Michael A Brockhurst

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. doi request reprint How does spatial dispersal network affect the evolution of parasite local adaptation?
    Tom Vogwill
    School of Biological Sciences, University of Liverpool, Biosciences Building, Crown Street, Liverpool, L69 7ZB, United Kingdom
    Evolution 64:1795-801. 2010
  2. pmc Differential impact of simultaneous migration on coevolving hosts and parasites
    Andrew D Morgan
    Department of Zoology, University of Oxford, Oxford, UK
    BMC Evol Biol 7:1. 2007
  3. ncbi request reprint Ecology: death and destruction determine diversity
    Michael A Brockhurst
    School of Biological Sciences, Biosciences Building, University of Liverpool, Liverpool, UK
    Curr Biol 17:R512-4. 2007
  4. ncbi request reprint The impact of migration from parasite-free patches on antagonistic host-parasite coevolution
    Michael A Brockhurst
    School of Biological Sciences, Biosciences Building, University of Liverpool, Crown Street, Liverpool L69 7ZB, United Kingdom
    Evolution 61:1238-43. 2007
  5. pmc Resource supply and the evolution of public-goods cooperation in bacteria
    Michael A Brockhurst
    School of Biological Sciences, Biosciences Building, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK
    BMC Biol 6:20. 2008
  6. ncbi request reprint Cooperation peaks at intermediate disturbance
    Michael A Brockhurst
    School of Biological Sciences, Biosciences Building, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK
    Curr Biol 17:761-5. 2007
  7. doi request reprint Source populations act as coevolutionary pacemakers in experimental selection mosaics containing hotspots and coldspots
    Tom Vogwill
    School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, United Kingdom
    Am Nat 173:E171-6. 2009
  8. ncbi request reprint Ecological drivers of the evolution of public-goods cooperation in bacteria
    Michael A Brockhurst
    School of Biological Sciences, Biosciences Building, University of Liverpool, Crown Street, Liverpool L69 7ZB, United Kingdom
    Ecology 91:334-40. 2010
  9. pmc Differential infection properties of three inducible prophages from an epidemic strain of Pseudomonas aeruginosa
    Chloe E James
    Institute of Infection and Global Health, University of Liverpool, 8 West Derby Street, Liverpool, L69 7BE, UK
    BMC Microbiol 12:216. 2012
  10. pmc Antagonistic coevolution accelerates molecular evolution
    Steve Paterson
    School of Biological Sciences, Biosciences Building, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK
    Nature 464:275-8. 2010

Detail Information

Publications32

  1. doi request reprint How does spatial dispersal network affect the evolution of parasite local adaptation?
    Tom Vogwill
    School of Biological Sciences, University of Liverpool, Biosciences Building, Crown Street, Liverpool, L69 7ZB, United Kingdom
    Evolution 64:1795-801. 2010
    ....
  2. pmc Differential impact of simultaneous migration on coevolving hosts and parasites
    Andrew D Morgan
    Department of Zoology, University of Oxford, Oxford, UK
    BMC Evol Biol 7:1. 2007
    ..However, previous studies suggest phages should benefit more from migration than bacteria; because in the absence of migration, phages are more genetically limited and have a lower evolutionary potential compared to the bacteria...
  3. ncbi request reprint Ecology: death and destruction determine diversity
    Michael A Brockhurst
    School of Biological Sciences, Biosciences Building, University of Liverpool, Liverpool, UK
    Curr Biol 17:R512-4. 2007
    ..New work confirms that predators can drive diversification of prey even in homogeneous environments, but suggests that this effect is crucially dependent upon the frequency and intensity of other mass-mortality events...
  4. ncbi request reprint The impact of migration from parasite-free patches on antagonistic host-parasite coevolution
    Michael A Brockhurst
    School of Biological Sciences, Biosciences Building, University of Liverpool, Crown Street, Liverpool L69 7ZB, United Kingdom
    Evolution 61:1238-43. 2007
    ....
  5. pmc Resource supply and the evolution of public-goods cooperation in bacteria
    Michael A Brockhurst
    School of Biological Sciences, Biosciences Building, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK
    BMC Biol 6:20. 2008
    ....
  6. ncbi request reprint Cooperation peaks at intermediate disturbance
    Michael A Brockhurst
    School of Biological Sciences, Biosciences Building, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK
    Curr Biol 17:761-5. 2007
    ..Given the ubiquity of disturbances in nature, these results suggest that they may play a major role in the evolution of social traits in microbes...
  7. doi request reprint Source populations act as coevolutionary pacemakers in experimental selection mosaics containing hotspots and coldspots
    Tom Vogwill
    School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, United Kingdom
    Am Nat 173:E171-6. 2009
    ..These results confirm theoretical predictions and suggest that source populations can act as coevolutionary "pacemakers" for recipient populations, overriding local conditions...
  8. ncbi request reprint Ecological drivers of the evolution of public-goods cooperation in bacteria
    Michael A Brockhurst
    School of Biological Sciences, Biosciences Building, University of Liverpool, Crown Street, Liverpool L69 7ZB, United Kingdom
    Ecology 91:334-40. 2010
    ....
  9. pmc Differential infection properties of three inducible prophages from an epidemic strain of Pseudomonas aeruginosa
    Chloe E James
    Institute of Infection and Global Health, University of Liverpool, 8 West Derby Street, Liverpool, L69 7BE, UK
    BMC Microbiol 12:216. 2012
    ..aerugionosa strains. LES phages confer a competitive advantage in a rat model of chronic lung infection and may, therefore underpin LES prevalence. Here the infective properties of three LES phages were characterised...
  10. pmc Antagonistic coevolution accelerates molecular evolution
    Steve Paterson
    School of Biological Sciences, Biosciences Building, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK
    Nature 464:275-8. 2010
    ..These results demonstrate, at both the genomic and phenotypic level, that antagonistic coevolution is a cause of rapid and divergent evolution, and is likely to be a major driver of evolutionary change within species...
  11. pmc Niche occupation limits adaptive radiation in experimental microcosms
    Michael A Brockhurst
    School of Biological Sciences, Biosciences Building, University of Liverpool, Crown Street, Liverpool, United Kingdom
    PLoS ONE 2:e193. 2007
    ..The breadth of adaptive radiation attainable by an invading lineage decreased with increasing niche occupation of the resident community. Our results highlight the importance of niche occupation as a constraint on adaptive radiation...
  12. pmc Sub-inhibitory concentrations of some antibiotics can drive diversification of Pseudomonas aeruginosa populations in artificial sputum medium
    Elli A Wright
    Institute of Infection and Global Health, University of Liverpool, The Ronald Ross Building, 8 West Derby Street, Liverpool, L69 7BE, UK
    BMC Microbiol 13:170. 2013
    ..We then characterised diversification with respect to 13 phenotypic and genotypic characteristics...
  13. pmc Coevolving parasites enhance the diversity-decreasing effect of dispersal
    Tom Vogwill
    Institute of Integrative Biology, University of Liverpool, Biosciences Building, Liverpool L69 7ZB, UK
    Biol Lett 7:578-80. 2011
    ..Thus, our results suggest that, while parasites can drive host diversification, host populations coevolving with parasites are more prone to homogenization through dispersal...
  14. doi request reprint Dispersal and natural enemies interact to drive spatial synchrony and decrease stability in patchy populations
    Tom Vogwill
    School of Biological Sciences, University of Liverpool, Liverpool, UK
    Ecol Lett 12:1194-200. 2009
    ..Taken together, our findings suggest that dispersal and natural enemies can interact to drive spatially synchronous population fluctuations that decrease stability at both the patch and population level...
  15. doi request reprint Two-step infection processes can lead to coevolution between functionally independent infection and resistance pathways
    Andy Fenton
    Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, United Kingdom
    Evolution 66:2030-41. 2012
    ..Such multistep infection processes are a fundamental, but overlooked feature of many host-pathogen interactions, and have important consequences for our understanding of host-pathogen coevolution...
  16. pmc Population bottlenecks promote cooperation in bacterial biofilms
    Michael A Brockhurst
    School of Biological Sciences, University of Liverpool, Liverpool, United Kingdom
    PLoS ONE 2:e634. 2007
    ..This result highlights the importance of ecologically mediated population bottlenecks in the maintenance of social traits in microbes...
  17. doi request reprint Pseudomonas aeruginosa population diversity and turnover in cystic fibrosis chronic infections
    Eilidh Mowat
    Institute of Infection and Global Health, University of Liverpool, Liverpool L69 3GA, UK
    Am J Respir Crit Care Med 183:1674-9. 2011
    ..Pseudomonas aeruginosa isolates from chronic cystic fibrosis lung infections display multiple phenotypes indicating extensive population diversity...
  18. doi request reprint Inverse-gene-for-gene infection genetics and coevolutionary dynamics
    Andrew Fenton
    School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L697ZB, United Kingdom
    Am Nat 174:E230-42. 2009
    ....
  19. doi request reprint The dual benefits of aposematism: predator avoidance and enhanced resource collection
    Michael P Speed
    School of Biological Sciences, Biosciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, United Kingdom
    Evolution 64:1622-33. 2010
    ..One conclusion is that aposematism could be a key evolutionary innovation, because by widening habitat use it may promote adaptive radiation as a byproduct of enhanced ecological opportunity...
  20. ncbi request reprint Experimental coevolution with bacteria and phage. The Pseudomonas fluorescens--Phi2 model system
    Michael A Brockhurst
    School of Biological Sciences, Biosciences Building, University of Liverpool, Liverpool L69 7ZB, UK
    Infect Genet Evol 7:547-52. 2007
    ..In this article we describe this model system and synthesise recent findings that address the causes and consequences of antagonistic coevolution...
  21. pmc Variation in Streptococcus pneumoniae susceptibility to human antimicrobial peptides may mediate intraspecific competition
    Michelle G J L Habets
    Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK
    Proc Biol Sci 279:3803-11. 2012
    ..AMP-mediated competition could therefore contribute to the maintenance of intraspecific genetic diversity in S. pneumoniae...
  22. ncbi request reprint Character displacement promotes cooperation in bacterial biofilms
    Michael A Brockhurst
    School of Biological Sciences, Biosciences Building, University of Liverpool, Crown Street, Liverpool L69 7ZB, United Kingdom
    Curr Biol 16:2030-4. 2006
    ..These results demonstrate that diversification into different ecological niches can minimize selection against cooperation in the face of local resource competition...
  23. doi request reprint Plasmid-mediated horizontal gene transfer is a coevolutionary process
    Ellie Harrison
    Institute of Integrative Biology, University of Liverpool, Bioscience Building, Liverpool, UK
    Trends Microbiol 20:262-7. 2012
    ..Drawing upon evidence from experimental evolution, we argue that HGT via conjugation can only be fully understood in a coevolutionary framework...
  24. pmc Therapeutic antimicrobial peptides may compromise natural immunity
    Michelle G J L Habets
    Institute of Integrative Biology, University of Liverpool, Liverpool, UK
    Biol Lett 8:416-8. 2012
    ..Our results therefore highlight grave potential risks of AMP therapies, with implications for their development...
  25. doi request reprint Next-generation sequencing as a tool to study microbial evolution
    Michael A Brockhurst
    Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK
    Mol Ecol 20:972-80. 2011
    ..These advances have important implications for our understanding of the within- and between-host evolution of microbial pathogens...
  26. pmc Epistatic interactions alter dynamics of multilocus gene-for-gene coevolution
    Andy Fenton
    School of Biological Sciences, University of Liverpool, Liverpool, United Kingdom
    PLoS ONE 2:e1156. 2007
    ..Our results demonstrate that the specific forms of interaction between multiple resistance or virulence genes are a crucial determinant of host-parasite coevolutionary dynamics...
  27. pmc Antagonistic coevolution with parasites increases the cost of host deleterious mutations
    Angus Buckling
    Department of Zoology, University of Oxford, Oxford OX1 3PS, UK
    Proc Biol Sci 273:45-9. 2006
    ..These data suggest that coevolution with parasites increases the rate at which deleterious mutations are purged from host populations...
  28. pmc The effect of spatial heterogeneity and parasites on the evolution of host diversity
    Michael A Brockhurst
    Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, UK
    Proc Biol Sci 271:107-11. 2004
    ..Such interactions between key ecological variables need to be considered when addressing diversification and coexistence in future studies...
  29. pmc The impact of phages on interspecific competition in experimental populations of bacteria
    Michael A Brockhurst
    Department of Plant Sciences, University of Oxford, Oxford, OX1 3RB, UK
    BMC Ecol 6:19. 2006
    ..Communities were propagated at two environmental temperatures that reversed the outcome of competition in the absence of phage...
  30. ncbi request reprint The interactive effects of parasites, disturbance, and productivity on experimental adaptive radiations
    Rebecca Benmayor
    Department of Zoology, University of Oxford, Oxford OX1 3PS, United Kingdom
    Evolution 62:467-77. 2008
    ..Parasites and other natural enemies are therefore likely to have a large effect in mitigating the influence of other environmental variables on the evolution and maintenance of diversity...
  31. ncbi request reprint The evolution of specificity in evolving and coevolving antagonistic interactions between a bacteria and its phage
    Virginie Poullain
    Institut des Sciences de l Evolution UM2 CNRS, Universite Montpellier II, Place Eugene Bataillon, 34095, Montpellier, France
    Evolution 62:1-11. 2008
    ....
  32. ncbi request reprint Siderophore-mediated cooperation and virulence in Pseudomonas aeruginosa
    Angus Buckling
    Department of Zoology, University of Oxford, Oxford, UK
    FEMS Microbiol Ecol 62:135-41. 2007
    ..Fourth, cooperative pyoverdin production is also shown to be favoured by kin selection in vivo (caterpillars), and results in more virulent infections. Finally, we briefly outline ongoing and future work using this experimental system...