Vladimir L Buchman

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi Organization of the mouse Ruk locus and expression of isoforms in mouse tissues
    Vladimir L Buchman
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, UK
    Gene 295:13-17. 2002
  2. ncbi Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice
    Darren C Robertson
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, UK
    J Neurochem 89:1126-36. 2004
  3. ncbi Peripheral sensory neurons survive in the absence of alpha- and gamma-synucleins
    Katerina Papachroni
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK
    J Mol Neurosci 25:157-64. 2005
  4. ncbi Multiple domains of Ruk/CIN85/SETA/CD2BP3 are involved in interaction with p85alpha regulatory subunit of PI 3-kinase
    Emma B Borthwick
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK
    J Mol Biol 343:1135-46. 2004
  5. ncbi Neurons expressing the highest levels of gamma-synuclein are unaffected by targeted inactivation of the gene
    Natalia Ninkina
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, U K
    Mol Cell Biol 23:8233-45. 2003
  6. ncbi Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein
    Steven L Senior
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Eur J Neurosci 27:947-57. 2008
  7. ncbi Adaptor protein Ruk/CIN85 is associated with a subset of COPI-coated membranes of the Golgi complex
    Serhiy Havrylov
    School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, Wales, UK
    Traffic 9:798-812. 2008
  8. ncbi Whole genome expression analyses of single- and double-knock-out mice implicate partially overlapping functions of alpha- and gamma-synuclein
    Melanie Kuhn
    Department of Medical Genetics, University of Tuebingen, Calwerstrasse 7, 72076 Tubingen, Germany
    Neurogenetics 8:71-81. 2007
  9. ncbi Expression pattern of dd4, a sole member of the d4 family of transcription factors in Drosophila melanogaster
    Elena Nabirochkina
    Institute of Gene Biology, Russian Academy of Sciences, 34 5, Vavilov Street, 117334 Moscow, Russia
    Mech Dev 114:119-23. 2002
  10. ncbi Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons
    Anirban R Saha
    Department of Neuroscience, PO Box 38, Institute of Psychiatry, King s College London, De Crespigny Park, London, SE5 8AF, UK
    J Cell Sci 117:1017-24. 2004

Collaborators

  • Alun M Davies
  • Paska A Permana
  • Olaf Riess
  • M A Utton
  • Natalia Ninkina
  • Emma B Borthwick
  • Katerina Papachroni
  • Darren C Robertson
  • Steven L Senior
  • Serhiy Havrylov
  • Pieter J Oort
  • Melanie Kuhn
  • Anirban R Saha
  • Oliver Schmidt
  • Kumlesh K Dev
  • Elena Nabirochkina
  • Karine Clement
  • Stephanie J Cragg
  • Richard Wade-Martins
  • Nadia Naour
  • Michel Grino
  • Kate Powell
  • Jean-Phillipe Bastard
  • Sean H Adams
  • Xunyi Luo
  • David Bannerman
  • Robert Deacon
  • Jean Phillipe Bastard
  • Masatoshi Maki
  • Tamara N Dunn
  • Trina A Knotts
  • Fumitaka Ichioka
  • Jolanta Baranska
  • Guohua Pan
  • Michael Bonin
  • Karina Haebig
  • Sven Poths
  • Anastasios Th Kalofoutis
  • Nikolai V Gnuchev
  • Julia Wanless
  • Ayodeji A Asuni
  • Victor R Drel
  • Brian H Anderton
  • Ludmila B Drobot
  • Christopher C Miller
  • Diane P Hanger
  • Yaroslav Ya Fedyshyn
  • John Sharkey
  • Courtney Luke
  • Paul A Jones
  • Josephine Hill
  • Andrew J Grierson
  • Igor V Korobko
  • Steven Ackerley
  • Francis O'Neill
  • Arnon Rosenthal
  • Felipe Court
  • Katja Hofele
  • Samuel Barbieri
  • Liz Delaney
  • Herman van der Putten
  • Susan M Fleetwood-Walker
  • Olga B Simonova
  • Dina A Kulikova
  • Ilja B Mertsalov
  • Nadezshda G Ladigina
  • Leonid I Korochkin

Detail Information

Publications12

  1. ncbi Organization of the mouse Ruk locus and expression of isoforms in mouse tissues
    Vladimir L Buchman
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, UK
    Gene 295:13-17. 2002
    ....
  2. ncbi Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice
    Darren C Robertson
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, UK
    J Neurochem 89:1126-36. 2004
    ....
  3. ncbi Peripheral sensory neurons survive in the absence of alpha- and gamma-synucleins
    Katerina Papachroni
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK
    J Mol Neurosci 25:157-64. 2005
    ..This suggests that other intraneuronal mechanisms and pathways effectively compensate the loss of synuclein function in null mutant animals...
  4. ncbi Multiple domains of Ruk/CIN85/SETA/CD2BP3 are involved in interaction with p85alpha regulatory subunit of PI 3-kinase
    Emma B Borthwick
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK
    J Mol Biol 343:1135-46. 2004
    ..Our data also suggest that homodimerisation via C-terminal coiled-coil domain affects both intra- and intermolecular interactions of Ruk proteins...
  5. ncbi Neurons expressing the highest levels of gamma-synuclein are unaffected by targeted inactivation of the gene
    Natalia Ninkina
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, U K
    Mol Cell Biol 23:8233-45. 2003
    ..Nerve injury led to similar changes in sensory function in wild-type and mutant mice. Taken together, our data suggest that like alpha-synuclein, gamma-synuclein is dispensable for the development and function of the nervous system...
  6. ncbi Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein
    Steven L Senior
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Eur J Neurosci 27:947-57. 2008
    ..Rather, we propose that loss of both alpha- and gamma-synuclein causes an increase in release probability from dopaminergic synapses...
  7. ncbi Adaptor protein Ruk/CIN85 is associated with a subset of COPI-coated membranes of the Golgi complex
    Serhiy Havrylov
    School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, Wales, UK
    Traffic 9:798-812. 2008
    ..Only a small pool of Ruk/CIN85 is present in compartments involved in clathrin-mediated endocytosis and sorting. These results suggest that endogenous Ruk/CIN85 may be involved in regulation of specific membrane trafficking processes...
  8. ncbi Whole genome expression analyses of single- and double-knock-out mice implicate partially overlapping functions of alpha- and gamma-synuclein
    Melanie Kuhn
    Department of Medical Genetics, University of Tuebingen, Calwerstrasse 7, 72076 Tubingen, Germany
    Neurogenetics 8:71-81. 2007
    ..beta-synuclein expression was not significantly altered in any of the models...
  9. ncbi Expression pattern of dd4, a sole member of the d4 family of transcription factors in Drosophila melanogaster
    Elena Nabirochkina
    Institute of Gene Biology, Russian Academy of Sciences, 34 5, Vavilov Street, 117334 Moscow, Russia
    Mech Dev 114:119-23. 2002
    ..In flies dd4 mRNA is found in most tissues but the highest level of expression is detected in ovaries...
  10. ncbi Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons
    Anirban R Saha
    Department of Neuroscience, PO Box 38, Institute of Psychiatry, King s College London, De Crespigny Park, London, SE5 8AF, UK
    J Cell Sci 117:1017-24. 2004
    ....
  11. ncbi Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease
    Kumlesh K Dev
    Novartis Pharma AG, Nervous System Research, WKL125.5.13, CH-4002 Basel, Switzerland
    Neuropharmacology 45:14-44. 2003
    ..Here, we summarize the main structural features of alphaSN and its functions, and discuss the molecular alphaSN species implicated in human disease and transgenic animal models of alpha-synucleinopathy in fly and rodents...
  12. ncbi Gamma-synuclein is an adipocyte-neuron gene coordinately expressed with leptin and increased in human obesity
    Pieter J Oort
    USDA Agricultural Research Service Western Human Nutrition Research Center, Davis, CA 95616, USA
    J Nutr 138:841-8. 2008
    ..0001; n = 44). Gamma-synuclein protein was observed in rodent and human WAT but not in negative control liver. These results are consistent with the hypothesis that gamma-synuclein plays an important role in adipocyte physiology...