Morris J Brown

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Influence of diabetes and type of hypertension on response to antihypertensive treatment
    M J Brown
    Clinical Pharmacology Unit, University of Cambridge, United Kingdom
    Hypertension 35:1038-42. 2000
  2. ncbi request reprint Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT)
    M J Brown
    Clinical Pharmacology Unit, University of Cambridge, UK
    Lancet 356:366-72. 2000
  3. ncbi request reprint Randomized double-blind placebo-controlled study of an angiotensin immunotherapeutic vaccine (PMD3117) in hypertensive subjects
    Morris J Brown
    Clinical Pharmacology Unit, Addenbrooke s Centre for Clinical Investigation, Box 110, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Clin Sci (Lond) 107:167-73. 2004
  4. ncbi request reprint Comparison of the effects of antihypertensive agents on central blood pressure and arterial stiffness in isolated systolic hypertension
    Isla S Mackenzie
    Clinical Pharmacology Unit, Addenbrooke s Hospital Box 110, Cambridge, CB2 0QQ United Kingdom
    Hypertension 54:409-13. 2009
  5. doi request reprint A comparison of atenolol and nebivolol in isolated systolic hypertension
    Zahid Dhakam
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    J Hypertens 26:351-6. 2008
  6. ncbi request reprint Atenolol and eprosartan: differential effects on central blood pressure and aortic pulse wave velocity
    Zahid Dhakam
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, England
    Am J Hypertens 19:214-9. 2006
  7. ncbi request reprint The spironolactone, amiloride, losartan, and thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio
    Susan J Hood
    Clinical Pharmacology Unit, Department of Medicine, University of Cambridge, UK
    Circulation 116:268-75. 2007
  8. ncbi request reprint Influence of drugs and gender on the arterial pulse wave and natriuretic peptide secretion in untreated patients with essential hypertension
    Alison J Deary
    Clinical Pharmacology Unit, University of Cambridge, Level 6, ACCI, Box 110, Addenbrooke s Hospital, Hills Road, UK
    Clin Sci (Lond) 103:493-9. 2002
  9. doi request reprint Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa- and zona fasciculata-like tumors
    Elena A B Azizan
    Department of Clinical Pharmacology, University of Cambridge, Box 110, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, United Kingdom
    J Clin Endocrinol Metab 97:E819-29. 2012
  10. doi request reprint A double-blind, placebo-controlled, crossover trial comparing the effects of amiloride and hydrochlorothiazide on glucose tolerance in patients with essential hypertension
    Anna J Stears
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Hypertension 59:934-42. 2012

Detail Information

Publications48

  1. ncbi request reprint Influence of diabetes and type of hypertension on response to antihypertensive treatment
    M J Brown
    Clinical Pharmacology Unit, University of Cambridge, United Kingdom
    Hypertension 35:1038-42. 2000
    ..Our findings suggest that in patients at high absolute risk of cardiovascular complications from hypertension, the risk factors themselves do not prevent the recommended BP targets from being achieved...
  2. ncbi request reprint Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT)
    M J Brown
    Clinical Pharmacology Unit, University of Cambridge, UK
    Lancet 356:366-72. 2000
    ..We compared the effects of the calcium-channel blocker nifedipine once daily with the diuretic combination co-amilozide on cardiovascular mortality and morbidity in high-risk patients with hypertension...
  3. ncbi request reprint Randomized double-blind placebo-controlled study of an angiotensin immunotherapeutic vaccine (PMD3117) in hypertensive subjects
    Morris J Brown
    Clinical Pharmacology Unit, Addenbrooke s Centre for Clinical Investigation, Box 110, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Clin Sci (Lond) 107:167-73. 2004
    ..Biochemical measurements show evidence of blockade of the renin system, but higher titres will be required to achieve a decrease in blood pressure...
  4. ncbi request reprint Comparison of the effects of antihypertensive agents on central blood pressure and arterial stiffness in isolated systolic hypertension
    Isla S Mackenzie
    Clinical Pharmacology Unit, Addenbrooke s Hospital Box 110, Cambridge, CB2 0QQ United Kingdom
    Hypertension 54:409-13. 2009
    ..Because central PP and increased wave reflections are considered important risk factors in patients with isolated systolic hypertension, the choice of therapy may be influenced by these findings in the future...
  5. doi request reprint A comparison of atenolol and nebivolol in isolated systolic hypertension
    Zahid Dhakam
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    J Hypertens 26:351-6. 2008
    ..The aim of the present study was to test this in a double-blind, randomized, cross-over study, in a cohort of subjects with isolated systolic hypertension...
  6. ncbi request reprint Atenolol and eprosartan: differential effects on central blood pressure and aortic pulse wave velocity
    Zahid Dhakam
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, England
    Am J Hypertens 19:214-9. 2006
    ..We hypothesized that that atenolol fails to reduce central BP as much as other agents. The aim of the present study was to compare the hemodynamic effects of atenolol and eprosartan in a double-blind, randomized, cross-over study...
  7. ncbi request reprint The spironolactone, amiloride, losartan, and thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio
    Susan J Hood
    Clinical Pharmacology Unit, Department of Medicine, University of Cambridge, UK
    Circulation 116:268-75. 2007
    ..Secondary objectives were to compare the dose response for each diuretic and to evaluate amiloride as an alternative to spironolactone...
  8. ncbi request reprint Influence of drugs and gender on the arterial pulse wave and natriuretic peptide secretion in untreated patients with essential hypertension
    Alison J Deary
    Clinical Pharmacology Unit, University of Cambridge, Level 6, ACCI, Box 110, Addenbrooke s Hospital, Hills Road, UK
    Clin Sci (Lond) 103:493-9. 2002
    ..These differences may help to explain cause-specific differences in outcome in recent trials...
  9. doi request reprint Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa- and zona fasciculata-like tumors
    Elena A B Azizan
    Department of Clinical Pharmacology, University of Cambridge, Box 110, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, United Kingdom
    J Clin Endocrinol Metab 97:E819-29. 2012
    ..Aldosterone-producing adenomas (APA) are heterogeneous. The recent finding of somatic KCNJ5 mutations suggests a genetic explanation...
  10. doi request reprint A double-blind, placebo-controlled, crossover trial comparing the effects of amiloride and hydrochlorothiazide on glucose tolerance in patients with essential hypertension
    Anna J Stears
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Hypertension 59:934-42. 2012
    ..No impairment was seen with K(+)-sparing diuretic or β(1)-selective blockade. Substitution or addition of amiloride may be the solution to preventing thiazide-induced diabetes mellitus...
  11. pmc Formulation of long-acting nifedipine tablets influences the heart rate and sympathetic nervous system response in hypertensive patients
    Morris J Brown
    University of Cambridge, Clinical Pharmacology Unit, Addenbrookes Hospital, Cambridge, UK
    Br J Clin Pharmacol 65:646-52. 2008
    ..The pharmacokinetics of short- vs. long-acting formulations of nifedipine is well known, but the pharmacokinetics of different once-a-day formulations of nifedipine is generally not well known by the practising physician...
  12. doi request reprint Primary hyperaldosteronism due to adrenal microadenoma: a curable cause of refractory hypertension
    Khin Swe Myint
    Department of Clinical Pharmacology, Addenbrooke s Hospital, Cambridge, UK
    J Renin Angiotensin Aldosterone Syst 9:103-6. 2008
    ..The diagnosis of primary hyperaldosteronism due to microadenoma or unilateral adrenal hyperplasia can be challenging, since hypokalaemic alkalosis, high plasma aldosterone and a definite adenoma on imaging may all be absent...
  13. doi request reprint Aliskiren and the calcium channel blocker amlodipine combination as an initial treatment strategy for hypertension control (ACCELERATE): a randomised, parallel-group trial
    Morris J Brown
    Clinical Pharmacology Unit, Department of Medicine, University of Cambridge, Cambridge, UK
    Lancet 377:312-20. 2011
    ....
  14. ncbi request reprint Hemodynamic effects of amlodipine, bisoprolol, and lisinopril in hypertensive patients after liver transplantation
    David A J Neal
    Department of Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    Transplantation 77:748-50. 2004
    ..Hypertension is common after liver transplantation. There are few published data on optimum treatment. Augmentation index (AIx) is a measure of arterial wave reflection determined by pulse wave analysis...
  15. ncbi request reprint Mechanisms of hypertension after liver transplantation
    David A J Neal
    University Department of Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ, England, UK
    Transplantation 79:935-40. 2005
    ..Elevation in plasma ET-1 and increases in arterial stiffness are potential important mechanisms underlying the development of hypertension after liver transplant...
  16. doi request reprint Somatic mutations affecting the selectivity filter of KCNJ5 are frequent in 2 large unselected collections of adrenal aldosteronomas
    Elena A B Azizan
    Clinical Pharmacology Unit, Department of Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Hypertension 59:587-91. 2012
    ..Hence, somatic KCNJ5 mutations are not restricted to large APAs (>2 cm), and their frequency in our unselected series suggests they are common and could be important in the molecular pathogenesis of many sporadic cases of APA...
  17. ncbi request reprint Double-blind, placebo-controlled crossover comparison of five classes of antihypertensive drugs
    Alison J Deary
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Hypertens 20:771-7. 2002
    ....
  18. doi request reprint Expression of the epithelial Na(+) channel and other components of an aldosterone response pathway in human adrenocortical cells
    Timothy J Burton
    Clinical Pharmacology, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Eur J Pharmacol 613:176-81. 2009
    ..Studies in H295R cells, however, suggest that ENaC is not an important mediator of (22)Na-uptake or aldosterone production. Further studies are required to determine the importance of an adrenal aldosterone response pathway...
  19. doi request reprint Characterization of a novel somatic KCNJ5 mutation delI157 in an aldosterone-producing adenoma
    Meena Murthy
    Clinical Pharmacology Unit, Department of Medicine, Addenbrooke s Hospital, Cambridge, UK
    J Hypertens 30:1827-33. 2012
    ..Here, we report the functional properties of KCNJ5 channels carrying this novel delI157 mutation...
  20. doi request reprint Evaluation of the sensitivity and specificity of (11)C-metomidate positron emission tomography (PET)-CT for lateralizing aldosterone secretion by Conn's adenomas
    Timothy J Burton
    Clinical Pharmacology Unit, Department of Medicine, University of Cambridge, Cambridge CB2 2QQ, UK
    J Clin Endocrinol Metab 97:100-9. 2012
    ..11)C-metomidate, a potent inhibitor of adrenal steroidogenic enzymes, is a positron emission tomography (PET) radiotracer that is selectively accumulated by Conn's adenomas...
  21. doi request reprint Success and failure of vaccines against renin-angiotensin system components
    Morris J Brown
    Clinical Pharmacology Unit, University of Cambridge, Cambridge, UK
    Nat Rev Cardiol 6:639-47. 2009
    ..Large studies now in progress will establish whether further modification of the immunogen or adjuvant is required to boost antibody titers...
  22. ncbi request reprint Increased stroke volume and aortic stiffness contribute to isolated systolic hypertension in young adults
    Carmel M McEniery
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Hypertension 46:221-6. 2005
    ..Long-term follow-up of these individuals is now required to determine whether they are at increased risk compared with age-matched normotensive individuals...
  23. ncbi request reprint AT2 receptor stimulation may halt progression of pheochromocytoma
    Morris J Brown
    Clinical Pharmacology Unit, University of Cambridge, and Department of Medicine, Addenbrookes Hospital, Box 110, Cambridge CB2 2QQ, UK
    Ann N Y Acad Sci 1073:436-43. 2006
    ..Similar observations in further patients should lead to a placebo-controlled study in patients with malignant or familial pheochromocytoma, or other tumors found to express the AT2 receptor...
  24. pmc Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor
    Maria Ban
    Department of Clinical Neuroscience, Addenbrooke s, Hospital, University of Cambridge, Cambridge, UK
    Eur J Hum Genet 17:1309-13. 2009
    ....
  25. ncbi request reprint Aldehyde dehydrogenase 2 plays a role in the bioactivation of nitroglycerin in humans
    Isla S Mackenzie
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Arterioscler Thromb Vasc Biol 25:1891-5. 2005
    ..We investigated the role of ALDH2 in the vascular effects of nitroglycerin (NTG) in humans in vivo...
  26. doi request reprint Therapeutic potential of vaccines in the management of hypertension
    Morris J Brown
    Clinical Pharmacology Unit, University of Cambridge, Addenbrookes Centre for Clinical Investigation, Addenbrookes Hospital, Cambridge, UK
    Drugs 68:2557-60. 2008
    ..Studies in patients with hypertension demonstrate some efficacy for both vaccines, but far short of what is seen with existing RAS inhibitors. Modification of the immunogen or adjuvant is required to boost the antibody titre...
  27. doi request reprint Aliskiren
    Morris J Brown
    University of Cambridge, Cambridge, UK
    Circulation 118:773-84. 2008
    ..It is hoped that long-term outcome studies with aliskiren will finally allow this question to be answered...
  28. pmc Renin: friend or foe?
    Morris J Brown
    Clinical Pharmacology Unit, Addenbrookes Hospital, Cambridge, UK
    Heart 93:1026-33. 2007
    ..Being a large and stable molecule, renin is among the easiest and cheapest of hormone measurements. Understanding the simple biochemistry and physiology of renin permits optimal use of the drugs acting to raise or suppress this hormone...
  29. ncbi request reprint Determinants of arterial stiffness in offspring of families with essential hypertension
    - Yasmin
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Am J Hypertens 17:292-8. 2004
    ..We investigated whether arterial stiffness measured as augmentation index and pulse wave velocity is increased in offspring of families with essential hypertension, and whether stiffness is related to various biochemical markers...
  30. doi request reprint Investigating the function of an aldosterone response pathway in primary human adrenocortical cells obtained from Conn's and phaeochromocytoma patients
    Timothy J Burton
    Clinical Pharmacology, University of Cambridge, Addenbrooke s Hospital, Box 110, Hills Road, Cambridge, CB2 0QQ, UK
    Eur J Pharmacol 657:184-9. 2011
    ....
  31. ncbi request reprint Pseudopheochromocytoma
    Isla S Mackenzie
    Clinical Pharmacology Unit, University of Cambridge, Cambridge, UK
    J Hypertens 25:2204-6. 2007
  32. ncbi request reprint Genetic profiling versus drug rotation in the optimisation of antihypertensive treatment
    Isla S Mackenzie
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital
    Clin Med 2:465-73. 2002
    ..Genotype is unlikely therefore to be useful in selecting treatment for most patients. The exception is patients who have the atypical phenotype for their age, illustrated by the rare Na+ dependent monogenic syndromes of the young...
  33. ncbi request reprint Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension
    Elena A B Azizan
    Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Nat Genet 45:1055-60. 2013
    ..Many APAs with these mutations were <1 cm in diameter and had been overlooked on conventional adrenal imaging. Recognition of the distinct genotype and phenotype for this subset of APAs could facilitate diagnosis. ..
  34. ncbi request reprint Heme oxygenase-1 gene transfer inhibits angiotensin II-mediated rat cardiac myocyte apoptosis but not hypertrophy
    Roger S Y Foo
    Division of Cardiovascular Medicine, School of Clinical Medicine, Addenbrooke s Hospital, University of Cambridge, UK
    J Cell Physiol 209:1-7. 2006
    ..Our findings identify the signalling pathways by which HO-1 gene transfer protects against apoptosis and suggest that overexpression of HO-1 in cardiomyopathies may delay the transition from myocyte hypertrophy to heart failure...
  35. pmc Hypertension and ethnic group
    Morris J Brown
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ
    BMJ 332:833-6. 2006
  36. pmc Effect of overexpressed adenylyl cyclase VI on beta 1- and beta 2-adrenoceptor responses in adult rat ventricular myocytes
    Joalice C C Stark
    Clinical Pharmacology Unit, Department of Medicine, Addenbrookes Hospital, Cambridge, UK
    Br J Pharmacol 143:465-76. 2004
    ..Native ACVI did not contribute to basal cAMP production or contraction amplitude and only to a minor extent to the forskolin response. beta(1)AR but not beta(2)AR coupling was dependent on ACVI...
  37. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  38. ncbi request reprint Functional responses of human beta1 adrenoceptors with defined haplotypes for the common 389R>G and 49S>G polymorphisms
    Alastair Sandilands
    Clinical Pharmacology Unit, Level 6, Addenbrooke s Centre for Clinical Investigation, Addenbrooke s Hospital, Cambridge, CM6 2EE, UK
    Pharmacogenetics 14:343-9. 2004
    ..These polymorphisms have only been studied in isolation, however, and not in the context of the four haplotypes (SR, SG, GR and GG) that exist in native beta1-ARs...
  39. pmc Overexpression of beta 1-adrenoceptors in adult rat ventricular myocytes enhances CGP 12177A cardiostimulation: implications for 'putative' beta 4-adrenoceptor pharmacology
    Clive J Lewis
    Clinical Pharmacology Unit, Department of Medicine, Cambridge University, Cambridge
    Br J Pharmacol 141:813-24. 2004
    ..Putative' beta(4)-adrenoceptor pharmacology appears to be mediated by activation of a novel affinity state of the beta(1)-adrenoceptor...
  40. pmc Bilateral adrenal masses: phaeochromocytoma or melanoma?
    Isla S Mackenzie
    Department of Nuclear Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    J R Soc Med 99:153-5. 2006
  41. pmc A rational basis for selection among drugs of the same class
    Morris J Brown
    Clinical Pharmacology Unit, Level 6, ACCI, Addenbrookes Hospital, Box 110, Cambridge CB2 2QQ, UK
    Heart 89:687-94. 2003
  42. ncbi request reprint Long-term cardiovascular consequences of diuretics vs calcium channel blockers vs angiotensin-converting enzyme inhibitors
    Christopher R Palmer
    JAMA 289:2066-7; author reply 2069-70. 2003
  43. pmc British Hypertension Society guidelines for hypertension management 2004 (BHS-IV): summary
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, Leicester
    BMJ 328:634-40. 2004
  44. ncbi request reprint Clinical significance of renal function in hypertensive patients at high risk: results from the INSIGHT trial
    Peter W de Leeuw
    Department of Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Arch Intern Med 164:2459-64. 2004
    ..To assess this role of renal function in more detail, we studied the evolution of renal function and the relationship of renal function with mortality and morbidity in the Intervention as a Goal in Hypertension Treatment (INSIGHT) study...
  45. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes...
  46. ncbi request reprint Glutathione S-transferase variants and hypertension
    Christian Delles
    British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    J Hypertens 26:1343-52. 2008
    ..We have recently demonstrated reduced expression of glutathione S-transferase mu type 1 (Gstm1) in a rat model of hypertension. Here, we examine the association between GSTM variants and hypertension in human...
  47. pmc Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    Sheila A Fisher
    Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Nat Genet 40:710-2. 2008
    ..These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases...
  48. pmc Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
    ....