Anthony Bugaut

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc An RNA hairpin to G-quadruplex conformational transition
    Anthony Bugaut
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    J Am Chem Soc 134:19953-6. 2012
  2. pmc 5'-UTR RNA G-quadruplexes: translation regulation and targeting
    Anthony Bugaut
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Nucleic Acids Res 40:4727-41. 2012
  3. ncbi SELEX and dynamic combinatorial chemistry interplay for the selection of conjugated RNA aptamers
    Anthony Bugaut
    INSERM U386, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Org Biomol Chem 4:4082-8. 2006
  4. pmc A LIN28-dependent structural change in pre-let-7g directly inhibits dicer processing
    Helen L Lightfoot
    Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
    Biochemistry 50:7514-21. 2011
  5. pmc Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex
    Anthony Bugaut
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UKCB2 1EW
    Org Biomol Chem 8:2771-6. 2010
  6. doi Aptamers targeting RNA molecules
    Marguerite Watrin
    Institut Europeen de Chimie et Biologie, Pessac, France, Universite Victor Segalen, Bordeaux, France
    Methods Mol Biol 535:79-105. 2009
  7. pmc Position and stability are determining factors for translation repression by an RNA G-quadruplex-forming sequence within the 5' UTR of the NRAS proto-oncogene
    Sunita Kumari
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom
    Biochemistry 47:12664-9. 2008
  8. pmc A sequence-independent analysis of the loop length dependence of intramolecular RNA G-quadruplex stability and topology
    Amy Y Q Zhang
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Biochemistry 50:7251-8. 2011
  9. ncbi Use of dynamic combinatorial chemistry for the identification of covalently appended residues that stabilize oligonucleotide complexes
    Anthony Bugaut
    INSERM U386, Universite Victor Segalen Bordeaux 2, 146, rue Leo Saignat, 33076 Bordeaux Cedex, France
    Angew Chem Int Ed Engl 43:3144-7. 2004
  10. pmc G-quadruplexes: the beginning and end of UTRs
    Julian Leon Huppert
    Cavendish Laboratory, University of Cambridge, JJ Thompson Ave, Cambridge, UK
    Nucleic Acids Res 36:6260-8. 2008

Collaborators

Detail Information

Publications16

  1. pmc An RNA hairpin to G-quadruplex conformational transition
    Anthony Bugaut
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    J Am Chem Soc 134:19953-6. 2012
    ..This work highlights a new and important level of complexity in RNA folding that could be relevant to the biological functions and targeting of RNAs comprising G-quadruplex motifs...
  2. pmc 5'-UTR RNA G-quadruplexes: translation regulation and targeting
    Anthony Bugaut
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Nucleic Acids Res 40:4727-41. 2012
    ..Finally, we close the review with a perspective on the future challenges in the field of 5'-UTR RNA G-quadruplex-mediated translation regulation...
  3. ncbi SELEX and dynamic combinatorial chemistry interplay for the selection of conjugated RNA aptamers
    Anthony Bugaut
    INSERM U386, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Org Biomol Chem 4:4082-8. 2006
    ..Its successful application for the selection of small-molecule conjugated RNA aptamers that bind tightly to the transactivation-response (TAR) element of HIV-1 is presented...
  4. pmc A LIN28-dependent structural change in pre-let-7g directly inhibits dicer processing
    Helen L Lightfoot
    Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
    Biochemistry 50:7514-21. 2011
    ..The data support a mechanism by which LIN28 can directly inhibit let-7g biogenesis at the Dicer processing step...
  5. pmc Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex
    Anthony Bugaut
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UKCB2 1EW
    Org Biomol Chem 8:2771-6. 2010
    ..The present study provides a first demonstration that natural 5' UTR mRNA G-quadruplexes have potential as molecular targets for small molecules that modulate translation...
  6. doi Aptamers targeting RNA molecules
    Marguerite Watrin
    Institut Europeen de Chimie et Biologie, Pessac, France, Universite Victor Segalen, Bordeaux, France
    Methods Mol Biol 535:79-105. 2009
    ..These different aspects of the SELEX technology have been applied to the trans-activating responsive element of the human immunodeficiency virus type 1, which is crucial for the transcription of the retroviral genome...
  7. pmc Position and stability are determining factors for translation repression by an RNA G-quadruplex-forming sequence within the 5' UTR of the NRAS proto-oncogene
    Sunita Kumari
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom
    Biochemistry 47:12664-9. 2008
    ..We have also demonstrated that the thermodynamic stability of the RNA G-quadruplex at its natural position within the NRAS 5' UTR is an important factor contributing toward its ability to repress translation...
  8. pmc A sequence-independent analysis of the loop length dependence of intramolecular RNA G-quadruplex stability and topology
    Amy Y Q Zhang
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Biochemistry 50:7251-8. 2011
    ..The systematic design of our study also revealed subtle loop length dependencies in RNA G-quadruplex structure...
  9. ncbi Use of dynamic combinatorial chemistry for the identification of covalently appended residues that stabilize oligonucleotide complexes
    Anthony Bugaut
    INSERM U386, Universite Victor Segalen Bordeaux 2, 146, rue Leo Saignat, 33076 Bordeaux Cedex, France
    Angew Chem Int Ed Engl 43:3144-7. 2004
  10. pmc G-quadruplexes: the beginning and end of UTRs
    Julian Leon Huppert
    Cavendish Laboratory, University of Cambridge, JJ Thompson Ave, Cambridge, UK
    Nucleic Acids Res 36:6260-8. 2008
    ....
  11. pmc An RNA G-quadruplex in the 5' UTR of the NRAS proto-oncogene modulates translation
    Sunita Kumari
    University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK
    Nat Chem Biol 3:218-21. 2007
    ..Bioinformatics analysis has revealed 2,922 other 5' UTR RNA G-quadruplex elements in the human genome. We propose that RNA G-quadruplexes in the 5' UTR modulate gene expression at the translational level...
  12. pmc LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans
    Nicolas J Lehrbach
    Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, The Henry Wellcome Building of Cancer and Developmental Biology, Cambridge, UK
    Nat Struct Mol Biol 16:1016-20. 2009
    ..Uridylation by a PUP-2 ortholog might regulate let-7 and additional miRNAs in other species. Given the roles of Lin28 and let-7 in stem cell and cancer biology, we propose that such poly(U) polymerases are potential therapeutic targets...
  13. pmc The BCL-2 5' untranslated region contains an RNA G-quadruplex-forming motif that modulates protein expression
    Ramla Shahid
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Biochemistry 49:8300-6. 2010
    ....
  14. pmc Exploring the differential recognition of DNA G-quadruplex targets by small molecules using dynamic combinatorial chemistry
    Anthony Bugaut
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Angew Chem Int Ed Engl 47:2677-80. 2008
  15. pmc A sequence-independent study of the influence of short loop lengths on the stability and topology of intramolecular DNA G-quadruplexes
    Anthony Bugaut
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Biochemistry 47:689-97. 2008
    ..This study provides a predictive framework that may help identify or classify biologically relevant G-quadruplex-forming sequences...
  16. pmc A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics
    Shang Te Danny Hsu
    University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom
    J Am Chem Soc 131:13399-409. 2009
    ....