J P Brockes

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Plasticity and reprogramming of differentiated cells in amphibian regeneration
    Jeremy P Brockes
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Rev Mol Cell Biol 3:566-74. 2002
  2. pmc The regenerative plasticity of isolated urodele myofibers and its dependence on MSX1
    Anoop Kumar
    Department of Biochemistry and Molecular Biology, University College London, London, United Kingdom
    PLoS Biol 2:E218. 2004
  3. pmc The Meis homeoprotein regulates the axolotl Prod 1 promoter during limb regeneration
    Nooreen Shaikh
    Institute of Structural and Molecular Biology, University College London, Gower Street, London, England WC1E 6BT, UK
    Gene 484:69-74. 2011
  4. ncbi request reprint Newts
    Jeremy Brockes
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Curr Biol 15:R42-4. 2005
  5. doi request reprint Evidence for the local evolution of mechanisms underlying limb regeneration in salamanders
    A Acely Garza-Garcia
    Division of Molecular Structure, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Integr Comp Biol 50:528-35. 2010
  6. pmc Regeneration as an evolutionary variable
    J P Brockes
    Department of Biochemistry and Molecular Biology, University College London, UK
    J Anat 199:3-11. 2001
  7. doi request reprint Comparative aspects of animal regeneration
    Jeremy P Brockes
    Institute of Structural and Molecular Biology, University College London, London WC1E 6BT, England
    Annu Rev Cell Dev Biol 24:525-49. 2008
  8. ncbi request reprint Appendage regeneration in adult vertebrates and implications for regenerative medicine
    Jeremy P Brockes
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Science 310:1919-23. 2005
  9. ncbi request reprint Topics in prion cell biology
    J P Brockes
    Department of Biochemistry and Molecular Biology University College London Gower Street, London, WC1E 6BT, UK
    Curr Opin Neurobiol 9:571-7. 1999
  10. ncbi request reprint Amphibian limb regeneration: rebuilding a complex structure
    J P Brockes
    Ludwig Institute for Cancer Research and Department of Biochemistry and Molecular Biology, University College London, 91 Riding House Street, London W1P 8BT, UK
    Science 276:81-7. 1997

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Plasticity and reprogramming of differentiated cells in amphibian regeneration
    Jeremy P Brockes
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Rev Mol Cell Biol 3:566-74. 2002
    ..The recent demonstrations of plasticity in mouse myotubes should facilitate comparative studies of the pathways that underlie the regenerative response, as well as proposing new approaches to promote mammalian regeneration...
  2. pmc The regenerative plasticity of isolated urodele myofibers and its dependence on MSX1
    Anoop Kumar
    Department of Biochemistry and Molecular Biology, University College London, London, United Kingdom
    PLoS Biol 2:E218. 2004
    ..The induction of Msx1 expression is required to activate this programme. Our understanding of the regulation of plasticity in postmitotic salamander cells should inform strategies to promote regeneration in other contexts...
  3. pmc The Meis homeoprotein regulates the axolotl Prod 1 promoter during limb regeneration
    Nooreen Shaikh
    Institute of Structural and Molecular Biology, University College London, Gower Street, London, England WC1E 6BT, UK
    Gene 484:69-74. 2011
    ....
  4. ncbi request reprint Newts
    Jeremy Brockes
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Curr Biol 15:R42-4. 2005
  5. doi request reprint Evidence for the local evolution of mechanisms underlying limb regeneration in salamanders
    A Acely Garza-Garcia
    Division of Molecular Structure, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Integr Comp Biol 50:528-35. 2010
    ..This hypothesis has significant implications for our outlook on regeneration in vertebrates, as well as for the strategies employed in extending regenerative ability in mammals...
  6. pmc Regeneration as an evolutionary variable
    J P Brockes
    Department of Biochemistry and Molecular Biology, University College London, UK
    J Anat 199:3-11. 2001
    ..Our approach to this question is to compare a differentiated newt cell with its mammalian counterpart in respect of the plasticity of differentiation...
  7. doi request reprint Comparative aspects of animal regeneration
    Jeremy P Brockes
    Institute of Structural and Molecular Biology, University College London, London WC1E 6BT, England
    Annu Rev Cell Dev Biol 24:525-49. 2008
    ..These mechanisms are reviewed here across a range of contexts. We also consider the evolutionary origins of regeneration and how regeneration may relate to both agametic reproduction and to ontogeny...
  8. ncbi request reprint Appendage regeneration in adult vertebrates and implications for regenerative medicine
    Jeremy P Brockes
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Science 310:1919-23. 2005
    ..The blastema can regenerate autonomously as a self-organizing system over variable linear dimensions. Here we consider the prospects for limb regeneration in mammals from this viewpoint...
  9. ncbi request reprint Topics in prion cell biology
    J P Brockes
    Department of Biochemistry and Molecular Biology University College London Gower Street, London, WC1E 6BT, UK
    Curr Opin Neurobiol 9:571-7. 1999
    ..Studies on two yeast prions have analysed the structure and phenotype of the aggregated conformers underlying the prion state, as well as the interactions regulating their formation and turnover within a dividing cell...
  10. ncbi request reprint Amphibian limb regeneration: rebuilding a complex structure
    J P Brockes
    Ludwig Institute for Cancer Research and Department of Biochemistry and Molecular Biology, University College London, 91 Riding House Street, London W1P 8BT, UK
    Science 276:81-7. 1997
    ..The possibility of inducing a blastema on a mammalian limb cannot be discounted, although the molecular constraints are becoming clearer as we understand more about the mechanisms of urodele regeneration...
  11. ncbi request reprint Mammalian postmitotic nuclei reenter the cell cycle after serum stimulation in newt/mouse hybrid myotubes
    C P Velloso
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, WC1E 6BT, London, United Kingdom
    Curr Biol 11:855-8. 2001
    ..The hybrid myotubes provide a new model for the manipulation of the postmitotic arrest in both mammalian and newt differentiated cells...
  12. pmc A critical role for thrombin in vertebrate lens regeneration
    Yutaka Imokawa
    Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, UK
    Philos Trans R Soc Lond B Biol Sci 359:765-76. 2004
    ..These data support the hypothesis that thrombin is a critical signal linking injury to regeneration, and offer a new perspective on the evolutionary and phylogenetic questions about regeneration...
  13. pmc Molecular basis for the nerve dependence of limb regeneration in an adult vertebrate
    Anoop Kumar
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Science 318:772-7. 2007
    ..Our analysis brings together the positional identity of the blastema and the classical nerve dependence of limb regeneration...
  14. pmc Regeneration, tissue injury and the immune response
    James W Godwin
    Department of Biochemistry and Molecular Biology, University College London, UK
    J Anat 209:423-32. 2006
    ..The possible relationships between the immune response and the regenerative response are considered with respect to phylogenetic variation of regeneration in general, and lens regeneration in particular...
  15. ncbi request reprint Selective activation of thrombin is a critical determinant for vertebrate lens regeneration
    Yutaka Imokawa
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, United Kingdom
    Curr Biol 13:877-81. 2003
    ..Our results indicate that selective activation of thrombin is the pivotal signal linking tissue injury to the initiation of vertebrate regeneration...
  16. ncbi request reprint The expression pattern of tomoregulin-1 in urodele limb regeneration and mouse limb development
    S Morais da Silva
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Mech Dev 104:125-8. 2001
    ..We report the cloning of the newt orthologue, and show that the expression of TMEFF1 is upregulated in the blastema during limb regeneration, and is also expressed in mouse embryonic limb development...
  17. ncbi request reprint Distinctive expression of Myf5 in relation to differentiation and plasticity of newt muscle cells
    Yutaka Imokawa
    Department of Biochemistry and Molecular Biology, University College London, London, U K
    Int J Dev Biol 48:285-91. 2004
    ..We have attempted to relate this striking difference from other vertebrates to the requirement for multinucleate urodele muscle cells to contribute to the regeneration blastema...
  18. ncbi request reprint The newt ortholog of CD59 is implicated in proximodistal identity during amphibian limb regeneration
    Sara Morais da Silva
    Department of Biochemistry and Molecular Biology, University College London, United Kingdom
    Dev Cell 3:547-55. 2002
    ..Prod 1 is therefore a cell surface protein implicated in the local cell-cell interactions mediating positional identity...
  19. ncbi request reprint Positional identity of adult stem cells in salamander limb regeneration
    Anoop Kumar
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    C R Biol 330:485-90. 2007
    ..Prod1 protein is up-regulated after treatment of distal blastemas with RA and this is particularly marked in cells of the dermis. These cells have previously been implicated in pattern formation during limb regeneration...
  20. ncbi request reprint Preparation of cultured myofibers from larval salamander limbs for cellular plasticity studies
    Anoop Kumar
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Protoc 2:939-47. 2007
    ..Here, we describe a detailed method for the isolation and culture of larval salamander myofibers in numbers suitable for cellular plasticity studies. The basic protocol for isolation and purification of cells can be completed in 4 h...
  21. ncbi request reprint Heterogeneous proliferative potential in regenerative adult newt cardiomyocytes
    Monica Bettencourt-Dias
    Department of Biochemistry, University College London, London WC1E 6BT, UK
    J Cell Sci 116:4001-9. 2003
    ..Understanding the nature of this block and why it arises in some but not other newt cardiomyocytes may lead to an augmentation of the regenerative potential in the mammalian heart...
  22. ncbi request reprint Thrombin activation of S-phase reentry by cultured pigmented epithelial cells of adult newt iris
    Andras Simon
    Department of Biochemistry and Molecular Biology, University College London, London, United Kingdom
    Exp Cell Res 281:101-6. 2002
    ..Based on these findings, and on previous experiments showing that newt skeletal myotubes reenter the cell cycle following thrombin stimulation, we suggest that thrombin is a critical signal for initiation of vertebrate regeneration...
  23. ncbi request reprint A single-cell analysis of myogenic dedifferentiation induced by small molecules
    Amy Duckmanton
    Department of Biochemistry and Molecular Biology, University College London, UK
    Chem Biol 12:1117-26. 2005
    ..Time-lapse microscopy has enabled us to analyze the fate of identified mononucleate progeny, and directly assess the extent of dedifferentiation...
  24. ncbi request reprint Plasticity and reprogramming of differentiated cells in amphibian regeneration: partial purification of a serum factor that triggers cell cycle re-entry in differentiated muscle cells
    Werner L Straube
    Max Planck Institute of Molecular Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Cloning Stem Cells 6:333-44. 2004
    ..The purification and molecular identification of the serum factor represents an important avenue in understanding regenerative ability and dedifferentiation capacity on a molecular basis...