Alistair Jp Brown

Summary

Affiliation: University of Aberdeen
Country: UK

Publications

  1. pmc Niche-specific regulation of central metabolic pathways in a fungal pathogen
    Caroline J Barelle
    School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Cell Microbiol 8:961-71. 2006
  2. pmc Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm-blooded animals
    Susan Nicholls
    Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Aberdeen AB25 2ZD, UK
    Mol Microbiol 74:844-61. 2009
  3. pmc Modelling the regulation of thermal adaptation in Candida albicans, a major fungal pathogen of humans
    Michelle D Leach
    School of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
    PLoS ONE 7:e32467. 2012
  4. pmc Combinatorial stresses kill pathogenic Candida species
    Despoina Kaloriti
    School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, UK
    Med Mycol 50:699-709. 2012
  5. pmc Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen
    Iuliana V Ene
    Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Cell Microbiol 14:1319-35. 2012
  6. pmc Carbon source-induced reprogramming of the cell wall proteome and secretome modulates the adherence and drug resistance of the fungal pathogen Candida albicans
    Iuliana V Ene
    Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
    Proteomics 12:3164-79. 2012
  7. pmc Fungal iron availability during deep seated candidiasis is defined by a complex interplay involving systemic and local events
    Joanna Potrykus
    Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom
    PLoS Pathog 9:e1003676. 2013
  8. pmc Molecular and proteomic analyses highlight the importance of ubiquitination for the stress resistance, metabolic adaptation, morphogenetic regulation and virulence of Candida albicans
    Michelle D Leach
    School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
    Mol Microbiol 79:1574-93. 2011
  9. pmc Reporters for the analysis of N-glycosylation in Candida albicans
    Shahida Shahana
    Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
    Fungal Genet Biol 56:107-15. 2013
  10. pmc Role of the Candida albicans MNN1 gene family in cell wall structure and virulence
    Steven Bates
    College of Life and Environmental Sciences, University of Exeter, Exeter, EX4 4QD, UK
    BMC Res Notes 6:294. 2013

Collaborators

Detail Information

Publications77

  1. pmc Niche-specific regulation of central metabolic pathways in a fungal pathogen
    Caroline J Barelle
    School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Cell Microbiol 8:961-71. 2006
    ....
  2. pmc Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm-blooded animals
    Susan Nicholls
    Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Aberdeen AB25 2ZD, UK
    Mol Microbiol 74:844-61. 2009
    ..albicans. Therefore, the main role of Hsf1 in this pathogen might be the homeostatic modulation of chaperone levels in response to growth temperature, rather than the activation of acute responses to sudden thermal transitions...
  3. pmc Modelling the regulation of thermal adaptation in Candida albicans, a major fungal pathogen of humans
    Michelle D Leach
    School of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
    PLoS ONE 7:e32467. 2012
    ....
  4. pmc Combinatorial stresses kill pathogenic Candida species
    Despoina Kaloriti
    School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, UK
    Med Mycol 50:699-709. 2012
    ..This was the case for combinations of osmotic plus oxidative stress and for oxidative plus nitrosative stress. We predict that combinatorial stresses may be highly significant in host defences against these pathogenic yeasts...
  5. pmc Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen
    Iuliana V Ene
    Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Cell Microbiol 14:1319-35. 2012
    ..Changes in carbon source also altered the virulence of C. albicans in models of systemic candidiasis and vaginitis, confirming the importance of alternative carbon sources within host niches during C. albicans infections...
  6. pmc Carbon source-induced reprogramming of the cell wall proteome and secretome modulates the adherence and drug resistance of the fungal pathogen Candida albicans
    Iuliana V Ene
    Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
    Proteomics 12:3164-79. 2012
    ..This plasticity influences important fitness and virulence attributes known to modulate the behavior of C. albicans in different host microenvironments during infection...
  7. pmc Fungal iron availability during deep seated candidiasis is defined by a complex interplay involving systemic and local events
    Joanna Potrykus
    Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom
    PLoS Pathog 9:e1003676. 2013
    ..Therefore, a complex interplay of systemic and local events influences iron homeostasis and pathogen-host dynamics during disease progression...
  8. pmc Molecular and proteomic analyses highlight the importance of ubiquitination for the stress resistance, metabolic adaptation, morphogenetic regulation and virulence of Candida albicans
    Michelle D Leach
    School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
    Mol Microbiol 79:1574-93. 2011
    ..This was confirmed by the observation that the virulence of C. albicans ubi4/ubi4 cells is significantly attenuated...
  9. pmc Reporters for the analysis of N-glycosylation in Candida albicans
    Shahida Shahana
    Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
    Fungal Genet Biol 56:107-15. 2013
    ..These reporters are useful tools for the experimental dissection of N-glycosylation and other related processes in C.albicans, such as secretion...
  10. pmc Role of the Candida albicans MNN1 gene family in cell wall structure and virulence
    Steven Bates
    College of Life and Environmental Sciences, University of Exeter, Exeter, EX4 4QD, UK
    BMC Res Notes 6:294. 2013
    ..Here we report the first analysis of the MNN1 gene family, which contains six members predicted to act as α-1,3 mannosyltransferases in the terminal stages of glycosylation...
  11. pmc A systems biology analysis of long and short-term memories of osmotic stress adaptation in fungi
    Tao You
    Institute for Complex Systems and Mathematical Biology, School of Natural and Computing Sciences, University of Aberdeen, Aberdeen, UK
    BMC Res Notes 5:258. 2012
    ..Candida albicans also adapts to hyperosmolarity via a HOG signaling network. However, it remains unknown whether Hog1 exerts integral or proportional control over glycerol production in C. albicans...
  12. pmc Genome-wide analysis of Candida albicans gene expression patterns during infection of the mammalian kidney
    Louise A Walker
    Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
    Fungal Genet Biol 46:210-9. 2009
    ..Indeed, we observed a poor correlation between the transcriptome and phenome for those genes that were regulated during kidney infection and that have been virulence tested...
  13. pmc Activation of the heat shock transcription factor Hsf1 is essential for the full virulence of the fungal pathogen Candida albicans
    Susan Nicholls
    School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, United Kingdom
    Fungal Genet Biol 48:297-305. 2011
    ..Using this HSF1 CE2 deletion mutant we demonstrate that Hsf1 activation, and hence thermal adaptation, contributes significantly to the virulence of C. albicans...
  14. pmc Analysing GCN4 translational control in yeast by stochastic chemical kinetics modelling and simulation
    Tao You
    School of Natural and Computing Sciences, University of Aberdeen, Institute of Complex System and Mathematical Biology, Aberdeen, UK
    BMC Syst Biol 5:131. 2011
    ..During amino acid starvation, levels of ternary complex are reduced. This overcomes the GCN4 translation attenuation effect via a scanning/reinitiation control mechanism dependent upon uORF spacing...
  15. pmc PEDRo: a database for storing, searching and disseminating experimental proteomics data
    Kevin Garwood
    Department of Computer Science, University of Manchester, Oxford Road, Manchester M13 9PL, UK
    BMC Genomics 5:68. 2004
    ..However, there is, as yet, no formally accepted standard representation to support the sharing of proteomics data, and little systematic dissemination of comprehensive proteomic data sets...
  16. pmc Phylogenetic diversity of stress signalling pathways in fungi
    Elissavet Nikolaou
    Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD, UK
    BMC Evol Biol 9:44. 2009
    ..These fungi, which include ascomycetes, basidiomycetes and microsporidia, occupy highly divergent niches from saline environments to plant or mammalian hosts...
  17. pmc Nitrosative and oxidative stress responses in fungal pathogenicity
    Alistair J P Brown
    School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
    Curr Opin Microbiol 12:384-91. 2009
    ..In contrast, there is a high degree of commonality in the cellular responses to reactive oxygen and nitrogen species evoked in evolutionarily divergent fungal pathogens...
  18. pmc The relevance of heat shock regulation in fungal pathogens of humans
    Alistair J P Brown
    Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Aberdeen, UK
    Virulence 1:330-2. 2010
    ..Hsf1 also regulates the expression of Hsp90, which controls the yeast-hypha transition in C. albicans, and we argue, might also control morphogenesis in other fungal pathogens of humans...
  19. ncbi request reprint Regulatory networks controlling Candida albicans morphogenesis
    A J Brown
    Dept of Molecular and Cell Biology, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK AB25 2ZD
    Trends Microbiol 7:333-8. 1999
    ..The regulatory networks that control morphogenesis are being elucidated; however, the primary signals that trigger morphogenesis remain obscure, and the physiological outputs of these networks are complex...
  20. ncbi request reprint Infection-related gene expression in Candida albicans
    Alistair J P Brown
    Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Curr Opin Microbiol 10:307-13. 2007
    ..These studies, together with analyses of C. albicans mutants, indicate that physiological fitness plays a central role in the pathogenicity of this fungus, alongside virulence factors...
  21. pmc Microbial signaling and systems biology
    Alistair J P Brown
    School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Aberdeen AB25 2ZD, UK
    Genome Biol 11:302. 2010
    ..A report of the symposium on Signaling and Systems Biology held during the Society for General Microbiology Spring Meeting, 29-30 March 2010, Edinburgh, UK...
  22. pmc Glucose promotes stress resistance in the fungal pathogen Candida albicans
    Alexandra Rodaki
    Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    Mol Biol Cell 20:4845-55. 2009
    ..The data suggest that, upon entering the bloodstream, C. albicans cells respond to glucose increasing their resistance to the oxidative and cationic stresses central to the armory of immunoprotective phagocytic cells...
  23. pmc Niche-specific activation of the oxidative stress response by the pathogenic fungus Candida albicans
    Brice Enjalbert
    Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    Infect Immun 75:2143-51. 2007
    ....
  24. ncbi request reprint Exposure of Candida albicans to antifungal agents affects expression of SAP2 and SAP9 secreted proteinase genes
    Vanessa M S Copping
    Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
    J Antimicrob Chemother 55:645-54. 2005
    ..To ascertain the effects of subinhibitory concentrations of several antifungal agents on a virulence factor: secreted proteinase (Sap) activity and expression of SAP genes in Candida albicans...
  25. pmc Melanin externalization in Candida albicans depends on cell wall chitin structures
    Claire A Walker
    Aberdeen Fungal Group, Institute of Medical Sciences, Aberdeen AB20 2ZD, UK
    Eukaryot Cell 9:1329-42. 2010
    ....
  26. pmc Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicans
    Brice Enjalbert
    Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom
    Mol Biol Cell 17:1018-32. 2006
    ..albicans has diverged from corresponding networks in model yeasts and that the C. albicans SAPK pathway functions in parallel with other pathways to regulate the core transcriptional response to stress...
  27. doi request reprint A proteomic analysis of the salt, cadmium and peroxide stress responses in Candida albicans and the role of the Hog1 stress-activated MAPK in regulating the stress-induced proteome
    Zhikang Yin
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
    Proteomics 9:4686-703. 2009
    ..We have also shown that the Hog1 stress-activated mitogen-activated protein kinase, which is activated in response to the stresses examined in this study, makes a major contribution to the C. albicans stress proteome...
  28. ncbi request reprint Candida albicans Pmr1p, a secretory pathway P-type Ca2+/Mn2+-ATPase, is required for glycosylation and virulence
    Steven Bates
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Scotland, UK
    J Biol Chem 280:23408-15. 2005
    ..In a murine model of systemic infection, the null mutant was severely attenuated in virulence. These results demonstrate the importance of glycosylation for cell wall structure and virulence of C. albicans...
  29. doi request reprint Genome-wide gene expression profiling and a forward genetic screen show that differential expression of the sodium ion transporter Ena21 contributes to the differential tolerance of Candida albicans and Candida dubliniensis to osmotic stress
    Brice Enjalbert
    Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Mol Microbiol 72:216-28. 2009
    ..albicans genomic sequences that increase salt tolerance in C. dubliniensis. Introduction of a single copy of CaENA21 was subsequently shown to be sufficient to confer salt tolerance upon C. dubliniensis...
  30. ncbi request reprint Antifungal agents: mechanisms of action
    Frank C Odds
    Aberdeen Fungal Group, University of Aberdeen, Department of Molecular and Cell Biology, Institute of Medical Sciences, Aberdeen AB25 2ZD, UK
    Trends Microbiol 11:272-9. 2003
    ..This review describes the targets and mechanisms of action of all classes of antifungal agents in clinical use or with clinical potential...
  31. ncbi request reprint Fungal morphogenesis and host invasion
    Neil A R Gow
    Department of Molecular and Cell Biology, Institute of Medical Sciences, University of Aberdeen, AB25 2ZD, Aberdeen, UK
    Curr Opin Microbiol 5:366-71. 2002
    ..This review considers the role of morphogenesis in fungal infection and argues that no simple, universal relationship can be drawn between morphology and the invasive potential of a fungus...
  32. doi request reprint Information quality in proteomics
    David A Stead
    School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
    Brief Bioinform 9:174-88. 2008
    ..Data quality issues are considered throughout the lifecycle of a proteomics experiment, from experiment design and technique selection, through data analysis, to archiving and sharing...
  33. pmc Property differences among the four major Candida albicans strain clades
    Donna M MacCallum
    Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
    Eukaryot Cell 8:373-87. 2009
    ..The study has extended the range of properties known to differ between C. albicans clades and suggests a possible but minor role of phosphate metabolism in the virulence of the species...
  34. pmc The PKC, HOG and Ca2+ signalling pathways co-ordinately regulate chitin synthesis in Candida albicans
    Carol A Munro
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Mol Microbiol 63:1399-413. 2007
    ..Therefore, at least three pathways co-ordinately regulate chitin synthesis and activation of chitin synthesis operates at both transcriptional and post-transcriptional levels...
  35. pmc Recognition and blocking of innate immunity cells by Candida albicans chitin
    Hector M Mora-Montes
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom
    Infect Immun 79:1961-70. 2011
    ..albicans cells but not with live cells. Therefore, chitin is normally not exposed to cells of the innate immune system but is capable of influencing immune recognition by blocking dectin-1-mediated engagement with fungal cell walls...
  36. pmc Effects of depleting the essential central metabolic enzyme fructose-1,6-bisphosphate aldolase on the growth and viability of Candida albicans: implications for antifungal drug target discovery
    Alexandra Rodaki
    Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom
    Eukaryot Cell 5:1371-7. 2006
    ..We conclude that an antifungal drug directed against Fba1p would have to be potent to be effective...
  37. pmc Candida albicans genome sequence: a platform for genomics in the absence of genetics
    Frank C Odds
    Aberdeen Fungal Group, Institute of Medical Sciences, Aberdeen AB25 2ZD, UK
    Genome Biol 5:230. 2004
    ..Comparative genomic analysis highlights genes that may contribute to C. albicans survival and its fitness as a human commensal and pathogen...
  38. pmc Differential regulation of kidney and spleen cytokine responses in mice challenged with pathology-standardized doses of Candida albicans mannosylation mutants
    Luis Castillo
    Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom
    Infect Immun 79:146-52. 2011
    ..We conclude that complex, multifactorial local responses offset and obscure any differences resulting from differences in surface mannosylation of C. albicans strains when infection results from pathology-standardized challenges...
  39. pmc Mnt1p and Mnt2p of Candida albicans are partially redundant alpha-1,2-mannosyltransferases that participate in O-linked mannosylation and are required for adhesion and virulence
    Carol A Munro
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    J Biol Chem 280:1051-60. 2005
    ..The double mutant was attenuated in virulence, underlining the importance of O-glycosylation in pathogenesis of C. albicans infections...
  40. pmc Phosphorylation regulates polarisation of chitin synthesis in Candida albicans
    Megan D Lenardon
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, Scotland, UK
    J Cell Sci 123:2199-206. 2010
    ..This is the first report demonstrating an essential role for chitin synthase phosphorylation in the polarised biosynthesis of fungal cell walls and suggests a new mechanism for the regulation of this class of glycosyl-transferase enzyme...
  41. pmc Immune recognition of Candida albicans beta-glucan by dectin-1
    Neil A R Gow
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom
    J Infect Dis 196:1565-71. 2007
    ..albicans was independent of the recognition of beta-glucans by dectin-1. In conclusion, C. albicans induces production of monocyte-derived and T cell-derived cytokines through distinct pathways dependent on or independent of dectin-1...
  42. pmc A multifunctional, synthetic Gaussia princeps luciferase reporter for live imaging of Candida albicans infections
    Brice Enjalbert
    School of Medical Sciences, University of Aberdeen, Aberdeen, UK
    Infect Immun 77:4847-58. 2009
    ..albicans infections. gLUC59 and related cell surface-exposed luciferase reporters might find wide applications in molecular biology, cell biology, pathobiology, and high-throughput screens...
  43. pmc A multifunctional mannosyltransferase family in Candida albicans determines cell wall mannan structure and host-fungus interactions
    Hector M Mora-Montes
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK
    J Biol Chem 285:12087-95. 2010
    ..Therefore, the MNT1/KRE2 gene family participates in three types of protein mannosylation in C. albicans, and these modifications play vital roles in fungal cell wall structure and cell surface recognition by the innate immune system...
  44. ncbi request reprint Azole antifungals induce up-regulation of SAP4, SAP5 and SAP6 secreted proteinase genes in filamentous Candida albicans cells in vitro and in vivo
    Caroline J Barelle
    Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
    J Antimicrob Chemother 61:315-22. 2008
    ..To test this hypothesis, we determined the effects of subinhibitory concentrations of three antifungal agents on expression of three secreted proteinase genes associated with virulence in filamentous forms of Candida albicans...
  45. pmc Global role of the protein kinase Gcn2 in the human pathogen Candida albicans
    Helene Tournu
    Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    Eukaryot Cell 4:1687-96. 2005
    ..Our comparison of the Gcn4 and Gcn2 regulons by transcript profiling reinforces the view that Gcn2 contributes to, but is not essential for, the activation of general amino acid control in C. albicans...
  46. pmc Candida albicans Iff11, a secreted protein required for cell wall structure and virulence
    Steven Bates
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom
    Infect Immun 75:2922-8. 2007
    ..This work provides the first evidence of the importance of this gene family in the host-fungal interaction and virulence...
  47. pmc Msn2- and Msn4-like transcription factors play no obvious roles in the stress responses of the fungal pathogen Candida albicans
    Susan Nicholls
    Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom
    Eukaryot Cell 3:1111-23. 2004
    ..These data suggest that CaMsn4 and Mnl1 do not contribute significantly to stress responses in C. albicans. The data are consistent with the idea that stress signaling in this fungus has diverged significantly from that in budding yeast...
  48. pmc Developmental regulation of an adhesin gene during cellular morphogenesis in the fungal pathogen Candida albicans
    Silvia Argimon
    School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    Eukaryot Cell 6:682-92. 2007
    ..The data suggest that multiple morphogenetic signaling pathways operate through the promoter of this adhesin gene to mediate its developmental regulation in this major fungal pathogen...
  49. ncbi request reprint GFP as a quantitative reporter of gene regulation in Candida albicans
    Caroline J Barelle
    Aberdeen Fungal Group, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
    Yeast 21:333-40. 2004
    ..Therefore, pACT1-GFP provides a useful control for this quantitative GFP-based system in future analyses of C. albicans molecular responses during fungal infections...
  50. pmc Gcn4 co-ordinates morphogenetic and metabolic responses to amino acid starvation in Candida albicans
    Gyanendra Tripathi
    Department of Molecular and Cell Biology, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
    EMBO J 21:5448-56. 2002
    ..CaGcn4 acts as a global regulator in C.albicans, co-ordinating both metabolic and morphogenetic responses to amino acid starvation...
  51. pmc Ectopic expression of URA3 can influence the virulence phenotypes and proteome of Candida albicans but can be overcome by targeted reintegration of URA3 at the RPS10 locus
    Alexandra Brand
    School of Medical Sciences, Institute of Medical Sciences, Aberdeen AB25 2ZD, Scotland, United Kingdom
    Eukaryot Cell 3:900-9. 2004
    ..Reintegration of URA3 at an appropriate expression locus such as RPS10 can offset most problems related to the phenotypic changes associated with gene knockout methodologies...
  52. ncbi request reprint Proteomic response to amino acid starvation in Candida albicans and Saccharomyces cerevisiae
    Zhikang Yin
    COGEME Proteome Research Facility 1, Molecular and Cell Biology, Institute of Medical Sciences, University of Aberdeen, UK
    Proteomics 4:2425-36. 2004
    ..cerevisiae, but were not significantly induced in C. albicans. These differences presumably reflect the contrasting niches of these relatively benign and pathogenic yeasts, respectively...
  53. pmc MNL1 regulates weak acid-induced stress responses of the fungal pathogen Candida albicans
    Mark Ramsdale
    Institute of Medical Sciences, School of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD, United Kingdom
    Mol Biol Cell 19:4393-403. 2008
    ..Our work defines a role for this YER130c orthologue in stress adaptation and cell death...
  54. pmc Global roles of Ssn6 in Tup1- and Nrg1-dependent gene regulation in the fungal pathogen, Candida albicans
    Susana Garcia-Sanchez
    Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    Mol Biol Cell 16:2913-25. 2005
    ..albicans one-hybrid system. These observations are explained in models that are generally consistent with the Tup1-Ssn6 paradigm in budding yeast...
  55. ncbi request reprint Proteomic changes associated with inactivation of the Candida glabrata ACE2 virulence-moderating gene
    David Stead
    COGEME Proteomics Research Facility 1, Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, UK
    Proteomics 5:1838-48. 2005
    ..Some of these functions are likely to contribute to the effects of Ace2 upon the virulence of C. glabrata...
  56. ncbi request reprint Expression of one-hybrid fusions with Staphylococcus aureus lexA in Candida albicans confirms that Nrg1 is a transcriptional repressor and that Gcn4 is a transcriptional activator
    Claire L Russell
    Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Fungal Genet Biol 42:676-83. 2005
    ..albicans. Using this one-hybrid system we have confirmed directly the positive and negative transcriptional activities of Nrg1 and Gcn4 in C. albicans...
  57. ncbi request reprint Impact of the transcriptional regulator, Ace2, on the Candida glabrata secretome
    David A Stead
    COGEME Proteomics Service Facility 1, School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Aberdeen, UK
    Proteomics 10:212-23. 2010
    ..glabrata ace2 cells. Ace2 inactivation also resulted in the detection of new proteins in the C. glabrata secretome. The release of such proteins might contribute to the hypervirulence of ace2 cells...
  58. ncbi request reprint Outer chain N-glycans are required for cell wall integrity and virulence of Candida albicans
    Steven Bates
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    J Biol Chem 281:90-8. 2006
    ..This demonstrates the importance of N-glycan outer chain epitopes to the host-fungal interaction and virulence...
  59. ncbi request reprint Universal metrics for quality assessment of protein identifications by mass spectrometry
    David A Stead
    School of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom
    Mol Cell Proteomics 5:1205-11. 2006
    ..Recommendations are made regarding the use of the metrics when reporting protein identification experiments...
  60. pmc Early-expressed chemokines predict kidney immunopathology in experimental disseminated Candida albicans infections
    Donna M MacCallum
    Aberdeen Fungal Group, Institute of Medical Sciences, Aberdeen, United Kingdom
    PLoS ONE 4:e6420. 2009
    ....
  61. ncbi request reprint Gene disruption in Candida albicans using a synthetic, codon-optimised Cre-loxP system
    Paul M J Dennison
    Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
    Fungal Genet Biol 42:737-48. 2005
    ..This system allows multiple and sequential genetic manipulations, which will facilitate the functional analysis of multigene families in C. albicans...
  62. ncbi request reprint Glucose triggers different global responses in yeast, depending on the strength of the signal, and transiently stabilizes ribosomal protein mRNAs
    Zhikang Yin
    Department of Molecular and Cell Biology, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
    Mol Microbiol 48:713-24. 2003
    ..In contrast, the regulation of metabolic functions in response to very low glucose signals presumably ensures that yeast can exploit even minute amounts of this preferred nutrient...
  63. pmc Candida albicans VAC8 is required for vacuolar inheritance and normal hyphal branching
    Caroline J Barelle
    School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    Eukaryot Cell 5:359-67. 2006
    ..albicans hyphae. The data support the hypothesis that cytoplasmic volume, rather than cell size, is critical for progression through G1...
  64. pmc Asynchronous cell cycle and asymmetric vacuolar inheritance in true hyphae of Candida albicans
    Caroline J Barelle
    Department of Molecular and Cell Biology, Institute of Molecular Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom
    Eukaryot Cell 2:398-410. 2003
    ....
  65. ncbi request reprint Protein A-tagging for purification of native macromolecular complexes from Candida albicans
    Chris Blackwell
    School of Cell and Molecular Biosciences, The Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Yeast 20:1235-41. 2003
    ..These new vectors comprise a useful addition to the C. albicans molecular toolbox...
  66. ncbi request reprint A systematic approach to modeling, capturing, and disseminating proteomics experimental data
    Chris F Taylor
    School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK
    Nat Biotechnol 21:247-54. 2003
    ..These make explicit what data might be most usefully captured about proteomics experiments and provide complementary routes toward the implementation of a proteome repository...
  67. pmc Endoplasmic reticulum alpha-glycosidases of Candida albicans are required for N glycosylation, cell wall integrity, and normal host-fungus interaction
    Hector M Mora-Montes
    Instituto de Investigacion en Biologia Experimental, Facultad de Quimica, Universidad de Guanajuato, Apartado Postal 187, Guanajuato, Gto CP 36000, Mexico
    Eukaryot Cell 6:2184-93. 2007
    ..Therefore, N-oligosaccharide processing by ER glycosidases is required for cell wall integrity and for host-fungus interactions...
  68. pmc APSES proteins regulate morphogenesis and metabolism in Candida albicans
    Thomas Doedt
    Institut fur Mikrobiologie, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
    Mol Biol Cell 15:3167-80. 2004
    ..Overall, the results suggest that Efh1p supports the regulatory functions of the primary regulator, Efg1p, and indicate a dual role for these APSES proteins in the regulation of fungal morphogenesis and metabolism...
  69. ncbi request reprint Impact of the unfolded protein response upon genome-wide expression patterns, and the role of Hac1 in the polarized growth, of Candida albicans
    Tithira T Wimalasena
    School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Fungal Genet Biol 45:1235-47. 2008
    ..albicans and in the expression of genes encoding cell surface proteins during ER stress, factors that are important in virulence of this fungal pathogen...
  70. ncbi request reprint The Candida albicans CaACE2 gene affects morphogenesis, adherence and virulence
    Mary T Kelly
    Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Mol Microbiol 53:969-83. 2004
    ..The CaAce2 protein is localized to the daughter nucleus of large budded cells at the end of mitosis. C. albicans Ace2p therefore plays a major role in morphogenesis and adherence and resembles S. cerevisiae Ace2p in function...
  71. ncbi request reprint Genomics and the development of new diagnostics and anti-Candida drugs
    Michael Weig
    Institute of Medical Microbiology and German National Reference Centre for Systemic Mycoses, University of Goettingen, Kreuzbergring 57, D 37075 Goettingen, Germany
    Trends Microbiol 15:310-7. 2007
    ..Recent advances in unravelling the genomics of these species should facilitate efforts to achieve these goals. We discuss the contribution of genomics to the development of novel antifungals and new diagnostic tools...
  72. pmc Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors
    Mihai G Netea
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Clin Invest 116:1642-50. 2006
    ..We concluded that recognition of C. albicans by monocytes/macrophages is mediated by 3 recognition systems of differing importance, each of which senses specific layers of the C. albicans cell wall...
  73. pmc A conserved stress-activated protein kinase regulates a core stress response in the human pathogen Candida albicans
    Deborah A Smith
    School of Cell and Molecular Biosciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom
    Mol Biol Cell 15:4179-90. 2004
    ..This niche specificity is reflected by the specific environmental conditions that drive the Hog1-regulated core stress response in C. albicans and by differences in the molecular circuitry that control this response...
  74. ncbi request reprint ALS3 and ALS8 represent a single locus that encodes a Candida albicans adhesin; functional comparisons between Als3p and Als1p
    Xiaomin Zhao
    Department of Veterinary Pathobiology, University of Illinois at Urbana Champaign, Urbana, IL 61802, USA
    Microbiology 150:2415-28. 2004
    ..Collectively, these results demonstrate functional similarities and differences between Als1p and Als3p, and suggest the potential for more complex interrelationships between the ALS genes and their encoded proteins...
  75. ncbi request reprint A transcriptome analysis of isoamyl alcohol-induced filamentation in yeast reveals a novel role for Gre2p as isovaleraldehyde reductase
    Michael Hauser
    Cardiff School of Biosciences, Cardiff University, Cardiff, UK
    FEMS Yeast Res 7:84-92. 2007
    ..These results indicate a previously unsuspected and novel role for the GRE2 gene product as a suppressor of filamentation by virtue of encoding isovaleraldehyde reductase activity...
  76. ncbi request reprint The zygomycetous fungus, Benjaminiella poitrasii contains a large family of differentially regulated chitin synthase genes
    Manisha V Chitnis
    Biochemical Sciences Division, National Chemical Laboratory, Pune, India
    Fungal Genet Biol 36:215-23. 2002
    ..These are the first B. poitrasii sequences to be reported. Based on CHS gene sequences, B. poitrasii chitin synthase genes place it with other zygomycetes on a fungal phylogenetic tree...
  77. doi request reprint Proteomic analysis of the pH response in the fungal pathogen Candida glabrata
    Pia Schmidt
    Institute of Medical Microbiology and National Reference Center for Systemic Mycoses, University of Gottingen, Gottingen, Germany
    Proteomics 8:534-44. 2008
    ..Our data suggest that C. glabrata perceives low pH as less stressful than higher pH. This contrasts with another opportunistic fungal pathogen of humans, Candida albicans...