Edward Bullmore

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. doi request reprint Brain graphs: graphical models of the human brain connectome
    Edward T Bullmore
    Behavioural and Clinical Neuroscience Institute, Department of Psychiatry, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0SZ, United Kingdom
    Annu Rev Clin Psychol 7:113-40. 2011
  2. pmc Broadband criticality of human brain network synchronization
    Manfred G Kitzbichler
    Behavioural and Clinical Neurosciences Institute, Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
    PLoS Comput Biol 5:e1000314. 2009
  3. pmc Hierarchical modularity in human brain functional networks
    David Meunier
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge Cambridge, UK
    Front Neuroinform 3:37. 2009
  4. pmc Disrupted modularity and local connectivity of brain functional networks in childhood-onset schizophrenia
    Aaron F Alexander-Bloch
    Department of Psychiatry, Behavioural and Clinical Neuroscience Institute, University of Cambridge Cambridge, UK
    Front Syst Neurosci 4:147. 2010
  5. pmc Modular and hierarchically modular organization of brain networks
    David Meunier
    Centre for Speech, Language and the Brain, Department of Experimental Psychology, University of Cambridge Cambridge, UK
    Front Neurosci 4:200. 2010
  6. pmc Topological isomorphisms of human brain and financial market networks
    Petra E Vértes
    Behavioural and Clinical Neuroscience Institute, University of Cambridge Cambridge, UK
    Front Syst Neurosci 5:75. 2011
  7. pmc Schizophrenia and abnormal brain network hubs
    Mikail Rubinov
    Author affiliations Brain Mapping Unit Behavioural and Clinical Neuroscience Institute Department of Psychiatry, University of Cambridge, UK Churchill College, University of Cambridge, UK
    Dialogues Clin Neurosci 15:339-49. 2013
  8. pmc Failure to deactivate the default mode network indicates a possible endophenotype of autism
    Michael D Spencer
    Department of Psychiatry, Autism Research Centre, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge, CB2 8AH, UK
    Mol Autism 3:15. 2012
  9. pmc Structural brain changes in First Episode Schizophrenia compared with Fronto-Temporal Lobar Degeneration: a meta-analysis
    Bayanne Olabi
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, EH10 5HF, UK
    BMC Psychiatry 12:104. 2012
  10. doi request reprint The future of functional MRI in clinical medicine
    Ed Bullmore
    University of Cambridge and GlaxoSmithKline, Cambridge, UK
    Neuroimage 62:1267-71. 2012

Research Grants

  1. Wavelets, fractals and fMRI of brain adaptivity
    Edward Bullmore; Fiscal Year: 2003
  2. Wavelets, fractals and fMRI of brain adaptivity
    Edward Bullmore; Fiscal Year: 2004
  3. Wavelets, fractals and fMRI of brain adaptivity
    Edward Bullmore; Fiscal Year: 2005
  4. Wavelets, fractals and fMRI of brain adaptivity
    Edward Bullmore; Fiscal Year: 2006
  5. Wavelets, fractals and fMRI of brain adaptivity
    Edward Bullmore; Fiscal Year: 2007

Detail Information

Publications80

  1. doi request reprint Brain graphs: graphical models of the human brain connectome
    Edward T Bullmore
    Behavioural and Clinical Neuroscience Institute, Department of Psychiatry, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0SZ, United Kingdom
    Annu Rev Clin Psychol 7:113-40. 2011
    ..Here we offer a conceptual review and methodological guide to graphical analysis of human neuroimaging data, with an emphasis on some of the key assumptions, issues, and trade-offs facing the investigator...
  2. pmc Broadband criticality of human brain network synchronization
    Manfred G Kitzbichler
    Behavioural and Clinical Neurosciences Institute, Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
    PLoS Comput Biol 5:e1000314. 2009
    ..05-0.11 to 62.5-125 Hz, confirming that criticality is a property of human brain functional network organization at all frequency intervals in the brain's physiological bandwidth...
  3. pmc Hierarchical modularity in human brain functional networks
    David Meunier
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge Cambridge, UK
    Front Neuroinform 3:37. 2009
    ..This could enable future investigations of Simon's original hypothesis that hierarchy or near-decomposability of physical symbol systems is a critical design feature for their fast adaptivity to changing environmental conditions...
  4. pmc Disrupted modularity and local connectivity of brain functional networks in childhood-onset schizophrenia
    Aaron F Alexander-Bloch
    Department of Psychiatry, Behavioural and Clinical Neuroscience Institute, University of Cambridge Cambridge, UK
    Front Syst Neurosci 4:147. 2010
    ....
  5. pmc Modular and hierarchically modular organization of brain networks
    David Meunier
    Centre for Speech, Language and the Brain, Department of Experimental Psychology, University of Cambridge Cambridge, UK
    Front Neurosci 4:200. 2010
    ....
  6. pmc Topological isomorphisms of human brain and financial market networks
    Petra E Vértes
    Behavioural and Clinical Neuroscience Institute, University of Cambridge Cambridge, UK
    Front Syst Neurosci 5:75. 2011
    ..There will be interesting scientific arbitrage opportunities in further work at the graph-theoretically mediated interface between systems neuroscience and the statistical physics of financial markets...
  7. pmc Schizophrenia and abnormal brain network hubs
    Mikail Rubinov
    Author affiliations Brain Mapping Unit Behavioural and Clinical Neuroscience Institute Department of Psychiatry, University of Cambridge, UK Churchill College, University of Cambridge, UK
    Dialogues Clin Neurosci 15:339-49. 2013
    ....
  8. pmc Failure to deactivate the default mode network indicates a possible endophenotype of autism
    Michael D Spencer
    Department of Psychiatry, Autism Research Centre, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge, CB2 8AH, UK
    Mol Autism 3:15. 2012
    ..abstract:..
  9. pmc Structural brain changes in First Episode Schizophrenia compared with Fronto-Temporal Lobar Degeneration: a meta-analysis
    Bayanne Olabi
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, EH10 5HF, UK
    BMC Psychiatry 12:104. 2012
    ..The authors sought to compare gray matter changes in First Episode Schizophrenia (FES) compared with Fronto-Temporal Lobar Degeneration (FTLD) using meta-analytic methods applied to neuro-imaging studies...
  10. doi request reprint The future of functional MRI in clinical medicine
    Ed Bullmore
    University of Cambridge and GlaxoSmithKline, Cambridge, UK
    Neuroimage 62:1267-71. 2012
    ..Here I provide a personal perspective on what has already been achieved, and imagine how the further development of fMRI over the medium term might lead to even greater engagement with clinical medicine...
  11. ncbi request reprint The economy of brain network organization
    Ed Bullmore
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Department of Psychiatry, Cambridge Biomedical Campus, Cambridge CB2 0SZ, UK
    Nat Rev Neurosci 13:336-49. 2012
    ..An economical analysis of neuropsychiatric disorders highlights the vulnerability of the more costly elements of brain networks to pathological attack or abnormal development...
  12. pmc Structural brain change in Attention Deficit Hyperactivity Disorder identified by meta-analysis
    Ian Ellison-Wright
    Avon and Wiltshire Mental Health Partnership NHS Trust, Salisbury, UK
    BMC Psychiatry 8:51. 2008
    ..The authors sought to map gray matter changes in Attention Deficit Hyperactivity Disorder (ADHD) using a novel technique incorporating neuro-imaging and genetic meta-analysis methods...
  13. doi request reprint Complex brain networks: graph theoretical analysis of structural and functional systems
    Ed Bullmore
    University of Cambridge, Behavioural and Clinical Neurosciences Institute, Department of Psychiatry, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Nat Rev Neurosci 10:186-98. 2009
    ..We also highlight some of the technical challenges and key questions to be addressed by future developments in this rapidly moving field...
  14. ncbi request reprint Why psychiatry can't afford to be neurophobic
    Ed Bullmore
    University of Cambridge, Department of Psychiatry, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Br J Psychiatry 194:293-5. 2009
    ..We suggest that there are several ways in which psychiatry could organise itself professionally to better advance and communicate the theoretical and therapeutic potential of a brain-based medicine of the mind...
  15. ncbi request reprint Wavelets and functional magnetic resonance imaging of the human brain
    Ed Bullmore
    Brain Mapping Unit and Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Neuroimage 23:S234-49. 2004
    ..We conclude that the wavelet domain is a rich source of new concepts and techniques to enhance the power of statistical analysis of human fMRI data...
  16. ncbi request reprint Generic aspects of complexity in brain imaging data and other biological systems
    Ed Bullmore
    Behavioural and Clinical Neurosciences Institute, University of Cambridge, Department of Psychiatry, Addenbrooke s, Hospital, Cambridge, UK
    Neuroimage 47:1125-34. 2009
    ..The aim is to provide a didactic, focussed and user-friendly introduction to the concepts of complexity science for neuroscientists and neuroimagers...
  17. pmc Practice and difficulty evoke anatomically and pharmacologically dissociable brain activation dynamics
    Ed Bullmore
    University of Cambridge, Department of Psychiatry, Addenbrooke s Hospital, Cambridge CB2 2QQ
    Cereb Cortex 13:144-54. 2003
    ..Difficulty and practice evoke anatomically and pharmacologically dissociable brain activation dynamics, which are probably mediated by different neurotransmitter systems in humans...
  18. ncbi request reprint Colored noise and computational inference in neurophysiological (fMRI) time series analysis: resampling methods in time and wavelet domains
    E Bullmore
    Department of Psychiatry, University of Cambridge, United Kingdom
    Hum Brain Mapp 12:61-78. 2001
    ..We conclude that wavelet resampling may be a generally useful method for inference on naturally complex time series...
  19. ncbi request reprint Change detection in children with autism: an auditory event-related fMRI study
    Marie Gomot
    Autism Research Centre, Department of Psychiatry, University of Cambridge, UK
    Neuroimage 29:475-84. 2006
    ..Abnormalities involved a cortical network known to have a role in attention switching and attentional resource distribution. These results throw light on the neurophysiological processes underlying autistic 'resistance to change'...
  20. pmc Endogenous multifractal brain dynamics are modulated by age, cholinergic blockade and cognitive performance
    John Suckling
    Brain Mapping Unit, University of Cambridge, Department of Psychiatry, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    J Neurosci Methods 174:292-300. 2008
    ....
  21. pmc Functional dysconnectivity in schizophrenia associated with attentional modulation of motor function
    Garry D Honey
    University of Cambridge, Department of Psychiatry, Cambridge, UK
    Brain 128:2597-611. 2005
    ..Furthermore, these data show evidence of additional functional deficits in patients with negative symptoms, deficits which may explain the accompanying attentional impairment...
  22. pmc Adaptive reconfiguration of fractal small-world human brain functional networks
    Danielle S Bassett
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    Proc Natl Acad Sci U S A 103:19518-23. 2006
    ..Human brain functional networks demonstrate a fractal small-world architecture that supports critical dynamics and task-related spatial reconfiguration while preserving global topological parameters...
  23. ncbi request reprint Standardized whole brain mapping of tubers and subependymal nodules in tuberous sclerosis complex
    Khanum Ridler
    University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Child Neurol 19:658-65. 2004
    ..Contemporary image processing tools can be used to enhance quantitative, whole brain analysis of lesion load in patients with tuberous sclerosis complex...
  24. ncbi request reprint Variations in the human cannabinoid receptor (CNR1) gene modulate striatal responses to happy faces
    Bhismadev Chakrabarti
    Autism Research Centre, Douglas House, 18 B, Trumpington Road, Cambridge CB2 2AH, UK
    Eur J Neurosci 23:1944-8. 2006
    ..This has implications for medical conditions involving hypo-responsivity to emotional and social stimuli, such as autism...
  25. doi request reprint A shift to randomness of brain oscillations in people with autism
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, United Kingdom
    Biol Psychiatry 68:1092-9. 2010
    ..5) to ordered (H = 1). Shifts in fractal scaling of physiological time series have been associated with neurological and cardiac conditions...
  26. ncbi request reprint Learning-related human brain activations reflecting individual finances
    Philippe N Tobler
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom
    Neuron 54:167-75. 2007
    ..The inverse relationship of behavioral and neuronal learning speed with personal finances is compatible with the general concept of decreasing marginal utility with increasing wealth...
  27. pmc Drug addiction endophenotypes: impulsive versus sensation-seeking personality traits
    Karen D Ersche
    Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 68:770-3. 2010
    ..However, it has not been clear whether these personality traits are a cause or an effect of stimulant drug dependence...
  28. doi request reprint The role of the orbitofrontal cortex in human discrimination learning
    Henry W Chase
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, UK
    Neuropsychologia 46:1326-37. 2008
    ..g. anterior cingulate cortex). These data support the notion that the OFC play a role in normal discrimination learning, and suggest qualitative similarities in learning performance of patients with OFC damage and medicated PD patients...
  29. doi request reprint Impaired visuospatial associative memory and attention in obsessive compulsive disorder but no evidence for differential dopaminergic modulation
    Sharon Morein-Zamir
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Box 189, CB2 2QQ, Cambridge, UK
    Psychopharmacology (Berl) 212:357-67. 2010
    ..Patients with obsessive compulsive disorder (OCD) demonstrate impaired cognition in some selected domains. Although serotoninergic dysfunction has been implicated in OCD, recent evidence suggests that dopamine may play a role as well...
  30. pmc Influence of compulsivity of drug abuse on dopaminergic modulation of attentional bias in stimulant dependence
    Karen D Ersche
    University of Cambridge, Behavioural and Clinical Neuroscience Institute, Department of Psychiatry, Cambridge, England
    Arch Gen Psychiatry 67:632-44. 2010
    ..We hypothesized that dopamine-related targets are relevant for treatment of stimulant dependence, and there will likely be individual differences in response to dopaminergic challenges...
  31. doi request reprint Atypical neural self-representation in autism
    Michael V Lombardo
    Autism Research Centre, Douglas House, Cambridge CB2 8AH, UK
    Brain 133:611-24. 2010
    ..These observations reveal that the atypical organization of neural circuitry preferentially coding for self-information is a key mechanism at the heart of both self-referential and social impairments in autism...
  32. doi request reprint Organizational effects of fetal testosterone on human corpus callosum size and asymmetry
    Lindsay R Chura
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK
    Psychoneuroendocrinology 35:122-32. 2010
    ..We suggest that this possible organizational effect of FT on callosal asymmetry may also play a role in shaping sexual dimorphism in functional and structural brain development, cognition, and behavior...
  33. pmc Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Box 189, Cambridge, CB2 2QQ UK
    Am J Psychiatry 164:335-8. 2007
    ..The aim was to assess inhibitory control processes in unaffected first-degree relatives of OCD patients for the first time with objective tests...
  34. ncbi request reprint Visuospatial learning and executive function are independently impaired in first-episode psychosis
    Jennifer H Barnett
    University of Cambridge Department of Psychiatry, Box 189, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Psychol Med 35:1031-41. 2005
    ....
  35. ncbi request reprint Shared neural circuits for mentalizing about the self and others
    Michael V Lombardo
    University of Cambridge, United Kingdom
    J Cogn Neurosci 22:1623-35. 2010
    ....
  36. ncbi request reprint The hippocampal region is involved in successful recognition of both remote and recent famous faces
    Frederic A Bernard
    Brain Mapping Unit and Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Neuroimage 22:1704-14. 2004
    ....
  37. pmc Distinct modulatory effects of satiety and sibutramine on brain responses to food images in humans: a double dissociation across hypothalamus, amygdala, and ventral striatum
    Paul C Fletcher
    Department of Psychiatry, University of Cambridge, GlaxoSmithKline Clinical Unit Cambridge, Addenbrooke s Centre for Clinical Investigations, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    J Neurosci 30:14346-55. 2010
    ..Furthermore, they support a regionally specific effect on brain function through which sibutramine exerts its clinical effect...
  38. ncbi request reprint Differential activation of the amygdala and the 'social brain' during fearful face-processing in Asperger Syndrome
    Chris Ashwin
    Autism Research Centre, University of Cambridge, Department of Psychiatry, Douglas House, 18b Trumpington Rd, Cambridge CB2 2AH, UK
    Neuropsychologia 45:2-14. 2007
    ..HFA/AS are associated with different patterns of activation of social brain areas during fearful emotion processing, and the absence in the HFA/AS brain of a response to varying emotional intensity...
  39. doi request reprint Dissociable roles of prefrontal subregions in self-ordered working memory performance
    Henry W Chase
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychologia 46:2650-61. 2008
    ..Moreover, we provide evidence for the first time that such functions are dependent on dissociable brain regions within the prefrontal cortex...
  40. ncbi request reprint Permutation testing of orthogonal factorial effects in a language-processing experiment using fMRI
    John Suckling
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, UK
    Hum Brain Mapp 27:425-33. 2006
    ..The small size of the BOLD effect necessitates sensitive methods of detection of brain activation. Permutation methods permit the necessary flexibility to develop novel test statistics to meet this challenge...
  41. pmc Peripheral biomarkers of cognitive response to dopamine receptor agonist treatment
    Karen D Ersche
    Department of Psychiatry, University of Cambridge, Herchel Smith Building for Brain and Mind Sciences, Cambridge Biomedical Campus, Cambridge, CB2 0SZ, UK
    Psychopharmacology (Berl) 214:779-89. 2011
    ..We investigated the use of dopamine receptor mRNA levels in circulating blood cells as predictors of cognitive response following dopamine agonist treatment, and as biomarkers of the severity of stimulant drug dependence...
  42. doi request reprint Differential cognitive deterioration in dementia: a two year longitudinal study
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    J Alzheimers Dis 24:125-36. 2011
    ..Follow-up studies in independent populations are needed to validate predictive algorithms identified...
  43. ncbi request reprint Are power calculations useful? A multicentre neuroimaging study
    John Suckling
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom Cambridge and Peterborough Foundation NHS Trust, Cambridge, United Kingdom
    Hum Brain Mapp 35:3569-77. 2014
    ..Hum Brain Mapp 35:3569-3577, 2014. © 2014 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc. ..
  44. doi request reprint Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Box 189, Cambridge CB2 0QQ, UK
    Science 321:421-2. 2008
    ....
  45. ncbi request reprint Frontal responses during learning predict vulnerability to the psychotogenic effects of ketamine: linking cognition, brain activity, and psychosis
    Philip R Corlett
    Brain Mapping Unit, Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge, England
    Arch Gen Psychiatry 63:611-21. 2006
    ..Establishing a neurobiological account of delusion formation that links cognitive processes, brain activity, and symptoms is important to furthering our understanding of psychosis...
  46. pmc Probing compulsive and impulsive behaviors, from animal models to endophenotypes: a narrative review
    Naomi A Fineberg
    Department of Psychiatry, National OCDs Specialist Centre, Hertfordshire Partnership NHS Foundation Trust, Queen Elizabeth II Hospital, Welwyn Garden City, Hertfordshire, UK
    Neuropsychopharmacology 35:591-604. 2010
    ..Targeted application of neurocognitive tasks, receptor-specific neurochemical probes, and brain systems neuroimaging techniques have potential for future research in this field...
  47. pmc Consistency and interpretation of changes in millimeter-scale cortical intrinsic curvature across three independent datasets in schizophrenia
    Lisa Ronan
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK
    Neuroimage 63:611-21. 2012
    ..The results suggest that reduced gyrification in schizophrenia is driven by a reduction in the expansion of upper cortical layers. This may plausibly be related to a reduction in short-range connectivity...
  48. doi request reprint Empathizing with basic emotions: common and discrete neural substrates
    Bhismadev Chakrabarti
    Department of Psychiatry, University of Cambridge, Cambridge, Cambridgeshire, UK
    Soc Neurosci 1:364-84. 2006
    ..This pattern of results is interpreted using a modification of Haxby et al.'s model of face perception...
  49. pmc Leptin regulates striatal regions and human eating behavior
    I Sadaf Farooqi
    University Department of Medicine and Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
    Science 317:1355. 2007
    ....
  50. pmc Fronto-cerebellar systems are associated with infant motor and adult executive functions in healthy adults but not in schizophrenia
    Khanum Ridler
    Brain Mapping Unit, Department of Psychiatry, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, United Kingdom
    Proc Natl Acad Sci U S A 103:15651-6. 2006
    ..Disruption of this anatomical system may underlie both the early developmental and adult cognitive abnormalities in schizophrenia...
  51. doi request reprint Atomoxetine modulates right inferior frontal activation during inhibitory control: a pharmacological functional magnetic resonance imaging study
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Biol Psychiatry 65:550-5. 2009
    ..However, the mechanisms by which atomoxetine improves inhibitory control have yet to be determined...
  52. pmc Individual differences in psychotic effects of ketamine are predicted by brain function measured under placebo
    Garry D Honey
    Department of Psychiatry, Brain Mapping Unit and Behavioural and Clinical Neurosciences Institute, University of Cambridge, School of Clinical Medicine, Cambridge CB2 2QQ, United Kingdom
    J Neurosci 28:6295-303. 2008
    ..These results demonstrate precise and predictive brain markers for individual profiles of vulnerability to drug-induced psychosis...
  53. ncbi request reprint Prediction error during retrospective revaluation of causal associations in humans: fMRI evidence in favor of an associative model of learning
    Philip R Corlett
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    Neuron 44:877-88. 2004
    ..Our results support a modified associative account of retrospective revaluation and demonstrate the potential of functional neuroimaging as a tool for evaluating competing learning models...
  54. doi request reprint The brain structural disposition to social interaction
    Maël Lebreton
    Brain Mapping Unit, University of Cambridge, Cambridge, UK
    Eur J Neurosci 29:2247-52. 2009
    ..These findings provide evidence for a brain structural disposition to social interaction, and that sensitivity to social reward shares a common neural basis with systems for processing primary reward information...
  55. pmc Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge, Cambridge CB2 2QQ, UK
    Br J Psychiatry 193:216-21. 2008
    ..Trichotillomania (repetitive hair-pulling) is an Axis I psychiatric disorder whose neurobiological basis is incompletely understood. Whole-brain trichotillomania neuroimaging studies are lacking...
  56. ncbi request reprint Regret and the negative evaluation of decision outcomes in major depression
    Henry W Chase
    University of Cambridge, Cambridge, England
    Cogn Affect Behav Neurosci 10:406-13. 2010
    ..The possible contribution of the orbitofrontal cortex to the phenomenology of regret is discussed. Supplemental materials for this article may be downloaded from http://cabn.psychonomic-journals.org/content/supplemental...
  57. pmc Endogenous human brain dynamics recover slowly following cognitive effort
    Anna Barnes
    Brain Mapping Unit, Behavioural and Clinical Neurosciences Institute, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 4:e6626. 2009
    ..effortful task significantly change fractal scaling properties of fMRI time series compared to their values before task performance? 2) If so, can we relate the extent of task-related perturbation to the difficulty of the task?..
  58. pmc Human brain networks in health and disease
    Danielle S Bassett
    Department of Psychiatry, Behavioral and Clinical Neurosciences Institute, Addenbrooke s Hospital, Cambridge, UK
    Curr Opin Neurol 22:340-7. 2009
    ..This review focuses on studies using graph theoretical measures applied to structural MRI, diffusion MRI, functional MRI, electroencephalography, and magnetoencephalography data...
  59. ncbi request reprint Impairment of specific episodic memory processes by sub-psychotic doses of ketamine: the effects of levels of processing at encoding and of the subsequent retrieval task
    Garry D Honey
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, P O Box 255, Hills Road, Cambridge, CB2 2QQ, UK
    Psychopharmacology (Berl) 181:445-57. 2005
    ..The precise nature of the impact of the N-methyl-D-aspartate antagonist, ketamine, upon human episodic memory, has yet to be elucidated fully...
  60. ncbi request reprint Modulation of effective connectivity by cognitive demand in phonological verbal fluency
    Cynthia H Y Fu
    Institute of Psychiatry, King s College London, 103 Denmark Hill, London, SE5 8AF, UK
    Neuroimage 30:266-71. 2006
    ....
  61. ncbi request reprint Increased duration of illness is associated with reduced volume in right medial temporal/anterior cingulate grey matter in patients with chronic schizophrenia
    Dennis Velakoulis
    Cognitive Neuropsychiatry Research and Academic Unit, Department of Psychiatry, University of Melbourne and Sunshine Hospital, St Albans, Australia
    Schizophr Res 57:43-9. 2002
    ..The inverse correlation between right frontal, temporal and cerebellar volumes and the time since the onset of schizophrenia could reflect progressive tissue loss following the first episode of the disorder...
  62. ncbi request reprint Novelty-related activation within the medial temporal lobes
    Nicola M Hunkin
    Academic Neurology Unit, Royal Hallamshire Hospital, University of Sheffield, UK
    Neuropsychologia 40:1456-64. 2002
    ..We argue that if the priming explanation is correct then this may account for our failure to observe an associative encoding MTL activation...
  63. ncbi request reprint De-coupling of cognitive performance and cerebral functional response during working memory in schizophrenia
    Garry D Honey
    Section of Cognitive Psychopharmacology, Institute of Psychiatry, London SE5 8AF, UK
    Schizophr Res 53:45-56. 2002
    ..This deficit, apparent within the performance capacity of the patients, may represent a fundamental abnormality in schizophrenia, and may compromise performance at higher cognitive loads...
  64. ncbi request reprint Functional neuroanatomy of successful paired associate learning in Alzheimer's disease
    Rebecca L Gould
    Section of Old Age Psychiatry, Box P070, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Am J Psychiatry 162:2049-60. 2005
    ..The purpose of the study was to develop a strategy for functional imaging of neurodegenerative disorders that overcomes confounds associated with differential performance between patient and comparison groups...
  65. ncbi request reprint Task instructions modulate neural responses to fearful facial expressions
    Kezia Lange
    Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 53:226-32. 2003
    ..Little is known, however, about the effect of task instructions upon the intensity of responses within these regions to fear-inducing stimuli...
  66. ncbi request reprint Task-induced deactivations during successful paired associates learning: an effect of age but not Alzheimer's disease
    Rebecca L Gould
    King s College London, MRC Centre for Neurodegeneration Research, Section of Old Age Psychiatry, Box P070, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Neuroimage 31:818-31. 2006
    ....
  67. ncbi request reprint Regional brain morphometry in patients with schizophrenia or bipolar disorder and their unaffected relatives
    Colm McDonald
    Division of Psychological Medicine, Institute of Psychiatry, London, UK
    Am J Psychiatry 163:478-87. 2006
    ..The authors used region-of-interest morphometry to volumetrically assess brain structures frequently implicated in psychotic illness in families affected with schizophrenia or psychotic bipolar disorder...
  68. ncbi request reprint A computational morphometric MRI study of schizophrenia: effects of hallucinations
    Jane Shapleske
    Department of Psychological Medicine, Institute of Psychiatry, London SE5 8AF, UK
    Cereb Cortex 12:1331-41. 2002
    ....
  69. ncbi request reprint Emotional memory in depersonalization disorder: a functional MRI study
    Nicholas Medford
    Division of Psychological Medicine, P O Box 68, Institute of Psychiatry, DeCrespigny Park, London SE5 8AF, UK
    Psychiatry Res 148:93-102. 2006
    ..This study provides further evidence that patients with DPD do not process emotionally salient material in the same way as healthy controls, in accordance with their subjective descriptions of reduced or absent emotional responses...
  70. ncbi request reprint Neural responses to happy facial expressions in major depression following antidepressant treatment
    Cynthia H Y Fu
    Institute of Psychiatry, King s College London, 103 Denmark Hill, London SE5 8AF, UK
    Am J Psychiatry 164:599-607. 2007
    ..However, depressed patients show impairments in this system. The present study investigated the neural correlates of implicit processing of happy facial expressions in depression and identified regions affected by antidepressant therapy...
  71. ncbi request reprint A longitudinal functional magnetic resonance imaging study of verbal working memory in depression after antidepressant therapy
    Nicholas D Walsh
    Institute of Psychiatry, King s College London, De Crespigny Park, 103 Denmark Hill, London, UK
    Biol Psychiatry 62:1236-43. 2007
    ..Impairments in the neural circuitry of verbal working memory are evident in depression. Factors of task demand and depressive state might have significant effects on its functional neuroanatomy...
  72. ncbi request reprint Hippocampus and amygdala volumes in schizophrenia and other psychoses in the Northern Finland 1966 birth cohort
    Päivikki Tanskanen
    University of Oulu, Department of Radiology, P O Box 50, FIN 90029 OYS, Finland
    Schizophr Res 75:283-94. 2005
    ..Perinatal events that have been suggested as of etiological importance in structural pathology of psychosis had no effect...
  73. ncbi request reprint Brain hyper-reactivity to auditory novel targets in children with high-functioning autism
    Marie Gomot
    INSERM U930, Centre de Pédopsychiatrie, CHU Bretonneau, Tours Cedex 9, France
    Brain 131:2479-88. 2008
    ..This finding may shed light on the neurophysiological process underlying narrow interests and what clinically is called 'need for sameness'...
  74. ncbi request reprint Association of genetic risks for schizophrenia and bipolar disorder with specific and generic brain structural endophenotypes
    Colm McDonald
    Division of Psychological Medicine, Institute of Psychiatry, London
    Arch Gen Psychiatry 61:974-84. 2004
    ..For more than a century, it has been uncertain whether or not the major diagnostic categories of psychosis--schizophrenia and bipolar disorder--are distinct disease entities with specific genetic causes and neuroanatomical substrates...
  75. ncbi request reprint Emotional memory: separating content and context
    Nicholas Medford
    Section of Cognitive Neuropsychiatry, Department of Psychological Medicine, Institute of Psychiatry and GKT School of Medicine, King s College, London SE5 8AF, UK
    Psychiatry Res 138:247-58. 2005
    ..These findings, if applicable to the wider population, may have application in a range of psychiatric disorders where interactions between emotion and cognition are relevant...
  76. ncbi request reprint Sex differences in functional brain activation during a lexical visual field task
    Susan L Rossell
    Department of Psychological Medicine and Neuroimaging, Institute of Psychiatry, London, UK
    Brain Lang 80:97-105. 2002
    ..The data show evidence of task-specific sex differences in the cerebral organization of language processing...
  77. ncbi request reprint Applications of fMRI in translational medicine and clinical practice
    Paul M Matthews
    Centre for Functional Magnetic Resonance Imaging of the Brain, Dept of Clinical Neurology, University of Oxford, UK
    Nat Rev Neurosci 7:732-44. 2006
    ..Realization of this potential will require changes in the way clinical neuroimaging services are planned and delivered...
  78. ncbi request reprint Attenuation of the neural response to sad faces in major depression by antidepressant treatment: a prospective, event-related functional magnetic resonance imaging study
    Cynthia H Y Fu
    Institute of Psychiatry, King s College London, London, England
    Arch Gen Psychiatry 61:877-89. 2004
    ..Depression is associated with interpersonal difficulties related to abnormalities in affective facial processing...
  79. ncbi request reprint Procedural learning in schizophrenia: a functional magnetic resonance imaging investigation
    Veena Kumari
    Section of Cognitive Psychopharmacology, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, UK
    Schizophr Res 57:97-107. 2002
    ....
  80. ncbi request reprint Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison
    Christos Pantelis
    Cognitive Neuropsychiatry Research and Academic Unit, and Melbourne Neuropsychiatry Centre, Mental Health Programme, Department of Psychiatry, University of Melbourne and Sunshine Hospital, Victoria, Melbourne, Australia
    Lancet 361:281-8. 2003
    ..We investigated this issue with MRI to study people with prodromal symptoms who are at ultra high-risk for the development of psychosis...

Research Grants5

  1. Wavelets, fractals and fMRI of brain adaptivity
    Edward Bullmore; Fiscal Year: 2003
    ..We will also test hypotheses concerning the main effect of aging and the interactive effect of drugs and age on brain adaptivity. ..
  2. Wavelets, fractals and fMRI of brain adaptivity
    Edward Bullmore; Fiscal Year: 2004
    ..We will also test hypotheses concerning the main effect of aging and the interactive effect of drugs and age on brain adaptivity. ..
  3. Wavelets, fractals and fMRI of brain adaptivity
    Edward Bullmore; Fiscal Year: 2005
    ..We will also test hypotheses concerning the main effect of aging and the interactive effect of drugs and age on brain adaptivity. ..
  4. Wavelets, fractals and fMRI of brain adaptivity
    Edward Bullmore; Fiscal Year: 2006
    ..We will also test hypotheses concerning the main effect of aging and the interactive effect of drugs and age on brain adaptivity. ..
  5. Wavelets, fractals and fMRI of brain adaptivity
    Edward Bullmore; Fiscal Year: 2007
    ..We will also test hypotheses concerning the main effect of aging and the interactive effect of drugs and age on brain adaptivity. ..