S B Brown

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. ncbi request reprint Clinical antimicrobial photodynamic therapy: phase II studies in chronic wounds
    Stan Brown
    Centre for Photobiology and Photodynamic Therapy, University of Leeds, United Kingdom
    J Natl Compr Canc Netw 10:S80-3. 2012
  2. ncbi request reprint The role of light in the treatment of non-melanoma skin cancer using methyl aminolevulinate
    S B Brown
    Centre for Photobiology and Photodynamic Therapy, School of Biochemistry and Molecular Biology University of Leeds, UK
    J Dermatolog Treat 14:11-4. 2003
  3. ncbi request reprint Verteporfin: a milestone in opthalmology and photodynamic therapy
    S B Brown
    Centre for Photobiology and Photodynamic Therapy, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
    Expert Opin Pharmacother 2:351-61. 2001
  4. ncbi request reprint The present and future role of photodynamic therapy in cancer treatment
    Stanley B Brown
    Centre for Photobiology and Photodynamic Therapy, School of Biochemistry and Microbiology, University of Leeds, UK
    Lancet Oncol 5:497-508. 2004
  5. ncbi request reprint A comparative study of the cellular uptake and photodynamic efficacy of three novel zinc phthalocyanines of differing charge
    D J Ball
    Centre for Photobiology and Photodynamic Therapy, School of Biochemistry and Molecular Biology, University of Leeds, UK
    Photochem Photobiol 69:390-6. 1999
  6. ncbi request reprint The characterisation of three substituted zinc phthalocyanines of differing charge for use in photodynamic therapy. A comparative study of their aggregation and photosensitising ability in relation to mTHPC and polyhaematoporphyrin
    D J Ball
    Centre for Photobiology and Photodynamic Therapy, University of Leeds, UK
    J Photochem Photobiol B 45:28-35. 1998
  7. ncbi request reprint Investigation of cross-resistance to a range of photosensitizers, hyperthermia and UV light in two radiation-induced fibrosarcoma cell strains resistant to photodynamic therapy in vitro
    S Mayhew
    Center for Photobiology and Photodynamic Therapy, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
    Photochem Photobiol 73:39-46. 2001
  8. pmc The photodynamic response of two rodent tumour models to four zinc (II)-substituted phthalocyanines
    J E Cruse Sawyer
    Research School of Medicine, Department of Biochemistry and Molecular Biology, Centre for Photobiology and Photodynamic Therapy, The University of Leeds, UK
    Br J Cancer 77:965-72. 1998
  9. pmc Porphyrin accumulation induced by 5-aminolaevulinic acid esters in tumour cells growing in vitro and in vivo
    R G Tunstall
    Centre for Photobiology and Photodynamic Therapy, University of Leeds, Leeds LS2 9JT, UK
    Br J Cancer 87:246-50. 2002
  10. ncbi request reprint Fluorescence photobleaching of ALA-induced protoporphyrin IX during photodynamic therapy of normal hairless mouse skin: the effect of light dose and irradiance and the resulting biological effect
    D J Robinson
    Centre for Photobiology and Photodynamic Therapy, Research School of Medicine, University of Leeds, UK
    Photochem Photobiol 67:140-9. 1998

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Clinical antimicrobial photodynamic therapy: phase II studies in chronic wounds
    Stan Brown
    Centre for Photobiology and Photodynamic Therapy, University of Leeds, United Kingdom
    J Natl Compr Canc Netw 10:S80-3. 2012
    ..Larger trials are needed to confirm its early promise and suggest its ultimate role in caring for chronic wounds...
  2. ncbi request reprint The role of light in the treatment of non-melanoma skin cancer using methyl aminolevulinate
    S B Brown
    Centre for Photobiology and Photodynamic Therapy, School of Biochemistry and Molecular Biology University of Leeds, UK
    J Dermatolog Treat 14:11-4. 2003
    ..The Aktilite lamp, specifically designed for use with Metvix cream, has an emission spectrum that closely matches the red light absorption profile of PpIX...
  3. ncbi request reprint Verteporfin: a milestone in opthalmology and photodynamic therapy
    S B Brown
    Centre for Photobiology and Photodynamic Therapy, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
    Expert Opin Pharmacother 2:351-61. 2001
    ..In this article, we look at the background to the development of BPD, primarily for its use in AMD, but also in other applications...
  4. ncbi request reprint The present and future role of photodynamic therapy in cancer treatment
    Stanley B Brown
    Centre for Photobiology and Photodynamic Therapy, School of Biochemistry and Microbiology, University of Leeds, UK
    Lancet Oncol 5:497-508. 2004
    ..Here, we review current use of PDT in oncology and look at its future potential as more selective photosensitising drugs become available...
  5. ncbi request reprint A comparative study of the cellular uptake and photodynamic efficacy of three novel zinc phthalocyanines of differing charge
    D J Ball
    Centre for Photobiology and Photodynamic Therapy, School of Biochemistry and Molecular Biology, University of Leeds, UK
    Photochem Photobiol 69:390-6. 1999
    ..This suggests that relocalization following low-level irradiation is a critical factor governing efficacy, and a diffuse cytoplasmic distribution may be a determinant of good photodynamic activity...
  6. ncbi request reprint The characterisation of three substituted zinc phthalocyanines of differing charge for use in photodynamic therapy. A comparative study of their aggregation and photosensitising ability in relation to mTHPC and polyhaematoporphyrin
    D J Ball
    Centre for Photobiology and Photodynamic Therapy, University of Leeds, UK
    J Photochem Photobiol B 45:28-35. 1998
    ..The anionic phthalocyanine is the least effective at photohaemolysis, whereas the cationic and hydrophobic phthalocyanines have improved activity over PHP and mTHPC...
  7. ncbi request reprint Investigation of cross-resistance to a range of photosensitizers, hyperthermia and UV light in two radiation-induced fibrosarcoma cell strains resistant to photodynamic therapy in vitro
    S Mayhew
    Center for Photobiology and Photodynamic Therapy, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
    Photochem Photobiol 73:39-46. 2001
    ....
  8. pmc The photodynamic response of two rodent tumour models to four zinc (II)-substituted phthalocyanines
    J E Cruse Sawyer
    Research School of Medicine, Department of Biochemistry and Molecular Biology, Centre for Photobiology and Photodynamic Therapy, The University of Leeds, UK
    Br J Cancer 77:965-72. 1998
    ..The tumours had the appearance of an infarct and, under the conditions used, the observed damage was shown to be mainly due to ischaemic processes, although some direct tumour cell damage could not be ruled out...
  9. pmc Porphyrin accumulation induced by 5-aminolaevulinic acid esters in tumour cells growing in vitro and in vivo
    R G Tunstall
    Centre for Photobiology and Photodynamic Therapy, University of Leeds, Leeds LS2 9JT, UK
    Br J Cancer 87:246-50. 2002
    ....
  10. ncbi request reprint Fluorescence photobleaching of ALA-induced protoporphyrin IX during photodynamic therapy of normal hairless mouse skin: the effect of light dose and irradiance and the resulting biological effect
    D J Robinson
    Centre for Photobiology and Photodynamic Therapy, Research School of Medicine, University of Leeds, UK
    Photochem Photobiol 67:140-9. 1998
    ..In the absence of oxygen, PpIX and its photoproducts are not photobleached. We present a method of calculating a therapeutic dose delivered during superficial PDT that demonstrates a strong correlation with PDT damage...
  11. ncbi request reprint Phthalocyanine-mediated photodynamic therapy induces cell death and a G0/G1 cell cycle arrest in cervical cancer cells
    S L Haywood-Small
    Centre for Photobiology and Photodynamic Therapy, School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, UK
    Biochem Biophys Res Commun 339:569-76. 2006
    ..Our results demonstrate cell death, inhibition of cell growth, and G(0)/G(1) cell cycle arrest during the phthalocyanine PDT-mediated response...
  12. ncbi request reprint The subcellular localization of Zn(II) phthalocyanines and their redistribution on exposure to light
    S R Wood
    Department of Biochemistry and Molecular Biology, University of Leeds, UK
    Photochem Photobiol 65:397-402. 1997
    ..This indicates that the primary sites of localization of these photosensitizers may not be as important as their secondary sites in producing cell killing during PDT, especially as the fluorescence intensity increases on relocalization...
  13. ncbi request reprint Improved response of plaque psoriasis after multiple treatments with topical 5-aminolaevulinic acid photodynamic therapy
    D J Robinson
    Centre for Photobiology and Photodynamic Therapy, Research School of Medicine, Medical Physics, University of Leeds, UK
    Acta Derm Venereol 79:451-5. 1999
    ..Therefore, although clinical efficacy improved with multiple treatments, unpredictable response and patient discomfort make ALA-PDT unsuitable for the treatment of psoriasis...
  14. ncbi request reprint Decreased efficiency of trypsinization of cells following photodynamic therapy: evaluation of a role for tissue transglutaminase
    D J Ball
    Center for Photobiology and Photodynamic Therapy, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
    Photochem Photobiol 73:47-53. 2001
    ....
  15. pmc Interstitial photodynamic therapy. Clinical experience with diffusing fibres in the treatment of cutaneous and subcutaneous tumours
    C P Lowdell
    Department of Radiotherapy, University of Leeds, Cookridge Hospital, UK
    Br J Cancer 67:1398-403. 1993
    ..The penetration depth of 630 nm light in human breast cancer tissue was determined as 4 mm. Little true tumour tissue selectivity was detected by analysis of porphyrin levels in biopsy material...
  16. pmc Photodynamic therapy effect of m-THPC (Foscan) in vivo: correlation with pharmacokinetics
    H J Jones
    DI Vernon School of Biochemistry and Molecular Biology, Centre for Photobiology and Photodynamic Therapy, University of Leeds, Leeds LS2 9JT, UK
    Br J Cancer 89:398-404. 2003
    ..These results indicate that the in vivo PDT effect of m-THPC occurs via several mechanisms...
  17. ncbi request reprint The advantages of aminolevulinic acid photodynamic therapy in dermatology
    E L Taylor
    Centre for Photobiology and Photodynamic Therapy, School of Biochemistry and Molecular Biology, University of Leeds, Leeds, UK
    J Dermatolog Treat 13:S3-11. 2002
    ....
  18. ncbi request reprint The quantitative determination of Photofrin and Polyhaematoporphyrin in plasma: pitfalls and inaccuracies
    D I Vernon
    Department of Biochemistry and Molecular Biology, University of Leeds, UK
    J Photochem Photobiol B 27:209-17. 1995
    ..As an example of its use in the present study, it was applied to the determination of the pharmacokinetics of PHP in the rat...
  19. ncbi request reprint Purification and identification of apophycocyanin alpha and beta subunits from soluble protein extracts of the red alga Cyanidium caldarium. Light exposure is not a prerequisite for biosynthesis of the protein moiety of this photosynthetic accessory pigme
    L Turner
    Department of Biochemistry and Molecular Biology, University of Leeds, UK
    Planta 201:78-83. 1997
    ..1992, Plant Physiol Biochem 30: 309-314). We now report on the protein's immunological and sequence identity with phycocyanin alpha and beta subunits, and provide further evidence that bilin-apoprotein ligation is light dependent...
  20. ncbi request reprint Guidelines for topical photodynamic therapy: report of a workshop of the British Photodermatology Group
    Colin A Morton
    Department of Dermatology, Falkirk Royal Infirmary, Falkirk FK1 5QE, U K
    Br J Dermatol 146:552-67. 2002
    ..A recent British Photodermatology Group workshop considered published evidence on topical PDT in order to establish guidelines to promote the efficacy and safety of this increasingly practised treatment modality...
  21. ncbi request reprint Comparison of high- vs low-dose 5-aminolevulinic acid for photodynamic therapy of Barrett's esophagus
    C J Kelty
    Academic Surgical Oncology Unit, University of Sheffield, Sheffield, England, UK
    Surg Endosc 18:452-8. 2004
    ..The aim of this study was to establish the optimum dosage regime for ALA-PDT for Barrett's esophagus...
  22. ncbi request reprint 5-Aminolaevulinic acid methyl ester transport on amino acid carriers in a human colon adenocarcinoma cell line
    O A Gederaas
    Institute of Laboratory Medicine, Department of Clinical Chemistry, Medical Faculty, Norwegain University of Science and Technology, Trondheim, Norway
    Photochem Photobiol 73:164-9. 2001
    ..In conclusion, the cellular uptake of 5-ALA-ME into WiDr cells seems to be due to active transport mechanisms, involving transporters of nonpolar amino acids...