Research Topics
| Lena BrydonSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Hostility and cellular aging in men from the Whitehall II cohortLena Brydon
Department of Epidemiology and Public Health, University College London, United Kingdom
Biol Psychiatry 71:767-73. 2012..Here we investigated the hypothesis that hostility might impact health by promoting cellular aging...
Stress-induced cytokine responses and central adiposity in young womenL Brydon
Department of Epidemiology and Public Health, Psychobiology Group, University College London, London, UK
Int J Obes (Lond) 32:443-50. 2008....
Peripheral inflammation is associated with altered substantia nigra activity and psychomotor slowing in humansLena Brydon
Department of Epidemiology and Public Health, Institute of Neurology at University College London, London, United Kingdom
Biol Psychiatry 63:1022-9. 2008..Systemic infections commonly cause sickness symptoms including psychomotor retardation. Inflammatory cytokines released during the innate immune response are implicated in the communication of peripheral inflammatory signals to the brain...- Circulating leptin and stress-induced cardiovascular activity in humansLena Brydon
Department of Epidemiology and Public Health, University College London, London, UK
Obesity (Silver Spring) 16:2642-7. 2008..Because cardiovascular and inflammatory stress responses are predictive of future cardiovascular disease, leptin may be a mechanism mediating the adverse effects of stress and obesity on women's cardiovascular health... - Adiposity, leptin and stress reactivity in humansLena Brydon
Psychobiology Group, Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, United Kingdom
Biol Psychol 86:114-20. 2011..Our findings suggest that the cytokines leptin and IL-1Ra may play a role in the association between obesity, stress and cardiovascular health... - Synergistic effects of psychological and immune stressors on inflammatory cytokine and sickness responses in humansLena Brydon
Psychobiology Group, Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, UK
Brain Behav Immun 23:217-24. 2009..Our findings suggest that, as seen in animals, psychological and immune stressors may act synergistically to promote inflammation and sickness behaviour in humans... - Hostility and physiological responses to laboratory stress in acute coronary syndrome patientsLena Brydon
Psychobiology Group, Department of Epidemiology and Public Health, University College London, London, United Kingdom
J Psychosom Res 68:109-16. 2010..This study set out to test whether hostile individuals with advanced CAD were also more stress responsive... - Dispositional optimism and stress-induced changes in immunity and negative moodLena Brydon
Psychobiology Group, Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London, UK
Brain Behav Immun 23:810-6. 2009..Together these findings suggest that optimism may promote health, by counteracting stress-induced increases in inflammation and boosting the adjuvant effects of acute stress... - Self-esteem levels and cardiovascular and inflammatory responses to acute stressKatie O'Donnell
Psychobiology Group, Department of Epidemiology and Public Health University College London, 1 19 Torrington Place, London WC1E 6BT, UK
Brain Behav Immun 22:1241-7. 2008..These responses could be processes through which self-esteem protects against the development of disease... - Exaggerated platelet and hemodynamic reactivity to mental stress in men with coronary artery diseasePhilip C Strike
Psychobiology Group, Department of Epidemiology and Public Health, University College London, London, UK
Psychosom Med 66:492-500. 2004..This study compared the effects of acute mental stress on cardiovascular and subjective responses and platelet activation in male patients with established coronary artery disease (CAD) and age-matched controls... - Pathophysiological processes underlying emotional triggering of acute cardiac eventsPhilip C Strike
Psychobiology Group, Department of Epidemiology and Public Health, University College London, London WC1E 6BT, United Kingdom
Proc Natl Acad Sci U S A 103:4322-7. 2006.... - Parental adiposity and cortisol awakening responses in young men and womenAndrew Steptoe
Psychobiology Group, Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, UK
Psychoneuroendocrinology 31:1117-26. 2006..The results of this study suggest that disturbances of cortisol secretion may present before the emergence of heightened adiposity in young men at raised risk for obesity... - Family history of cardiovascular disease is associated with cardiovascular responses to stress in healthy young men and womenCaroline E Wright
Psychobiology Group, Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London, UK
Int J Psychophysiol 63:275-82. 2007..The findings indicate that a family history of cardiovascular disease risk influences stress responsivity which may in turn contribute to risk of future cardiovascular disorders... - Educational attainment but not measures of current socioeconomic circumstances are associated with leukocyte telomere length in healthy older men and womenAndrew Steptoe
Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, UK
Brain Behav Immun 25:1292-8. 2011..Education may also promote problem-solving skills leading to reduced biological stress responsivity, with favorable consequences for biological aging... - Loneliness and neuroendocrine, cardiovascular, and inflammatory stress responses in middle-aged men and womenAndrew Steptoe
Psychobiology Group, Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, UK
Psychoneuroendocrinology 29:593-611. 2004..046). We conclude that loneliness is a psychological experience with potentially adverse effects on biological stress processes that may be relevant to health... - Arterial stiffness and inflammatory response to psychophysiological stressElizabeth Ellins
Vascular Physiology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
Brain Behav Immun 22:941-8. 2008..We conclude that individual differences in inflammatory responses to psychophysiological stress are independently related to structural changes in artery walls that reflect increased cardiovascular disease risk... - Stress-induced increases in interleukin-6 and fibrinogen predict ambulatory blood pressure at 3-year follow-upLena Brydon
The Psychobiology Group, Department of Epidemiology and Public Health, University College London, UK
J Hypertens 23:1001-7. 2005..CONCLUSION: Given the important roles of interleukin-6 and fibrinogen in hypertensive pathophysiology, these results indicate that psychological stress could promote hypertension through stimulating these inflammatory proteins... - Psychological stress activates interleukin-1beta gene expression in human mononuclear cellsLena Brydon
The Psychobiology Group, Department of Epidemiology and Public Health, University College London, London, UK
Brain Behav Immun 19:540-6. 2005..Stress-induced activation of mononuclear IL-1beta is a novel mechanism potentially linking stress and heart disease. This mechanism could also play a role in other inflammatory diseases exacerbated by stress... - Platelets, coronary heart disease, and stressLena Brydon
The Psychobiology Group, Department of Epidemiology and Public Health, University College London, London, UK
Brain Behav Immun 20:113-9. 2006..Platelet activation may be a mechanism linking psychosocial stress with increased coronary risk, and may also play a role in the emotional triggering of acute coronary syndromes in patients with advanced coronary disease... - Loneliness and stress-related inflammatory and neuroendocrine responses in older men and womenRuth A Hackett
Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, UK
Psychoneuroendocrinology 37:1801-9. 2012..008). The impact of loneliness on health in women may be mediated in part through dysregulation of inflammatory and neuroendocrine systems... - Changes in financial strain over three years, ambulatory blood pressure, and cortisol responses to awakeningAndrew Steptoe
Department of Epidemiology and Public Health, University College London, London WC1E 6BT, United Kingdom
Psychosom Med 67:281-7. 2005..We assessed the influence of changes in financial strain on ambulatory blood pressure and salivary cortisol... - The influence of psychological stress and socioeconomic status on platelet activation in menAndrew Steptoe
Department of Epidemiology and Public Health, Psychobiology Group, University College London, UK
Atherosclerosis 168:57-63. 2003..Socioeconomic status is inversely associated with risk of coronary heart disease. We assessed the impact of psychological stress on leukocyte-platelet aggregates in men from higher and lower socioeconomic status groups... - Emotional triggering of cardiac eventsAndrew Steptoe
Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, UK
Neurosci Biobehav Rev 33:63-70. 2009..These factors in turn promote coronary plaque disruption, myocardial ischaemia, cardiac dysrhythmia and thrombus formation. The implications of these findings for patient care and ACS prevention are outlined... - Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivityNeil A Harrison
Wellcome Trust, Centre for Neuroimaging, Institute of Cognitive Neuroscience, UCL, 17 Queen Square, London WC1N 3AR, UK
Biol Psychiatry 66:407-14. 2009..Similarly in humans, therapeutic interferon-alpha induces clinical depression in a third of patients. Conversely, patients with depression also show elevated pro-inflammatory cytokines... - Neural origins of human sickness in interoceptive responses to inflammationNeil A Harrison
Wellcome Trust, Centre for Neuroimaging, Institute of Cognitive Neuroscience, UCL, 17 Queen Square, London WC1N 3AR, UK
Biol Psychiatry 66:415-22. 2009..Studies in rodents suggest an afferent interoceptive neural mechanism, although comparable data in humans are lacking... - Acute inflammation and negative mood: mediation by cytokine activationC E Wright
Psychobiology Group, Department of Epidemiology and Public Health, University College London, London, UK
Brain Behav Immun 19:345-50. 2005..Implications for depressed mood in physical illness are discussed... - Central adiposity and cortisol responses to waking in middle-aged men and womenA Steptoe
Department of Epidemiology and Public Health, University College London, London, UK
Int J Obes Relat Metab Disord 28:1168-73. 2004..We investigated whether central adiposity indexed by waist/hip ratio is related to cortisol responses to waking and other measures of salivary cortisol over the working day... - Socioeconomic status and stress-induced increases in interleukin-6L Brydon
The Psychobiology Group, Department of Epidemiology and Public Health, University College London, London, UK
Brain Behav Immun 18:281-90. 2004..Prolonged stress-induced increases in IL-6 in low SES groups represents a novel mechanism potentially linking socioeconomic position and heart disease... - Associations between acute lipid stress responses and fasting lipid levels 3 years laterAndrew Steptoe
Department of Epidemiology and Public Health, University College London, UK
Health Psychol 24:601-7. 2005..Acute lipid stress responsivity may reflect processes that contribute to the development of elevated blood cholesterol concentration... - Distribution of melatonin MT1 receptor immunoreactivity in human retinaEgemen Savaskan
Department of Gerontopsychiatry, Psychiatric University Clinic, University of Basel, Wilhelm Klein Strasse 27, CH 4025 Basel, Switzerland
J Histochem Cytochem 50:519-26. 2002..In AD cases photoreceptor cells were degenerated and showed low MT1 expression...