N H Brown

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane
    C G Zervas
    Wellcome CRC Institute and Department of Anatomy, University of Cambridge, Cambridge CB2 1QR, United Kingdom
    J Cell Biol 152:1007-18. 2001
  2. ncbi Talin is essential for integrin function in Drosophila
    Nicholas H Brown
    Wellcome Trust Cancer Research UK Institute, University of Cambridge, United Kingdom
    Dev Cell 3:569-79. 2002
  3. ncbi An integrin chicken and egg problem: which comes first, the extracellular matrix or the cytoskeleton?
    N H Brown
    Wellcome CRC Institute and Department of Anatomy, University of Cambridge, Tennis Court Rd, CB2 1QR, Cambridge, UK
    Curr Opin Cell Biol 12:629-33. 2000
  4. ncbi Cell-cell adhesion via the ECM: integrin genetics in fly and worm
    N H Brown
    Wellcome CRC Institute and Department of Anatomy, University of Cambridge, Tennis Court Rd, CB2 1QR, Cambridge, UK
    Matrix Biol 19:191-201. 2000
  5. ncbi The localized assembly of extracellular matrix integrin ligands requires cell-cell contact
    M D Martin-Bermudo
    Wellcome CRC Institute, Cambridge University, Tennis Court Road, Cambridge CB2 1QR, UK
    J Cell Sci 113:3715-23. 2000
  6. ncbi Migration of the Drosophila primordial midgut cells requires coordination of diverse PS integrin functions
    M D Martin-Bermudo
    Wellcome CRC Institute and Department of Anatomy, Cambridge University, Tennis Court Road, Cambridge CB2 1QR, UK cam ac uk
    Development 126:5161-9. 1999
  7. pmc kakapo, a gene required for adhesion between and within cell layers in Drosophila, encodes a large cytoskeletal linker protein related to plectin and dystrophin
    S L Gregory
    Wellcome CRC Institute and Department of Anatomy, University of Cambridge, Cambridge CB2 1QR, United Kingdom
    J Cell Biol 143:1271-82. 1998
  8. pmc Uncoupling integrin adhesion and signaling: the betaPS cytoplasmic domain is sufficient to regulate gene expression in the Drosophila embryo
    M D Martin-Bermudo
    Wellcome Trust Cancer Research Campaign Institute of Cancer and Developmental Biology, and Department of Anatomy, University of Cambridge, Cambridge CB2 1QR, UK
    Genes Dev 13:729-39. 1999
  9. pmc A screen to identify Drosophila genes required for integrin-mediated adhesion
    E P Walsh
    Wellcome CRC Institute and Department of Biochemistry, Cambridge CB2 1QR, United Kingdom
    Genetics 150:791-805. 1998
  10. ncbi Absence of PS integrins or laminin A affects extracellular adhesion, but not intracellular assembly, of hemiadherens and neuromuscular junctions in Drosophila embryos
    A Prokop
    Department of Zoology, Downing Street, Cambridge, CB2 3EJ, United Kingdom
    Dev Biol 196:58-76. 1998

Collaborators

Detail Information

Publications22

  1. pmc Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane
    C G Zervas
    Wellcome CRC Institute and Department of Anatomy, University of Cambridge, Cambridge CB2 1QR, United Kingdom
    J Cell Biol 152:1007-18. 2001
    ..Our data suggest that ILK is a component of the structure linking the cytoskeleton and the plasma membrane at sites of integrin-mediated adhesion...
  2. ncbi Talin is essential for integrin function in Drosophila
    Nicholas H Brown
    Wellcome Trust Cancer Research UK Institute, University of Cambridge, United Kingdom
    Dev Cell 3:569-79. 2002
    ..These results indicate that talin is essential for integrin function and acts by stably linking clusters of ECM-linked integrins to the cytoskeleton...
  3. ncbi An integrin chicken and egg problem: which comes first, the extracellular matrix or the cytoskeleton?
    N H Brown
    Wellcome CRC Institute and Department of Anatomy, University of Cambridge, Tennis Court Rd, CB2 1QR, Cambridge, UK
    Curr Opin Cell Biol 12:629-33. 2000
    ..Analysis of integrin function in the developing embryos of worms and flies suggests that, although the extracellular matrix directs integrins to organise intracellular proteins, the cytoskeleton may have the first word...
  4. ncbi Cell-cell adhesion via the ECM: integrin genetics in fly and worm
    N H Brown
    Wellcome CRC Institute and Department of Anatomy, University of Cambridge, Tennis Court Rd, CB2 1QR, Cambridge, UK
    Matrix Biol 19:191-201. 2000
    ..The continued use of genetic approaches to identify proteins required for integrin function in these two model organisms should lead to the identification of the minimal set of conserved components that form integrin adhesive structures...
  5. ncbi The localized assembly of extracellular matrix integrin ligands requires cell-cell contact
    M D Martin-Bermudo
    Wellcome CRC Institute, Cambridge University, Tennis Court Road, Cambridge CB2 1QR, UK
    J Cell Sci 113:3715-23. 2000
    ..Thus, interaction between cells generates an extracellular environment capable of nucleating extracellular matrix assembly...
  6. ncbi Migration of the Drosophila primordial midgut cells requires coordination of diverse PS integrin functions
    M D Martin-Bermudo
    Wellcome CRC Institute and Department of Anatomy, Cambridge University, Tennis Court Road, Cambridge CB2 1QR, UK cam ac uk
    Development 126:5161-9. 1999
    ..Thus integrins are involved in mediating migration by creating an optimal substratum for adhesion, adhering to that substratum and possibly by activating Rac and Cdc42...
  7. pmc kakapo, a gene required for adhesion between and within cell layers in Drosophila, encodes a large cytoskeletal linker protein related to plectin and dystrophin
    S L Gregory
    Wellcome CRC Institute and Department of Anatomy, University of Cambridge, Cambridge CB2 1QR, United Kingdom
    J Cell Biol 143:1271-82. 1998
    ..Kakapo is also expressed more widely at a lower level where it is essential for epidermal cell layer stability. These results suggest that the Kakapo protein forms essential links among integrins, actin, and microtubules...
  8. pmc Uncoupling integrin adhesion and signaling: the betaPS cytoplasmic domain is sufficient to regulate gene expression in the Drosophila embryo
    M D Martin-Bermudo
    Wellcome Trust Cancer Research Campaign Institute of Cancer and Developmental Biology, and Department of Anatomy, University of Cambridge, Cambridge CB2 1QR, UK
    Genes Dev 13:729-39. 1999
    ..Therefore, oligomerization of the 47-amino-acid betaPS intracellular domain is sufficient to initiate a signaling pathway that regulates gene expression in the developing embryo...
  9. pmc A screen to identify Drosophila genes required for integrin-mediated adhesion
    E P Walsh
    Wellcome CRC Institute and Department of Biochemistry, Cambridge CB2 1QR, United Kingdom
    Genetics 150:791-805. 1998
    ..Thus several of these loci are good candidates for genes encoding cytoplasmic proteins required for integrin function...
  10. ncbi Absence of PS integrins or laminin A affects extracellular adhesion, but not intracellular assembly, of hemiadherens and neuromuscular junctions in Drosophila embryos
    A Prokop
    Department of Zoology, Downing Street, Cambridge, CB2 3EJ, United Kingdom
    Dev Biol 196:58-76. 1998
    ..We suggest that neuromuscular contact in part requires basement membrane adhesion to the general muscle surface, and this form of adhesion is completely abolished in the absence of laminin A...
  11. pmc Genetic analysis of the Drosophila alphaPS2 integrin subunit reveals discrete adhesive, morphogenetic and sarcomeric functions
    J W Bloor
    Wellcome CRC Institute, Cambridge, United Kingdom
    Genetics 148:1127-42. 1998
    ..One new allele reveals that the PS2 integrin is required for the development of the adult halteres and legs as well as the wing...
  12. ncbi Null mutations in the alpha PS2 and beta PS integrin subunit genes have distinct phenotypes
    N H Brown
    Wellcome CRC Institute, Cambridge, UK
    Development 120:1221-31. 1994
    ....
  13. ncbi Rotation and asymmetry of the mitotic spindle direct asymmetric cell division in the developing central nervous system
    J A Kaltschmidt
    Wellcome CRC Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Nat Cell Biol 2:7-12. 2000
    ..This observation contradicts the widely held hypothesis that the cleavage furrow is always placed midway between the two centrosomes...
  14. pmc A conserved double-stranded RNA-binding domain
    D St Johnston
    Wellcome Cancer Research Campaign Institute, Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 89:10979-83. 1992
    ..On the basis of the binding studies and computer analysis, we have derived a consensus sequence that defines a 65- to 68-amino acid dsRNA-binding domain...
  15. pmc Intracellular signals direct integrin localization to sites of function in embryonic muscles
    M D Martin-Bermudo
    Wellcome CRC Institute, Cambridge, England
    J Cell Biol 134:217-26. 1996
    ..Our results challenge the view that the transmission of signals from the extracellular environment via integrins is required for the organization of the cytoskeleton and the resultant cellular polarity...
  16. pmc Specificity of PS integrin function during embryogenesis resides in the alpha subunit extracellular domain
    M D Martin-Bermudo
    Wellcome CRC Institute, and Department of Biochemistry, Cambridge University, UK
    EMBO J 16:4184-93. 1997
    ..We conclude that the two alpha subunits are not equivalent and have distinct functions which reside in the extracellular domains...
  17. pmc Modulation of integrin activity is vital for morphogenesis
    M D Martin-Bermudo
    Wellcome CRC Institute, Cambridge CB2 1QR, England and Department of Biochemistry, Cambridge University, Cambridge CB2 1QW, England
    J Cell Biol 141:1073-81. 1998
    ..These results suggest that the alphaPS2 subunit cytoplasmic domain is required for inside-out regulation of integrin affinity, as has been seen with the integrin alphaIIbbeta3...
  18. pmc Isolation and characterization of the Drosophila translational elongation factor 2 gene
    Y Grinblat
    Biological Laboratories, Harvard University, Cambridge, MA 02138
    Nucleic Acids Res 17:7303-14. 1989
    ....
  19. ncbi Developmentally regulated alternative splicing of Drosophila integrin PS2 alpha transcripts
    N H Brown
    Department of Cellular and Developmental Biology, Harvard University Biological Laboratories, Cambridge, Massachusetts 02138
    Cell 59:185-95. 1989
    ..We suggest that the variable region A may be important in determining the specificity and affinity of integrin receptors for their ligands...
  20. pmc Specific tracheal migration is mediated by complementary expression of cell surface proteins
    M Boube
    Institut de Biologia de Biologia Molecular de Barcelona CSIC, 08034 Barcelona, Spain
    Genes Dev 15:1554-62. 2001
    ....
  21. ncbi Drosophila development. Exploring signalling pathways
    N H Brown
    Nature 370:414-5. 1994
  22. ncbi Embryonic expression pattern of a family of Drosophila proteins that interact with a central nervous system regulatory element
    S J Bray
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115
    Genes Dev 3:1130-45. 1989
    ..The antibodies also were used to isolate cDNA clones encoding Elf-1. Alternate forms of Elf-1 mRNA result in at least three protein isoforms...