Research Topics

Genomes and Genes

Species

D R Brown

Summary

Affiliation: University of Bath
Country: UK

Publications

  1. McDowall J, Brown D. Alpha-synuclein: relating metals to structure, function and inhibition. Metallomics. 2016;8:385-97 pubmed publisher
    ..The recent proposal that alpha-synuclein is a ferrireductase is important as it can possibly catalyse the formation of such reactive species and as a result exacerbate neurodegeneration. ..
  2. Cichon A, Brown D. Nrf-2 regulation of prion protein expression is independent of oxidative stress. Mol Cell Neurosci. 2014;63:31-7 pubmed publisher
    ..Furthermore, Nrf-2 has no impact on PrP expression when cells are infected with scrapie. These findings highlight that Nrf-2 can regulate PrP expression, but that this regulation becomes uncoupled during cellular stress. ..
  3. request reprint
    Brown D. Prion protein expression modulates neuronal copper content. J Neurochem. 2003;87:377-85 pubmed
    ..Loss of normal Cu binding by the prion protein altered age-related increases in metals in the brain. This may explain why many forms of human prion disease do not develop until late in life. ..
  4. McDowall J, Ntai I, Honeychurch K, Hart J, Colin P, Schneider B, et al. Alpha-synuclein ferrireductase activity is detectible in vivo, is altered in Parkinson's disease and increases the neurotoxicity of DOPAL. Mol Cell Neurosci. 2017;85:1-11 pubmed publisher
    ..These findings demonstrate that ?-synuclein ferrireductase activity is present in vivo and its alteration may play a role in neuron loss in disease. ..
  5. Angelova D, Jones H, Brown D. Levels of ?- and ?-synuclein regulate cellular susceptibility to toxicity from ?-synuclein oligomers. FASEB J. 2017;: pubmed publisher
    ..Angelova, D. M., Jones, H. B. L., Brown, D. R. Levels of ?- and ?-synuclein regulate cellular susceptibility to toxicity from ?-synuclein oligomers...

Detail Information

Publications5

  1. McDowall J, Brown D. Alpha-synuclein: relating metals to structure, function and inhibition. Metallomics. 2016;8:385-97 pubmed publisher
    ..The recent proposal that alpha-synuclein is a ferrireductase is important as it can possibly catalyse the formation of such reactive species and as a result exacerbate neurodegeneration. ..
  2. Cichon A, Brown D. Nrf-2 regulation of prion protein expression is independent of oxidative stress. Mol Cell Neurosci. 2014;63:31-7 pubmed publisher
    ..Furthermore, Nrf-2 has no impact on PrP expression when cells are infected with scrapie. These findings highlight that Nrf-2 can regulate PrP expression, but that this regulation becomes uncoupled during cellular stress. ..
  3. request reprint
    Brown D. Prion protein expression modulates neuronal copper content. J Neurochem. 2003;87:377-85 pubmed
    ..Loss of normal Cu binding by the prion protein altered age-related increases in metals in the brain. This may explain why many forms of human prion disease do not develop until late in life. ..
  4. McDowall J, Ntai I, Honeychurch K, Hart J, Colin P, Schneider B, et al. Alpha-synuclein ferrireductase activity is detectible in vivo, is altered in Parkinson's disease and increases the neurotoxicity of DOPAL. Mol Cell Neurosci. 2017;85:1-11 pubmed publisher
    ..These findings demonstrate that ?-synuclein ferrireductase activity is present in vivo and its alteration may play a role in neuron loss in disease. ..
  5. Angelova D, Jones H, Brown D. Levels of ?- and ?-synuclein regulate cellular susceptibility to toxicity from ?-synuclein oligomers. FASEB J. 2017;: pubmed publisher
    ..Angelova, D. M., Jones, H. B. L., Brown, D. R. Levels of ?- and ?-synuclein regulate cellular susceptibility to toxicity from ?-synuclein oligomers...