Gordon D Brown

Summary

Affiliation: University of Aberdeen
Country: UK

Publications

  1. Brown G. Innate antifungal immunity: the key role of phagocytes. Annu Rev Immunol. 2011;29:1-21 pubmed publisher
    ..This review covers the functions of phagocytes in innate antifungal immunity, along with selected examples of the strategies that are used by fungal pathogens to subvert these defenses. ..
  2. Brown G, Netea M. Exciting developments in the immunology of fungal infections. Cell Host Microbe. 2012;11:422-4 pubmed publisher
  3. Dambuza I, Brown G. C-type lectins in immunity: recent developments. Curr Opin Immunol. 2015;32:21-7 pubmed publisher
    ..In this review, we describe their newly identified roles in anti-microbial host defence, homeostasis, autoimmunity, allergy and their functions in the recognition and response to dead and cancerous cells. ..
  4. Brown G, Willment J, Whitehead L. C-type lectins in immunity and homeostasis. Nat Rev Immunol. 2018;18:374-389 pubmed publisher
    ..In this Review, we present an overview of the roles of C-type lectins in immunity and homeostasis, with an emphasis on the most exciting recent discoveries. ..
  5. Brown G, Meintjes G, Kolls J, Gray C, Horsnell W, Achan B, et al. AIDS-related mycoses: the way forward. Trends Microbiol. 2014;22:107-9 pubmed publisher
  6. Drummond R, Wallace C, Reid D, Way S, Kaplan D, Brown G. Cutting edge: Failure of antigen-specific CD4+ T cell recruitment to the kidney during systemic candidiasis. J Immunol. 2014;193:5381-5 pubmed publisher
    ..Therefore, our data explain the redundancy of CD4(+) T cells for defense against systemic infection with C. albicans and have important implications for our understanding of antifungal immunity and the control of renal infections. ..
  7. Brown G. Trimming Surface Sugars Protects Histoplasma from Immune Attack. MBio. 2016;7:e00553-16 pubmed publisher
    ..mBio 7(2):e01388-15, 2016, http://dx.doi.org/10.1128/mBio.01388-15]. The trimming of these sugars reduces immune recognition through Dectin-1 and subsequent inflammatory responses, enhancing the pathogenesis of H. capsulatum. ..
  8. Hadebe S, Kirstein F, Fierens K, Redelinghuys P, Murray G, Williams D, et al. ?-Glucan exacerbates allergic airway responses to house dust mite allergen. Respir Res. 2016;17:35 pubmed publisher
    ..We therefore provide definitive evidence that ?-glucan can influence allergic pulmonary inflammation. ..
  9. Wilson G, Marakalala M, Hoving J, van Laarhoven A, Drummond R, Kerscher B, et al. The C-type lectin receptor CLECSF8/CLEC4D is a key component of anti-mycobacterial immunity. Cell Host Microbe. 2015;17:252-9 pubmed publisher
    ..Notably, a CLECSF8 polymorphism identified in humans is associated with an increased susceptibility to pulmonary tuberculosis. We conclude that CLECSF8 plays a non-redundant role in anti-mycobacterial immunity in mouse and in man. ..

More Information

Publications11

  1. Stoppelkamp S, Reid D, Yeoh J, Taylor J, McKenzie E, Brown G, et al. Murine pattern recognition receptor dectin-1 is essential in the development of experimental autoimmune uveoretinitis. Mol Immunol. 2015;67:398-406 pubmed publisher
    ..Thus dectin-1 plays a critical role in the ability of complete Freund's adjuvant to induce EAU in mice. ..
  2. Kerscher B, Dambuza I, Christofi M, Reid D, Yamasaki S, Willment J, et al. Signalling through MyD88 drives surface expression of the mycobacterial receptors MCL (Clecsf8, Clec4d) and Mincle (Clec4e) following microbial stimulation. Microbes Infect. 2016;18:505-9 pubmed publisher
    ..Thus this "two-step" model for induction of these key receptors provides new insights into the underlying mechanisms of anti-mycobacterial immunity. ..