P J Brophy


Affiliation: University of Edinburgh
Country: UK


  1. Brivio V, Faivre Sarrailh C, Peles E, Sherman D, Brophy P. Assembly of CNS Nodes of Ranvier in Myelinated Nerves Is Promoted by the Axon Cytoskeleton. Curr Biol. 2017;27:1068-1073 pubmed publisher
    ..These data demonstrate a role for the axon cytoskeleton in the assembly of a critical neuronal domain, the node of Ranvier. ..
  2. Grove M, Brophy P. FAK is required for Schwann cell spreading on immature basal lamina to coordinate the radial sorting of peripheral axons with myelination. J Neurosci. 2014;34:13422-34 pubmed publisher
    ..Hence, FAK has a critical role in the response of SCs to limiting BL by promoting proliferation and preventing premature SC differentiation. ..
  3. Zhang A, Desmazieres A, Zonta B, Melrose S, Campbell G, Mahad D, et al. Neurofascin 140 is an embryonic neuronal neurofascin isoform that promotes the assembly of the node of Ranvier. J Neurosci. 2015;35:2246-54 pubmed publisher
    ..This expands the critical role of the Nfasc gene in the function of myelinated axons and reveals further redundancy in the mechanisms required for the formation of this crucial structure in the vertebrate nervous system. ..