M J Brodie

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi Zonisamide as adjunctive therapy for refractory partial seizures
    Martin J Brodie
    Epilepsy Unit, Western Infirmary, Glasgow, Scotland G11 6NT, UK
    Epilepsy Res 68:S11-6. 2006
  2. ncbi Levetiracetam for people with mental retardation and refractory epilepsy
    Kevin Kelly
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    Epilepsy Behav 5:878-83. 2004
  3. doi Road to refractory epilepsy: the Glasgow story
    Martin J Brodie
    Epilepsy Unit, Western Infirmary, Glasgow, United Kingdom
    Epilepsia 54:5-8. 2013
  4. doi Current position of phenobarbital in epilepsy and its future
    Martin J Brodie
    Epilepsy Unit, Western Infirmary, Glasgow, United Kingdom
    Epilepsia 53:40-6. 2012
  5. doi Enzyme induction with antiepileptic drugs: cause for concern?
    Martin J Brodie
    Epilepsy Unit, Western Infirmary, Glasgow, United Kingdom
    Epilepsia 54:11-27. 2013
  6. ncbi Novel trial designs for monotherapy
    Martin J Brodie
    Epilepsy Unit, Western Infirmary, Glasgow, Scotland, UK
    Epileptic Disord 14:132-7. 2012
  7. doi Efficacy and safety of adjunctive ezogabine (retigabine) in refractory partial epilepsy
    M J Brodie
    Epilepsy Unit, Western Infirmary, Glasgow, Scotland, UK
    Neurology 75:1817-24. 2010
  8. doi Epilepsy in later life
    Martin J Brodie
    Epilepsy Unit, Western Infirmary, Scotland, UK
    Lancet Neurol 8:1019-30. 2009
  9. doi Rufinamide for the adjunctive treatment of partial seizures in adults and adolescents: a randomized placebo-controlled trial
    Martin J Brodie
    Epilepsy Unit, Western Infirmary, Glasgow, Scotland, United Kingdom
    Epilepsia 50:1899-909. 2009
  10. doi Should all patients be told about sudden unexpected death in epilepsy (SUDEP)? Pros and Cons
    Martin J Brodie
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, United Kingdom
    Epilepsia 49:99-101. 2008

Detail Information

Publications109 found, 100 shown here

  1. ncbi Zonisamide as adjunctive therapy for refractory partial seizures
    Martin J Brodie
    Epilepsy Unit, Western Infirmary, Glasgow, Scotland G11 6NT, UK
    Epilepsy Res 68:S11-6. 2006
    ..These data support the use of zonisamide in combination with commonly used antiepileptic drugs to provide efficacious and well-tolerated treatment for patients with refractory partial seizures...
  2. ncbi Levetiracetam for people with mental retardation and refractory epilepsy
    Kevin Kelly
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    Epilepsy Behav 5:878-83. 2004
    ..001). LEV improved seizure control in the majority of patients with mental retardation and may also have enhanced their quality of life...
  3. doi Road to refractory epilepsy: the Glasgow story
    Martin J Brodie
    Epilepsy Unit, Western Infirmary, Glasgow, United Kingdom
    Epilepsia 54:5-8. 2013
    ..Novel approaches to identifying and treating the processes underpinning the generation and propagation of seizures are required if the current rather disappointing scenario is to be substantially improved...
  4. doi Current position of phenobarbital in epilepsy and its future
    Martin J Brodie
    Epilepsy Unit, Western Infirmary, Glasgow, United Kingdom
    Epilepsia 53:40-6. 2012
    ..All these data predict a healthy future for phenobarbital, particularly in helping to close the treatment gap in low- and middle-income countries during its second century of clinical use...
  5. doi Enzyme induction with antiepileptic drugs: cause for concern?
    Martin J Brodie
    Epilepsy Unit, Western Infirmary, Glasgow, United Kingdom
    Epilepsia 54:11-27. 2013
    ..Modern AEDs that do not possess this property have similar efficacy for the common epilepsies. Accordingly, perhaps consideration should be given to starting treatment with, or even switching patients to, non-enzyme-inducing AEDs...
  6. ncbi Novel trial designs for monotherapy
    Martin J Brodie
    Epilepsy Unit, Western Infirmary, Glasgow, Scotland, UK
    Epileptic Disord 14:132-7. 2012
    ....
  7. doi Efficacy and safety of adjunctive ezogabine (retigabine) in refractory partial epilepsy
    M J Brodie
    Epilepsy Unit, Western Infirmary, Glasgow, Scotland, UK
    Neurology 75:1817-24. 2010
    ..This study assessed the efficacy and safety of the neuronal potassium channel opener ezogabine (US adopted name; EZG)/retigabine (international nonproprietary name; RTG) as adjunctive therapy for refractory partial-onset seizures...
  8. doi Epilepsy in later life
    Martin J Brodie
    Epilepsy Unit, Western Infirmary, Scotland, UK
    Lancet Neurol 8:1019-30. 2009
    ....
  9. doi Rufinamide for the adjunctive treatment of partial seizures in adults and adolescents: a randomized placebo-controlled trial
    Martin J Brodie
    Epilepsy Unit, Western Infirmary, Glasgow, Scotland, United Kingdom
    Epilepsia 50:1899-909. 2009
    ..To evaluate efficacy and safety of adjunctive treatment with rufinamide 1600 mg twice daily in subjects aged > or = 16 years with refractory partial seizures...
  10. doi Should all patients be told about sudden unexpected death in epilepsy (SUDEP)? Pros and Cons
    Martin J Brodie
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, United Kingdom
    Epilepsia 49:99-101. 2008
    ..Both authors agree that additional studies into the pathophysiology and prevention of SUDEP are urgently needed...
  11. ncbi Epilepsy: randomised trials and genetic tribulations
    Martin J Brodie
    Western Infirmary, Glasgow G11 6NT, UK
    Lancet Neurol 7:7-8. 2008
  12. doi Antiepileptic drug therapy the story so far
    Martin J Brodie
    Epilepsy Unit, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    Seizure 19:650-5. 2010
    ....
  13. ncbi Zonisamide clinical trials: European experience
    Martin J Brodie
    Epilepsy Unit, Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland G11 6NT, UK
    Seizure 13:S66-70; discussion S71-2. 2004
    ..Collectively, these findings corroborate those of US and Asian clinical trials, which also show that zonisamide is safe and effective for adjunctive therapy of partial seizures...
  14. doi Antiepileptic drug therapy: does mechanism of action matter?
    Martin J Brodie
    Epilepsy Unit, Western Infirmary, Glasgow, UK
    Epilepsy Behav 21:331-41. 2011
    ....
  15. ncbi Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy
    M J Brodie
    Epilepsy Unit, Western Infirmary, Glasgow, G11 6NT, Scotland, UK
    Neurology 68:402-8. 2007
    ....
  16. ncbi Neurochemical studies with the novel anticonvulsant levetiracetam in mouse brain
    G J Sills
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, UK
    Eur J Pharmacol 325:35-40. 1997
    ..Single dose and repeated levetiracetam treatments were without effect on all of the parameters investigated. The anticonvulsant action of levetiracetam is unlikely to be mediated via an action on the GABAergic system...
  17. ncbi Concentration-effect studies with topiramate on selected enzymes and intermediates of the GABA shunt
    G J Sills
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    Epilepsia 41:S30-4. 2000
    ..Recent evidence has, however, suggested that the drug also increases brain GABA concentrations in humans. These studies were designed to investigate the neurochemical basis of this observation...
  18. ncbi Vigabatrin and tiagabine are pharmacologically different drugs. A pre-clinical study
    G J Sills
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland, UK
    Seizure 8:404-11. 1999
    ..It is possible, then, that these drugs will have different spectra of activity and toxicity profiles in human epilepsy...
  19. ncbi Double-blind substitution of vigabatrin and valproate in carbamazepine-resistant partial epilepsy. 012 Study group
    M J Brodie
    Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland, UK
    Epilepsy Res 34:199-205. 1999
    ..This lends credence to the hypothesis in support of a mechanistic approach to the management of epilepsy...
  20. ncbi A neurochemical study of the novel antiepileptic drug retigabine in mouse brain
    G J Sills
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    Pharmacol Res 42:553-7. 2000
    ..In addition, the drug may also lower brain concentrations of the excitatory neurotransmitter glutamate and its precursor, glutamine. These effects may contribute to the antiepileptic action of retigabine...
  21. ncbi Does the cause of localisation-related epilepsy influence the response to antiepileptic drug treatment?
    L J Stephen
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    Epilepsia 42:357-62. 2001
    ..We investigated the response to antiepileptic drug (AED) therapy in patients with localisation-related epilepsy associated with different underlying causes...
  22. ncbi Hormone profiles in young adults with epilepsy treated with sodium valproate or lamotrigine monotherapy
    L J Stephen
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland, UK
    Epilepsia 42:1002-6. 2001
    ..However, only a minority of obese females exhibited biochemical characteristics suggestive of PCOS. Biochemical screening may allow women at risk of developing PCOS to avoid VPA...
  23. ncbi Circulating hormones and pituitary responsiveness in young epileptic men receiving long-term antiepileptic medication
    G J Macphee
    Clinical Pharmacology Unit, University Department of Medicine, Western Infirmary, Glasgow, Scotland
    Epilepsia 29:468-75. 1988
    ..01) and a fall in DHAS (p less than 0.001). Basal LH was also elevated, but this just failed to reach statistical significance (p less than 0.1).(ABSTRACT TRUNCATED AT 250 WORDS)..
  24. ncbi Management strategies for refractory localization-related seizures
    M J Brodie
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, G11 6NT, Scotland
    Epilepsia 42:27-30. 2001
    ..This article discusses some of the pharmacologic strategies used in treating patients with refractory localization-related epilepsy...
  25. ncbi A double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy with health-related quality of life as an outcome measure
    R Gillham
    Southern General Hospital, Glasgow, UK
    Seizure 9:375-9. 2000
    ..In general practice, the use of the SEALS Inventory to assess HRQOL has the potential to improve quality of care for people with epilepsy...
  26. ncbi Multicentre, double-blind, randomised comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy. The UK Lamotrigine Elderly Study Group
    M J Brodie
    Department of Medicine and Therapeutics, Western Infirmary, Glasgow, UK
    Epilepsy Res 37:81-7. 1999
    ..In conclusion, LTG can be regarded as an acceptable choice as initial treatment for elderly patients with newly diagnosed epilepsy...
  27. ncbi Lamotrigine substitution study: evidence for synergism with sodium valproate? 105 Study Group
    M J Brodie
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, UK
    Epilepsy Res 26:423-32. 1997
    ..This effect was seen for partial (VPA, 57%; CBZ, 39%; PHT, 39%; P < 0.02) as well as tonic-clonic seizures (VPA, 70%; CBZ, 53%; PHT, 50%; NS). These data lend credence to the suggestion of therapeutic synergy between LTG and VPA...
  28. ncbi Na(+) channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes
    Sarah Santangeli
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    Eur J Pharmacol 438:63-8. 2002
    ..Desglycinyl-remacemide may have an additional action on Na(+) homeostasis that merits further exploration...
  29. ncbi Monotherapy trials: prerequisite data
    M J Brodie
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, G11 6NT, Glasgow, UK
    Epilepsy Res 45:61-4; discussion 65-6. 2001
    ..Sponsors should be able to seek a licence for their drug either as a first choice treatment in newly diagnosed epilepsy or as substitution monotherapy once treatment with at least one other AED has failed...
  30. pmc Concentration-effect relationships for oxprenolol in patients with essential hypertension
    G T McInnes
    University Department of Medicine, Gardiner Institute, Western Infirmary, Glasgow
    Br J Clin Pharmacol 25:539-45. 1988
    ..No such kinetic-dynamic relationship could be defined for post-exercise systolic or diastolic BP...
  31. ncbi Diagnosing refractory epilepsy: response to sequential treatment schedules
    R Mohanraj
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, UK
    Eur J Neurol 13:277-82. 2006
    ..Those who do not attain long-term seizure freedom with the first three treatment schedules are likely to have refractory epilepsy...
  32. ncbi Effectiveness of first antiepileptic drug
    P Kwan
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    Epilepsia 42:1255-60. 2001
    ..002). CONCLUSIONS: Nearly 50% of newly diagnosed patients became seizure-free on the first-ever AED, with >90% doing so at moderate or even modest dosing. Tolerability was as important as efficacy in determining overall effectiveness...
  33. ncbi Visual field constriction: accumulation of vigabatrin but not tiagabine in the retina
    G J Sills
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    Neurology 57:196-200. 2001
    ..We investigated the pharmacokinetic and pharmacodynamic profiles of VGB and TGB in rat brain and eye...
  34. pmc Psychopathology in people with epilepsy and intellectual disability; an investigation of potential explanatory variables
    C A Espie
    Department of Psychological Medicine, University of Glasgow, Academic Centre, Gartnavel Royal Hospital, 1055 Great Western Road, Glasgow G12 OXH, UK
    J Neurol Neurosurg Psychiatry 74:1485-92. 2003
    ..The aims of this study, therefore, were to identify reliable, epilepsy-specific predictors of psychiatric and behavioural disorder in these patients, and to investigate reliable predictors of carer stress...
  35. ncbi Pharmacological outcomes in people with mental retardation and epilepsy
    Kevin Kelly
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    Epilepsy Behav 5:67-71. 2004
    ..These findings suggest that AED therapy can result in seizure freedom in more than 40% of mentally retarded people with epilepsy without producing unacceptable toxicity...
  36. ncbi Pregabalin as adjunctive therapy for partial seizures
    Martin J Brodie
    Epilepsy Unit, University of Glasgow, Glasgow G11 6NT, Scotland, UK
    Epilepsia 45:19-27. 2004
    ..These results indicate that pregabalin is highly effective as adjunctive therapy in the treatment of patients with partial seizures with or without secondary generalization...
  37. ncbi Pharmacological outcomes in newly diagnosed epilepsy
    Rajiv Mohanraj
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, G11 6NT, Scotland, UK
    Epilepsy Behav 6:382-7. 2005
    ..The majority of patients with newly diagnosed epilepsy responding to treatment did so rapidly and completely with moderate doses of AEDs, with no differences in time to first seizure...
  38. ncbi Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment
    Graeme J Sills
    Epilepsy Unit, Section of Clinical Pharmacology and Stroke Medicine, University Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland
    Epilepsia 46:643-7. 2005
    ..We have investigated the prevalence of this polymorphism in a series of patients attending a specialist epilepsy clinic...
  39. ncbi Levetiracetam in refractory epilepsy: a prospective observational study
    Rajiv Mohanraj
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, UK
    Seizure 14:23-7. 2005
    ..LEV is an effective adjunctive treatment for refractory idiopathic and localisation-related epilepsies. Many patients who responded optimally to LEV did so at 1000 mg per day or less...
  40. ncbi Dose-dependent safety and efficacy of zonisamide: a randomized, double-blind, placebo-controlled study in patients with refractory partial seizures
    Martin J Brodie
    Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, United Kingdom
    Epilepsia 46:31-41. 2005
    ..To evaluate the safety and efficacy of zonisamide (ZNS) as adjunctive treatment in patients with refractory localization-related epilepsy...
  41. ncbi Medical therapy of epilepsy: when to initiate treatment and when to combine?
    Martin J Brodie
    Epilepsy Unit, Western Infirmary, Glasgow, G11 6NT, Scotland, UK
    J Neurol 252:125-30. 2005
    ....
  42. doi Genetic variants in microsomal epoxide hydrolase influence carbamazepine dosing
    Mohd Makmor-Bakry
    Epilepsy Unit, Section of Clinical Pharmacology and Stroke Medicine, University Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland
    Clin Neuropharmacol 32:205-12. 2009
    ..We investigated polymorphic variants in various genes involved in the pharmacokinetics and pharmacodynamics of carbamazepine in an effort to identify predictors of maintenance dose...
  43. ncbi Role of levetiracetam in the treatment of epilepsy
    Martin J Brodie
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, United Kingdom
    Epileptic Disord 5:S65-72. 2003
    ..Levetiracetam has specific characteristics that make it an optimal choice for many patient populations...
  44. ncbi EUCARE--past, present, and future
    Martin J Brodie
    EUCARE Management Group, Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, G11 6NT, Scotland, Glasgow, UK
    Lancet Neurol 2:269. 2003
  45. pmc Epilepsy in elderly people
    Martin J Brodie
    Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow G11 6NT
    BMJ 331:1317-22. 2005
  46. ncbi Differential effects of remacemide and desglycinyl-remacemide on epileptiform burst firing in the rat hippocampal slice
    Sarah Santangeli
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    Neurosci Lett 321:33-6. 2002
    ..These findings suggest that remacemide is not sufficiently potent at the Na(+) channel or NMDA receptor to attenuate epileptiform activity in this model and that the anticonvulsant effects of the drug may be mediated by DGR...
  47. ncbi Pharmacodynamic interaction studies with topiramate in the pentylenetetrazol and maximal electroshock seizure models
    Graeme J Sills
    Epilepsy Unit, Clinical Pharmacology Section, University Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    Seizure 13:287-95. 2004
    ....
  48. ncbi Vigabatrin, but not gabapentin or topiramate, produces concentration-related effects on enzymes and intermediates of the GABA shunt in rat brain and retina
    Graeme J Sills
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    Epilepsia 44:886-92. 2003
    ..We compared the concentration-related effects of VGB in rat brain and eye with those of gabapentin (GBP) and topiramate (TPM), both of which have been reported to elevate brain GABA concentrations in humans...
  49. ncbi Building new understandings in epilepsy: maximizing patient outcomes without sacrificing seizure control
    Martin J Brodie
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland
    Epilepsia 44:1-2. 2003
  50. ncbi Influence of cytochrome P450 induction on the pharmacokinetics and pharmacodynamics of remacemide hydrochloride
    Graeme J Sills
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow G116NT, UK
    Epilepsy Res 49:247-54. 2002
    ..However, this hypothesis does not explain the similarly questionable efficacy of RMD monotherapy in newly diagnosed epilepsy, an observation that may have wider pharmacological implications...
  51. ncbi Response to antiepileptic drug therapy: winners and losers
    Martin J Brodie
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, U K
    Epilepsia 46:31-2. 2005
    ..Two patients with symptomatic epilepsy secondary to underlying cortical dysplasias are presented to illustrate these different scenarios. Clinical observations can provide insights to the processes underlying pharmacoresistance...
  52. ncbi Gabapentin versus lamotrigine monotherapy: a double-blind comparison in newly diagnosed epilepsy
    Martin J Brodie
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    Epilepsia 43:993-1000. 2002
    ..This randomised, double-blind study compared the newer antiepileptic drugs (AEDs) gabapentin (GBP) and lamotrigine (LTG) as monotherapy in newly diagnosed epilepsy...
  53. pmc Patterns of treatment response in newly diagnosed epilepsy
    M J Brodie
    Western Infirmary, Glasgow
    Neurology 78:1548-54. 2012
    ..To delineate the temporal patterns of outcome and to determine the probability of seizure freedom with successive antiepileptic drug regimens in newly diagnosed epilepsy...
  54. ncbi The mechanisms of action of commonly used antiepileptic drugs
    P Kwan
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    Pharmacol Ther 90:21-34. 2001
    ..In this review, we will attempt to introduce the concepts of ion channel and neurotransmitter modulation and, thereafter, group currently used antiepileptic drugs according to their principal mechanisms of action...
  55. ncbi The star systems: overview and use in determining antiepileptic drug choice
    M J Brodie
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    CNS Drugs 15:1-12; discussion 13-5. 2001
    ..Such an individualised approach to management will optimise the chance of attaining remission and help many more patients achieve a fulfilling life...
  56. doi Adjunctive pregabalin for uncontrolled partial-onset seizures: findings from a prospective audit
    L J Stephen
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, UK
    Acta Neurol Scand 124:142-5. 2011
    ..Pregabalin (PGB) was licensed in Europe as an add-on antiepileptic drug (AED) for the treatment of partial-onset seizures in 2004. This audit assessed the response to adjunctive PGB in patients with uncontrolled seizures...
  57. ncbi Neuropsychological effects of epilepsy and antiepileptic drugs
    P Kwan
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    Lancet 357:216-22. 2001
    ..Each person should be assessed individually with respect to factors unique to his or her seizure disorder and its treatment...
  58. ncbi Update on the mechanisms of action of antiepileptic drugs
    G J Sills
    Epilepsy Unit, Department of Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, Scotland
    Epileptic Disord 3:165-72. 2001
    ..This review provides an update on the principal mechanisms of action of a range of established and modern antiepileptic drugs...
  59. ncbi Erectile dysfunction associated with pregabalin add-on treatment in patients with partial seizures: five case reports
    Nikolas Hitiris
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, UK
    Epilepsy Behav 8:418-21. 2006
    ..We present the cases of 5 men who reported mild to moderate erectile dysfunction or impotence for the first time when treated with the new antiepileptic drug pregabalin as add-on therapy...
  60. ncbi Predictors of pharmacoresistant epilepsy
    Nikolas Hitiris
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    Epilepsy Res 75:192-6. 2007
    ....
  61. ncbi Pharmacological outcomes in older people with newly diagnosed epilepsy
    Linda J Stephen
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, UK
    Epilepsy Behav 8:434-7. 2006
    ..Old age is the most common time in life to develop epilepsy. Despite this, there are few published data exploring pharmacological outcomes in this population...
  62. doi Binasal visual field defects are not specific to vigabatrin
    Pedro Gonzalez
    Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow, Scotland, UK
    Epilepsy Behav 16:521-6. 2009
    ..Assessment by conventional static perimetry may neither be sufficiently sensitive nor specific to reliably identify retinal toxicity associated with VGB...
  63. ncbi Regional expression of multidrug resistance genes in genetically epilepsy-prone rat brain after a single audiogenic seizure
    Patrick Kwan
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    Epilepsia 43:1318-23. 2002
    ..We investigated the regional expression of mdr genes in genetically epilepsy-prone rat (GEPR) brain after a single audiogenic seizure...
  64. ncbi Topiramate in patients with learning disability and refractory epilepsy
    Kevin Kelly
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    Epilepsia 43:399-402. 2002
    ..This prospective study explored the efficacy and tolerability of adjunctive topiramate (TPM) in patients with learning disability and refractory epilepsy attending a single centre...
  65. ncbi Do we need any more new antiepileptic drugs?
    M J Brodie
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, G11 6NT, Scotland, UK
    Epilepsy Res 45:3-6. 2001
    ..An efficient regulatory trial programme will ensure rapid availability of new AEDs for the many children and adults whose lives continue to be blighted by seizures...
  66. ncbi Development and validation of the Glasgow Epilepsy Outcome Scale (GEOS): a new instrument for measuring concerns about epilepsy in people with mental retardation
    C A Espie
    Department of Psychological Medicine, University of Glasgow, Scotland, UK
    Epilepsia 42:1043-51. 2001
    ..To develop a measure for use with adults with epilepsy and mental retardation, capable of assessing both clinical and care concerns and of quantifying treatment outcomes...
  67. ncbi Management of epilepsy in adolescents and adults
    M J Brodie
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland, UK
    Lancet 356:323-9. 2000
    ..Eight new antiepileptic drugs were licensed in the 1990s with more to come. These new drugs along with earlier resective surgery have led to a better outcome for many more people with this condition...
  68. ncbi Measuring the efficacy of antiepileptic drugs
    Rajiv Mohanraj
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, UK
    Seizure 12:413-43. 2003
    ..Data from regulatory trials should be complemented by postmarketing studies and longer term studies of outcome to help clinicians decide the best way of utilising new AEDs and establishing their role in the therapeutic armamentarium...
  69. ncbi Sudden unexpected death in epilepsy: a search for risk factors
    Nikolas Hitiris
    Epilepsy Unit, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    Epilepsy Behav 10:138-41. 2007
    ..There is an urgent need for a large-scale, prospective, international, community-based study of SUDEP to explore more closely the risk factors to plan preventive strategies...
  70. ncbi Staged approach to epilepsy management
    Martin J Brodie
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    Neurology 58:S2-8. 2002
    ..A staged approach to the pharmacologic management and, when appropriate, surgical work-up for each epilepsy syndrome will optimize the chance of perfect seizure control and help more patients achieve a fulfilling life...
  71. ncbi Seizure freedom with more than one antiepileptic drug
    Linda J Stephen
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    Seizure 11:349-51. 2002
    ..Treatment with two or three but not four AEDs may be a useful therapeutic option for patients not responding to monotherapy. Further explorations of the best regimens for individual seizure types and epilepsy syndromes is required...
  72. ncbi Mortality in epilepsy
    Nikolas Hitiris
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, UK
    Epilepsy Behav 10:363-76. 2007
    ..Future studies of mortality should be prospective and follow agreed guidelines to better quantify risk and causation in individual populations...
  73. doi Management of a first seizure. Special problems: adults and elderly
    Linda J Stephen
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, United Kingdom
    Epilepsia 49:45-9. 2008
    ..Treatment following a first seizure should balance risk factors for recurrence with the informed opinion of the patients and their family...
  74. doi A prospective audit of adjunctive zonisamide in an everyday clinical setting
    Linda J Stephen
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, UK
    Epilepsy Behav 17:455-60. 2010
    ..Around 80% of patients who became seizure free on ZNS or had the drug withdrawn did so on a dose 200mg. ZNS is an effective broad-spectrum AED that can also produce a range of dose-dependent and idiosyncratic side effects...
  75. ncbi Quality of life and psychosocial development in adolescents with epilepsy: a qualitative investigation using focus group methods
    M J McEwan
    Department of Psychological Medicine, University of Glasgow, Glasgow, Scotland, UK
    Seizure 13:15-31. 2004
    ..No significant age-related differences in issues were identified. A conceptual model representing these findings is presented and clinical implications and suggestions for future research are reported...
  76. ncbi Sodium valproate versus lamotrigine: a randomised comparison of efficacy, tolerability and effects on circulating androgenic hormones in newly diagnosed epilepsy
    Linda J Stephen
    Epilepsy Unit, University Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    Epilepsy Res 75:122-9. 2007
    ..No difference in efficacy was found between VPA and LTG in our patients with newly diagnosed epilepsy. LTG appeared to be better tolerated. Neither drug appeared to alter the circulating levels of androgenic hormones...
  77. ncbi Evaluation of two oxprenolol oral osmotic (OROS) delivery systems in patients with essential hypertension
    G T McInnes
    University Department of Medicine, Gardiner Institute, Western Infirmary, Glasgow, Scotland
    Eur J Clin Pharmacol 34:605-11. 1988
    ..These observations suggest that both oxprenolol OROS systems display sustained drug release and on once daily dosing provide 24 h beta-blockade and control of blood pressure at rest and following exercise...
  78. pmc Which electroencephalography (EEG) for epilepsy? The relative usefulness of different EEG protocols in patients with possible epilepsy
    J P Leach
    Epilepsy Unit, Western Infirmary, Glasgow G11 6NT, UK
    J Neurol Neurosurg Psychiatry 77:1040-2. 2006
    ..Electroencephalography (EEG) is an essential investigative tool for use in young people with epilepsy. This study assesses the effects of different EEG protocols on the yield of EEG abnormalities in young people with possible new epilepsy...
  79. ncbi Diagnosing and predicting refractory epilepsy
    M J Brodie
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, UK
    Acta Neurol Scand Suppl 181:36-9. 2005
    ..For most of these individuals, combination therapy using AEDs with complementary modes of action is the recommended treatment approach...
  80. doi Selection of antiepileptic drugs in adults
    Linda J Stephen
    Division of Cardiovascular and Medical Sciences, Epilepsy Unit, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    Neurol Clin 27:967-92. 2009
    ..In the past 20 years, the explosion of 13 new agents into the marketplace has greatly increased the potential for therapeutic intervention. This article explores the rationale for treatment selection in adults with epilepsy...
  81. ncbi Differential expression of multidrug resistance genes in naïve rat brain
    Patrick Kwan
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, G11 6NT, Scotland, Glasgow, United Kingdom
    Neurosci Lett 339:33-6. 2003
    ..These findings reveal a differential expression of mdr1 genes in normal rodent brain tissue and suggest that P-gp may afford a broader protection of the hippocampus than other brain structures...
  82. doi Response to drug treatment in newly diagnosed epilepsy: a pilot study of (1)H NMR- and MS-based metabonomic analysis
    Muhammed Al Zweiri
    Strathclyde Institute for Pharmaceutical and Biomedical Sciences, University of Strathclyde, Glasgow, UK
    Epilepsy Res 88:189-95. 2010
    ....
  83. ncbi Outcomes in newly diagnosed localization-related epilepsies
    Rajiv Mohanraj
    Division of Cardiovascular and Medical Sciences, Epilepsy Unit, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    Seizure 14:318-23. 2005
    ..More than 50% of patients developing localization-related epilepsy during adolescence or in adulthood had a good outcome. Prognosis in those with underlying hippocampal atrophy or cortical dysplasia was not always bad...
  84. ncbi Outcomes in elderly patients with newly diagnosed and treated epilepsy
    Martin J Brodie
    Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, UK
    Int Rev Neurobiol 81:253-63. 2007
    ..Choice of drug may depend on comorbidity and comedication, among other factors. Initial dosing should be low with a slow titration schedule. A holistic approach to care helps optimize the outcome for elderly people with epilepsy...
  85. ncbi Modern antiepileptic drugs: guidelines and beyond
    Nikolas Hitiris
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow G11 6NT, UK
    Curr Opin Neurol 19:175-80. 2006
    ..Ten antiepileptic drugs have been licensed since 1990. Their usage will be briefly reviewed focusing on new data and inclusion in guidelines. The hypotheses exploring the underlying basis of pharmacoresistance will be presented...
  86. ncbi Evidence-based treatment of idiopathic generalized epilepsies with older antiepileptic drugs
    Nikolas Hitiris
    Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow, Scotland, United Kingdom
    Epilepsia 46:149-53. 2005
    ..Further randomized controlled trials of older antiepileptic drugs are recommended to solidify the evidence-based treatment of the idiopathic generalized epilepsies...
  87. ncbi Development and validation of a measure of the impact of epilepsy on a young person's quality of life: Glasgow epilepsy outcome scale for young persons (GEOS-YP)
    Kathryn H Townshend
    Department of Clinical Psychology, Royal Hospital for Sick Children, Yorkhill, Dalnair St, Glasgow, G3 8SJ Scotland, UK
    Epilepsy Behav 12:115-23. 2008
    ..The goal of the work described here was to develop and validate a measure of the impact of epilepsy on an adolescent's quality of life that is based on direct exploration of the adolescent's views...
  88. ncbi Outcomes from a nurse-led clinic for adolescents with epilepsy
    Linda J Stephen
    Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland, UK
    Seizure 12:539-44. 2003
    ..We established a nurse-led clinic for young people with suspected or diagnosed epilepsy. Outcomes in all patients referred during the first 4 years after its inception are reported...
  89. ncbi Pregabalin add-on treatment in patients with partial seizures: a novel evaluation of flexible-dose and fixed-dose treatment in a double-blind, placebo-controlled study
    Christian E Elger
    Universit├Ątsklinik Bonn, Klinik fuer Epileptologie, Bonn, Germany
    Epilepsia 46:1926-36. 2005
    ..To evaluate pregabalin as add-on therapy for patients with partial seizures administered as fixed dose or as flexible dose adjusted to optimal seizure reduction and tolerability...
  90. ncbi Phenobarbital for the treatment of epilepsy in the 21st century: a critical review
    Patrick Kwan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Epilepsia 45:1141-9. 2004
    ....
  91. ncbi Combination therapy in epilepsy: when and what to use
    Patrick Kwan
    Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    Drugs 66:1817-29. 2006
    ..Care should be taken to avoid excessive drug load, which is associated with increased toxicity. Bigger and better randomised, controlled studies are needed to determine the optimal time and way to combine AEDs...
  92. ncbi Drug treatment of epilepsy: when does it fail and how to optimize its use?
    Patrick Kwan
    Department of Medicine and Therapeutics, Division of Neurology, Prince of Whales Hospital, Chinese University of Hong Kong, China
    CNS Spectr 9:110-9. 2004
    ..An orderly approach to each epilepsy syndrome will optimize the chance of perfect seizure control and help more patients achieve a fulfilling life...
  93. ncbi Topiramate and lamotrigine pharmacokinetics during repetitive monotherapy and combination therapy in epilepsy patients
    Dennis R Doose
    Johnson and Johnson Pharmaceutical Research and Development L L C, Raritan, New Jersey, U S A
    Epilepsia 44:917-22. 2003
    ....
  94. ncbi Clinical trials of antiepileptic medications in newly diagnosed patients with epilepsy
    Patrick Kwan
    Division of Neurology, Department of Medicine, United Christian Hospital, Kwun Tong, Hong Kong
    Neurology 60:S2-12. 2003
    ....
  95. ncbi Success or failure with antiepileptic drug therapy: Beyond empiricism?
    Martin J Brodie
    Neurology 60:162-3. 2003
  96. ncbi Mortality in adults with newly diagnosed and chronic epilepsy: a retrospective comparative study
    Rajiv Mohanraj
    Department of Neurology, Royal Preston Hospital, Preston, Lancashire, UK
    Lancet Neurol 5:481-7. 2006
    ..Many clinicians are unsure whether and when this issue should be broached with their patients. We analysed mortality in patients with newly diagnosed and chronic epilepsy over a 20-year period...
  97. ncbi Potential role of drug transporters in the pathogenesis of medically intractable epilepsy
    Patrick Kwan
    Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Epilepsia 46:224-35. 2005
    ..Further studies to delineate the exact role, if any, of P-gp and other efflux transporters in drug-resistant epilepsy are warranted...
  98. ncbi Levetiracetam intravenous infusion as an alternative to oral dosing in patients with partial-onset seizures
    Michel Baulac
    Hopital de la Pitie Salpetriere, Service de Neurologie 1, Paris, France
    Epilepsia 48:589-92. 2007
    ..This multicenter, open-label study evaluated the short-term tolerability of intravenously (IV)-infused levetiracetam (LEV; 500-1,500 mg/100 ml, 15 min, b.i.d.) as a substitute for the same oral dose...
  99. ncbi Active control comparisons: the ideal trial design
    Martin J Brodie
    Epilepsy Res 68:69-73. 2006
    ..The authors describe an endpoint including efficacy and tolerability, and a stopping rule that uses a series of interim analyses in order to reach a conclusion as efficiently as possible without sacrificing reliability...
  100. ncbi Emerging drugs for epilepsy
    Patrick Kwan
    The Chinese University of Hong Kong, Division of Neurology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong, China
    Expert Opin Emerg Drugs 12:407-22. 2007
    ..The ultimate goal is to develop novel agents that can prevent the occurrence of seizures and the progression of epilepsy in at risk individuals...
  101. ncbi Pregabalin drug interaction studies: lack of effect on the pharmacokinetics of carbamazepine, phenytoin, lamotrigine, and valproate in patients with partial epilepsy
    Martin J Brodie
    Pfizer, Global Research and Development, Ann Arbor, Michigan 48105, USA
    Epilepsia 46:1407-13. 2005
    ..Pregabalin (PGB) is an alpha2-delta ligand with demonstrated efficacy in epilepsy, neuropathic pain, and anxiety disorders. PGB is highly efficacious as adjunctive therapy in patients with refractory partial seizures...