M J Brodie

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi request reprint Multicentre, double-blind, randomised comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy. The UK Lamotrigine Elderly Study Group
    M J Brodie
    Department of Medicine and Therapeutics, Western Infirmary, Glasgow, UK
    Epilepsy Res 37:81-7. 1999
  2. ncbi request reprint Neurochemical studies with the novel anticonvulsant levetiracetam in mouse brain
    G J Sills
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, UK
    Eur J Pharmacol 325:35-40. 1997
  3. ncbi request reprint Concentration-effect studies with topiramate on selected enzymes and intermediates of the GABA shunt
    G J Sills
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    Epilepsia 41:S30-4. 2000
  4. ncbi request reprint Vigabatrin and tiagabine are pharmacologically different drugs. A pre-clinical study
    G J Sills
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland, UK
    Seizure 8:404-11. 1999
  5. ncbi request reprint Double-blind substitution of vigabatrin and valproate in carbamazepine-resistant partial epilepsy. 012 Study group
    M J Brodie
    Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland, UK
    Epilepsy Res 34:199-205. 1999
  6. ncbi request reprint Hormone profiles in young adults with epilepsy treated with sodium valproate or lamotrigine monotherapy
    L J Stephen
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland, UK
    Epilepsia 42:1002-6. 2001
  7. ncbi request reprint Does the cause of localisation-related epilepsy influence the response to antiepileptic drug treatment?
    L J Stephen
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    Epilepsia 42:357-62. 2001
  8. ncbi request reprint Management strategies for refractory localization-related seizures
    M J Brodie
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, G11 6NT, Scotland
    Epilepsia 42:27-30. 2001
  9. doi request reprint Efficacy and safety of adjunctive ezogabine (retigabine) in refractory partial epilepsy
    M J Brodie
    Epilepsy Unit, Western Infirmary, Glasgow, Scotland, UK
    Neurology 75:1817-24. 2010
  10. ncbi request reprint A neurochemical study of the novel antiepileptic drug retigabine in mouse brain
    G J Sills
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    Pharmacol Res 42:553-7. 2000

Detail Information

Publications37

  1. ncbi request reprint Multicentre, double-blind, randomised comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy. The UK Lamotrigine Elderly Study Group
    M J Brodie
    Department of Medicine and Therapeutics, Western Infirmary, Glasgow, UK
    Epilepsy Res 37:81-7. 1999
    ..In conclusion, LTG can be regarded as an acceptable choice as initial treatment for elderly patients with newly diagnosed epilepsy...
  2. ncbi request reprint Neurochemical studies with the novel anticonvulsant levetiracetam in mouse brain
    G J Sills
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, UK
    Eur J Pharmacol 325:35-40. 1997
    ..Single dose and repeated levetiracetam treatments were without effect on all of the parameters investigated. The anticonvulsant action of levetiracetam is unlikely to be mediated via an action on the GABAergic system...
  3. ncbi request reprint Concentration-effect studies with topiramate on selected enzymes and intermediates of the GABA shunt
    G J Sills
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    Epilepsia 41:S30-4. 2000
    ..Recent evidence has, however, suggested that the drug also increases brain GABA concentrations in humans. These studies were designed to investigate the neurochemical basis of this observation...
  4. ncbi request reprint Vigabatrin and tiagabine are pharmacologically different drugs. A pre-clinical study
    G J Sills
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland, UK
    Seizure 8:404-11. 1999
    ..It is possible, then, that these drugs will have different spectra of activity and toxicity profiles in human epilepsy...
  5. ncbi request reprint Double-blind substitution of vigabatrin and valproate in carbamazepine-resistant partial epilepsy. 012 Study group
    M J Brodie
    Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland, UK
    Epilepsy Res 34:199-205. 1999
    ..This lends credence to the hypothesis in support of a mechanistic approach to the management of epilepsy...
  6. ncbi request reprint Hormone profiles in young adults with epilepsy treated with sodium valproate or lamotrigine monotherapy
    L J Stephen
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland, UK
    Epilepsia 42:1002-6. 2001
    ..However, only a minority of obese females exhibited biochemical characteristics suggestive of PCOS. Biochemical screening may allow women at risk of developing PCOS to avoid VPA...
  7. ncbi request reprint Does the cause of localisation-related epilepsy influence the response to antiepileptic drug treatment?
    L J Stephen
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    Epilepsia 42:357-62. 2001
    ..We investigated the response to antiepileptic drug (AED) therapy in patients with localisation-related epilepsy associated with different underlying causes...
  8. ncbi request reprint Management strategies for refractory localization-related seizures
    M J Brodie
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, G11 6NT, Scotland
    Epilepsia 42:27-30. 2001
    ..This article discusses some of the pharmacologic strategies used in treating patients with refractory localization-related epilepsy...
  9. doi request reprint Efficacy and safety of adjunctive ezogabine (retigabine) in refractory partial epilepsy
    M J Brodie
    Epilepsy Unit, Western Infirmary, Glasgow, Scotland, UK
    Neurology 75:1817-24. 2010
    ..This study assessed the efficacy and safety of the neuronal potassium channel opener ezogabine (US adopted name; EZG)/retigabine (international nonproprietary name; RTG) as adjunctive therapy for refractory partial-onset seizures...
  10. ncbi request reprint A neurochemical study of the novel antiepileptic drug retigabine in mouse brain
    G J Sills
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    Pharmacol Res 42:553-7. 2000
    ..In addition, the drug may also lower brain concentrations of the excitatory neurotransmitter glutamate and its precursor, glutamine. These effects may contribute to the antiepileptic action of retigabine...
  11. ncbi request reprint Effectiveness of first antiepileptic drug
    P Kwan
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    Epilepsia 42:1255-60. 2001
    ..002). CONCLUSIONS: Nearly 50% of newly diagnosed patients became seizure-free on the first-ever AED, with >90% doing so at moderate or even modest dosing. Tolerability was as important as efficacy in determining overall effectiveness...
  12. ncbi request reprint A double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy with health-related quality of life as an outcome measure
    R Gillham
    Southern General Hospital, Glasgow, UK
    Seizure 9:375-9. 2000
    ..In general practice, the use of the SEALS Inventory to assess HRQOL has the potential to improve quality of care for people with epilepsy...
  13. ncbi request reprint Circulating hormones and pituitary responsiveness in young epileptic men receiving long-term antiepileptic medication
    G J Macphee
    Clinical Pharmacology Unit, University Department of Medicine, Western Infirmary, Glasgow, Scotland
    Epilepsia 29:468-75. 1988
    ..01) and a fall in DHAS (p less than 0.001). Basal LH was also elevated, but this just failed to reach statistical significance (p less than 0.1).(ABSTRACT TRUNCATED AT 250 WORDS)..
  14. ncbi request reprint Lamotrigine substitution study: evidence for synergism with sodium valproate? 105 Study Group
    M J Brodie
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, UK
    Epilepsy Res 26:423-32. 1997
    ..This effect was seen for partial (VPA, 57%; CBZ, 39%; PHT, 39%; P < 0.02) as well as tonic-clonic seizures (VPA, 70%; CBZ, 53%; PHT, 50%; NS). These data lend credence to the suggestion of therapeutic synergy between LTG and VPA...
  15. ncbi request reprint Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy
    M J Brodie
    Epilepsy Unit, Western Infirmary, Glasgow, G11 6NT, Scotland, UK
    Neurology 68:402-8. 2007
    ....
  16. ncbi request reprint Visual field constriction: accumulation of vigabatrin but not tiagabine in the retina
    G J Sills
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    Neurology 57:196-200. 2001
    ..We investigated the pharmacokinetic and pharmacodynamic profiles of VGB and TGB in rat brain and eye...
  17. pmc Concentration-effect relationships for oxprenolol in patients with essential hypertension
    G T McInnes
    University Department of Medicine, Gardiner Institute, Western Infirmary, Glasgow
    Br J Clin Pharmacol 25:539-45. 1988
    ..No such kinetic-dynamic relationship could be defined for post-exercise systolic or diastolic BP...
  18. pmc Patterns of treatment response in newly diagnosed epilepsy
    M J Brodie
    Western Infirmary, Glasgow
    Neurology 78:1548-54. 2012
    ..To delineate the temporal patterns of outcome and to determine the probability of seizure freedom with successive antiepileptic drug regimens in newly diagnosed epilepsy...
  19. doi request reprint Adjunctive pregabalin for uncontrolled partial-onset seizures: findings from a prospective audit
    L J Stephen
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, UK
    Acta Neurol Scand 124:142-5. 2011
    ..Pregabalin (PGB) was licensed in Europe as an add-on antiepileptic drug (AED) for the treatment of partial-onset seizures in 2004. This audit assessed the response to adjunctive PGB in patients with uncontrolled seizures...
  20. ncbi request reprint Monotherapy trials: prerequisite data
    M J Brodie
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, G11 6NT, Glasgow, UK
    Epilepsy Res 45:61-4; discussion 65-6. 2001
    ..Sponsors should be able to seek a licence for their drug either as a first choice treatment in newly diagnosed epilepsy or as substitution monotherapy once treatment with at least one other AED has failed...
  21. ncbi request reprint Update on the mechanisms of action of antiepileptic drugs
    G J Sills
    Epilepsy Unit, Department of Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, Scotland
    Epileptic Disord 3:165-72. 2001
    ..This review provides an update on the principal mechanisms of action of a range of established and modern antiepileptic drugs...
  22. ncbi request reprint Neuropsychological effects of epilepsy and antiepileptic drugs
    P Kwan
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    Lancet 357:216-22. 2001
    ..Each person should be assessed individually with respect to factors unique to his or her seizure disorder and its treatment...
  23. ncbi request reprint The star systems: overview and use in determining antiepileptic drug choice
    M J Brodie
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    CNS Drugs 15:1-12; discussion 13-5. 2001
    ..Such an individualised approach to management will optimise the chance of attaining remission and help many more patients achieve a fulfilling life...
  24. ncbi request reprint The mechanisms of action of commonly used antiepileptic drugs
    P Kwan
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    Pharmacol Ther 90:21-34. 2001
    ..In this review, we will attempt to introduce the concepts of ion channel and neurotransmitter modulation and, thereafter, group currently used antiepileptic drugs according to their principal mechanisms of action...
  25. ncbi request reprint Management of epilepsy in adolescents and adults
    M J Brodie
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland, UK
    Lancet 356:323-9. 2000
    ..Eight new antiepileptic drugs were licensed in the 1990s with more to come. These new drugs along with earlier resective surgery have led to a better outcome for many more people with this condition...
  26. ncbi request reprint Diagnosing refractory epilepsy: response to sequential treatment schedules
    R Mohanraj
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, UK
    Eur J Neurol 13:277-82. 2006
    ..Those who do not attain long-term seizure freedom with the first three treatment schedules are likely to have refractory epilepsy...
  27. ncbi request reprint Do we need any more new antiepileptic drugs?
    M J Brodie
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, G11 6NT, Scotland, UK
    Epilepsy Res 45:3-6. 2001
    ..An efficient regulatory trial programme will ensure rapid availability of new AEDs for the many children and adults whose lives continue to be blighted by seizures...
  28. ncbi request reprint Evaluation of two oxprenolol oral osmotic (OROS) delivery systems in patients with essential hypertension
    G T McInnes
    University Department of Medicine, Gardiner Institute, Western Infirmary, Glasgow, Scotland
    Eur J Clin Pharmacol 34:605-11. 1988
    ..These observations suggest that both oxprenolol OROS systems display sustained drug release and on once daily dosing provide 24 h beta-blockade and control of blood pressure at rest and following exercise...
  29. pmc Which electroencephalography (EEG) for epilepsy? The relative usefulness of different EEG protocols in patients with possible epilepsy
    J P Leach
    Epilepsy Unit, Western Infirmary, Glasgow G11 6NT, UK
    J Neurol Neurosurg Psychiatry 77:1040-2. 2006
    ..Electroencephalography (EEG) is an essential investigative tool for use in young people with epilepsy. This study assesses the effects of different EEG protocols on the yield of EEG abnormalities in young people with possible new epilepsy...
  30. ncbi request reprint Diagnosing and predicting refractory epilepsy
    M J Brodie
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, UK
    Acta Neurol Scand Suppl 181:36-9. 2005
    ..For most of these individuals, combination therapy using AEDs with complementary modes of action is the recommended treatment approach...
  31. pmc Psychopathology in people with epilepsy and intellectual disability; an investigation of potential explanatory variables
    C A Espie
    Department of Psychological Medicine, University of Glasgow, Academic Centre, Gartnavel Royal Hospital, 1055 Great Western Road, Glasgow G12 OXH, UK
    J Neurol Neurosurg Psychiatry 74:1485-92. 2003
    ..The aims of this study, therefore, were to identify reliable, epilepsy-specific predictors of psychiatric and behavioural disorder in these patients, and to investigate reliable predictors of carer stress...
  32. ncbi request reprint Topiramate, carbamazepine and valproate monotherapy: double-blind comparison in newly diagnosed epilepsy
    M D Privitera
    Department of Neurology, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    Acta Neurol Scand 107:165-75. 2003
    ..To compare topiramate (TPM) with investigator's choice of carbamazepine (CBZ) or valproate (VPA) for initial treatment in patients with newly diagnosed epilepsy...
  33. ncbi request reprint A crossover, add-on trial of talampanel in patients with refractory partial seizures
    A S Chappell
    Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Neurology 58:1680-2. 2002
    ..001) with a median seizure reduction of 21%. Eighty percent of patients had fewer seizures on talampanel than on placebo. Dizziness (52%) and ataxia (26%) were the only significant adverse events...
  34. ncbi request reprint Outcomes of newly diagnosed idiopathic generalized epilepsy syndromes in a non-pediatric setting
    R Mohanraj
    Department of Neurology, Hope Hospital, Salford, Lancashire, UK
    Acta Neurol Scand 115:204-8. 2007
    ..The prognosis of idiopathic generalized epilepsy syndromes (IGES) in the adult setting may vary from that in children owing to differences in genetic, environmental and lifestyle factors...
  35. ncbi request reprint Epileptogenesis and rational therapeutic strategies
    H Stefan
    Epilepsy Centre Neurological Clinic, University Erlangen Nuernberg, Erlangen, Germany
    Acta Neurol Scand 113:139-55. 2006
    ....
  36. pmc Major congenital malformations and antiepileptic drugs: prospective observations
    M J Brodie
    J Neurol Neurosurg Psychiatry 77:145. 2006
  37. ncbi request reprint A randomised open-label study of tiagabine given two or three times daily in refractory epilepsy
    S Arroyo
    Hospital Clinico de Barcelona, Servicio de Neurologia, C Villarroel 170, 08036 Barcelona, Spain
    Seizure 14:81-4. 2005
    ..i.d. group. Our results suggest that during titration tiagabine is better tolerated with t.i.d. dosing, but during long-term maintenance, a t.i.d. schedule is as effective and well tolerated as b.i.d...