Jeremy S Brown

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Maturation of Streptococcus pneumoniae lipoproteins by a type II signal peptidase is required for ABC transporter function and full virulence
    Suneeta Khandavilli
    Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, London WC1E 6JJ, UK
    Mol Microbiol 67:541-57. 2008
  2. pmc Effects of deletion of the Streptococcus pneumoniae lipoprotein diacylglyceryl transferase gene lgt on ABC transporter function and on growth in vivo
    Suneeta Chimalapati
    Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, London, United Kingdom
    PLoS ONE 7:e41393. 2012
  3. pmc The effects of methionine acquisition and synthesis on Streptococcus pneumoniae growth and virulence
    Shilpa Basavanna
    Department of Microbiology and Molecular Genetics, University of Texas Houston Medical School, Houston, Texas, United States of America
    PLoS ONE 8:e49638. 2013
  4. ncbi request reprint Community-acquired pneumonia
    Jeremy S Brown
    University College London
    Clin Med 12:538-43. 2012
  5. doi request reprint What's new in respiratory infections and tuberculosis 2008-2010
    Jeremy S Brown
    Centre for Respiratory Research, Department of Medicine, University College Medical School, Rayne Institute, London WC1E 6JJ, UK
    Thorax 67:350-4. 2012
  6. pmc Characterization of a new mouse model of empyema and the mechanisms of pleural invasion by Streptococcus pneumoniae
    Sylwia Wilkosz
    Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, 5 University Street, London, UK
    Am J Respir Cell Mol Biol 46:180-7. 2012
  7. ncbi request reprint Oral biofilms, periodontitis and pulmonary infections
    J S Brown
    Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, London, UK
    Oral Dis 13:513-4. 2007
  8. pmc phgABC, a three-gene operon required for growth of Streptococcus pneumoniae in hyperosmotic medium and in vivo
    Jeremy S Brown
    Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, 5 University Street, London WC1E 6JJ, United Kingdom
    Infect Immun 72:4579-88. 2004
  9. pmc A locus contained within a variable region of pneumococcal pathogenicity island 1 contributes to virulence in mice
    Jeremy S Brown
    Centre for Respiratory Research, Department of Medicine, Rayne Institute, Royal Free and University College Medical School, London WC1E 6JJ, United Kingdom
    Infect Immun 72:1587-93. 2004
  10. pmc Screening of Streptococcus pneumoniae ABC transporter mutants demonstrates that LivJHMGF, a branched-chain amino acid ABC transporter, is necessary for disease pathogenesis
    Shilpa Basavanna
    Centre for Respiratory Research, Department of Medicine, University College Medical School, Rayne Institute, London, United Kingdom
    Infect Immun 77:3412-23. 2009

Collaborators

Detail Information

Publications31

  1. pmc Maturation of Streptococcus pneumoniae lipoproteins by a type II signal peptidase is required for ABC transporter function and full virulence
    Suneeta Khandavilli
    Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, London WC1E 6JJ, UK
    Mol Microbiol 67:541-57. 2008
    ..pneumoniae Lsp resulted in several phenotypes associated with impaired lipoprotein function and reduced S. pneumoniae replication in animal models of infection...
  2. pmc Effects of deletion of the Streptococcus pneumoniae lipoprotein diacylglyceryl transferase gene lgt on ABC transporter function and on growth in vivo
    Suneeta Chimalapati
    Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, London, United Kingdom
    PLoS ONE 7:e41393. 2012
    ..These data suggest that for S. pneumoniae loss of surface localisation of lipoproteins has widespread effects on ABC transporter functions that collectively prevent the Δlgt mutant from establishing invasive infection...
  3. pmc The effects of methionine acquisition and synthesis on Streptococcus pneumoniae growth and virulence
    Shilpa Basavanna
    Department of Microbiology and Molecular Genetics, University of Texas Houston Medical School, Houston, Texas, United States of America
    PLoS ONE 8:e49638. 2013
    ..Although Sp_0149 and Sp_0585-Sp_0586 make a contribution towards full virulence, neither was essential for S. pneumoniae survival during infection...
  4. ncbi request reprint Community-acquired pneumonia
    Jeremy S Brown
    University College London
    Clin Med 12:538-43. 2012
    ..Both research into host-microbial interactions in the lung and clinical trials of different management and preventative treatments are urgently needed to combat the increasing morbidity and mortality associated with CAP...
  5. doi request reprint What's new in respiratory infections and tuberculosis 2008-2010
    Jeremy S Brown
    Centre for Respiratory Research, Department of Medicine, University College Medical School, Rayne Institute, London WC1E 6JJ, UK
    Thorax 67:350-4. 2012
    ....
  6. pmc Characterization of a new mouse model of empyema and the mechanisms of pleural invasion by Streptococcus pneumoniae
    Sylwia Wilkosz
    Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, 5 University Street, London, UK
    Am J Respir Cell Mol Biol 46:180-7. 2012
    ..The data suggest that transmigration of bacteria through mesothelial cells could be important in empyema development. Furthermore, upon entry the pleural cavity offers a protected compartment for the bacteria...
  7. ncbi request reprint Oral biofilms, periodontitis and pulmonary infections
    J S Brown
    Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, London, UK
    Oral Dis 13:513-4. 2007
  8. pmc phgABC, a three-gene operon required for growth of Streptococcus pneumoniae in hyperosmotic medium and in vivo
    Jeremy S Brown
    Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, 5 University Street, London WC1E 6JJ, United Kingdom
    Infect Immun 72:4579-88. 2004
    ....
  9. pmc A locus contained within a variable region of pneumococcal pathogenicity island 1 contributes to virulence in mice
    Jeremy S Brown
    Centre for Respiratory Research, Department of Medicine, Rayne Institute, Royal Free and University College Medical School, London WC1E 6JJ, United Kingdom
    Infect Immun 72:1587-93. 2004
    ..Gene variation within horizontally acquired DNA such as that of PPI1 may be one factor modulating differences in virulence among strains...
  10. pmc Screening of Streptococcus pneumoniae ABC transporter mutants demonstrates that LivJHMGF, a branched-chain amino acid ABC transporter, is necessary for disease pathogenesis
    Shilpa Basavanna
    Centre for Respiratory Research, Department of Medicine, University College Medical School, Rayne Institute, London, United Kingdom
    Infect Immun 77:3412-23. 2009
    ..These data demonstrate a previously unsuspected role for BCAA transport during infection for S. pneumoniae and provide more evidence that functioning ABC transporters are required for the full virulence of bacterial pathogens...
  11. pmc Streptococcus pneumoniae resistance to complement-mediated immunity is dependent on the capsular serotype
    Catherine Hyams
    Centre for Respiratory Research, Department of Medicine, University College Medical School, Rayne Institute, 5 University Street, London WC1E 6JJ, United Kingdom
    Infect Immun 78:716-25. 2010
    ..This might be one mechanism by which the capsular serotype can affect the relative invasiveness of different S. pneumoniae strains...
  12. pmc The effects of PspC on complement-mediated immunity to Streptococcus pneumoniae vary with strain background and capsular serotype
    Jose Yuste
    Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, London WC1E 6JJ, United Kingdom
    Infect Immun 78:283-92. 2010
    ..However, data obtained from infection in complement-deficient mice demonstrated that differences between strains in the effects of PspC on complement surprisingly did not influence the development of septicemia...
  13. ncbi request reprint Impaired opsonization with complement and phagocytosis of Streptococcus pyogenes in sera from subjects with inherited C2 deficiency
    Jose Yuste
    Centre for Respiratory Research, Royal Free and University College Medical School, Rayne Institute, London, United Kingdom
    Microbes Infect 12:626-34. 2010
    ..pyogenes. Impaired opsonisation with C3b/iC3b and phagocytosis was not related to reduced recognition of the bacteria by antibody. These data suggest that patients with C2 deficiency are at increased risk of S. pyogenes infections...
  14. pmc Effects of Streptococcus pneumoniae strain background on complement resistance
    Catherine Hyams
    Centre for Respiratory Research, Department of Medicine, University College Medical School, Rayne Institute, London, United Kingdom
    PLoS ONE 6:e24581. 2011
    ..pneumoniae strains that may affect complement-mediated immunity. We have therefore investigated whether genetically distinct S. pneumoniae strains with the same capsular serotype vary in their sensitivity to complement mediated immunity...
  15. pmc Streptococcus pneumoniae capsular serotype invasiveness correlates with the degree of factor H binding and opsonization with C3b/iC3b
    Catherine Hyams
    Centre for Inflammation and Tissue Repair, Division of Medicine, University College Medical School, Rayne Institute, London, United Kingdom
    Infect Immun 81:354-63. 2013
    ..These data suggest that variations in complement resistance between S. pneumoniae strains and the association of a serotype with invasiveness could be related to capsular serotype effects on FH binding...
  16. pmc Contributions of capsule, lipoproteins and duration of colonisation towards the protective immunity of prior Streptococcus pneumoniae nasopharyngeal colonisation
    Jonathan M Cohen
    Centre for Respiratory Research, Department of Medicine, UCL, London, United Kingdom
    Vaccine 30:4453-9. 2012
    ..The data presented here aid our understanding of why only certain live attenuated strains are able to function as effective vaccines, and may be valuable in informing the constituents of future live attenuated vaccines...
  17. ncbi request reprint Roles of the alternative complement pathway and C1q during innate immunity to Streptococcus pyogenes
    Jose Yuste
    Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, 5 University Street, London, United Kingdom
    J Immunol 176:6112-20. 2006
    ..pyogenes and suggest that C1q-mediated innate immunity to at least some strains of S. pyogenes may involve mechanisms that are independent of C3b on the bacteria...
  18. pmc Infection with conditionally virulent Streptococcus pneumoniae Δpab strains induces antibody to conserved protein antigens but does not protect against systemic infection with heterologous strains
    Suneeta Chimalapati
    Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, 5 University Street, London WC1E 6JF, United Kingdom
    Infect Immun 79:4965-76. 2011
    ..The failure of cross-protection after systemic vaccination with Δpab bacteria suggests that parenteral administration of a live attenuated vaccine is not an attractive approach for preventing S. pneumoniae infection...
  19. ncbi request reprint Lack of cross-protection against invasive pneumonia caused by heterologous strains following murine Streptococcus pneumoniae nasopharyngeal colonisation despite whole cell ELISAs showing significant cross-reactive IgG
    Jonathan M Cohen
    Centre for Respiratory Research, Department of Medicine, UCL, London
    Vaccine 31:2328-32. 2013
    ..Thus, flow cytometric binding to whole bacteria maybe a more reliable correlate of cross-protection for novel species-wide vaccines than whole cell ELISA...
  20. pmc The Streptococcus pneumoniae capsule inhibits complement activity and neutrophil phagocytosis by multiple mechanisms
    Catherine Hyams
    Centre for Respiratory Research, Department of Medicine, University College Medical School, Rayne Building, 5 University Street, London WC1E 6JF, United Kingdom
    Infect Immun 78:704-15. 2010
    ..Overall, these data show that the S. pneumoniae capsule affects multiple aspects of complement- and neutrophil-mediated immunity, resulting in a profound inhibition of opsonophagocytosis...
  21. pmc Impaired opsonization with C3b and phagocytosis of Streptococcus pneumoniae in sera from subjects with defects in the classical complement pathway
    Jose Yuste
    Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, 5 University St, London WC1E 6JJ, United Kingdom
    Infect Immun 76:3761-70. 2008
    ..These data confirm that the classical pathway is vital for complement-mediated phagocytosis of S. pneumoniae and demonstrate why subjects with a C2 deficiency have a marked increase in susceptibility to S. pneumoniae infections...
  22. pmc Protective contributions against invasive Streptococcus pneumoniae pneumonia of antibody and Th17-cell responses to nasopharyngeal colonisation
    Jonathan M Cohen
    Centre for Respiratory Research, Department of Medicine, University College London, London, United Kingdom
    PLoS ONE 6:e25558. 2011
    ..These data suggest that whilst nasopharyngeal colonisation induces a range of immune responses, the effective protective responses depend upon the site of subsequent infection...
  23. pmc Changes in capsular serotype alter the surface exposure of pneumococcal adhesins and impact virulence
    Carlos J Sanchez
    Department of Microbiology and Immunology, The University of Texas Health Science Center, San Antonio, Texas, United States of America
    PLoS ONE 6:e26587. 2011
    ..These findings show that serotype impacts the accessibility of surface adhesins and, in particular, affects virulence within the respiratory tract. They highlight the complex interplay between capsule and protein virulence determinants...
  24. ncbi request reprint Additive inhibition of complement deposition by pneumolysin and PspA facilitates Streptococcus pneumoniae septicemia
    Jose Yuste
    Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, London, United Kingdom
    J Immunol 175:1813-9. 2005
    ..pneumoniae to successfully cause septicemia. Targeting mechanisms of complement inhibition could be an effective therapeutic strategy for patients with septicemia due to S. pneumoniae or other bacterial pathogens...
  25. pmc Serum amyloid P aids complement-mediated immunity to Streptococcus pneumoniae
    Jose Yuste
    Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, London, United Kingdom
    PLoS Pathog 3:1208-19. 2007
    ....
  26. ncbi request reprint Iron acquisition by Gram-positive bacterial pathogens
    Jeremy S Brown
    Department of Infectious Diseases, Faculty of Medicine, Imperial College School of Science, Technology and Medicine, Flowers Building, Armstrong Road, SW7 2AZ, London, UK
    Microbes Infect 4:1149-56. 2002
    ..This review provides an overview of the existing knowledge on the genetic basis of iron transport for important Gram-positive pathogens...
  27. pmc Natural human antibodies to pneumococcus have distinctive molecular characteristics and protect against pneumococcal disease
    H E Baxendale
    Infectious Diseases and Microbiology Unit, Institute of Child Health, University College London, London, UK
    Clin Exp Immunol 151:51-60. 2008
    ..4 (+/-4.2) and selective use of IGHD6 (P < 0.001) and IGHJ6 (P < 0.01) family genes. The clones expressing IGHV1-69 and IGHV 3-21 provided significant passive protection against invasive pneumococcal disease in vivo...
  28. pmc C3b/iC3b deposition on Streptococcus pneumoniae is not affected by HIV infection
    Catherine Hyams
    Department of Medicine, University College Medical School, Rayne Institute, Centre for Respiratory Research, London, United Kingdom
    PLoS ONE 5:e8902. 2010
    ..We found no correlation between C3 deposition on S. pneumoniae and CD4 cell count in HIV infected individuals. Hence we have demonstrated no failure of complement immunity in HIV positive patients...
  29. pmc Antibodies to the iron uptake ABC transporter lipoproteins PiaA and PiuA promote opsonophagocytosis of Streptococcus pneumoniae
    Maha Jomaa
    Centre for Biological Sciences, Imperial College London, UK
    Infect Immun 73:6852-9. 2005
    ..pneumoniae by the human neutrophil cell line HL60. Hence, vaccination with PiaA and PiuA protects against S. pneumoniae infection by inducing antibodies that promote bacterial opsonophagocytosis rather than inhibiting iron transport...
  30. pmc The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice
    Jeremy S Brown
    Centre for Molecular Microbiology and Infection and Rheumatology Section, Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, United Kingdom
    Proc Natl Acad Sci U S A 99:16969-74. 2002
    ..pneumoniae, loss of which results in rapidly progressing septicemia and impaired macrophage activation. These data demonstrate the vital role of the classical pathway for innate immunity to a bacterial pathogen...
  31. pmc Characterization of pit, a Streptococcus pneumoniae iron uptake ABC transporter
    Jeremy S Brown
    Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Faculty of Medicine, Imperial College School of Medicine, London SW7 2AZ, United Kingdom
    Infect Immun 70:4389-98. 2002
    ....