Vishwanie S Budhram-Mahadeo

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1)
    Vishwanie Budram-Mahadeo
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Oncogene 21:6123-31. 2002
  2. ncbi request reprint Targeting Brn-3b in breast cancer therapy
    Vishwanie S Budhram-Mahadeo
    Medical Molecular Biology Unit, Institute of Child Health, University College London, London WC1N 1EH, UK
    Expert Opin Ther Targets 10:15-25. 2006
  3. pmc Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression
    Vishwanie S Budhram-Mahadeo
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Nucleic Acids Res 34:6640-52. 2006
  4. ncbi request reprint Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells
    V S Budhram-Mahadeo
    Medical Molecular Biology Unit, Institute of Child Health, University College London, London, UK
    Oncogene 27:145-54. 2008
  5. ncbi request reprint Brn-3a transcription factor blocks p53-mediated activation of proapoptotic target genes Noxa and Bax in vitro and in vivo to determine cell fate
    Chantelle D Hudson
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom
    J Biol Chem 280:11851-8. 2005
  6. ncbi request reprint Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter
    Sonia A Lee
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Cancer Res 65:3072-80. 2005
  7. pmc Proliferation-associated POU4F2/Brn-3b transcription factor expression is regulated by oestrogen through ERα and growth factors via MAPK pathway
    Samir Ounzain
    Medical Molecular Biology Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Breast Cancer Res 13:R5. 2011
  8. pmc A simple technique for the prediction of interacting proteins reveals a direct Brn-3a-androgen receptor interaction
    Daniel C Berwick
    Medical Molecular Biology Unit, University College London Institute of Child Health, London, UK
    J Biol Chem 285:15286-95. 2010

Collaborators

Detail Information

Publications8

  1. ncbi request reprint The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1)
    Vishwanie Budram-Mahadeo
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Oncogene 21:6123-31. 2002
    ..Thus, we show that Brn-3a antagonises the anti-apoptotic effect of p53 but co-operates with p53 to induce cell cycle arrest. The potential role of Brn-3a in determining the outcome of enhanced p53 levels is discussed...
  2. ncbi request reprint Targeting Brn-3b in breast cancer therapy
    Vishwanie S Budhram-Mahadeo
    Medical Molecular Biology Unit, Institute of Child Health, University College London, London WC1N 1EH, UK
    Expert Opin Ther Targets 10:15-25. 2006
    ..This review discusses the effect of altering Brn-3b in these cancer cells and possible approaches to targeting Brn-3b as a strategy for therapy in treatment of breast cancers...
  3. pmc Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression
    Vishwanie S Budhram-Mahadeo
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Nucleic Acids Res 34:6640-52. 2006
    ..Thus, the ability of Brn-3b to interact with p53 and modulate Bax expression may demonstrate an important mechanism that helps to determine the fate of cells when p53 is induced...
  4. ncbi request reprint Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells
    V S Budhram-Mahadeo
    Medical Molecular Biology Unit, Institute of Child Health, University College London, London, UK
    Oncogene 27:145-54. 2008
    ..Site-directed mutagenesis of this sequence resulted in loss of transactivation of the CD1 promoter by Brn-3b. Thus, Brn-3b may act to alter growth properties of breast cancer and NB cells by enhancing CD1 expression in these cells...
  5. ncbi request reprint Brn-3a transcription factor blocks p53-mediated activation of proapoptotic target genes Noxa and Bax in vitro and in vivo to determine cell fate
    Chantelle D Hudson
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom
    J Biol Chem 280:11851-8. 2005
    ..These results support a crucial role for Brn-3a in determining the pathway taken by p53 when co-expressed during development and thus in controlling the fate of these cells...
  6. ncbi request reprint Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter
    Sonia A Lee
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Cancer Res 65:3072-80. 2005
    ..Thus, Brn-3b can, directly and indirectly (via interaction with the ER), activate HSP-27 expression, and this may represent one mechanism by which Brn-3b mediates its effects in breast cancer cells...
  7. pmc Proliferation-associated POU4F2/Brn-3b transcription factor expression is regulated by oestrogen through ERα and growth factors via MAPK pathway
    Samir Ounzain
    Medical Molecular Biology Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Breast Cancer Res 13:R5. 2011
    ..Brn-3b regulates distinct groups of key target genes that control cell growth and behaviour. Brn-3b is elevated in >65% of breast cancer biopsies, but mechanisms controlling its expression in these cells are not known...
  8. pmc A simple technique for the prediction of interacting proteins reveals a direct Brn-3a-androgen receptor interaction
    Daniel C Berwick
    Medical Molecular Biology Unit, University College London Institute of Child Health, London, UK
    J Biol Chem 285:15286-95. 2010
    ..7, leading to a synergistic increase in its expression. Thus, these data define AR as a direct Brn-3a interactor and verify a simple interacting protein prediction methodology that is likely to be useful for many other proteins...