Vladimir L Buchman

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi Chicken synucleins: cloning and expression in the developing embryo
    A A Tiunova
    P K Anokhin Institute of Normal Physiology, Baltyiskaya Street, Moscow, Russia
    Mech Dev 99:195-8. 2000
  2. ncbi Organization of the mouse Ruk locus and expression of isoforms in mouse tissues
    Vladimir L Buchman
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, UK
    Gene 295:13-17. 2002
  3. ncbi Peripheral sensory neurons survive in the absence of alpha- and gamma-synucleins
    Katerina Papachroni
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK
    J Mol Neurosci 25:157-64. 2005
  4. ncbi Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice
    Darren C Robertson
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, UK
    J Neurochem 89:1126-36. 2004
  5. ncbi Multiple domains of Ruk/CIN85/SETA/CD2BP3 are involved in interaction with p85alpha regulatory subunit of PI 3-kinase
    Emma B Borthwick
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK
    J Mol Biol 343:1135-46. 2004
  6. pmc Neurons expressing the highest levels of gamma-synuclein are unaffected by targeted inactivation of the gene
    Natalia Ninkina
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, U K
    Mol Cell Biol 23:8233-45. 2003
  7. ncbi Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons
    Anirban R Saha
    Department of Neuroscience, PO Box 38, Institute of Psychiatry, King s College London, De Crespigny Park, London, SE5 8AF, UK
    J Cell Sci 117:1017-24. 2004
  8. ncbi Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease
    Kumlesh K Dev
    Novartis Pharma AG, Nervous System Research, WKL125 5 13, CH 4002 Basel, Switzerland
    Neuropharmacology 45:14-44. 2003
  9. ncbi Expression pattern of dd4, a sole member of the d4 family of transcription factors in Drosophila melanogaster
    Elena Nabirochkina
    Institute of Gene Biology, Russian Academy of Sciences, 34 5, Vavilov Street, 117334 Moscow, Russia
    Mech Dev 114:119-23. 2002
  10. pmc Whole genome expression analyses of single- and double-knock-out mice implicate partially overlapping functions of alpha- and gamma-synuclein
    Melanie Kuhn
    Department of Medical Genetics, University of Tuebingen, Calwerstrasse 7, 72076 Tubingen, Germany
    Neurogenetics 8:71-81. 2007

Collaborators

  • Alun M Davies
  • Paska A Permana
  • Olaf Riess
  • M A Utton
  • Natalia Ninkina
  • Emma B Borthwick
  • Katerina Papachroni
  • Darren C Robertson
  • Steven L Senior
  • Pieter J Oort
  • Serhiy Havrylov
  • Melanie Kuhn
  • Anirban R Saha
  • Oliver Schmidt
  • Kumlesh K Dev
  • Elena Nabirochkina
  • A A Tiunova
  • Michel Grino
  • Sean H Adams
  • Karine Clement
  • David Bannerman
  • Tamara N Dunn
  • Trina A Knotts
  • Richard Wade-Martins
  • Robert Deacon
  • Fumitaka Ichioka
  • Jean Phillipe Bastard
  • Masatoshi Maki
  • Kate Powell
  • Nadia Naour
  • Jolanta Baranska
  • Guohua Pan
  • Stephanie J Cragg
  • Xunyi Luo
  • Karina Haebig
  • Sven Poths
  • Michael Bonin
  • Nikolai V Gnuchev
  • Anastasios Th Kalofoutis
  • Julia Wanless
  • John Sharkey
  • Yaroslav Ya Fedyshyn
  • Diane P Hanger
  • Ludmila B Drobot
  • Ayodeji A Asuni
  • Igor V Korobko
  • Steven Ackerley
  • Christopher C Miller
  • Josephine Hill
  • Courtney Luke
  • Victor R Drel
  • Brian H Anderton
  • Paul A Jones
  • Andrew J Grierson
  • Herman van der Putten
  • Liz Delaney
  • Felipe Court
  • Katja Hofele
  • Samuel Barbieri
  • Francis O'Neill
  • Susan M Fleetwood-Walker
  • Arnon Rosenthal
  • Dina A Kulikova
  • Nadezshda G Ladigina
  • Leonid I Korochkin
  • Olga B Simonova
  • Ilja B Mertsalov
  • B H Anderton
  • A R Saha
  • D P Hanger
  • N N Ninkina
  • K V Anokhin
  • O Schmidt

Detail Information

Publications13

  1. ncbi Chicken synucleins: cloning and expression in the developing embryo
    A A Tiunova
    P K Anokhin Institute of Normal Physiology, Baltyiskaya Street, Moscow, Russia
    Mech Dev 99:195-8. 2000
    ..Our results demonstrate that primary structures and expression patterns of synucleins are similar in birds and mammals, suggesting that conserved function of synucleins is important for embryonic development of vertebrates...
  2. ncbi Organization of the mouse Ruk locus and expression of isoforms in mouse tissues
    Vladimir L Buchman
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, UK
    Gene 295:13-17. 2002
    ....
  3. ncbi Peripheral sensory neurons survive in the absence of alpha- and gamma-synucleins
    Katerina Papachroni
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK
    J Mol Neurosci 25:157-64. 2005
    ..This suggests that other intraneuronal mechanisms and pathways effectively compensate the loss of synuclein function in null mutant animals...
  4. ncbi Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice
    Darren C Robertson
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, UK
    J Neurochem 89:1126-36. 2004
    ....
  5. ncbi Multiple domains of Ruk/CIN85/SETA/CD2BP3 are involved in interaction with p85alpha regulatory subunit of PI 3-kinase
    Emma B Borthwick
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK
    J Mol Biol 343:1135-46. 2004
    ..Our data also suggest that homodimerisation via C-terminal coiled-coil domain affects both intra- and intermolecular interactions of Ruk proteins...
  6. pmc Neurons expressing the highest levels of gamma-synuclein are unaffected by targeted inactivation of the gene
    Natalia Ninkina
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, U K
    Mol Cell Biol 23:8233-45. 2003
    ..Nerve injury led to similar changes in sensory function in wild-type and mutant mice. Taken together, our data suggest that like alpha-synuclein, gamma-synuclein is dispensable for the development and function of the nervous system...
  7. ncbi Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons
    Anirban R Saha
    Department of Neuroscience, PO Box 38, Institute of Psychiatry, King s College London, De Crespigny Park, London, SE5 8AF, UK
    J Cell Sci 117:1017-24. 2004
    ....
  8. ncbi Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease
    Kumlesh K Dev
    Novartis Pharma AG, Nervous System Research, WKL125 5 13, CH 4002 Basel, Switzerland
    Neuropharmacology 45:14-44. 2003
    ..Here, we summarize the main structural features of alphaSN and its functions, and discuss the molecular alphaSN species implicated in human disease and transgenic animal models of alpha-synucleinopathy in fly and rodents...
  9. ncbi Expression pattern of dd4, a sole member of the d4 family of transcription factors in Drosophila melanogaster
    Elena Nabirochkina
    Institute of Gene Biology, Russian Academy of Sciences, 34 5, Vavilov Street, 117334 Moscow, Russia
    Mech Dev 114:119-23. 2002
    ..In flies dd4 mRNA is found in most tissues but the highest level of expression is detected in ovaries...
  10. pmc Whole genome expression analyses of single- and double-knock-out mice implicate partially overlapping functions of alpha- and gamma-synuclein
    Melanie Kuhn
    Department of Medical Genetics, University of Tuebingen, Calwerstrasse 7, 72076 Tubingen, Germany
    Neurogenetics 8:71-81. 2007
    ..beta-synuclein expression was not significantly altered in any of the models...
  11. doi Adaptor protein Ruk/CIN85 is associated with a subset of COPI-coated membranes of the Golgi complex
    Serhiy Havrylov
    School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, Wales, UK
    Traffic 9:798-812. 2008
    ..Only a small pool of Ruk/CIN85 is present in compartments involved in clathrin-mediated endocytosis and sorting. These results suggest that endogenous Ruk/CIN85 may be involved in regulation of specific membrane trafficking processes...
  12. pmc Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein
    Steven L Senior
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Eur J Neurosci 27:947-57. 2008
    ..Rather, we propose that loss of both alpha- and gamma-synuclein causes an increase in release probability from dopaminergic synapses...
  13. pmc Gamma-synuclein is an adipocyte-neuron gene coordinately expressed with leptin and increased in human obesity
    Pieter J Oort
    USDA Agricultural Research Service Western Human Nutrition Research Center, Davis, CA 95616, USA
    J Nutr 138:841-8. 2008
    ..0001; n = 44). Gamma-synuclein protein was observed in rodent and human WAT but not in negative control liver. These results are consistent with the hypothesis that gamma-synuclein plays an important role in adipocyte physiology...