Research Topics
Genomes and Genes | Valerie G BruntonSummaryAffiliation: University of Edinburgh Country: UK Publications
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Publications
Src and focal adhesion kinase as therapeutic targets in cancerValerie G Brunton
Institute of Genetics and Molecular Medicine, Division of Cancer Biology, University of Edinburgh, Crewe Road South, Edinburgh, United Kingdom
Curr Opin Pharmacol 8:427-32. 2008..These adhesion-linked kinases are involved in a number of pathways that have impact on the behaviour of tumour cells and the challenge is now, how to take these forward in the clinical setting...
Use of photoactivation and photobleaching to monitor the dynamic regulation of E-cadherin at the plasma membraneMarta Canel
Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh, UK
Cell Adh Migr 4:491-501. 2010....- The role of focal adhesion kinase catalytic activity on the proliferation and migration of squamous cell carcinoma cellsAlan Serrels
Edinburgh Cancer Research Centre, Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
Int J Cancer 131:287-97. 2012..These data support the further development of FAK kinase inhibitors as agents that have the potential to inhibit both tumour cell migration and proliferation... - Src/FAK-mediated regulation of E-cadherin as a mechanism for controlling collective cell movement: insights from in vivo imagingAlan Serrels
Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
Cell Adh Migr 5:360-5. 2011..We focus on the regulatory crosstalk between the Src/FAK signaling axis and E-cadherin in vivo... - Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamicsMarta Canel
Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
Cancer Res 70:9413-22. 2010.... - E7080, a multi-targeted tyrosine kinase inhibitor suppresses tumor cell migration and invasionHilary Glen
Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh, UK
BMC Cancer 11:309. 2011..It has been shown to inhibit tumor angiogenesis by targeting endothelial cells. A number of the targets of E7080 are also expressed on tumor cells and here we have looked at the direct effects of E7080 on tumor cell behavior... - Autophagic targeting of Src promotes cancer cell survival following reduced FAK signallingEmma Sandilands
Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XR, UK
Nat Cell Biol 14:51-60. 2012..This exposes a previously unrecognized cancer cell vulnerability that may provide a new therapeutic opportunity... - A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarityBryan Serrels
Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, UK
Curr Biol 20:1086-92. 2010..FAK/RACK1/PDE4D5 is a novel 'direction-sensing' complex that acts to recruit specific components of the cAMP second-messenger system to nascent integrin adhesions and to the leading edge of polarizing cells... 
Combining imaging and pathway profiling: an alternative approach to cancer drug discoveryNeil O Carragher
Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, UK
Drug Discov Today 17:203-14. 2012..The implementation of such approaches at early stages of the drug discovery process enables more informed decisions on candidate drug selection and how to maximise and predict efficacy before clinical development...- Src kinase inhibitors: promising cancer therapeutics?Helen Creedon
Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
Crit Rev Oncog 17:145-59. 2012..Taking this integrated approach will hopefully help to realize the true potential of Src kinase inhibitors... - Diversity of matriptase expression level and function in breast cancerArkadiusz Welman
Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, United Kingdom
PLoS ONE 7:e34182. 2012..This correlated with downregulation of the cell-cell adhesion molecule E-cadherin. These results suggest that the functions of matriptase in breast cancer are likely to be variable and cell context dependent... - A novel Src kinase inhibitor reduces tumour formation in a skin carcinogenesis modelBryan Serrels
Institute of Genetics and Molecular Medicine, Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh, UK
Carcinogenesis 30:249-57. 2009..Thus, Src inhibitors such as AZD0530 may therefore have chemopreventative properties in patients with hyperproliferative epidermal disorders... - Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug developmentAlan Serrels
Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
Cancer Res 69:2714-9. 2009..Furthermore, this work highlights critical differences in molecular dynamics in vitro and in vivo, which have important implications for the use of cultured disease models as surrogates for living tissue... - Two-color photoactivatable probe for selective tracking of proteins and cellsArkadiusz Welman
Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, Scotland, United Kingdom
J Biol Chem 285:11607-16. 2010..The in vivo utility of G(PA)C is exemplified by tracking hemocyte movements using a versatile transgenic Drosophila model engineered to express G(PA)C in tissues and cells of interest under the control of the GAL4-inducible promoter...