G D Brown

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint The mycosins of Mycobacterium tuberculosis H37Rv: a family of subtilisin-like serine proteases
    G D Brown
    Department of Medical Biochemistry MRC Centre for Molecular and Cellular Biology, University of Stellenbosch, 7505, Tygerberg, South Africa
    Gene 254:147-55. 2000
  2. ncbi request reprint Fungal beta-glucans and mammalian immunity
    Gordon D Brown
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 RE, United Kingdom
    Immunity 19:311-5. 2003
  3. pmc Mycosin-1, a subtilisin-like serine protease of Mycobacterium tuberculosis, is cell wall-associated and expressed during infection of macrophages
    Joel A Dave
    Department of Medical Biochemistry, University of Cape Town Medical School, Observatory 7925, Cape Town, South Africa
    BMC Microbiol 2:30. 2002
  4. pmc Dectin-1 mediates the biological effects of beta-glucans
    Gordon D Brown
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, United Kingdom
    J Exp Med 197:1119-24. 2003
  5. pmc Dectin-1 is a major beta-glucan receptor on macrophages
    Gordon D Brown
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Exp Med 196:407-12. 2002
  6. ncbi request reprint Immune recognition. A new receptor for beta-glucans
    G D Brown
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nature 413:36-7. 2001
  7. pmc The ESAT-6 gene cluster of Mycobacterium tuberculosis and other high G+C Gram-positive bacteria
    N C Gey Van Pittius
    US MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch, Tygerberg, 7505, South Africa
    Genome Biol 2:RESEARCH0044. 2001
  8. ncbi request reprint Characterization of the human beta -glucan receptor and its alternatively spliced isoforms
    J A Willment
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, United Kingdom
    J Biol Chem 276:43818-23. 2001
  9. ncbi request reprint Macrophage receptors and immune recognition
    P R Taylor
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom, USA
    Annu Rev Immunol 23:901-44. 2005
  10. pmc Dectin-1 is required for beta-glucan recognition and control of fungal infection
    Philip R Taylor
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX13RE, UK
    Nat Immunol 8:31-8. 2007

Collaborators

Detail Information

Publications61

  1. ncbi request reprint The mycosins of Mycobacterium tuberculosis H37Rv: a family of subtilisin-like serine proteases
    G D Brown
    Department of Medical Biochemistry MRC Centre for Molecular and Cellular Biology, University of Stellenbosch, 7505, Tygerberg, South Africa
    Gene 254:147-55. 2000
    ..Mycosin-2 was modified by cleavage in all three mycobacterial species. The multiplicity and constitutive expression of these proteins suggests that they have an important role in the biology of M. tuberculosis...
  2. ncbi request reprint Fungal beta-glucans and mammalian immunity
    Gordon D Brown
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 RE, United Kingdom
    Immunity 19:311-5. 2003
    ..Recent studies, however, are starting to shed some light on the cellular receptors and molecular mechanisms involved, which also have direct relevance on the innate immune response to fungal pathogens...
  3. pmc Mycosin-1, a subtilisin-like serine protease of Mycobacterium tuberculosis, is cell wall-associated and expressed during infection of macrophages
    Joel A Dave
    Department of Medical Biochemistry, University of Cape Town Medical School, Observatory 7925, Cape Town, South Africa
    BMC Microbiol 2:30. 2002
    ..bovis BCG (bacille de Calmette et Guérin) and was selected for further analyses due to the absence of expression in this organism...
  4. pmc Dectin-1 mediates the biological effects of beta-glucans
    Gordon D Brown
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, United Kingdom
    J Exp Med 197:1119-24. 2003
    ..Furthermore, these studies implicate Dectin-1 in the production of TNF-alpha in response to fungi, a critical step required for the successful control of these pathogens...
  5. pmc Dectin-1 is a major beta-glucan receptor on macrophages
    Gordon D Brown
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Exp Med 196:407-12. 2002
    ..Furthermore, these results identify Dectin-1 as a new target for examining the immunomodulatory properties of beta-glucans for therapeutic drug design...
  6. ncbi request reprint Immune recognition. A new receptor for beta-glucans
    G D Brown
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nature 413:36-7. 2001
    ..1), there is evidence that another beta-glucan receptor is present on macrophages. Here we identify this unknown receptor as dectin-1 (ref. 2), a finding that provides new insights into the innate immune recognition of beta-glucans...
  7. pmc The ESAT-6 gene cluster of Mycobacterium tuberculosis and other high G+C Gram-positive bacteria
    N C Gey Van Pittius
    US MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch, Tygerberg, 7505, South Africa
    Genome Biol 2:RESEARCH0044. 2001
    ..These membrane-associated and energy-providing proteins may function to secrete members of the ESAT-6 and CFP-10 protein families, and the proteases may be involved in processing the secreted peptide...
  8. ncbi request reprint Characterization of the human beta -glucan receptor and its alternatively spliced isoforms
    J A Willment
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, United Kingdom
    J Biol Chem 276:43818-23. 2001
    ..The human receptor also binds T-lymphocytes at a site distinct from the beta-glucan binding site, indicating that this receptor can recognize both endogenous and exogenous ligands...
  9. ncbi request reprint Macrophage receptors and immune recognition
    P R Taylor
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom, USA
    Annu Rev Immunol 23:901-44. 2005
    ....
  10. pmc Dectin-1 is required for beta-glucan recognition and control of fungal infection
    Philip R Taylor
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX13RE, UK
    Nat Immunol 8:31-8. 2007
    ..Our results establish a fundamental function for beta-glucan recognition by dectin-1 in antifungal immunity and demonstrate a signaling non-Toll-like pattern-recognition receptor required for the induction of protective immune responses...
  11. ncbi request reprint Soluble Dectin-1 as a tool to detect beta-glucans
    Lisa M Graham
    Institute of Infectious Disease and Molecular Medicine, CLS, Faculty of Health Sciences, University of Cape Town, Observatory, 7925 Cape Town, South Africa
    J Immunol Methods 314:164-9. 2006
    ....
  12. ncbi request reprint Human MICL (CLEC12A) is differentially glycosylated and is down-regulated following cellular activation
    Andrew S J Marshall
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Eur J Immunol 36:2159-69. 2006
    ..This suggests that human MICL may be involved in the control of myeloid cell activation during inflammation...
  13. ncbi request reprint C-type lectin-like receptors on myeloid cells
    Elwira Pyz
    The Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    Ann Med 38:242-51. 2006
    ..Although few of the myeloid-expressed C-type lectins have been characterized in detail, we review here each of these receptors and highlight their prospective roles in innate and adaptive immunity...
  14. ncbi request reprint Prolonged reduction of leukocyte membrane-associated Dectin-1 levels following beta-glucan administration
    Tammy R Ozment-Skelton
    Department of Surgery, P O Box 70575, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    J Pharmacol Exp Ther 318:540-6. 2006
    ..These data may have important implications for developing dosing regimens for immunomodulatory carbohydrates...
  15. ncbi request reprint The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose
    Eamon P McGreal
    Sir William Dunn School of Pathology, Oxford University, Oxford OX1 3RE, UK
    Glycobiology 16:422-30. 2006
    ....
  16. ncbi request reprint Regulation of cytosolic phospholipase A2 activation and cyclooxygenase 2 expression in macrophages by the beta-glucan receptor
    Saritha Suram
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Biol Chem 281:5506-14. 2006
    ....
  17. ncbi request reprint Ligands for the beta-glucan receptor, Dectin-1, assigned using "designer" microarrays of oligosaccharide probes (neoglycolipids) generated from glucan polysaccharides
    Angelina S Palma
    Glycosciences Laboratory, Faculty of Medicine, Imperial College London, Northwick Park and St Mark s Campus, Watford Road, Harrow, Middlesex HA1 3UJ, United Kingdom
    J Biol Chem 281:5771-9. 2006
    ....
  18. pmc The beta-glucan receptor dectin-1 recognizes specific morphologies of Aspergillus fumigatus
    Chad Steele
    Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pennsylvania, USA
    PLoS Pathog 1:e42. 2005
    ..fumigatus and to our knowledge provides the first in vivo evidence for the role of dectin-1 in fungal innate defense...
  19. ncbi request reprint Dectin-1 promotes fungicidal activity of human neutrophils
    Adam D Kennedy
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Eur J Immunol 37:467-78. 2007
    ..8% for beta-glucan and 36.2% for GE2, p<0.01). Our results reveal a mechanism whereby PMN dectin-1 plays a key role in the recognition and killing of fungal pathogens by the innate immune system...
  20. ncbi request reprint Macrophage receptors and innate immunity: insights from dectin-1
    Gordon D Brown
    Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, 7925, Cape Town, South Africa
    Novartis Found Symp 279:114-23; discussion 123-6, 216-9. 2006
    ....
  21. ncbi request reprint Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17
    Salome Leibundgut-Landmann
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, London WC2A 3PX, UK
    Nat Immunol 8:630-8. 2007
    ..Our data indicate that signaling through Syk and CARD9 can couple innate to adaptive immunity independently of Toll-like receptor signals and that CARD9 is required for the development of T(H)-17 responses to some pathogens...
  22. ncbi request reprint The induction of inflammation by dectin-1 in vivo is dependent on myeloid cell programming and the progression of phagocytosis
    Marcela Rosas
    Medical Biochemistry and Immunology, Cardiff University School of Medicine, Cardiff, United Kingdom
    J Immunol 181:3549-57. 2008
    ..This has implications for the mechanism by which myeloid cells are activated during fungal infections and the processes involved in the therapeutic manipulation of the immune system via exogenous dectin-1 stimulation or blockade...
  23. ncbi request reprint Costimulation of dectin-1 and DC-SIGN triggers the arachidonic acid cascade in human monocyte-derived dendritic cells
    Isela Valera
    Instituto de Biologia y Genetica Molecular, Consejo Superior de Investigaciones Cientificas, Universidad de Valladolid, Valladolid, Spain
    J Immunol 180:5727-36. 2008
    ..These findings help explain the distinct functional properties of DC matured by immune complexes vs those matured by beta-glucans...
  24. pmc Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors
    Kevin M Dennehy
    Institute of Infectious Disease and Molecular Medicine, Clinical Laboratory Sciences Division of Immunology, University of Cape Town, Cape Town, South Africa
    Eur J Immunol 38:500-6. 2008
    ..These findings establish the first example of Syk- and MyD88-coupled PRR collaboration, further supporting the concept that paired receptors collaborate to control infectious agents...
  25. doi request reprint Differential high-affinity interaction of dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side-chain branching
    Elizabeth L Adams
    Department of Surgery, PO Box 70575, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    J Pharmacol Exp Ther 325:115-23. 2008
    ....
  26. doi request reprint Sensing necrosis with Mincle
    Gordon D Brown
    Institute of Infectious Disease and Molecular Medicine, Clinical Laboratory Sciences, Division of Immunology, University of Cape Town, Observatory 7925, Cape Town, South Africa
    Nat Immunol 9:1099-100. 2008
    ..The mechanisms that lead to inflammation after necrotic cell death are poorly understood. New data show that the C-type lectin Mincle is involved in this process...
  27. pmc Immune recognition of Candida albicans beta-glucan by dectin-1
    Neil A R Gow
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom
    J Infect Dis 196:1565-71. 2007
    ..albicans was independent of the recognition of beta-glucans by dectin-1. In conclusion, C. albicans induces production of monocyte-derived and T cell-derived cytokines through distinct pathways dependent on or independent of dectin-1...
  28. ncbi request reprint Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells
    Antonio Gigliotti Rothfuchs
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 179:3463-71. 2007
    ..tuberculosis-induced IL-12p40 production by DC in which the receptor augments bacterial-host cell interaction and enhances the subsequent cytokine response through an unknown mechanism involving Syk signaling...
  29. ncbi request reprint The role of the beta-glucan receptor Dectin-1 in control of fungal infection
    Kevin M Dennehy
    Institute for Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    J Leukoc Biol 82:253-8. 2007
    ..We propose that Dectin-1 is the first of many pattern recognition receptors that can mediate their own signaling, as well as synergize with TLR to initiate specific responses to infectious agents...
  30. pmc Structure of the fungal beta-glucan-binding immune receptor dectin-1: implications for function
    James Brown
    CR UK Receptor Structure Research Group, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom
    Protein Sci 16:1042-52. 2007
    ..These combined structural and biophysical data considerably extend the current knowledge of dectin-1 structure and function, and suggest potential mechanisms of defense against fungal pathogens...
  31. ncbi request reprint Syk-dependent ERK activation regulates IL-2 and IL-10 production by DC stimulated with zymosan
    Emma C Slack
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, UK
    Eur J Immunol 37:1600-12. 2007
    ..Furthermore, the lack of receptor compensation observed here suggests that responses induced by complex innate stimuli cannot always be predicted by the signalling pathways downstream of individual receptors...
  32. ncbi request reprint Dectin-1: a signalling non-TLR pattern-recognition receptor
    Gordon D Brown
    Institute of Infectious Disease and Molecular Medicine, CLS, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, 7925, South Africa
    Nat Rev Immunol 6:33-43. 2006
    ....
  33. ncbi request reprint Glycosylation influences the lectin activities of the macrophage mannose receptor
    Yunpeng Su
    Glycobiology Institute and the Biochemistry Department, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    J Biol Chem 280:32811-20. 2005
    ..i) It is required for mannose recognition; and (ii) it modulates the tendency of MR to self-associate, effectively regulating the avidity of the CR domain for sulfated sugar ligands...
  34. pmc The potential for Toll-like receptors to collaborate with other innate immune receptors
    Subhankar Mukhopadhyay
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK
    Immunology 112:521-30. 2004
    ....
  35. ncbi request reprint Expression of the beta-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions
    Delyth M Reid
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, RG20 7NN, UK
    J Leukoc Biol 76:86-94. 2004
    ..Tissue localization thus revealed potential roles of Dectin-1 in leukocyte interactions during innate immune responses and T cell development...
  36. ncbi request reprint Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes
    Andrew S J Marshall
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    J Biol Chem 279:14792-802. 2004
    ..These data suggest that MICL is a negative regulator of granulocyte and monocyte function...
  37. ncbi request reprint The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophages
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford OX1 3RE, United Kingdom
    J Immunol 172:1157-62. 2004
    ..These studies have identified SIGNR1 as a major MR for fungal and other pathogens present on specific subsets of Mphi...
  38. ncbi request reprint Dectin-1 and its role in the recognition of beta-glucans by macrophages
    Jurgen Herre
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Mol Immunol 40:869-76. 2004
    ..In addition to beta-glucans, Dectin-1 also recognizes an endogenous ligand on T cells. The ligand and the immunological role of Dectin-1 mediated T cell interactions remain to be described...
  39. pmc Alveolar macrophage-mediated killing of Pneumocystis carinii f. sp. muris involves molecular recognition by the Dectin-1 beta-glucan receptor
    Chad Steele
    Department of Pediatrics, Division of Pulmonology, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Exp Med 198:1677-88. 2003
    ..Taken together, these results show that nonopsonic phagocytosis and subsequent killing of P. carinii by alveolar macrophages is dependent upon recognition by the Dectin-1 beta-glucan receptor...
  40. ncbi request reprint Dectin-1 expression and function are enhanced on alternatively activated and GM-CSF-treated macrophages and are negatively regulated by IL-10, dexamethasone, and lipopolysaccharide
    Janet A Willment
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    J Immunol 171:4569-73. 2003
    ..These results correlate with the known effects of these cytokines and other agents on the ability of the immune system to recognize and respond to fungal pathogens...
  41. ncbi request reprint Pattern recognition receptors and differentiation antigens define murine myeloid cell heterogeneity ex vivo
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, Oxford, GB
    Eur J Immunol 33:2090-7. 2003
    ....
  42. ncbi request reprint Analysis of mannose receptor regulation by IL-4, IL-10, and proteolytic processing using novel monoclonal antibodies
    Luisa Martinez-Pomares
    Sir William Dunn School of Pathology, Oxford, United Kingdom
    J Leukoc Biol 73:604-13. 2003
    ..These data support a role for the MR in T helper cell type 2 cytokine-driven, immune responses and suggest a non-M(phi) contribution to sMR production in vivo...
  43. ncbi request reprint The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, Oxford, United Kingdom
    J Immunol 169:3876-82. 2002
    ..These observations imply the existence of an additional mannan-dependent receptor involved in the recognition of zymosan by resident peritoneal Mphi...
  44. ncbi request reprint Loss of cell wall mannosylphosphate in Candida albicans does not influence macrophage recognition
    Richard P Hobson
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, United Kingdom
    J Biol Chem 279:39628-35. 2004
    ..albicans infection. The null mutant was also not affected in its interaction with macrophages. Mannosylphosphate is therefore not required for macrophage interactions or for virulence of C. albicans...
  45. ncbi request reprint Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages
    Jurgen Herre
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    Blood 104:4038-45. 2004
    ..Furthermore, intracellular trafficking of this receptor was influenced by the nature of the beta-glucan ligand, which has significance for the biologic activity of these immunomodulatory carbohydrates...
  46. ncbi request reprint Dectin-1 escape by fungal dimorphism
    Sigrid E M Heinsbroek
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK OX1 3RE
    Trends Immunol 26:352-4. 2005
    ..Here, we discuss the insights these results provide in relation to macrophage interactions with C. albicans and pathogen entry...
  47. ncbi request reprint Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins
    Neil C Rogers
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Immunity 22:507-17. 2005
    ..These results identify a novel signaling pathway involved in pattern recognition by C type lectins and suggest a potential role for Syk kinase in regulation of innate immunity...
  48. ncbi request reprint Dectin-2 is predominantly myeloid restricted and exhibits unique activation-dependent expression on maturing inflammatory monocytes elicited in vivo
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, Oxford, UK
    Eur J Immunol 35:2163-74. 2005
    ..These observations show Dectin-2 expression to be characteristic of monocyte activation/maturation at an inflammatory lesion and provide a new perspective on the interpretation of Dectin-2 function in vivo...
  49. ncbi request reprint The human beta-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells
    Janet A Willment
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Eur J Immunol 35:1539-47. 2005
    ....
  50. pmc A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice
    Hiroyuki Yoshitomi
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    J Exp Med 201:949-60. 2005
    ....
  51. ncbi request reprint Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge
    Peter J Rice
    Department of Pharmacology, East Tennessee State University, Johnson City, TN 37614, USA
    J Pharmacol Exp Ther 314:1079-86. 2005
    ..The glucans are bound by GI epithelial and GALT cells, and they modulate the expression of pattern recognition receptors in the GALT, increase IL-12 expression, and induce protection against infectious challenge...
  52. ncbi request reprint Expression of functionally different dectin-1 isoforms by murine macrophages
    Sigrid E M Heinsbroek
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    J Immunol 176:5513-8. 2006
    ..These results are the first evidence that dectin-1 isoforms are functionally distinct and indicate that differential isoform usage may represent a mechanism of regulating cellular responses to beta-glucans...
  53. pmc Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on Toll-like receptor 2 and Dectin-1
    Suganya Viriyakosol
    Veterans Affairs San Diego Healthcare System 111F, 3350 La Jolla Village Dr, San Diego, CA 92161, USA
    Infect Immun 73:1553-60. 2005
    ..Taken together, these results show that cytokine responses in mouse peritoneal macrophages to C. posadasii spherules are dependent on TLR2, MyD88, and Dectin-1...
  54. ncbi request reprint The role of Dectin-1 in antifungal immunity
    Jurgen Herre
    Sir William Dunn School of Pathology, University of Oxford, UK
    Crit Rev Immunol 24:193-203. 2004
    ..This review will highlight the current knowledge of Dectin-1 and its potential role in antifungal immunity, as well as deficiencies in our understanding...
  55. pmc CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes
    Cristal Huysamen
    Division of Immunology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, 7925, South Africa
    J Biol Chem 283:16693-701. 2008
    ..These data indicate that CLEC9A functions as an activation receptor...
  56. ncbi request reprint Microarray analyses identify molecular biomarkers of Atlantic salmon macrophage and hematopoietic kidney response to Piscirickettsia salmonis infection
    Matthew L Rise
    Great Lakes Wisconsin Aquatic Technology and Environmental Research WATER Institute, University of Wisconsin Milwaukee
    Physiol Genomics 20:21-35. 2004
    ..salmonis infection, characterized by immune-relevant functional annotations and high fold differences in expression between infected and noninfected samples, may aid in the development of anti-piscirickettsial vaccines and therapeutics...
  57. pmc Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand
    Elwira Pyz
    The Institute of Infectious Disease and Molecular Medicine, Division of Immunology, University of Cape Town, Cape Town, South Africa
    Eur J Immunol 38:1157-63. 2008
    ..Finally, we show that mMICL recognises an endogenous ligand in a variety of murine tissues, suggesting that the receptor plays a role in homeostasis...
  58. ncbi request reprint Immune recognition of fungal beta-glucans
    Gordon D Brown
    Institute of Infectious Disease and Molecular Medicine, CLS, Faculty of Health Sciences, University of Cape Town, Observatory, 7925, Cape Town, South Africa
    Cell Microbiol 7:471-9. 2005
    ..In this review, we will highlight all the known receptors for beta-glucans and will discuss the various immune responses they can initiate, with reference to fungal infection, in both vertebrates and invertebrates...
  59. ncbi request reprint An integrated model of the recognition of Candida albicans by the innate immune system
    Mihai G Netea
    Department of Medicine and Nijmegen University Centre for Infectious Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Nat Rev Microbiol 6:67-78. 2008
    ..In this Review, we use the fungal pathogen Candida albicans as a model for the complex interaction that exists between the host pattern-recognition systems and invading microbial pathogens...
  60. pmc An ectromelia virus profilin homolog interacts with cellular tropomyosin and viral A-type inclusion protein
    Christine Butler-Cole
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada
    Virol J 4:76. 2007
    ..In this study, a poxviral profilin homolog, ectromelia virus strain Moscow gene 141 (ECTV-PH), was investigated by a variety of experimental and bioinformatics techniques to characterize its interactions with cellular and viral proteins...
  61. ncbi request reprint C-type lectin receptors in antifungal immunity
    Janet A Willment
    Institute of Infectious Disease and Molecular Medicine, Division of Immunology, CLS, University of Cape Town, Observatory, Cape Town, 7925, South Africa
    Trends Microbiol 16:27-32. 2008
    ..Here, we review the roles of each of these receptors, describing how they contribute to fungal recognition, uptake and killing and also participate in the induction and/or modulation of the host immune response...