P Brown

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Basal ganglia local field potential activity: character and functional significance in the human
    Peter Brown
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Clin Neurophysiol 116:2510-9. 2005
  2. pmc Effects of low-frequency stimulation of the subthalamic nucleus on movement in Parkinson's disease
    Alexandre Eusebio
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Exp Neurol 209:125-30. 2008
  3. pmc Synchronisation in the beta frequency-band--the bad boy of parkinsonism or an innocent bystander?
    Alexandre Eusebio
    Department of Neurology and Movement Disorders, CHU Timone, Marseille, France
    Exp Neurol 217:1-3. 2009
  4. pmc Boosting cortical activity at Beta-band frequencies slows movement in humans
    Alek Pogosyan
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London WC1N 3BG, UK
    Curr Biol 19:1637-41. 2009
  5. ncbi request reprint Effects of stimulation of the subthalamic area on oscillatory pallidal activity in Parkinson's disease
    Peter Brown
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London WCIN 3BG, UK
    Exp Neurol 188:480-90. 2004
  6. ncbi request reprint Oscillatory nature of human basal ganglia activity: relationship to the pathophysiology of Parkinson's disease
    Peter Brown
    Sobell Department of Neurophysiology and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 18:357-63. 2003
  7. ncbi request reprint Involvement of human basal ganglia in offline feedback control of voluntary movement
    Peter Brown
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Curr Biol 16:2129-34. 2006
  8. doi request reprint Abnormal oscillatory synchronisation in the motor system leads to impaired movement
    P Brown
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London WC1N 3BG, UK
    Curr Opin Neurobiol 17:656-64. 2007
  9. ncbi request reprint Paradoxes of functional neurosurgery: clues from basal ganglia recordings
    Peter Brown
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London WC1N 3BG, United Kingdom
    Mov Disord 23:12-20; quiz 158. 2008
  10. ncbi request reprint The startle syndrome
    Peter Brown
    Sobell Department of Neurophysiology, Institute of Neurology, London, United Kingdom
    Mov Disord 17:S79-82. 2002

Collaborators

Detail Information

Publications109 found, 100 shown here

  1. ncbi request reprint Basal ganglia local field potential activity: character and functional significance in the human
    Peter Brown
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Clin Neurophysiol 116:2510-9. 2005
    ..The available evidence points to the 8-30 Hz activity being essentially antikinetic in character and inversely related to motor processing. Its exaggeration may therefore contribute to the bradykinesia of Parkinson's disease...
  2. pmc Effects of low-frequency stimulation of the subthalamic nucleus on movement in Parkinson's disease
    Alexandre Eusebio
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Exp Neurol 209:125-30. 2008
    ....
  3. pmc Synchronisation in the beta frequency-band--the bad boy of parkinsonism or an innocent bystander?
    Alexandre Eusebio
    Department of Neurology and Movement Disorders, CHU Timone, Marseille, France
    Exp Neurol 217:1-3. 2009
    ....
  4. pmc Boosting cortical activity at Beta-band frequencies slows movement in humans
    Alek Pogosyan
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London WC1N 3BG, UK
    Curr Biol 19:1637-41. 2009
    ....
  5. ncbi request reprint Effects of stimulation of the subthalamic area on oscillatory pallidal activity in Parkinson's disease
    Peter Brown
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London WCIN 3BG, UK
    Exp Neurol 188:480-90. 2004
    ..If this activity is unchecked by synchronisation at higher frequency, then pathological 20-Hz oscillations may cascade through the basal ganglia, increasing at subsequent levels of processing...
  6. ncbi request reprint Oscillatory nature of human basal ganglia activity: relationship to the pathophysiology of Parkinson's disease
    Peter Brown
    Sobell Department of Neurophysiology and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 18:357-63. 2003
    ..The lower frequency oscillations facilitate slow idling rhythms in the motor areas of the cortex, whereas synchronisation at high frequency restores dynamic task-related cortical ensemble activity in the gamma band...
  7. ncbi request reprint Involvement of human basal ganglia in offline feedback control of voluntary movement
    Peter Brown
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Curr Biol 16:2129-34. 2006
    ..This relationship is disrupted by electrical stimulation of the nucleus at high frequency. Thus, the human subthalamic nucleus is involved in feedback-based learning...
  8. doi request reprint Abnormal oscillatory synchronisation in the motor system leads to impaired movement
    P Brown
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London WC1N 3BG, UK
    Curr Opin Neurobiol 17:656-64. 2007
    ..Here, pathologically synchronised discharges of pyramidal neurons are transmitted to the healthy spinal cord. The result is the synchronous discharge of motor units leading to rhythmic jerking...
  9. ncbi request reprint Paradoxes of functional neurosurgery: clues from basal ganglia recordings
    Peter Brown
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London WC1N 3BG, United Kingdom
    Mov Disord 23:12-20; quiz 158. 2008
    ..Whether true, oversimplified or simply incorrect, the noisy signal hypothesis has served to focus attention on the detailed character of basal ganglia discharge and its variation with disease and therapy...
  10. ncbi request reprint The startle syndrome
    Peter Brown
    Sobell Department of Neurophysiology, Institute of Neurology, London, United Kingdom
    Mov Disord 17:S79-82. 2002
  11. ncbi request reprint Cortical drives to human muscle: the Piper and related rhythms
    P Brown
    Medical Research Council Human Movement and Balance Unit, Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK
    Prog Neurobiol 60:97-108. 2000
    ..The basal ganglia have a pivotal role in this regard, and inadequate output from these nuclei leads to a disappearance of the beta and Piper drives to muscle. This may in turn contribute to slowness and weakness in Parkinson's disease...
  12. ncbi request reprint Cortical network resonance and motor activity in humans
    P Brown
    Medical Research Council Human Movement and Balance Unit, Institute of Neurology and National Hospital for Neurology and Neurosurgery, London
    Neuroscientist 7:518-27. 2001
    ..Synchronization at specific frequencies may therefore link disparate cortical activities into the functional ensembles underlying voluntary movement in humans...
  13. pmc Suppression of beta oscillations in the subthalamic nucleus following cortical stimulation in humans
    L M F Doyle Gaynor
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Eur J Neurosci 28:1686-95. 2008
    ..The results may have implications for mechanisms underlying the reported therapeutic benefits of cortical stimulation...
  14. ncbi request reprint Involvement of the sensorimotor cortex in physiological force and action tremor
    J F Marsden
    Sobell Department of Neurophysiology, Institute of Neurology, Queen Square, London WC1 3BG, UK
    Neuroreport 12:1937-41. 2001
    ..We conclude that the sensorimotor cortex is differentially involved in physiological force and action tremor at the wrist...
  15. ncbi request reprint Corrective movements in response to displacements in visual feedback are more effective during periods of 13-35 Hz oscillatory synchrony in the human corticospinal system
    Alexandros G Androulidakis
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London WC1N 3BG, UK
    Eur J Neurosci 24:3299-304. 2006
    ..Beta activity may index a motor state in which processing relevant to the control of positional hold tasks is promoted, with behavioural consequences...
  16. ncbi request reprint Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease
    P Brown
    Medical Research Council Human Movement and Balance Unit, Institute of Neurology, London WCIN 3BG, United Kingdom
    J Neurosci 21:1033-8. 2001
    ..Synchronization of activity does occur between pallidum and STN, and its pattern is critically dependent on the level of dopaminergic activity...
  17. ncbi request reprint Dopamine-dependent changes in the functional connectivity between basal ganglia and cerebral cortex in humans
    David Williams
    Sobell Department of Neurophysiology, Institute of Neurology, London, UK
    Brain 125:1558-69. 2002
    ....
  18. ncbi request reprint Intermuscular coherence in Parkinson's disease: effects of subthalamic nucleus stimulation
    J Marsden
    MRC Human Movement and Balance Unit, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Neuroreport 12:1113-7. 2001
    ..STN stimulation increased coherence in the 15-30 Hz band, so that it approached that in healthy subjects. The results suggest that STN stimulation facilitates the normal cortical drive to muscles...
  19. ncbi request reprint Task-related EEG-EEG coherence depends on dopaminergic activity in Parkinson's disease
    M Cassidy
    MRC Human Movement and Balance Unit, Institute of Neurology, National Hospital for Neurology, London, UK
    Neuroreport 12:703-7. 2001
    ..Ascending dopaminergic projections from the ventral mesencephalon may therefore be important in determining the pattern and extent of corticocortical coupling during executive tasks...
  20. pmc Involvement of the subthalamic nucleus in engagement with behaviourally relevant stimuli
    Paul Sauleau
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London WC1N3BG, UK
    Eur J Neurosci 29:931-42. 2009
    ..The latter process is partly modulated by dopamine. Weakness in this function might contribute to the behavioural impairment that can follow BG lesions and surgery...
  21. ncbi request reprint Evidence for subcortical involvement in the visual control of human reaching
    B L Day
    MRC Human Movement Group, Institute of Neurology, London, UK
    Brain 124:1832-40. 2001
    ..This is the same value as the mean interhemispheric transfer time obtained in the simple reaction time tasks and may indicate right-hemispheric dominance for saccadic eye movement control...
  22. doi request reprint Parkinsonian impairment correlates with spatially extensive subthalamic oscillatory synchronization
    A Pogosyan
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, WC1N 3BG UK
    Neuroscience 171:245-57. 2010
    ..In addition, they strengthen the link between pathological synchronization and the different motor features of Parkinsonism...
  23. ncbi request reprint Event-related beta desynchronization in human subthalamic nucleus correlates with motor performance
    Andrea A Kuhn
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WCIN 3BG, UK
    Brain 127:735-46. 2004
    ....
  24. ncbi request reprint Oscillatory pallidal local field potential activity inversely correlates with limb dyskinesias in Parkinson's disease
    Paul Silberstein
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WCIN 3BG, UK
    Exp Neurol 194:523-9. 2005
    ..This observation links the suppression of oscillatory synchronization in the pallidum with dyskinetic muscle activity in PD...
  25. ncbi request reprint Dopaminergic therapy promotes lateralized motor activity in the subthalamic area in Parkinson's disease
    Alexandros G Androulidakis
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Brain 130:457-68. 2007
    ..These findings suggest that dopaminergic therapy restores a more physiological pattern of reactivity in the STN of patients with Parkinson's disease...
  26. ncbi request reprint BOLD correlates of EMG spectral density in cortical myoclonus: description of method and case report
    Mark P Richardson
    Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK
    Neuroimage 32:558-65. 2006
    ....
  27. pmc Resonance in subthalamo-cortical circuits in Parkinson's disease
    Alexandre Eusebio
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, UK
    Brain 132:2139-50. 2009
    ..This resonance phenomenon may underlie the propagation and amplification of activities synchronized around this frequency. Crucially, dopamine acts to increase damping and thereby limit resonance in this basal ganglia-cortical network...
  28. ncbi request reprint Oscillatory pallidal local field potential activity correlates with involuntary EMG in dystonia
    C C Chen
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Neurology 66:418-20. 2006
    ..The data suggest that the neuronal synchronization indexed by LFP oscillations in the globus pallidus may be mechanistically linked to dystonic EMG activity...
  29. ncbi request reprint Autosomal dominant cortical myoclonus and epilepsy (ADCME) with complex partial and generalized seizures: A newly recognized epilepsy syndrome with linkage to chromosome 2p11.1-q12.2
    R Guerrini
    Neurosciences Unit, Institute of Child Health and Great Ormond Street Hospital for Children, London, UK
    Brain 124:2459-75. 2001
    ..We hypothesize that the responsible gene causes cortical hyperexcitability that is widespread but particularly involves the frontotemporal circuits...
  30. pmc Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients
    A Eusebio
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    J Neurol Neurosurg Psychiatry 82:569-73. 2011
    ..One possibility is that DBS suppresses local pathologically synchronised oscillatory activity...
  31. ncbi request reprint Intermuscular coherence in Parkinson's disease: relationship to bradykinesia
    P Brown
    Sobell Department of Neurophysiology, Institute of Neurology, Queen Square, London, WCIN 3BG, UK
    Neuroreport 12:2577-81. 2001
    ....
  32. ncbi request reprint Pallidal activity recorded in patients with implanted electrodes predictively correlates with eventual performance in a timing task
    Peter Brown
    Sobell Department of Neurophysiology, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neurosci Lett 330:188-92. 2002
    ..We conclude that the human pallidum may be involved in the prediction of movement timings and that such internal estimates may be reflected in amplitude modulation of oscillatory activity around 25 Hz...
  33. ncbi request reprint Activation of the subthalamic region during emotional processing in Parkinson disease
    A A Kühn
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, WC1N 3BG, UK
    Neurology 65:707-13. 2005
    ..To elucidate the involvement of the human subthalamic nucleus (STN) region in the processing or transmission of emotional information...
  34. ncbi request reprint Levodopa-induced modulation of subthalamic beta oscillations during self-paced movements in patients with Parkinson's disease
    L M F Doyle
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, 8 11, Queen Square, London WC1N 3BG, UK
    Eur J Neurosci 21:1403-12. 2005
    ..These findings suggest that the beta ERD recorded in the STN area reflects motor-preparative processes that are at least partly dependent on dopaminergic activity within the basal ganglia...
  35. ncbi request reprint Corticocortical coupling in chronic stroke: its relevance to recovery
    L H A Strens
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK
    Neurology 63:475-84. 2004
    ..Here, the authors investigate whether different cortical areas interact to form dynamic assemblies that may then compensate for disability...
  36. ncbi request reprint Abnormal corticomuscular and intermuscular coupling in high-frequency rhythmic myoclonus
    P Grosse
    Sobell Department of Clinical Neurophysiology, Institute of Neurology, London, UK
    Brain 126:326-42. 2003
    ..Thus, the processes sustaining myoclonic discharges may differ for proximal and distal muscles and between patients...
  37. ncbi request reprint Behavioural cues are associated with modulations of synchronous oscillations in the human subthalamic nucleus
    David Williams
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WCIN 3BG, UK
    Brain 126:1975-85. 2003
    ....
  38. ncbi request reprint Cortico-cortical coupling in Parkinson's disease and its modulation by therapy
    Paul Silberstein
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Brain 128:1277-91. 2005
    ..This mechanistic similarity may underscore the strong clinical correlation between the therapeutic effects of these treatment modalities...
  39. ncbi request reprint Force platform recordings in the diagnosis of primary orthostatic tremor
    K Yarrow
    MRC Human Movement and Balance Unit, National Hospital for Neurology and Neurosurgery, 8-11 Queen Square, London, WC1N 3BG, UK
    Gait Posture 13:27-34. 2001
    ..These data show a high correlation between EMG and posturography and confirm that OT may be diagnosed using short epochs of force platform recordings...
  40. ncbi request reprint Existing motor state is favored at the expense of new movement during 13-35 Hz oscillatory synchrony in the human corticospinal system
    Thomas Gilbertson
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 25:7771-9. 2005
    ..The findings are of relevance to Parkinson's disease, in which subcortical and cortical beta-band synchronization is exaggerated in the setting of increased tone and slowed movements...
  41. pmc Directional analysis of coherent oscillatory field potentials in the cerebral cortex and basal ganglia of the rat
    Andrew Sharott
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Physiol 562:951-63. 2005
    ....
  42. ncbi request reprint Oscillatory local field potentials recorded from the subthalamic nucleus of the alert rat
    Peter Brown
    Sobell Department of Neurophysiology, Institute of Neurology, London, WCIN 3BG, United Kingdom
    Exp Neurol 177:581-5. 2002
    ....
  43. ncbi request reprint Reciprocal interactions between oscillatory activities of different frequencies in the subthalamic region of patients with Parkinson's disease
    Noa Fogelson
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Eur J Neurosci 22:257-66. 2005
    ....
  44. doi request reprint Oscillatory activity in the pedunculopontine area of patients with Parkinson's disease
    Alexandros G Androulidakis
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, UK
    Exp Neurol 211:59-66. 2008
    ..The subcortical oscillations are coupled to cortical alpha activity and possibly allied to motor related attentional processes...
  45. ncbi request reprint Excessive synchronization of basal ganglia neurons at 20 Hz slows movement in Parkinson's disease
    Chiung Chu Chen
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Exp Neurol 205:214-21. 2007
    ..This effect was frequency selective. The current data provide proof of the principle that excessive beta synchrony within the basal ganglia-cortical loop may contribute to the slowing of movements in Parkinson's disease...
  46. ncbi request reprint Effects of combined cortical and acoustic stimuli on muscle activity
    R J Fisher
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, 8 11 Queen Square, London, WC1N 3BG, UK
    Exp Brain Res 157:1-9. 2004
    ..Effects were similar with TMS over premotor and primary motor cortex...
  47. ncbi request reprint The relationship between oscillatory activity and motor reaction time in the parkinsonian subthalamic nucleus
    David Williams
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Eur J Neurosci 21:249-58. 2005
    ..The results are consistent with the hypothesis that reductions in 8-30 Hz population synchrony in the STN area are related to the processing required for motor preparation, particularly response selection...
  48. ncbi request reprint Deep brain stimulation of the subthalamic nucleus: a two-edged sword
    Chiung Chu Chen
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Curr Biol 16:R952-3. 2006
  49. ncbi request reprint Intra-operative recordings of local field potentials can help localize the subthalamic nucleus in Parkinson's disease surgery
    Chiung Chu Chen
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WCIN 3BG, UK
    Exp Neurol 198:214-21. 2006
    ..Functional physiological localization of STN by the on-line spectral analysis of LFPs is quick to perform and may provide information directly relevant to the position of the electrode contact actually used for DBS...
  50. ncbi request reprint Frequency dependent effects of subthalamic nucleus stimulation in Parkinson's disease
    Noa Fogelson
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WCIN 3BG, UK
    Neurosci Lett 382:5-9. 2005
    ..This is consistent with the hypothesis that spontaneous activities in these bands might promote bradykinesia...
  51. pmc Effects of dopamine depletion on network entropy in the external globus pallidus
    Ana V Cruz
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurophysiol 102:1092-102. 2009
    ..Thus it is possible that reduced information coding capacity within basal ganglia networks may contribute to the behavioral deficits accompanying PD...
  52. ncbi request reprint Different functional loops between cerebral cortex and the subthalmic area in Parkinson's disease
    Noa Fogelson
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Cereb Cortex 16:64-75. 2006
    ..Tuning to distinct frequencies may provide a means of marking and segregating related processing, over and above any anatomical segregation of processing streams...
  53. doi request reprint Deep brain stimulation modulates effects of motivation in Parkinson's disease
    Paul Sauleau
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK
    Neuroreport 20:622-6. 2009
    ..This finding may be relevant to some of the cognitive and emotional changes associated with bilateral subthalamic stimulation...
  54. ncbi request reprint The effects of subthreshold 1 Hz repetitive TMS on cortico-cortical and interhemispheric coherence
    Lucy H A Strens
    Sobell Department of Neurophysiology, Institute of Neurology, Queen Square, London, UK
    Clin Neurophysiol 113:1279-85. 2002
    ..To this end we assessed cortico-cortical and interhemispheric coherence before and after low frequency, subthreshold rTMS of the left motor cortex...
  55. ncbi request reprint Elevations in local gamma activity are accompanied by changes in the firing rate and information coding capacity of neurons in the region of the subthalamic nucleus in Parkinson's disease
    Alek Pogosyan
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, WCIN 3BG, UK
    Exp Neurol 202:271-9. 2006
    ..We conclude that overall there was a net elevation in firing rate and potential information coding capacity, assessed in terms of baud, amongst neurons during periods of elevated gamma LFP activity in the subthalamic region...
  56. ncbi request reprint Phasic increases in cortical beta activity are associated with alterations in sensory processing in the human
    Elodie Lalo
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Exp Brain Res 177:137-45. 2007
    ....
  57. ncbi request reprint Patterning of globus pallidus local field potentials differs between Parkinson's disease and dystonia
    Paul Silberstein
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WCIN 3BG, UK
    Brain 126:2597-608. 2003
    ..We conclude that untreated and treated Parkinson's disease and dystonia are characterized by different spatiotemporal patterns of activity in the human pallidum...
  58. ncbi request reprint EEG-EMG, MEG-EMG and EMG-EMG frequency analysis: physiological principles and clinical applications
    P Grosse
    Sobell Department of Motor Neuroscience and Movement Disorders Box 146, Institute of Neurology, Queen Square 8 11, 2nd Floor, London WC1 3BG, UK
    Clin Neurophysiol 113:1523-31. 2002
  59. ncbi request reprint Hidden Markov based autoregressive analysis of stationary and non-stationary electrophysiological signals for functional coupling studies
    M J Cassidy
    Sobell Department of Neurophysiology, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    J Neurosci Methods 116:35-53. 2002
    ....
  60. pmc Death rates in HIV-positive antiretroviral-naive patients with CD4 count greater than 350 cells per microL in Europe and North America: a pooled cohort observational study
    Rebecca K Lodwick
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, UCL Medical School, Royal Free Campus, London, UK
    Lancet 376:340-5. 2010
    ..We aimed to examine this by analysis of pooled data from industrialised countries...
  61. ncbi request reprint Patterns of abnormal motor cortex excitability in atypical parkinsonian syndromes
    A A Kühn
    Department of Neurology, Charite, Humboldt University Berlin, 13353 Berlin, Augustenburger Platz 1, Germany
    Clin Neurophysiol 115:1786-95. 2004
    ..We hypothesised that these atypical parkinsonian syndromes (APS) will show distinctive patterns in their motor output upon transcranial magnetic stimulation (TMS) due to their different underlying anatomico-functional deficits...
  62. ncbi request reprint Modulation of beta oscillations in the subthalamic area during motor imagery in Parkinson's disease
    Andrea A Kuhn
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Brain 129:695-706. 2006
    ....
  63. pmc Optimized beamforming for simultaneous MEG and intracranial local field potential recordings in deep brain stimulation patients
    Vladimir Litvak
    UCL Institute of Neurology, Queen Square, WC1N 3BG, London, UK
    Neuroimage 50:1578-88. 2010
    ..Our findings demonstrate that physiologically meaningful information can be extracted from heavily contaminated MEG signals and pave the way for further analysis of combined MEG-LFP recordings in DBS patients...
  64. ncbi request reprint Anticipatory changes in beta synchrony in the human corticospinal system and associated improvements in task performance
    Alexandros G Androulidakis
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, WC1N 3BG, UK
    Eur J Neurosci 25:3758-65. 2007
    ..The results suggest that the beta state is modulated in a task-relevant way with accompanying behavioural consequences...
  65. ncbi request reprint Neuronal activity in globus pallidus interna can be synchronized to local field potential activity over 3-12 Hz in patients with dystonia
    Chiung Chu Chen
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, WCIN 3BG, UK
    Exp Neurol 202:480-6. 2006
    ..This lends support to a pathophysiological relationship between LFP activity at 3-12 Hz and dystonia...
  66. ncbi request reprint The functional role of interhemispheric synchronization in the control of bimanual timing tasks
    Deborah J Serrien
    Sobell Department of Motor Neuroscience and Movement Disorders Box 146, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Exp Brain Res 147:268-72. 2002
    ..Overall, these results support a significant role for interhemispheric synchronization in the control of bimanual movements...
  67. ncbi request reprint Reduction in subthalamic 8-35 Hz oscillatory activity correlates with clinical improvement in Parkinson's disease
    Andrea A Kuhn
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WCIN 3BG, UK
    Eur J Neurosci 23:1956-60. 2006
    ..Our results support a link between levodopa-induced improvements in bradykinesia and rigidity and reductions in population synchrony at frequencies < 35 Hz in the region of the STN in patients with PD...
  68. ncbi request reprint Corticomuscular and intermuscular frequency analysis
    Pascal Grosse
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London WC1N 3BG, UK
    Suppl Clin Neurophysiol 57:570-6. 2004
  69. ncbi request reprint Lateralization of event-related beta desynchronization in the EEG during pre-cued reaction time tasks
    Louise M F Doyle
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, 8 11, Queen Square, London WC1N 3BG, UK
    Clin Neurophysiol 116:1879-88. 2005
    ..Specifically, we sought evidence for a contralaterally dominant component of the beta ERD that is limited to trials in which motor selection is possible prior to any imperative cue to move, with attendant behavioural advantage...
  70. ncbi request reprint Influence of working memory on patterns of motor related cortico-cortical coupling
    Deborah J Serrien
    Sobell Department of Motor Neuroscience and Movement Disorders Box 146, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Exp Brain Res 155:204-10. 2004
    ....
  71. ncbi request reprint Coherence analysis in the myoclonus of corticobasal degeneration
    Pascal Grosse
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Mov Disord 18:1345-50. 2003
    ..We conclude that an inflated EMG-EMG coherence is found in some patients with CBD and that this is unlikely to be due to an exaggerated cortical drive...
  72. ncbi request reprint Transient increases of synchronized neural activity during movement preparation: influence of cognitive constraints
    Deborah J Serrien
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, WC1N 3BG, UK
    Exp Brain Res 153:27-34. 2003
    ..These findings suggest an association between neural dynamics and behavioural performance and emphasize that response predictability biases information processing in goal-oriented behaviour...
  73. ncbi request reprint The ipsilateral human motor cortex can functionally compensate for acute contralateral motor cortex dysfunction
    Lucy H A Strens
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WCIN 3BG, United Kingdom
    Curr Biol 13:1201-5. 2003
    ....
  74. ncbi request reprint Bilaterally coherent tremor resembling enhanced physiological tremor: report of three cases
    John D O'Sullivan
    National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
    Mov Disord 17:387-91. 2002
    ..We postulate that these unusual tremors originate from a single brainstem source or from bilateral oscillators closely linked at or below this level...
  75. ncbi request reprint Movement-related changes in synchronization in the human basal ganglia
    Michael Cassidy
    Sobell Department of Neurophysiology, Institute of Neurology, Queen Square, London, UK
    Brain 125:1235-46. 2002
    ..This organization is critically dependent on the level of dopaminergic activity...
  76. ncbi request reprint Spectral phase estimates in the setting of multidirectional coupling
    Michael Cassidy
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WCIN 3BG, UK
    J Neurosci Methods 127:95-103. 2003
    ....
  77. ncbi request reprint Acoustic startle evokes bilaterally synchronous oscillatory EMG activity in the healthy human
    Pascal Grosse
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London WC1 3BG, United Kingdom
    J Neurophysiol 90:1654-61. 2003
    ....
  78. ncbi request reprint The integration of cortical and behavioural dynamics during initial learning of a motor task
    Deborah J Serrien
    Sobell Department of Motor Neuroscience and Movement Disorders Box 146, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Eur J Neurosci 17:1098-104. 2003
    ....
  79. ncbi request reprint Repetitive transcranial magnetic stimulation of the supplementary motor area (SMA) degrades bimanual movement control in humans
    Deborah J Serrien
    Sobell Department of Neurophysiology Box 146, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neurosci Lett 328:89-92. 2002
    ..These data suggest that rTMS of the SMA can modify interhemispheric communication and accordingly modulate interlimb behavior...
  80. ncbi request reprint The importance of the dominant hemisphere in the organization of bimanual movements
    Deborah J Serrien
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Hum Brain Mapp 18:296-305. 2003
    ..The close association between changes in interhemispheric coupling and behavioral performance indicates that synchronization of neural activity in the beta band is exploited for the control of goal-directed movement...
  81. ncbi request reprint Cortico-cortical coupling patterns during dual task performance
    Deborah J Serrien
    Sobell Department of Motor Neuroscience and Movement Disorders Box 146, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Exp Brain Res 157:79-84. 2004
    ..The data demonstrate that the pattern of cortico-cortical coupling during bimanual actions is not just the sum of that associated with its component parts, but is increased according to coordinative demands and processing load...
  82. ncbi request reprint Motor cortex inhibition induced by acoustic stimulation
    Andrea A Kuhn
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Exp Brain Res 158:120-4. 2004
    ..1+/-4.3%, amplitude: 116.9+/-6.9%). We conclude that a startle-evoked activation of reticulo-cortical projections transiently inhibits the motor cortex...
  83. ncbi request reprint Functional significance of the ipsilateral hemisphere during movement of the affected hand after stroke
    Deborah J Serrien
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Exp Neurol 190:425-32. 2004
    ..Patients making a fuller recovery organize movement-related cortical activity from the hemisphere contralateral to movement...
  84. ncbi request reprint Changes in functional coupling patterns during bimanual task performance
    Deborah J Serrien
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London WC1N 3BG, UK
    Neuroreport 15:1387-90. 2004
    ..These findings suggest that inter-regional synchronization changes dynamically across task execution in line with behavioral performance...
  85. ncbi request reprint Motor inhibition in patients with Gilles de la Tourette syndrome: functional activation patterns as revealed by EEG coherence
    Deborah J Serrien
    Sobell Department of Motor Neuroscience and Movement Disorders Box 146, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Brain 128:116-25. 2005
    ..It is concluded that the gain in inhibitory frontomesial cortical networks is adaptively heightened in TS, and that the same network can also be engaged in the voluntary suppression of tics...
  86. ncbi request reprint Online prediction of self-paced hand-movements from subthalamic activity using neural networks in Parkinson's disease
    Constantinos Loukas
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WCIN 3BG, UK
    J Neurosci Methods 137:193-205. 2004
    ..We conclude that oscillatory LFP activity in STN is directly or indirectly related to processes involved in motor preparation. The ability to predict movement in real-time may open up several experimental and therapeutic possibilities...
  87. ncbi request reprint Patterns of EMG-EMG coherence in limb dystonia
    Pascal Grosse
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Mov Disord 19:758-69. 2004
    ..We conclude that the nature of the abnormal drive to dystonic muscles may vary according to the muscles under consideration and, particularly, with aetiology...
  88. ncbi request reprint Frequency analysis of EMG activity in patients with idiopathic torticollis
    M A Tijssen
    MRC Human Movement and Balance Unit, Institute of Neurology, London, UK
    Brain 123:677-86. 2000
    ..Clinically, the pattern of SPL EMG autospectra and of SCM-SPL coherence may provide a sensitive and specific feature distinguishing dystonic from psychogenic torticollis...
  89. pmc β band stability over time correlates with Parkinsonian rigidity and bradykinesia
    S Little
    Department of Clinical Neurology, Oxford University, 6th Floor, West Wing, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK
    Exp Neurol 236:383-8. 2012
    ..The CV of LFP beta band amplitude may potentially provide an additional index of clinical state suitable for feedback control in closed loop stimulation therapy...
  90. pmc Late onset startle induced tics
    M A Tijssen
    MRC Human Movement and Balance Unit, The Institute of Neurology, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 67:782-4. 1999
    ..Reflex tics may occur in Gilles de la Tourette's syndrome, but have not been described in late onset Tourette's syndrome. Such tics must be distinguished from psychogenic myoclonus and the culture bound startle syndromes...
  91. ncbi request reprint Quality of life in patients with orthostatic tremor
    W Gerschlager
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Neurol 250:212-5. 2003
    ..The BDI score correlated significantly with several SF-36 subscores. We conclude that OT strongly impacts on QoL. The results highlight the importance of recognizing and treating depression in patients with OT...
  92. ncbi request reprint Cannabinoids control spasticity and tremor in a multiple sclerosis model
    D Baker
    Department of Neurochemistry, Institute of Neurology, University College London, UK
    Nature 404:84-7. 2000
    ..This provides a rationale for patients' indications of the therapeutic potential of cannabis in the control of the symptoms of multiple sclerosis, and provides a means of evaluating more selective cannabinoids in the future...
  93. ncbi request reprint Illusory perceptions of space and time preserve cross-saccadic perceptual continuity
    K Yarrow
    Sobell Department of Neurophysiology, Institute of Neurology, 8 11 Queen Square, London WC1N 3BG, UK
    Nature 414:302-5. 2001
    ..The effect is critically linked to perceptual mechanisms that identify a target's spatial stability...
  94. ncbi request reprint Digital nerve anaesthesia decreases EMG-EMG coherence in a human precision grip task
    R J Fisher
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Exp Brain Res 145:207-14. 2002
    ..We conclude that during a precision grip task, cutaneous input enhances oscillatory synchrony between pairs of hand muscles...
  95. pmc Intravenous immunoglobulin in neurological disease: a specialist review
    C M Wiles
    Sobell Department of Neurophysiology, Institute of Neurology, Queen Square, London WCIN 3BG, UK
    J Neurol Neurosurg Psychiatry 72:440-8. 2002
    ..Evidence of efficacy has been classified into levels for healthcare interventions (tables 1 and 2)...
  96. ncbi request reprint Subthalamic gamma activity in patients with Parkinson's disease
    Thomas Trottenberg
    Department of Neurology, Charité University Medicine Campus Virchow, Humboldt University, Berlin, Germany
    Exp Neurol 200:56-65. 2006
    ..Gamma band oscillations in the LFP are therefore likely to represent synchronous activity in populations of neurons in the upper STN and bordering zona incerta of patients with PD...
  97. ncbi request reprint Defective cortical drive to muscle in Parkinson's disease and its improvement with levodopa
    Stephan Salenius
    Brain Research Unit, Low Temperature Laboratory, Helsinki University of Technology, Espoo, Finland
    Brain 125:491-500. 2002
    ..Abnormalities in this aspect of basal ganglia function may directly contribute to bradykinesia and weakness in Parkinson's disease...
  98. doi request reprint Patterns of bidirectional communication between cortex and basal ganglia during movement in patients with Parkinson disease
    Elodie Lalo
    Laboratory of Motor Activity and Ergonomics, University of Orleans, 45067 Orleans Cedex 2, France
    J Neurosci 28:3008-16. 2008
    ..The results confirm a bidirectional pattern of cortico-basal ganglia communication that is differentially patterned across frequency bands and changes with movement and dopaminergic input...
  99. pmc Delayed synchronization of activity in cortex and subthalamic nucleus following cortical stimulation in the rat
    Peter J Magill
    Medical Research Council Anatomical Neuropharmacology Unit, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK
    J Physiol 574:929-46. 2006
    ..These findings suggest that STN neurons responding to corticosubthalamic inputs may provide a delayed input to cortex, via BG output nuclei, and thence, thalamocortical pathways...
  100. ncbi request reprint Changes in functional connectivity within the rat striatopallidal axis during global brain activation in vivo
    Peter J Magill
    Medical Research Council Anatomical Neuropharmacology Unit, University of Oxford, Oxford, OX1 3TH, United Kingdom
    J Neurosci 26:6318-29. 2006
    ....
  101. ncbi request reprint Brain state-dependency of coherent oscillatory activity in the cerebral cortex and basal ganglia of the rat
    Peter J Magill
    MRC Anatomical Neuropharmacology Unit, University of Oxford, Mansfield Road, Oxford OX1 3TH, United Kingdom
    J Neurophysiol 92:2122-36. 2004
    ..These attributes further suggest that synchronized activity should be considered as one of a number of candidate mechanisms underlying the functional organization of these brain circuits...