), a class of compounds extensively glucuronidated by human UGT1A6. Based on sequence homology and common catalytic activity, this dog UGT1A protein appears to be the canine orthologue of human UGT1A6...
  15. pmc Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family
    R Wooster
    Biochemical Medicine, University of Dundee, Ninewells Hospital and Medical School, Scotland, U K
    Biochem J 278:465-9. 1991
    ..These results suggest that the two isoenzymes may be derived from the same gene by differential splicing of the gene product...
  16. ncbi request reprint Expression of a human liver cDNA encoding a UDP-glucuronosyltransferase catalysing the glucuronidation of hyodeoxycholic acid in cell culture
    S Fournel-Gigleux
    Department of Biochemistry, Medical Sciences Institute, The University, Dundee, Scotland
    FEBS Lett 243:119-22. 1989
    ..These results suggest that this UDPGT isoenzyme may be responsible for the glucuronidation of 6 alpha-hydroxy bile acids in human liver...
  17. pmc Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells
    D Harding
    Department of Biochemistry, The University, Dundee, Scotland
    Proc Natl Acad Sci U S A 85:8381-5. 1988
    ..The glucuronidation of testosterone, androsterone, and estrone was not catalyzed by this cloned UDP-glucuronosyltransferase...
  18. ncbi request reprint DD angiotensin-converting enzyme gene polymorphism is associated with endothelial dysfunction in normal humans
    R Butler
    University Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, UK
    Hypertension 33:1164-8. 1999
    ..These data demonstrate that the DD ACE genotype in a young population is associated with a blunting of stimulated endothelial NO and donated NO responses but not to non-NO vasodilators or vasoconstrictors...
  19. ncbi request reprint Identification of an A-to-G missense mutation in exon 2 of the UGT1 gene complex that causes Crigler-Najjar syndrome type 2
    N Moghrabi
    Department of Biochemical Medicine, University of Dundee, Ninewells Hospital and Medical School, Scotland, United Kingdom
    Genomics 18:171-3. 1993
  20. pmc Expression of human liver epoxide hydrolase in Saccharomyces pombe
    M R Jackson
    Department of Biochemistry, The University, Scotland, U K
    Biochem J 251:931-3. 1988
    ..This method will provide a useful source of human liver epoxide hydrolase, avoiding the problems of obtaining human tissue...
  21. pmc Cloning and characterization of a novel human olfactory UDP-glucuronosyltransferase
    G Jedlitschky
    Department of Molecular and Cellular Pathology, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Biochem J 340:837-43. 1999
    ..Furthermore, some steroids, especially androgens, some drugs and carcinogens were conjugated. The results support a role of the enzyme in olfactory perception and in protection of the neural system against airborne hazardous chemicals...
  22. ncbi request reprint Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13
    G Monaghan
    Department of Biochemical Medicine, University of Dundee, Ninewells Hospital Medical School, Scotland, United Kingdom
    Genomics 23:496-9. 1994
    ..These data permitted a provisional ordering of the genes as UGT2B9-UGT2B4-UGT2B15. Fluorescence in situ hybridization analysis, using the YAC DNA, permitted the regional localization of this gene cluster to chromosome 4q13...
  23. ncbi request reprint Characterisation of glucuronidation and transport in V79 cells co-expressing UGT1A1 and MRP1
    R L Cuff
    Department of Molecular and Cellular Pathology, Ninewells Hospital and Medical School, University of Dundee, Scotland DD1 9SY, Dundee, UK
    Toxicol Lett 120:43-9. 2001
    ..V79 cells expressing both UGT1A1 and MRP1 have been established. The ability of these cell lines to both glucuronidate and transport compounds was assessed ex vivo using estradiol and bilirubin as substrates...
  24. ncbi request reprint Use of cloned and expressed human UDP-glucuronosyltransferases for the assessment of human drug conjugation and identification of potential drug interactions
    B T Ethell
    Department of Molecular and Cellular Pathology, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland
    Drug Metab Dispos 29:48-53. 2001
    ..This study shows the utility of the expressed human UDP-glucuronosyltransferases in determining substrate structure-activity relationships and potential drug-drug interactions...
  25. ncbi request reprint Merits and limitations of recombinant models for the study of human P450-mediated drug metabolism and toxicity: an intralaboratory comparison
    T Friedberg
    Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Scotland, UK
    Drug Metab Rev 31:523-44. 1999
    ..For toxicological studies, however, expression of P450s in mammalian cells was most appropriate. This is exemplified here by studies into the role of human P450s in the activation and inactivation of chemotherapeutic drugs...
  26. ncbi request reprint Cloning and functional expression of an apparent splice variant of the murine 5-HT3 receptor A subunit
    A G Hope
    Department of Biochemical Medicine, Ninewells Hospital and Medical School, Dundee, UK
    Eur J Pharmacol 245:187-92. 1993
    ..Upon expression in Xenopus oocytes, the homo-oligomeric receptor displayed pharmacological properties which define it as a functional 5-HT3 receptor...
  27. ncbi request reprint The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence
    B Burchell
    Department of Biochemical Medicine, Ninewells Hospital and Medical School, Dundee, Scotland
    DNA Cell Biol 10:487-94. 1991
    ..We suggest that the human nomenclature system be used for species other than the mouse. We anticipate that this UGT gene nomenclature system will require updating on a regular basis...
  28. ncbi request reprint Chromosomal assignment of human phenol and bilirubin UDP-glucuronosyltransferase genes (UGT1A-subfamily)
    N Moghrabi
    University Department of Biochemical Medicine, Ninewells Hospital and Medical School, Dundee, Scotland
    Ann Hum Genet 56:81-91. 1992
    ..The results obtained indicate that all four cDNA clones are encoded by gene(s) located on human chromosome 2...
  29. pmc Nucleotide and deduced amino acid sequence of human liver microsomal epoxide hydrolase
    M R Jackson
    Department of Biochemistry, University of Dundee, UK
    Nucleic Acids Res 15:7188. 1987
  30. pmc Farnesol is glucuronidated in human liver, kidney and intestine in vitro, and is a novel substrate for UGT2B7 and UGT1A1
    Adam G Staines
    Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Biochem J 384:637-45. 2004
    ..Thus glucuronidation may modulate the physiological and/or pharmacological properties of this potent signalling molecule...
  31. ncbi request reprint Glucuronidation of HMR1098 in human microsomes: evidence for the involvement of UGT1A1 in the formation of S-glucuronides
    Brian T Ethell
    Department of Molecular and Cellular Pathology, Ninewells Hospital and Medical School, University of Dendee, Dundee, Scotland, DD1 9SY, UK
    Drug Metab Dispos 31:1027-34. 2003
    ....
  32. ncbi request reprint The effect of valproic acid on drug and steroid glucuronidation by expressed human UDP-glucuronosyltransferases
    Brian T Ethell
    Department of Molecular and Cellular Pathology, Ninewells Hospital and Medical School, University of Dundee, DD1 9SY, Scotland, Dundee, UK
    Biochem Pharmacol 65:1441-9. 2003
    ..No significant inhibition of UGT1A1 or UGT1A6 by valproic acid was observed. These data indicate that valproic acid inhibition of glucuronidation reactions is not always due to simple competitive inhibition of substrates...
  33. ncbi request reprint Cloning and characterisation of the first drug-metabolising canine UDP-glucuronosyltransferase of the 2B subfamily
    Matthew G Soars
    Department of Molecular and Cellular Pathology, Ninewells Hospital and Medical School, Dundee, DD1 9SY, Scotland, UK
    Biochem Pharmacol 65:1251-9. 2003
    ..The results suggest that UGT2B31 plays a crucial role in drug detoxification by the dog and may be the canine equivalent of human UGT2B7...
  34. ncbi request reprint Substrate specificity of human hepatic udp-glucuronosyltransferases
    Brian Burchell
    Department of Molecular and Cellular Pathology, Ninewells Hospital and Medical School, University of Dundee, Scotland, United Kingdom
    Methods Enzymol 400:46-57. 2005
    ..Specific substrates for the five individual UGTs have been identified. These five probe substrates could be used to predict the drug clearance catalyzed by individual UGTs in vivo...
  35. ncbi request reprint Quantitative structure activity relationships for the glucuronidation of simple phenols by expressed human UGT1A6 and UGT1A9
    Brian T Ethell
    Department of Molecular and Cellular Pathology, Ninewells Hospital and Medical School, Dundee, United Kingdom
    Drug Metab Dispos 30:734-8. 2002
    ..The K(m) values for UGT1A9 showed a similar relationship to UGT1A6 but with much lower K(m) values and greater variability in range of this value...
  36. ncbi request reprint N-glucuronidation of carbamazepine in human tissues is mediated by UGT2B7
    Adam G Staines
    Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    J Pharmacol Exp Ther 311:1131-7. 2004
    ..79 pmol/mg/min. In addition to revealing the isoform responsible for CBZ glucuronidation, this is the first example of primary amine glucuronidation by UGT2B7...
  37. pmc Molecular and functional characterization of microsomal UDP-glucuronic acid uptake by members of the nucleotide sugar transporter (NST) family
    Tsutomu Kobayashi
    Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Biochem J 400:281-9. 2006
    ..The cell line H4IIE is a useful model for the study of UDPGA transporters for glucuronidation reactions...
  38. ncbi request reprint Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily
    Peter I Mackenzie
    Department of Clinical Pharmacology, Flinders University School of Medicine, Flinders Medical Center, Bedford Park, Australia
    Pharmacogenet Genomics 15:677-85. 2005
    ..Most UGT1 and UGT8 enzymes have been characterized in detail; however, the catalytic functions of the UGT3A enzymes and several UGT2 enzymes remain to be characterized...
  39. ncbi request reprint Amino terminal domains of human UDP-glucuronosyltransferases (UGT) 2B7 and 2B15 associated with substrate selectivity and autoactivation
    Benjamin C Lewis
    Department of Clinical Pharmacology, Flinders University and Flinders Medical Centre, Adelaide, Australia
    Biochem Pharmacol 73:1463-73. 2007
    ....
  40. ncbi request reprint Assessment of catechol induction and glucuronidation in rat liver microsomes
    Eivor Elovaara
    Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, FIN 00250 Helsinki, Finland
    Drug Metab Dispos 32:1426-33. 2004
    ..6 nmol/min/mg). In conclusion, catechols are poor inducers of their own glucuronidation supported by several UGT isoforms. Their administration is unlikely to affect the glucuronidation of other drugs administered concomitantly...
  41. ncbi request reprint Identification of the human liver UDP-glucuronosyltransferase involved in the metabolism of p-ethoxyphenylurea (dulcin)
    Yoshihiro Uesawa
    Department of Pharmaceutics, Clinical Pharmaceutics Laboratory, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo, 204 8588, Japan
    Arch Toxicol 81:163-8. 2007
    ..356 mM), but bilirubin, a substrate for UGT1A1, did not. These results suggest that UGT1A9 is a key enzyme catalyzing the glucuronidation of DL...
  42. ncbi request reprint Identification of the rabbit liver UDP-glucuronosyltransferase catalyzing the glucuronidation of 4-ethoxyphenylurea (dulcin)
    Yoshihiro Uesawa
    Clinical Pharmaceutics Laboratory, Department of Pharmaceutics, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo 204 8588, Japan
    Drug Metab Dispos 32:1476-81. 2004
    ..Octylgallate was further shown to competitively inhibit DNG production by RabLM (Ki = 0.149 mM). These results demonstrate that UGT1A7 is the major isoform catalyzing the N-glucuronidation of DL in RabLM...
  43. ncbi request reprint Glucuronidation of SN-38 and NU/ICRF 505 in human colon cancer and adjacent normal colon
    Jeffrey Cummings
    Cancer Research UK, Edinburgh Oncology Unit, Western General Hospital, Edinburgh, UK
    Anticancer Res 26:2189-96. 2006
    ..To safely reverse this mechanism in vivo, it is essential to identify which isoforms of UDP-glucuronosyltransferases are responsible for catalysing this drug metabolism in tumour tissue...
  44. ncbi request reprint Glucuronidation as a mechanism of intrinsic drug resistance in human colon cancer: reversal of resistance by food additives
    Jeffrey Cummings
    Cancer Research UK, Edinburgh Oncology Unit, Western General Hospital, Edinburgh, United Kingdom
    Cancer Res 63:8443-50. 2003
    ..Glucuronidation may represent a mechanism of intrinsic drug resistance in colon cancer open to modulation by a range of food additives and proprietary medicines...
  45. ncbi request reprint Conjugation of catechols by recombinant human sulfotransferases, UDP-glucuronosyltransferases, and soluble catechol O-methyltransferase: structure-conjugation relationships and predictive models
    Jyrki Taskinen
    Department of Pharmacy, University of Helsinki, Helsinki, Finland
    Drug Metab Dispos 31:1187-97. 2003
    ..Several structural factors governing the conjugation of catechol hormones, metabolites, and drugs were identified. The results have significant implications for predicting the metabolic fate of catechols...
  46. ncbi request reprint Glucuronidation of catechols by human hepatic, gastric, and intestinal microsomal UDP-glucuronosyltransferases (UGT) and recombinant UGT1A6, UGT1A9, and UGT2B7
    Laurence Antonio
    UMR 7561 CNRS University Henri Poincaré Nancy I, Vandoeuvre les Nancy, France
    Arch Biochem Biophys 411:251-61. 2003
    ..51 to 64.0 nmol/mgprotein x min. These results demonstrate for the first time glucuronidation of catechols by gastric and intestinal microsomal UGTs and three human recombinant UGT isoforms...
  47. ncbi request reprint Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases
    Kenneth F Ilett
    Department of Pharmacology, University of Western Australia, Crawley, Western Australia
    Drug Metab Dispos 30:1005-12. 2002
    ..There was no significant metabolism of DHA by cytochrome-P450 oxidation or by cytosolic sulfotransferases. We conclude that alpha-DHA-G is an important metabolite of DHA in humans and that its formation is catalyzed by UGT1A9 and UGT2B7...
  48. pmc Histone 2A stimulates glucose-6-phosphatase activity by permeabilization of liver microsomes
    Angelo Benedetti
    Dipartimento di Fisiopatologia e Medicina Sperimentale, University of Siena, 53100 Siena, Italy
    Biochem J 367:505-10. 2002
    ..Finally, histone 2A renders microsomal vesicles permeable to non-permeant compounds. Taken together, the results demonstrate that histone 2A stimulates glucose-6-phosphatase activity by permeabilizing the microsomal membrane...
  49. ncbi request reprint The importance of cysteine 126 in the human liver UDP-glucuronosyltransferase UGT1A6
    Claire Senay
    UMR 7561 CNRS Université Henri Poincaré Nancy 1, Faculte de Medecine, 9, avenue de la Forêt de Haye, BP184 54505 Vandoeuvre lès Nancy Cedex, France
    Biochim Biophys Acta 1597:90-6. 2002
    ..These results support the conclusion that Cys126 is an essential residue for the integrity of the substrate binding site of UGT1A6...
  50. ncbi request reprint Tissue-specific regulation of canine intestinal and hepatic phenol and morphine UDP-glucuronosyltransferases by beta-naphthoflavone in comparison with humans
    Karl Walter Bock
    Institute of Toxicology, University of Tubingen, Tubingen, Germany
    Biochem Pharmacol 63:1683-90. 2002
    ..The results suggest marked differences in tissue-specific regulation of canine vs. human hepatic and intestinal phenol or morphine UGTs...
  51. ncbi request reprint Ethanol-dependent induction of bilirubin UDP-glucuronosyl-transferase in rat liver is mediated by Kupffer cells
    Tamas Kardon
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    Life Sci 70:1205-12. 2002
    ..These results suggest that Kupffer cells play a major role in the mediation of ethanol-stimulated induction of UGT1A1 in liver parenchymal cells...
  52. ncbi request reprint Characterization of catechol glucuronidation in rat liver
    Laurence Antonio
    Unité Mixte Recherche 7561 Centre National de la Recherche Scientifique Université Henri Poincaré Nancy, Vandoeuvre les Nancy, France
    Drug Metab Dispos 30:199-207. 2002
    ..Hydrogen bonding and steric effects also were important to account for to predict the glucuronidation rates...