Timothy D H Bugg

Summary

Affiliation: University of Warwick
Country: UK

Publications

  1. doi request reprint How to break the rules of dioxygen activation
    Timothy D H Bugg
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK Electronic address
    Chem Biol 21:168-9. 2014
  2. pmc Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF
    Catherine Paradis-Bleau
    Département de Biologie médicale, Universite Laval, Sainte Foy, Quebec G1K 7P4, Canada
    BMC Biochem 9:33. 2008
  3. doi request reprint Bacterial cell wall assembly: still an attractive antibacterial target
    Timothy D H Bugg
    Department of Chemistry, University of Warwick, Coventry CV47AL, UK
    Trends Biotechnol 29:167-73. 2011
  4. ncbi request reprint Phospho-MurNAc-pentapeptide translocase (MraY) as a target for antibacterial agents and antibacterial proteins
    Timothy D H Bugg
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    Infect Disord Drug Targets 6:85-106. 2006
  5. ncbi request reprint Non-heme iron-dependent dioxygenases: unravelling catalytic mechanisms for complex enzymatic oxidations
    Timothy D H Bugg
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    Curr Opin Chem Biol 12:134-40. 2008
  6. doi request reprint Pathways for degradation of lignin in bacteria and fungi
    Timothy D H Bugg
    Department of Chemistry, University of Warwick, Coventry, UK
    Nat Prod Rep 28:1883-96. 2011
  7. doi request reprint The emerging role for bacteria in lignin degradation and bio-product formation
    Timothy D H Bugg
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    Curr Opin Biotechnol 22:394-400. 2011
  8. ncbi request reprint Diverse catalytic activities in the alphabeta-hydrolase family of enzymes: activation of H2O, HCN, H2O2, and O2
    Timothy D H Bugg
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    Bioorg Chem 32:367-75. 2004
  9. ncbi request reprint Catalytic role for arginine 188 in the C-C hydrolase catalytic mechanism for Escherichia coli MhpC and Burkholderia xenovorans LB400 BphD
    Chen Li
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    Biochemistry 45:12470-9. 2006
  10. ncbi request reprint Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan
    Adrian J Lloyd
    Departments of Biological Sciences and Chemistry, University of Warwick, Gibbet Hill Road, Coventry, United Kingdom
    J Biol Chem 283:6402-17. 2008

Collaborators

Detail Information

Publications52

  1. doi request reprint How to break the rules of dioxygen activation
    Timothy D H Bugg
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK Electronic address
    Chem Biol 21:168-9. 2014
    ....
  2. pmc Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF
    Catherine Paradis-Bleau
    Département de Biologie médicale, Universite Laval, Sainte Foy, Quebec G1K 7P4, Canada
    BMC Biochem 9:33. 2008
    ..As MurF acts on a dipeptide, we exploited a phage display approach to identify peptide ligands having high binding affinities for the enzyme...
  3. doi request reprint Bacterial cell wall assembly: still an attractive antibacterial target
    Timothy D H Bugg
    Department of Chemistry, University of Warwick, Coventry CV47AL, UK
    Trends Biotechnol 29:167-73. 2011
    ....
  4. ncbi request reprint Phospho-MurNAc-pentapeptide translocase (MraY) as a target for antibacterial agents and antibacterial proteins
    Timothy D H Bugg
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    Infect Disord Drug Targets 6:85-106. 2006
    ..The availability of high throughput assays and prospects of MraY as an antibacterial target are also discussed...
  5. ncbi request reprint Non-heme iron-dependent dioxygenases: unravelling catalytic mechanisms for complex enzymatic oxidations
    Timothy D H Bugg
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    Curr Opin Chem Biol 12:134-40. 2008
    ..The article reviews recent developments in the study of the reaction mechanisms of non-heme iron-dependent dioxygenase enzymes, especially the catechol dioxygenases and arene (Rieske) dioxygenases...
  6. doi request reprint Pathways for degradation of lignin in bacteria and fungi
    Timothy D H Bugg
    Department of Chemistry, University of Warwick, Coventry, UK
    Nat Prod Rep 28:1883-96. 2011
    ....
  7. doi request reprint The emerging role for bacteria in lignin degradation and bio-product formation
    Timothy D H Bugg
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    Curr Opin Biotechnol 22:394-400. 2011
    ..If biocatalytic routes for lignin breakdown could be developed, then lignin represents a potentially rich source of renewable aromatic chemicals...
  8. ncbi request reprint Diverse catalytic activities in the alphabeta-hydrolase family of enzymes: activation of H2O, HCN, H2O2, and O2
    Timothy D H Bugg
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    Bioorg Chem 32:367-75. 2004
    ..One common feature of these novel activities is the activation of a small diatomic molecule, but via diverse chemistry. Possible mechanisms of catalysis are discussed...
  9. ncbi request reprint Catalytic role for arginine 188 in the C-C hydrolase catalytic mechanism for Escherichia coli MhpC and Burkholderia xenovorans LB400 BphD
    Chen Li
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    Biochemistry 45:12470-9. 2006
    ....
  10. ncbi request reprint Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan
    Adrian J Lloyd
    Departments of Biological Sciences and Chemistry, University of Warwick, Gibbet Hill Road, Coventry, United Kingdom
    J Biol Chem 283:6402-17. 2008
    ..It is anticipated that definition of the minimal structural features of MurM substrates will allow development of novel resistance inhibitors that will restore the efficacy of beta-lactams for treatment of pneumococcal infection...
  11. pmc Kinetic characterization of lipid II-Ala:alanyl-tRNA ligase (MurN) from Streptococcus pneumoniae using semisynthetic aminoacyl-lipid II substrates
    Gianfranco de Pascale
    Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, United Kingdom
    J Biol Chem 283:34571-9. 2008
    ..pneumoniae, with ligase MurM showing the major difference between penicillin-resistant and penicillin-sensitive strains...
  12. ncbi request reprint Structure and mechanism of HpcH: a metal ion dependent class II aldolase from the homoprotocatechuate degradation pathway of Escherichia coli
    Dean Rea
    Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK
    J Mol Biol 373:866-76. 2007
    ..6 A and 2.0 A, respectively. Comparison with similar structures of the homologous 2-dehydro-3-deoxygalactarate aldolase, coupled with site-directed mutagenesis data, implicate histidine 45 and arginine 70 as key catalytic residues...
  13. ncbi request reprint Fluorescent reagents for in vitro studies of lipid-linked steps of bacterial peptidoglycan biosynthesis: derivatives of UDPMurNAc-pentapeptide containing d-cysteine at position 4 or 5
    James A Schouten
    Department of Chemistry, University of Warwick, Coventry, UK CV4 7AL
    Mol Biosyst 2:484-91. 2006
    ..Pyrene-labelled lipid intermediates I and II can be generated using Micrococcus flavus membranes, enabling the study of the later lipid-linked steps...
  14. ncbi request reprint Investigation of a general base mechanism for ester hydrolysis in C-C hydrolase enzymes of the alpha/beta-hydrolase superfamily: a novel mechanism for the serine catalytic triad
    Jian Jun Li
    Department of Chemistry, University of Warwick, Coventry, UK CV4 7AL
    Org Biomol Chem 5:507-13. 2007
    ....
  15. doi request reprint Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors
    Elena Cressina
    Department of Chemistry, University of Warwick, Coventry, UK
    Bioorg Med Chem 17:3443-55. 2009
    ..These compounds are the first small molecule inhibitors of the Fem ligase family of peptidyltransferases found in Gram-positive bacteria...
  16. ncbi request reprint Catalytic mechanism of C-C hydrolase MhpC from Escherichia coli: kinetic analysis of His263 and Ser110 site-directed mutants
    Chen Li
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    J Mol Biol 346:241-51. 2005
    ..A catalytic mechanism is proposed involving stabilisation of reactive intermediates and activation of a nucleophilic water molecule by Ser110...
  17. ncbi request reprint Evidence for a gem-diol reaction intermediate in bacterial C-C hydrolase enzymes BphD and MhpC from 13C NMR spectroscopy
    Jian Jun Li
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    Biochemistry 45:12461-9. 2006
    ..The direct observation of a gem-diol intermediate provides further evidence that supports a general base mechanism for this family of enzymes...
  18. ncbi request reprint Directed evolution of a non-heme-iron-dependent extradiol catechol dioxygenase: identification of mutants with intradiol oxidative cleavage activity
    Janne Schlosrich
    Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK
    Chembiochem 7:1899-908. 2006
    ....
  19. ncbi request reprint Interaction of the transmembrane domain of lysis protein E from bacteriophage phiX174 with bacterial translocase MraY and peptidyl-prolyl isomerase SlyD
    Sharon Mendel
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    Microbiology 152:2959-67. 2006
    ..These results imply that the interaction of E with MraY is not at the MraY active site, and suggest that a protein-protein interaction is formed between E and MraY at a site within the transmembrane region...
  20. ncbi request reprint Adenosine phosphonate inhibitors of lipid II: alanyl tRNA ligase MurM from Streptococcus pneumoniae
    Elena Cressina
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    Bioorg Med Chem Lett 17:4654-6. 2007
    ..Adenosine and 2'-deoxyadenosine phosphonate transition state analogues act as the first inhibitors for the MurMN/FemABX family of tRNA-dependent ligases implicated in high-level penicillin resistance in gram-positive bacteria...
  21. doi request reprint Investigation of acid-base catalysis in the extradiol and intradiol catechol dioxygenase reactions using a broad specificity mutant enzyme and model chemistry
    Michela Brivio
    Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK
    Org Biomol Chem 7:1368-73. 2009
    ..It is therefore proposed that bifunctional acid-base catalysis is required for iron (ii)-dependent extradiol catechol cleavage, whereas the rate-determining step for intradiol catechol cleavage does not involve acid-base catalysis...
  22. doi request reprint Crystal structure and functional assignment of YfaU, a metal ion dependent class II aldolase from Escherichia coli K12
    Dean Rea
    Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry, UK
    Biochemistry 47:9955-65. 2008
    ..Crystal structures suggest these enzymes use an Asp-His intersubunit dyad to activate a metal-bound water or hydroxide for proton transfer during catalysis...
  23. doi request reprint Identification of DypB from Rhodococcus jostii RHA1 as a lignin peroxidase
    Mark Ahmad
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    Biochemistry 50:5096-107. 2011
    ..jostii RHA1, is able to oxidize both polymeric lignin and a lignin model compound, and appears to have both Mn(II) and lignin oxidation sites. This is the first detailed characterization of a recombinant bacterial lignin peroxidase...
  24. ncbi request reprint Catalytic promiscuity in the alpha/beta-hydrolase superfamily: hydroxamic acid formation, C--C bond formation, ester and thioester hydrolysis in the C--C hydrolase family
    Chen Li
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    Chembiochem 9:71-6. 2008
    ..The results provide experimental support for the catalytic promiscuity shown in this family of enzymes, and indicate that differences in catalytic function can be introduced by point mutations...
  25. ncbi request reprint Acid-base catalysis in the extradiol catechol dioxygenase reaction mechanism: site-directed mutagenesis of His-115 and His-179 in Escherichia coli 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB)
    Sharon Mendel
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    Biochemistry 43:13390-6. 2004
    ..A catalytic mechanism involving His-179 and His-115 as acid-base catalytic residues is proposed...
  26. pmc Inhibition of Escherichia coli glycosyltransferase MurG and Mycobacterium tuberculosis Gal transferase by uridine-linked transition state mimics
    Amy E Trunkfield
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom
    Bioorg Med Chem 18:2651-63. 2010
    ..The library was also tested against Mycobacterium tuberculosis galactosyltransferase GlfT2, and one compound showed effective inhibition at 1mM concentration...
  27. ncbi request reprint Expression, purification, crystallization and preliminary characterization of uridine 5'-diphospho-N-acetylmuramoyl L-alanyl-D-glutamate:lysine ligase (MurE) from Streptococcus pneumoniae 110K/70
    Anne M Blewett
    Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, England
    Acta Crystallogr D Biol Crystallogr 60:359-61. 2004
    ..4, c = 74.8 A, alpha = 73.4, beta = 80.5, gamma = 72.3 degrees. Crystals grown in the presence of UDP-MurNAc-L-Ala-D-Glu alone belong to space group P2(1), with unit-cell parameters a = 71.1, b = 129.4, c = 74.6 A, beta = 106.3 degrees...
  28. pmc Expression, purification and preliminary crystallographic analysis of 2,4-dihydroxy-hepta-2-ene-1,7-dioate aldolase (HpcH) from Escherichia coli C
    Dean Rea
    Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, England
    Acta Crystallogr Sect F Struct Biol Cryst Commun 61:821-4. 2005
    ..5 belong to space group I222, with unit-cell parameters a = 133.39, b = 155.39, c = 168.80 A. Complete data sets were collected to 1.6 and 2.0 A from type I and type II crystals, respectively, using synchrotron radiation...
  29. pmc Selective inhibition of carotenoid cleavage dioxygenases: phenotypic effects on shoot branching
    Martin J Sergeant
    Warwick HRI, University of Warwick, Wellesbourne CV35, 9EF, United Kingdom
    J Biol Chem 284:5257-64. 2009
    ..Application of certain inhibitors at 100 microm to Arabidopsis node explants or whole plants led to increased shoot branching, consistent with inhibition of 9,10-cleavage...
  30. doi request reprint Development of novel assays for lignin degradation: comparative analysis of bacterial and fungal lignin degraders
    Mark Ahmad
    Department of Chemistry, University of Warwick, Coventry, UK CV4 7AL
    Mol Biosyst 6:815-21. 2010
    ..These assays could be used to identify novel lignin degraders for breakdown of plant lignocellulose...
  31. ncbi request reprint Synthetic 6-aryl-2-hydroxy-6-ketohexa-2,4-dienoic acid substrates for C-C hydrolase BphD: investigation of a general base catalytic mechanism
    Damian M Speare
    Department of Chemistry, University of Warwick, Coventry, UK
    Org Biomol Chem 2:2942-50. 2004
    ..A series of para-substituted 2-hydroxy-6-keto-6-phenylhexa-2,4-dienoic acid substrates were assayed against BphD, and the derived Hammett plot (rho=-0.71) is consistent with a departing carbanion in the transition state for C-C cleavage...
  32. ncbi request reprint Evidence from mechanistic probes for distinct hydroperoxide rearrangement mechanisms in the intradiol and extradiol catechol dioxygenases
    Meite Xin
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    J Am Chem Soc 130:10422-30. 2008
    ....
  33. doi request reprint Assembly in vitro of Rhodococcus jostii RHA1 encapsulin and peroxidase DypB to form a nanocompartment
    Rahman Rahmanpour
    Department of Chemistry, University of Warwick, Coventry, UK
    FEBS J 280:2097-104. 2013
    ..The measured stoichiometry of 8.6 μmol encapsulin/μmol DypB in the complex was similar to the value of 10 predicted from the crystal structure...
  34. pmc Phospho-N-acetyl-muramyl-pentapeptide translocase from Escherichia coli: catalytic role of conserved aspartic acid residues
    Adrian J Lloyd
    Department of Chemistry, University of Warwick, Coventry, United Kingdom
    J Bacteriol 186:1747-57. 2004
    ....
  35. ncbi request reprint Biomimetic formation of 2-tropolones by dioxygenase-catalysed ring expansion of substituted 2,4-cyclohexadienones
    Meite Xin
    Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK
    Chembiochem 11:272-6. 2010
    ..This is a novel transformation for non-haem iron-dependent enzymes, and this is the first experimental demonstration of the proposed ring-expansion reaction in tropolone biosynthesis...
  36. doi request reprint Enzymology of the carotenoid cleavage dioxygenases: reaction mechanisms, inhibition and biochemical roles
    Peter J Harrison
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom
    Arch Biochem Biophys 544:105-11. 2014
    ..Here, we review the biochemical roles of CCDs, discuss the mechanisms by which CCD cleavage is proposed to occur, and discuss recent reports of selective CCD enzyme inhibitors. ..
  37. pmc Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota
    Yijun Zhu
    School of Life Sciences and Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom
    Proc Natl Acad Sci U S A 111:4268-73. 2014
    ....
  38. doi request reprint Breaking down lignin to high-value chemicals: the conversion of lignocellulose to vanillin in a gene deletion mutant of Rhodococcus jostii RHA1
    Paul D Sainsbury
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, U K
    ACS Chem Biol 8:2151-6. 2013
    ..5% wheat straw lignocellulose and 0.05% glucose, was found to accumulate vanillin with yields of up to 96 mg/L after 144 h, together with smaller amounts of ferulic acid and 4-hydroxybenzaldehyde. ..
  39. doi request reprint Detection of Staphylococcus aureus cell walls by enzyme-linked immunoassay using antibodies prepared from a semi-synthetic peptidoglycan precursor
    Sandeep Sandhu
    Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK
    Analyst 137:1130-6. 2012
    ..These data demonstrate that it is possible to generate antibodies with high affinity and selectivity for the (Gly)(5) containing monomer in S. aureus peptidoglycan, that could be used to develop an immunoassay for S. aureus...
  40. ncbi request reprint Synthesis and activity of 5'-uridinyl dipeptide analogues mimicking the amino terminal peptide chain of nucleoside antibiotic mureidomycin A
    Nigel I Howard
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    Bioorg Med Chem 11:3083-99. 2003
    ..Enzyme inhibition was shown to be competitive with Mg(2+). It is proposed that the primary amino terminus of the inhibitor binds in place of the Mg(2+) cofactor at the MraY active site, positioned via a cis-N-methyl amide linkage...
  41. ncbi request reprint 2-hydroxy-6-keto-nona-2,4-diene 1,9-dioic acid 5,6-hydrolase: evidence from 18O isotope exchange for gem-diol intermediate
    Timothy D H Bugg
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom
    Methods Enzymol 354:106-18. 2002
  42. doi request reprint Identification of a novel beta-replacement reaction in the biosynthesis of 2,3-diaminobutyric acid in peptidylnucleoside mureidomycin A
    Wai Ho Lam
    University of Warwick, Department of Chemistry, Coventry, United Kingdom
    Org Biomol Chem 6:1912-7. 2008
    ..These results are consistent with literature proposals for the biosynthesis of 2,3-diaminopropanoic acid from the viomycin biosynthetic gene cluster...
  43. ncbi request reprint Identification of a novel inhibition site in translocase MraY based upon the site of interaction with lysis protein E from bacteriophage ϕX174
    Maria T Rodolis
    Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL UK
    Chembiochem 15:1300-8. 2014
    ..As this site is on the exterior face of the cytoplasmic membrane, it constitutes a potential new site for antimicrobial action, and provides a new cellular target for cationic antimicrobial peptides...
  44. ncbi request reprint A density functional investigation of the extradiol cleavage mechanism in non-heme iron catechol dioxygenases
    Robert J Deeth
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    J Biol Inorg Chem 8:409-18. 2003
    ..The subsequent collapse of the epoxide, attack by the coordinated hydroxide and final product formation proceeds with an overall exoergicity of approximately 75 kcal mol(-1) on the U4 surface...
  45. ncbi request reprint Multivalent conjugates of poly-gamma-D-glutamic acid from Bacillus licheniformis with antibody F(ab') and glycopeptide ligands
    Emmanuel J F Prodhomme
    Department of Chemistry, University of Warwick, Coventry, UK
    Bioconjug Chem 14:1148-55. 2003
    ..The PGA-vancomycin conjugate showed slightly lower antibacterial activity than free vancomycin versus susceptible Bacillus subtilis, but slightly higher activity versus intrinsically resistant Leuconostoc mesenteroides...
  46. ncbi request reprint Biological properties of N-acyl and N-haloacetyl neuraminic acids: processing by enzymes of sialic acid metabolism, and interaction with influenza virus
    Andrew J Humphrey
    Department of Chemistry, University of Southampton, Highfield, Southampton, UK
    Bioorg Med Chem 10:3175-85. 2002
    ..CMP-N-propionyl neuraminic acid was found not to be a substrate for CMP-N-acetyl neuraminic acid hydroxylase from pig submandibular gland...
  47. ncbi request reprint The biosynthesis of peptidoglycan lipid-linked intermediates
    Ahmed Bouhss
    Laboratoire des Enveloppes Bactériennes et Antibiotiques, Institut de Biochimie et Biophysique Moleculaire et Cellulaire, UMR 8619 CNRS, Univ Paris Sud, Orsay, France
    FEMS Microbiol Rev 32:208-33. 2008
    ..Enzyme inhibitors and antibacterial compounds interfering with these essential metabolic steps and interesting targets are presented...
  48. ncbi request reprint Arene cis-dihydrodiol formation: from biology to application
    Derek R Boyd
    School of Chemistry and Centre for Theory and Application of Catalysis, Queen s University of Belfast, Belfast, UKBT9 5AG
    Org Biomol Chem 4:181-92. 2006
    ....
  49. ncbi request reprint Antibiotic action and peptidoglycan formation on tethered lipid bilayer membranes
    Michael J Spencelayh
    Centre for Self Organising Molecular systems University of Leeds, Leeds, LS2 9JT, UK
    Angew Chem Int Ed Engl 45:2111-6. 2006
  50. ncbi request reprint Selection of peptide inhibitors against the Pseudomonas aeruginosa MurD cell wall enzyme
    Catherine Paradis-Bleau
    CREFSIP, Département de Biologie médicale, Faculte de Medecine, Universite Laval, Sainte Foy, Quebec, Canada G1K 7P4
    Peptides 27:1693-700. 2006
    ..The approach proposed and results obtained suggest that efficient peptide inhibitors as well as protein-protein interaction domains can be identified by phage display...
  51. ncbi request reprint Recent advances in antimicrobial nucleoside antibiotics targeting cell wall biosynthesis
    Ken ichi Kimura
    Department of Agro bioscience, Iwate University, Iwate 020 8550, Japan
    Nat Prod Rep 20:252-73. 2003
    ..In this review we will describe three nucleoside translocase I inhibitors, mureidomycin, tunicamycin and liposidomycin...
  52. ncbi request reprint Synthesis of gem-difluorinated nucleoside analogues of the liposidomycins and evaluation as MraY inhibitors
    Xiu Hua Xu
    Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 354 Fenglin Lu, Shanghai 200032, China
    Org Biomol Chem 6:157-61. 2008
    ..This unusual process may be correlated with the presence of the electron-withdrawing gem-difluoro substituents at the C-2 position of furanose. Compound 3 demonstrated 29% inhibition of MraY at 11.4 mM...