Valerie G Brunton

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. doi request reprint Src and focal adhesion kinase as therapeutic targets in cancer
    Valerie G Brunton
    Institute of Genetics and Molecular Medicine, Division of Cancer Biology, University of Edinburgh, Crewe Road South, Edinburgh, United Kingdom
    Curr Opin Pharmacol 8:427-32. 2008
  2. doi request reprint E-cadherin-integrin crosstalk in cancer invasion and metastasis
    Marta Canel
    Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK
    J Cell Sci 126:393-401. 2013
  3. pmc Use of photoactivation and photobleaching to monitor the dynamic regulation of E-cadherin at the plasma membrane
    Marta Canel
    Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh, UK
    Cell Adh Migr 4:491-501. 2010
  4. doi request reprint The role of focal adhesion kinase catalytic activity on the proliferation and migration of squamous cell carcinoma cells
    Alan Serrels
    Edinburgh Cancer Research Centre, Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
    Int J Cancer 131:287-97. 2012
  5. pmc Src/FAK-mediated regulation of E-cadherin as a mechanism for controlling collective cell movement: insights from in vivo imaging
    Alan Serrels
    Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
    Cell Adh Migr 5:360-5. 2011
  6. pmc Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics
    Marta Canel
    Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
    Cancer Res 70:9413-22. 2010
  7. doi request reprint Kindlin-1 regulates mitotic spindle formation by interacting with integrins and Plk-1
    Hitesh Patel
    Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK
    Nat Commun 4:2056. 2013
  8. pmc E7080, a multi-targeted tyrosine kinase inhibitor suppresses tumor cell migration and invasion
    Hilary Glen
    Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh, UK
    BMC Cancer 11:309. 2011
  9. doi request reprint Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling
    Emma Sandilands
    Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XR, UK
    Nat Cell Biol 14:51-60. 2012
  10. doi request reprint A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity
    Bryan Serrels
    Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, UK
    Curr Biol 20:1086-92. 2010

Collaborators

Detail Information

Publications18

  1. doi request reprint Src and focal adhesion kinase as therapeutic targets in cancer
    Valerie G Brunton
    Institute of Genetics and Molecular Medicine, Division of Cancer Biology, University of Edinburgh, Crewe Road South, Edinburgh, United Kingdom
    Curr Opin Pharmacol 8:427-32. 2008
    ..These adhesion-linked kinases are involved in a number of pathways that have impact on the behaviour of tumour cells and the challenge is now, how to take these forward in the clinical setting...
  2. doi request reprint E-cadherin-integrin crosstalk in cancer invasion and metastasis
    Marta Canel
    Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK
    J Cell Sci 126:393-401. 2013
    ..In particular, we will discuss the role of the adhesion-linked kinases Src, focal adhesion kinase (FAK) and integrin-linked kinase (ILK), and the Rho family of GTPases...
  3. pmc Use of photoactivation and photobleaching to monitor the dynamic regulation of E-cadherin at the plasma membrane
    Marta Canel
    Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh, UK
    Cell Adh Migr 4:491-501. 2010
    ....
  4. doi request reprint The role of focal adhesion kinase catalytic activity on the proliferation and migration of squamous cell carcinoma cells
    Alan Serrels
    Edinburgh Cancer Research Centre, Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
    Int J Cancer 131:287-97. 2012
    ..These data support the further development of FAK kinase inhibitors as agents that have the potential to inhibit both tumour cell migration and proliferation...
  5. pmc Src/FAK-mediated regulation of E-cadherin as a mechanism for controlling collective cell movement: insights from in vivo imaging
    Alan Serrels
    Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
    Cell Adh Migr 5:360-5. 2011
    ..We focus on the regulatory crosstalk between the Src/FAK signaling axis and E-cadherin in vivo...
  6. pmc Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics
    Marta Canel
    Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
    Cancer Res 70:9413-22. 2010
    ....
  7. doi request reprint Kindlin-1 regulates mitotic spindle formation by interacting with integrins and Plk-1
    Hitesh Patel
    Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK
    Nat Commun 4:2056. 2013
    ..Our work identifies a novel cellular role for Kindlin-1 in ensuring mitotic spindle assembly and cellular survival that is controlled by phosphorylation via Polo-like kinase 1. ..
  8. pmc E7080, a multi-targeted tyrosine kinase inhibitor suppresses tumor cell migration and invasion
    Hilary Glen
    Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh, UK
    BMC Cancer 11:309. 2011
    ..It has been shown to inhibit tumor angiogenesis by targeting endothelial cells. A number of the targets of E7080 are also expressed on tumor cells and here we have looked at the direct effects of E7080 on tumor cell behavior...
  9. doi request reprint Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling
    Emma Sandilands
    Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XR, UK
    Nat Cell Biol 14:51-60. 2012
    ..This exposes a previously unrecognized cancer cell vulnerability that may provide a new therapeutic opportunity...
  10. doi request reprint A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity
    Bryan Serrels
    Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, UK
    Curr Biol 20:1086-92. 2010
    ..FAK/RACK1/PDE4D5 is a novel 'direction-sensing' complex that acts to recruit specific components of the cAMP second-messenger system to nascent integrin adhesions and to the leading edge of polarizing cells...
  11. ncbi request reprint Combining imaging and pathway profiling: an alternative approach to cancer drug discovery
    Neil O Carragher
    Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, UK
    Drug Discov Today 17:203-14. 2012
    ..The implementation of such approaches at early stages of the drug discovery process enables more informed decisions on candidate drug selection and how to maximise and predict efficacy before clinical development...
  12. doi request reprint Selective tyrosine kinase inhibition of insulin-like growth factor-1 receptor inhibits human and mouse breast cancer-induced bone cell activity, bone remodeling, and osteolysis
    John G Logan
    Bone and Cancer Group, Edinburgh Cancer Research Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK
    J Bone Miner Res 28:1229-42. 2013
    ..Therefore, PQIP, and its novel derivatives that are currently in advanced clinical development for the treatment of a number of solid tumors, may be of value in the treatment of osteolytic bone disease associated with breast cancer...
  13. doi request reprint QD-filled micelles which combine SPECT and optical imaging with light-induced activation of a platinum(IV) prodrug for anticancer applications
    Carmen R Maldonado
    School of Chemistry, University of Edinburgh, Edinburgh, UK
    Chem Commun (Camb) 49:3985-7. 2013
    ..The fac-[(99m)Tc(OH2)3(CO)3](+) complex reacts with QD-filled micelles to create a bimodal SPECT-optical imaging probe which upon visible light irradiation generates cisplatin from an inert Pt(IV) prodrug...
  14. pmc Diversity of matriptase expression level and function in breast cancer
    Arkadiusz Welman
    Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    PLoS ONE 7:e34182. 2012
    ..This correlated with downregulation of the cell-cell adhesion molecule E-cadherin. These results suggest that the functions of matriptase in breast cancer are likely to be variable and cell context dependent...
  15. ncbi request reprint Src kinase inhibitors: promising cancer therapeutics?
    Helen Creedon
    Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
    Crit Rev Oncog 17:145-59. 2012
    ..Taking this integrated approach will hopefully help to realize the true potential of Src kinase inhibitors...
  16. doi request reprint A novel Src kinase inhibitor reduces tumour formation in a skin carcinogenesis model
    Bryan Serrels
    Institute of Genetics and Molecular Medicine, Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh, UK
    Carcinogenesis 30:249-57. 2009
    ..Thus, Src inhibitors such as AZD0530 may therefore have chemopreventative properties in patients with hyperproliferative epidermal disorders...
  17. doi request reprint Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development
    Alan Serrels
    Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
    Cancer Res 69:2714-9. 2009
    ..Furthermore, this work highlights critical differences in molecular dynamics in vitro and in vivo, which have important implications for the use of cultured disease models as surrogates for living tissue...
  18. pmc Two-color photoactivatable probe for selective tracking of proteins and cells
    Arkadiusz Welman
    Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, Scotland, United Kingdom
    J Biol Chem 285:11607-16. 2010
    ..The in vivo utility of G(PA)C is exemplified by tracking hemocyte movements using a versatile transgenic Drosophila model engineered to express G(PA)C in tissues and cells of interest under the control of the GAL4-inducible promoter...