Andrzej M Brzozowski

Summary

Affiliation: University of York
Country: UK

Publications

  1. ncbi request reprint Structural origins of the interfacial activation in Thermomyces (Humicola) lanuginosa lipase
    A M Brzozowski
    York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, YO10 5DD, U K
    Biochemistry 39:15071-82. 2000
  2. ncbi request reprint Structural origins of the functional divergence of human insulin-like growth factor-I and insulin
    Andrzej M Brzozowski
    Structural Biology Laboratory, Chemistry Department, University of York, Heslington, York YO10 5DD, United Kingdom
    Biochemistry 41:9389-97. 2002
  3. ncbi request reprint The crystal structure of the AAA domain of the ATP-dependent protease FtsH of Escherichia coli at 1.5 A resolution
    Szymon Krzywda
    Structural Biology Laboratory, Department of Chemistry, University of York, United Kingdom
    Structure 10:1073-83. 2002
  4. ncbi request reprint The crystal structure of gankyrin, an oncoprotein found in complexes with cyclin-dependent kinase 4, a 19 S proteasomal ATPase regulator, and the tumor suppressors Rb and p53
    Szymon Krzywda
    Structural Biology Laboratory, University of York, York YO10 5YW, United Kingdom
    J Biol Chem 279:1541-5. 2004
  5. pmc The crystal structure of superoxide dismutase from Plasmodium falciparum
    Ian W Boucher
    Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5YW, UK
    BMC Struct Biol 6:20. 2006
  6. pmc Structural and biochemical characterization of a mitochondrial peroxiredoxin from Plasmodium falciparum
    Ian W Boucher
    Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5YW, UK
    Mol Microbiol 61:948-59. 2006
  7. ncbi request reprint Structures of Plasmodium falciparum purine nucleoside phosphorylase complexed with sulfate and its natural substrate inosine
    Claudia Schnick
    Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5YW, England
    Acta Crystallogr D Biol Crystallogr 61:1245-54. 2005
  8. pmc N-myristoyltransferase from Leishmania donovani: structural and functional characterisation of a potential drug target for visceral leishmaniasis
    James A Brannigan
    York Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5YW, UK
    J Mol Biol 396:985-99. 2010
  9. ncbi request reprint Crystallization of gankyrin, an oncoprotein that interacts with CDK4 and the S6b (rpt3) ATPase of the 19S regulator of the 26S proteasome
    Szymon Krzywda
    Department of Chemistry, University of York, York YO10 5YW, England
    Acta Crystallogr D Biol Crystallogr 59:1294-5. 2003
  10. pmc Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of variants of monoamine oxidase from Aspergillus niger
    Kate E Atkin
    Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5YW, England
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:182-5. 2008

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Structural origins of the interfacial activation in Thermomyces (Humicola) lanuginosa lipase
    A M Brzozowski
    York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, YO10 5DD, U K
    Biochemistry 39:15071-82. 2000
    ..This suggests that the sequence of the structural changes, as exemplified in various TlL crystal structures, mirror those that may occur during interfacial activation...
  2. ncbi request reprint Structural origins of the functional divergence of human insulin-like growth factor-I and insulin
    Andrzej M Brzozowski
    Structural Biology Laboratory, Chemistry Department, University of York, Heslington, York YO10 5DD, United Kingdom
    Biochemistry 41:9389-97. 2002
    ..The equivalent region of proinsulin is involved in hormone processing demanding a reassessment of the structural integrity of hIGF-I in relation to its biological function...
  3. ncbi request reprint The crystal structure of the AAA domain of the ATP-dependent protease FtsH of Escherichia coli at 1.5 A resolution
    Szymon Krzywda
    Structural Biology Laboratory, Department of Chemistry, University of York, United Kingdom
    Structure 10:1073-83. 2002
    ..A sulfate anion in the ATP binding pocket mimics the beta-phosphate group of an adenine nucleotide. A hexamer form of FtsH has been modeled, providing insights into possible modes of nucleotide binding and intersubunit catalysis...
  4. ncbi request reprint The crystal structure of gankyrin, an oncoprotein found in complexes with cyclin-dependent kinase 4, a 19 S proteasomal ATPase regulator, and the tumor suppressors Rb and p53
    Szymon Krzywda
    Structural Biology Laboratory, University of York, York YO10 5YW, United Kingdom
    J Biol Chem 279:1541-5. 2004
    ..Comparison with the structures of other ankyrin repeat proteins suggests that interactions with partner proteins are mediated by residues situated on this concave surface...
  5. pmc The crystal structure of superoxide dismutase from Plasmodium falciparum
    Ian W Boucher
    Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5YW, UK
    BMC Struct Biol 6:20. 2006
    ..Thus, inhibitors of P. falciparum SODs have potential as anti-malarial compounds. As a step towards their development we have determined the crystal structure of the parasite's cytosolic iron superoxide dismutase...
  6. pmc Structural and biochemical characterization of a mitochondrial peroxiredoxin from Plasmodium falciparum
    Ian W Boucher
    Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5YW, UK
    Mol Microbiol 61:948-59. 2006
    ..These results show that the mitochondrial peroxiredoxin of P. falciparum occurs in both dimeric and decameric forms when purified under non-reducing conditions...
  7. ncbi request reprint Structures of Plasmodium falciparum purine nucleoside phosphorylase complexed with sulfate and its natural substrate inosine
    Claudia Schnick
    Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5YW, England
    Acta Crystallogr D Biol Crystallogr 61:1245-54. 2005
    ..Together, these structures serve as a basis for better understanding of ligand binding and mechanism that can be further exploited to optimize the specificity of anti-PfPNP drugs...
  8. pmc N-myristoyltransferase from Leishmania donovani: structural and functional characterisation of a potential drug target for visceral leishmaniasis
    James A Brannigan
    York Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5YW, UK
    J Mol Biol 396:985-99. 2010
    ..These studies validate L. donovani NMT as a potential target for development of new therapeutic agents against visceral leishmaniasis...
  9. ncbi request reprint Crystallization of gankyrin, an oncoprotein that interacts with CDK4 and the S6b (rpt3) ATPase of the 19S regulator of the 26S proteasome
    Szymon Krzywda
    Department of Chemistry, University of York, York YO10 5YW, England
    Acta Crystallogr D Biol Crystallogr 59:1294-5. 2003
    ..Gankyrin has been crystallized from polyethylene glycol solutions and diffraction data have been obtained from these crystals that extend to 2.1 A spacing...
  10. pmc Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of variants of monoamine oxidase from Aspergillus niger
    Kate E Atkin
    Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5YW, England
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:182-5. 2008
    ..Solution of these structures will help shed light on the molecular determinants of improved activity and high enantioselectivity towards a broad range of substrates...
  11. ncbi request reprint Microscale vapour diffusion for protein crystallization
    Justyna Korczynska
    Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5YW, England
    Acta Crystallogr D Biol Crystallogr 63:1009-15. 2007
    ....
  12. ncbi request reprint The interaction of RNA with TRAP: the role of triplet repeats and separating spacer nucleotides
    Nicholas H Hopcroft
    York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5YW, UK
    J Mol Biol 338:43-53. 2004
    ..This is accompanied by the disruption of stacking interactions between the bases of the other nucleotides, contributing to the increase in entropy that drives binding...
  13. ncbi request reprint Crystallization of the AAA domain of the ATP-dependent protease FtsH of Escherichia coli
    Szymon Krzywda
    Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5DD, England
    Acta Crystallogr D Biol Crystallogr 58:1066-7. 2002
    ..The ATPase domain of FtsH from Escherichia coli has been crystallized from ammonium sulfate solutions and crystals diffracting to 1.5 A resolution have been obtained...