Simon B Brown

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. doi request reprint Skin exposure to micro- and nano-particles can cause haemostasis in zebrafish larvae
    Jennifer A McLeish
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK
    Thromb Haemost 103:797-807. 2010
  2. pmc Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death
    Murray C H Clarke
    Centre for Inflammation Research, Department of Clinical and Surgical Sciences Internal Medicine, Royal Infirmary Edinburgh, Edinburgh EH3 9YW, UK
    J Cell Biol 160:577-87. 2003
  3. ncbi request reprint Phagocytosis triggers macrophage release of Fas ligand and induces apoptosis of bystander leukocytes
    S B Brown
    Division of Renal and Inflammatory Disease, University Hospital, Nottingham, United Kingdom
    J Immunol 162:480-5. 1999
  4. ncbi request reprint Constitutive death of platelets leading to scavenger receptor-mediated phagocytosis. A caspase-independent cell clearance program
    S B Brown
    Centre for Inflammation Research, Department of Clinical Sciences, Royal Infirmary, Edinburgh, EH3 9YW
    J Biol Chem 275:5987-96. 2000
  5. ncbi request reprint Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment
    Simon Brown
    Inflammation Repair Group, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh EH8 9AG, UK
    Nature 418:200-3. 2002
  6. doi request reprint Electric fields and inflammation: may the force be with you
    Simon B Brown
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    ScientificWorldJournal 8:1280-94. 2008
  7. ncbi request reprint Promoting apoptosis in disease management: a panacea or Trojan horse?
    Simon B Brown
    Inflammation Repair Group, MRC Centre for Inflammation Research, University of Edinburgh College of Medicine and Veterinary Medicine, Edinburgh EH8 9AG, UK
    Curr Opin Pharmacol 5:444-8. 2005
  8. ncbi request reprint Class III antiarrhythmic methanesulfonanilides inhibit leukocyte recruitment in zebrafish
    Simon B Brown
    MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    J Leukoc Biol 82:79-84. 2007
  9. ncbi request reprint CD31 delays phagocyte membrane repolarization to promote efficient binding of apoptotic cells
    Elizabeth F Vernon-Wilson
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, UK
    J Leukoc Biol 82:1278-88. 2007
  10. ncbi request reprint CD31 promotes beta1 integrin-dependent engulfment of apoptotic Jurkat T lymphocytes opsonized for phagocytosis by fibronectin
    Elizabeth F Vernon-Wilson
    MRC Centre for Inflammation Research, C2 05 Queen s Medical Research Institute, Little France Crescent, Edinburgh EH16 4TJ, UK
    J Leukoc Biol 79:1260-7. 2006

Collaborators

Detail Information

Publications18

  1. doi request reprint Skin exposure to micro- and nano-particles can cause haemostasis in zebrafish larvae
    Jennifer A McLeish
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK
    Thromb Haemost 103:797-807. 2010
    ....
  2. pmc Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death
    Murray C H Clarke
    Centre for Inflammation Research, Department of Clinical and Surgical Sciences Internal Medicine, Royal Infirmary Edinburgh, Edinburgh EH3 9YW, UK
    J Cell Biol 160:577-87. 2003
    ..Thus, progenitor cell death by apoptosis can result in birth of multiple functional anucleate daughter cells...
  3. ncbi request reprint Phagocytosis triggers macrophage release of Fas ligand and induces apoptosis of bystander leukocytes
    S B Brown
    Division of Renal and Inflammatory Disease, University Hospital, Nottingham, United Kingdom
    J Immunol 162:480-5. 1999
    ....
  4. ncbi request reprint Constitutive death of platelets leading to scavenger receptor-mediated phagocytosis. A caspase-independent cell clearance program
    S B Brown
    Centre for Inflammation Research, Department of Clinical Sciences, Royal Infirmary, Edinburgh, EH3 9YW
    J Biol Chem 275:5987-96. 2000
    ....
  5. ncbi request reprint Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment
    Simon Brown
    Inflammation Repair Group, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh EH8 9AG, UK
    Nature 418:200-3. 2002
    ....
  6. doi request reprint Electric fields and inflammation: may the force be with you
    Simon B Brown
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    ScientificWorldJournal 8:1280-94. 2008
    ..In this way, direct-current electric fields generated at a site of tissue injury can promote the galvanotaxis or directed migration of cells involved in tissue repair and inflammation...
  7. ncbi request reprint Promoting apoptosis in disease management: a panacea or Trojan horse?
    Simon B Brown
    Inflammation Repair Group, MRC Centre for Inflammation Research, University of Edinburgh College of Medicine and Veterinary Medicine, Edinburgh EH8 9AG, UK
    Curr Opin Pharmacol 5:444-8. 2005
    ....
  8. ncbi request reprint Class III antiarrhythmic methanesulfonanilides inhibit leukocyte recruitment in zebrafish
    Simon B Brown
    MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    J Leukoc Biol 82:79-84. 2007
    ..Our results suggest that ERG-specific Class III antiarrhythmic drugs can modulate inflammatory responses to infection...
  9. ncbi request reprint CD31 delays phagocyte membrane repolarization to promote efficient binding of apoptotic cells
    Elizabeth F Vernon-Wilson
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, UK
    J Leukoc Biol 82:1278-88. 2007
    ..Our results identify ERG as a downstream effector of CD31 in the regulation of integrin-dependent binding of apoptotic cells by macrophages...
  10. ncbi request reprint CD31 promotes beta1 integrin-dependent engulfment of apoptotic Jurkat T lymphocytes opsonized for phagocytosis by fibronectin
    Elizabeth F Vernon-Wilson
    MRC Centre for Inflammation Research, C2 05 Queen s Medical Research Institute, Little France Crescent, Edinburgh EH16 4TJ, UK
    J Leukoc Biol 79:1260-7. 2006
    ..Thus, selective "tethering" of apoptotic leukocytes by phagocyte CD31 not only discriminates dying from viable cells but also selectively activates phagocyte integrins for the engulfment of apoptotic cells...
  11. ncbi request reprint Hypoglycaemia predisposes platelets to death by affecting calcium homeostasis and mitochondrial integrity
    Paul S Hartley
    Inflammation Repair Group, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh EH8 9AG, UK
    Platelets 18:103-12. 2007
    ..These data suggest that extracellular glucose is utilised by platelets for calcium homeostasis and maintenance of mitochondrial integrity and that hypoglycaemia primes platelets for death...
  12. ncbi request reprint Phagocytosis of apoptotic cells by human macrophages: analysis by multiparameter flow cytometry
    Hubertus P A Jersmann
    MRC Centre for Inflammation Research, University of Edinburgh Medical School, Edinburgh, United Kingdom
    Cytometry A 51:7-15. 2003
    ..Third, microscopic quantification is time consuming and has the potential for significant interobserver error. Fourth, subsequent analysis of phagocyte populations is difficult...
  13. doi request reprint A role for potassium permeability in the recognition, clearance, and anti-inflammatory effects of apoptotic cells
    Jingxuan Zhang
    MRC Center for Inflammation Research, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, EH164TJ, UK
    Mol Neurobiol 42:17-24. 2010
    ..We speculate that how a tissue-resident macrophage responds to strong depolarizing stimuli has wider implications for inflammation and autoimmunity...
  14. doi request reprint Selective inhibitors of Kv11.1 regulate IL-6 expression by macrophages in response to TLR/IL-1R ligands
    Cheryl Hunter
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh
    ScientificWorldJournal 10:1580-96. 2010
    ..Our data might also explain the altered phenotypes displayed by PECAM-1 knockout mice in several disease models...
  15. pmc Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin
    Irini Bournazou
    The University of Edinburgh Medical Research Council MRC Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, UK
    J Clin Invest 119:20-32. 2009
    ....
  16. ncbi request reprint The death of human platelets during incubation in citrated plasma involves shedding of CD42b and aggregation of dead platelets
    Paul S Hartley
    MRC Human Genetics Unit, Edinburgh EH4 2XU, UK
    Thromb Haemost 95:100-6. 2006
    ....
  17. ncbi request reprint Apoptosis: eating sensibly
    Christopher D Gregory
    Nat Cell Biol 7:1161-3. 2005
  18. ncbi request reprint Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor
    Jon R Ward
    Section of Functional Genomics, University of Sheffield, UK
    Thromb Haemost 94:831-8. 2005
    ....