M W Brown

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi request reprint Recognition memory: neuronal substrates of the judgement of prior occurrence
    M W Brown
    Department of Anatomy, University of Bristol, School of Medical Sciences, UK
    Prog Neurobiol 55:149-89. 1998
  2. ncbi request reprint Recognition memory: material, processes, and substrates
    Malcolm W Brown
    MRC Centre for Synaptic Plasticity, Department of Anatomy, Medical School, Bristol BS81TD, United Kingdom
    Hippocampus 20:1228-44. 2010
  3. ncbi request reprint Recognition memory: what are the roles of the perirhinal cortex and hippocampus?
    M W Brown
    Medical Research Council, Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol Medical School, Bristol BS8 1TD, UK
    Nat Rev Neurosci 2:51-61. 2001
  4. doi request reprint Recognition memory: what's new in novelty signals?
    Malcolm W Brown
    University of Bristol, MRC Centre for Synaptic Plasticity, Department of Anatomy, Medical School, Bristol BS8 1TD, UK
    Curr Biol 19:R645-7. 2009
  5. pmc An experimental test of the role of postsynaptic calcium levels in determining synaptic strength using perirhinal cortex of rat
    K Cho
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, UK
    J Physiol 532:459-66. 2001
  6. ncbi request reprint Activation of muscarinic receptors induces protein synthesis-dependent long-lasting depression in the perirhinal cortex
    P V Massey
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Eur J Neurosci 14:145-52. 2001
  7. ncbi request reprint Comparison of differential neuronal responsiveness for different regions of the prefrontal cortex in a conditional visual discrimination task
    J Z Xiang
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK
    Eur J Neurosci 25:2916-26. 2007
  8. ncbi request reprint Fos imaging reveals differential neuronal activation of areas of rat temporal cortex by novel and familiar sounds
    H Wan
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol, BS8 1TD, UK
    Eur J Neurosci 14:118-24. 2001
  9. doi request reprint A role for calcium-calmodulin-dependent protein kinase II in the consolidation of visual object recognition memory
    C J Tinsley
    Department of Anatomy, Medical Research Council Centre for Synaptic Plasticity, Bristol University, University Walk, Bristol, UK
    Eur J Neurosci 30:1128-39. 2009
  10. ncbi request reprint Benzodiazepine impairment of perirhinal cortical plasticity and recognition memory
    H Wan
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1 TD, UK
    Eur J Neurosci 20:2214-24. 2004

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Recognition memory: neuronal substrates of the judgement of prior occurrence
    M W Brown
    Department of Anatomy, University of Bristol, School of Medical Sciences, UK
    Prog Neurobiol 55:149-89. 1998
    ..Unsolved problems and avenues for future experimentation, including determining the nature of possible underlying synaptic plastic changes, are discussed...
  2. ncbi request reprint Recognition memory: material, processes, and substrates
    Malcolm W Brown
    MRC Centre for Synaptic Plasticity, Department of Anatomy, Medical School, Bristol BS81TD, United Kingdom
    Hippocampus 20:1228-44. 2010
    ....
  3. ncbi request reprint Recognition memory: what are the roles of the perirhinal cortex and hippocampus?
    M W Brown
    Medical Research Council, Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol Medical School, Bristol BS8 1TD, UK
    Nat Rev Neurosci 2:51-61. 2001
    ..A resolution is vital not only for uncovering the neural substrates of these key aspects of memory, but also for understanding the processes disrupted in medial temporal lobe amnesia and the validity of animal models of this syndrome...
  4. doi request reprint Recognition memory: what's new in novelty signals?
    Malcolm W Brown
    University of Bristol, MRC Centre for Synaptic Plasticity, Department of Anatomy, Medical School, Bristol BS8 1TD, UK
    Curr Biol 19:R645-7. 2009
    ..A new study indicates that signals distinguishing between new and old stimuli are present very rapidly in the human brain, but only when subjects are motivated by explicit reward instructions...
  5. pmc An experimental test of the role of postsynaptic calcium levels in determining synaptic strength using perirhinal cortex of rat
    K Cho
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, UK
    J Physiol 532:459-66. 2001
    ..This suggests that the transition between LTD and LTP is due to the lack of induction of both of these processes and also suggests that these two processes are induced independently of one another...
  6. ncbi request reprint Activation of muscarinic receptors induces protein synthesis-dependent long-lasting depression in the perirhinal cortex
    P V Massey
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Eur J Neurosci 14:145-52. 2001
    ..An understanding of CCh-induced LLD may thus provide clues to the mechanisms underlying lasting neuronal decrements that occur in the perirhinal cortex and hence for neural substrates of visual recognition memory...
  7. ncbi request reprint Comparison of differential neuronal responsiveness for different regions of the prefrontal cortex in a conditional visual discrimination task
    J Z Xiang
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK
    Eur J Neurosci 25:2916-26. 2007
    ..A comparison of such differential latencies between temporal and prefrontal cortex indicated that potential information flow was likely to be primarily from temporal to prefrontal cortex rather than vice versa...
  8. ncbi request reprint Fos imaging reveals differential neuronal activation of areas of rat temporal cortex by novel and familiar sounds
    H Wan
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol, BS8 1TD, UK
    Eur J Neurosci 14:118-24. 2001
    ..It is suggested that this latter difference is related to the nature of the particular auditory and visual stimuli used...
  9. doi request reprint A role for calcium-calmodulin-dependent protein kinase II in the consolidation of visual object recognition memory
    C J Tinsley
    Department of Anatomy, Medical Research Council Centre for Synaptic Plasticity, Bristol University, University Walk, Bristol, UK
    Eur J Neurosci 30:1128-39. 2009
    ..Thus, increased CAMKII activity is essential for the consolidation of long-term object recognition memory but continuation of that increased activity throughout the 24 h memory delay is not necessary for maintenance of the memory...
  10. ncbi request reprint Benzodiazepine impairment of perirhinal cortical plasticity and recognition memory
    H Wan
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1 TD, UK
    Eur J Neurosci 20:2214-24. 2004
    ....
  11. ncbi request reprint Mechanisms of synaptic plasticity and recognition memory in the perirhinal cortex
    P J Banks
    School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom
    Prog Mol Biol Transl Sci 122:193-209. 2014
    ..Therefore, we provide strong evidence that synaptic plastic mechanisms are necessary for the information processing and storage that underlies object recognition memory. ..
  12. pmc What pharmacological interventions indicate concerning the role of the perirhinal cortex in recognition memory
    M W Brown
    MRC Centre for Synaptic Plasticity, Department of Physiology and Pharmacology, Bristol University, Bristol, BS8 1TD, UK
    Neuropsychologia 50:3122-40. 2012
    ....
  13. ncbi request reprint Galanin regulates spatial memory but not visual recognition memory or synaptic plasticity in perirhinal cortex
    P V Massey
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, BS8 1TD, Bristol, UK
    Neuropharmacology 44:40-8. 2003
    ..Therefore, these results suggest that galanin has a differential role in hippocampal-dependent and perirhinal cortex-dependent memory...
  14. pmc Evidence concerning how neurons of the perirhinal cortex may effect familiarity discrimination
    M W Brown
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Philos Trans R Soc Lond B Biol Sci 357:1083-95. 2002
    ..Processes that occur in long-term depression within the perirhinal cortex provide candidate synaptic plastic mechanisms for that underlying the change, but such linkage remains to be experimentally established...
  15. ncbi request reprint Chronic treatment with oestradiol does not alter in vitro LTP in subfield CA1 of the female rat hippocampus
    D J Barraclough
    Department of Anatomy, University of Bristol, School of Medical Sciences, UK
    Neuropharmacology 38:65-71. 1999
    ....
  16. ncbi request reprint Model of familiarity discrimination in the perirhinal cortex
    R Bogacz
    Department of Computer Science, University of Bristol, UK
    J Comput Neurosci 10:5-23. 2001
    ..This efficiency and speed of detecting novelty provides an evolutionary advantage, thereby providing a reason for the existence of a familiarity discrimination network in addition to networks used for recollection...
  17. ncbi request reprint Recognition memory and synaptic plasticity in the perirhinal and prefrontal cortices
    P J Banks
    Department of Physiology and Pharmacology, MRC Centre for Synaptic Plasticity, University of Bristol, Bristol BS1 3NY, United Kingdom
    Hippocampus 22:2012-31. 2012
    ..However, the case for medial prefrontal cortex acting as a store requires further support. © 2012 Wiley Periodicals, Inc...
  18. pmc Mechanisms and physiological role of enhancement of mGlu5 receptor function by group II mGlu receptor activation in rat perirhinal cortex
    K Cho
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK
    J Physiol 540:895-906. 2002
    ..Similar mechanisms of synergistic interaction may also be important in other physiological processes dependent on mGlu receptors...