C E Brightling

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. pmc Profiling of sputum inflammatory mediators in asthma and chronic obstructive pulmonary disease
    M Bafadhel
    Institute for Lung Health, University of Leicester, Leicester, UK
    Respiration 83:36-44. 2012
  2. pmc Eosinophilic airway inflammation in COPD
    Shironjit Saha
    Institute for Lung Health, University Hospitals of Leicester, Leicester, UK
    Int J Chron Obstruct Pulmon Dis 1:39-47. 2006
  3. pmc Procalcitonin and C-reactive protein in hospitalized adult patients with community-acquired pneumonia or exacerbation of asthma or COPD
    Mona Bafadhel
    Institute for Lung Health, University of Leicester, Leicester, England
    Chest 139:1410-8. 2011
  4. pmc Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes
    Sumit Gupta
    Institute for Lung Health, Department of Infection, Inflammation and Immunity, University of Leicester, Leicester LE3 9QP, UK
    Thorax 65:775-81. 2010
  5. pmc Airway smooth muscle chemokine receptor expression and function in asthma
    R Saunders
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, UK
    Clin Exp Allergy 39:1684-92. 2009
  6. pmc Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD
    Camille Doe
    Institute for Lung Health, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Groby Rd, Leicester, LE3 9QP, England
    Chest 138:1140-7. 2010
  7. pmc Airway smooth muscle proliferation and survival is not modulated by mast cells
    D Kaur
    Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester, Leicester, UK
    Clin Exp Allergy 40:279-88. 2010
  8. pmc Synthetic response of stimulated respiratory epithelium: modulation by prednisolone and iKK2 inhibition
    Lucy Bianca Woodman
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, England
    Chest 143:1656-66. 2013
  9. pmc Airway smooth muscle hypercontractility in asthma
    Rachid Berair
    Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester, Leicester LE3 9QP, UK
    J Allergy (Cairo) 2013:185971. 2013
  10. pmc Airway wall expression of OX40/OX40L and interleukin-4 in asthma
    Salman Siddiqui
    Institute of Lung Health, Department of Infection, Inflammation and Immunity, University of Leicester, Leicester, LE3 9QP, England
    Chest 137:797-804. 2010

Detail Information

Publications97

  1. pmc Profiling of sputum inflammatory mediators in asthma and chronic obstructive pulmonary disease
    M Bafadhel
    Institute for Lung Health, University of Leicester, Leicester, UK
    Respiration 83:36-44. 2012
    ..Asthma and chronic obstructive pulmonary disease (COPD) display features of overlap in airway physiology and airway inflammation. Whether inflammatory phenotypes in airway disease describe similar mediator expression is unknown...
  2. pmc Eosinophilic airway inflammation in COPD
    Shironjit Saha
    Institute for Lung Health, University Hospitals of Leicester, Leicester, UK
    Int J Chron Obstruct Pulmon Dis 1:39-47. 2006
    ..Whether controlling eosinophilic inflammation in COPD patients with an airway eosinophilia will modify disease progression and possibly alter mortality is unknown, but warrants further investigation...
  3. pmc Procalcitonin and C-reactive protein in hospitalized adult patients with community-acquired pneumonia or exacerbation of asthma or COPD
    Mona Bafadhel
    Institute for Lung Health, University of Leicester, Leicester, England
    Chest 139:1410-8. 2011
    ..We aimed to compare the usefulness of the biomarkers procalcitonin and C-reactive protein (CRP) in patients with pneumonia or exacerbations of asthma or COPD...
  4. pmc Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes
    Sumit Gupta
    Institute for Lung Health, Department of Infection, Inflammation and Immunity, University of Leicester, Leicester LE3 9QP, UK
    Thorax 65:775-81. 2010
    ..The aim of this study was to assess whether airway remodelling is restricted to specific subphenotypes of severe asthma...
  5. pmc Airway smooth muscle chemokine receptor expression and function in asthma
    R Saunders
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, UK
    Clin Exp Allergy 39:1684-92. 2009
    ..The expression profile of other chemokine receptors by ASM and their function needs to be further explored...
  6. pmc Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD
    Camille Doe
    Institute for Lung Health, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Groby Rd, Leicester, LE3 9QP, England
    Chest 138:1140-7. 2010
    ..The T helper (Th) 17 cytokines IL-17A and IL-17F have been implicated in the development of neutrophilic airway inflammation, but their expression in asthma and COPD is uncertain...
  7. pmc Airway smooth muscle proliferation and survival is not modulated by mast cells
    D Kaur
    Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester, Leicester, UK
    Clin Exp Allergy 40:279-88. 2010
    ..The cause of this increased ASM mass is uncertain and whether it is a consequence of ASM-mast cell interactions is unknown...
  8. pmc Synthetic response of stimulated respiratory epithelium: modulation by prednisolone and iKK2 inhibition
    Lucy Bianca Woodman
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, England
    Chest 143:1656-66. 2013
    ..We sought to examine the synthetic function of epithelial cells from different locations in the airway tree from subjects with and without asthma and to determine the effects of antiinflammatory therapies upon this synthetic capacity...
  9. pmc Airway smooth muscle hypercontractility in asthma
    Rachid Berair
    Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester, Leicester LE3 9QP, UK
    J Allergy (Cairo) 2013:185971. 2013
    ....
  10. pmc Airway wall expression of OX40/OX40L and interleukin-4 in asthma
    Salman Siddiqui
    Institute of Lung Health, Department of Infection, Inflammation and Immunity, University of Leicester, Leicester, LE3 9QP, England
    Chest 137:797-804. 2010
    ..We sought to examine OX40/OX40L and interleukin (IL)-4 expression in asthma across severities...
  11. pmc Origins of increased airway smooth muscle mass in asthma
    Rachid Berair
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE3 9QP, UK
    BMC Med 11:145. 2013
    ....
  12. pmc Sputum mediator profiling and relationship to airway wall geometry imaging in severe asthma
    Dhananjay Desai
    Institute for Lung Health, NIHR Respiratory Biomedical Research Unit, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
    Respir Res 14:17. 2013
    ..We sought to define sputum mediator profiles in severe asthmatics categorised by CT-determined airway geometry and sputum differential cell counts...
  13. doi request reprint Lung damage and airway remodelling in severe asthma
    C E Brightling
    Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester, Leicester, UK
    Clin Exp Allergy 42:638-49. 2012
    ....
  14. pmc OX40/OX40 ligand interactions in T-cell regulation and asthma
    Davinder Kaur
    Institute for Lung Health, Department of Infection, Inflammation, and Immunity, University of Leicester, Glenfield Hospital, Leicester, LE3 9QP, England
    Chest 141:494-9. 2012
    ..Biologic therapies directed toward OX40/OX40L are in early phases of development, and results from these studies are eagerly awaited...
  15. pmc Increased nicotinamide adenine dinucleotide phosphate oxidase 4 expression mediates intrinsic airway smooth muscle hypercontractility in asthma
    Amanda Sutcliffe
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, United Kingdom
    Am J Respir Crit Care Med 185:267-74. 2012
    ..Asthma is characterized by disordered airway physiology as a consequence of increased airway smooth muscle contractility. The underlying cause of this hypercontractility is poorly understood...
  16. pmc Expression and activation of the oxytocin receptor in airway smooth muscle cells: Regulation by TNFalpha and IL-13
    Yassine Amrani
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, TRL Suite 1200, 125 South 31st Street, Philadelphia, PA 19104, USA
    Respir Res 11:104. 2010
    ..The purpose of this study was to define the role of oxytocin in modulating human airway smooth muscle (HASMCs) function in the presence and absence of IL-13 and TNFalpha, cytokines known to be important in asthma...
  17. pmc IL-13 expression by blood T cells and not eosinophils is increased in asthma compared to non-asthmatic eosinophilic bronchitis
    Salman Siddiqui
    Institute of Lung Health, University of Leicester, Leicester, UK
    BMC Pulm Med 9:34. 2009
    ..In asthma interleukin (IL)-13 is increased in the airway compared with non-asthmatic eosinophilic bronchitis. Whether this differential expression is specific to the airway or is more generalised is uncertain...
  18. pmc Airways disease: phenotyping heterogeneity using measures of airway inflammation
    Salman Siddiqui
    Institute of Lung Health, Leicester, UK
    Allergy Asthma Clin Immunol 3:60-9. 2007
    ..New developments in phenotyping inflammation and other facets of airway disease mean that we are entering an era where careful phenotyping will lead to targeted therapy...
  19. ncbi request reprint The re-emergence of the mast cell as a pivotal cell in asthma pathogenesis
    Christopher E Brightling
    Institute for Lung Health, Department of Respiratory Medicine, University of Leicester and Warwick Medical School, University Hospitals of Leicester, Groby Road, Leicester, LE3 9QP, UK
    Curr Allergy Asthma Rep 5:130-5. 2005
    ..This suggests that interactions between mast cells and airway smooth muscle cells are critical for the development of the disordered airway physiology in asthma...
  20. ncbi request reprint The CXCL10/CXCR3 axis mediates human lung mast cell migration to asthmatic airway smooth muscle
    Christopher E Brightling
    Institute for Lung Health, Department of Infection, Inflammation and Immunity, Leicester Warwick Medical School and University Hospitals of Leicester, Leicester, United Kingdom
    Am J Respir Crit Care Med 171:1103-8. 2005
    ..These results suggest that inhibition of the CXCL10/CXCR3 axis offers a novel target for the treatment of asthma...
  21. pmc Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease
    C E Brightling
    Institute for Lung Health, Clinical Sciences Wing, University Hospitals of Leicester, Groby Road, Leicester LE3 9QP, UK
    Thorax 60:193-8. 2005
    ..Whether the response to inhaled corticosteroids is related to the presence of eosinophilic inflammation is unclear...
  22. ncbi request reprint Chronic cough due to nonasthmatic eosinophilic bronchitis: ACCP evidence-based clinical practice guidelines
    Christopher E Brightling
    Institute for Lung Health, University Hospitals of Leicester NHS Trust Glenfield Hospital, Groby Rd, Leicester LE3 9QP, UK
    Chest 129:116S-121S. 2006
    ..Nonasthmatic eosinophilic bronchitis is a newly recognized cause of chronic cough. Our objective was to review the pathogenesis, natural history, diagnosis, and treatment of this condition...
  23. doi request reprint Eosinophils, bronchitis and asthma: pathogenesis of cough and airflow obstruction
    C E Brightling
    Institute for Lung Health, Department of Infection, Inflammation and Immunity, University of Leicester, Glenfield Hospital, LE3 9QP Leicester, UK
    Pulm Pharmacol Ther 24:324-7. 2011
    ..Interestingly, improvement in airway remodeling in response to anti-IL5 observed using CT imaging and analysis of sub-epithelial matrix deposition does suggest that the eosinophil may play a causal role in airway remodeling...
  24. pmc The utility of the mannitol challenge in the assessment of chronic cough: a pilot study
    Amisha Singapuri
    Institute of Lung Health, University of Leicester, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK
    Cough 4:10. 2008
    ..In conclusion, the mannitol challenge my have potential as a novel cough challenge test and further work is required to extend our findings and to assess whether it has utility in different causes of chronic cough...
  25. ncbi request reprint Immunopathogenesis of severe asthma
    Christopher E Brightling
    Institute for Lung Health, Department of Infection, Inflammation and Immunity, University of Leicester, UK
    Curr Pharm Des 17:667-73. 2011
    ....
  26. ncbi request reprint Biomarkers predicting response to corticosteroid therapy in asthma
    Christopher E Brightling
    Institute for Lung Health, University of Leicester and University Hospitals of Leicester, Leicester, UK
    Treat Respir Med 4:309-16. 2005
    ....
  27. ncbi request reprint Clinical applications of induced sputum
    Christopher E Brightling
    Institute for Lung Health, University of Leicester, Glenfield Hospital, Groby Rd, Leicester, LE3 9QP, UK
    Chest 129:1344-8. 2006
    ..Thus, it is time for sputum induction to move from the research laboratory to the clinic...
  28. doi request reprint Cough due to asthma and nonasthmatic eosinophilic bronchitis
    Christopher E Brightling
    Institute for Lung Health, Department of Infection, Inflammation and Immunity, University of Leicester, Glenfield Hospital, LE3 9QP, Leicester, UK
    Lung 188:S13-7. 2010
    ..In general, response to therapy in both conditions is very good and the limited long-term data available suggest that both usually have a benign course, although in some cases persistent airflow obstruction may occur...
  29. ncbi request reprint Differential expression of CCR3 and CXCR3 by human lung and bone marrow-derived mast cells: implications for tissue mast cell migration
    Christopher E Brightling
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, Leicester Warwick Medical School and University Hospitals of Leicester, Groby Road, Leicester, LE3 9QP, UK
    J Leukoc Biol 77:759-66. 2005
    ..As CXCR3 ligands are elevated in many pulmonary diseases, CXCR3 may be important for determining the anatomical microlocalization of mast cells within the human lung...
  30. ncbi request reprint Targeting TNF-alpha: a novel therapeutic approach for asthma
    Christopher Brightling
    Institute of Lung Health, University of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 121:5-10; quiz 11-2. 2008
    ..Therefore the challenge for clinicians is to evaluate the risk/benefit ratio of these therapies in individual patients with asthma...
  31. doi request reprint Interleukin-13: prospects for new treatments
    C E Brightling
    Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester, Leicester, UK
    Clin Exp Allergy 40:42-9. 2010
    ..Early clinical trials of anti-IL-13 therapies in asthma have shown promise, and the results of further efficacy studies are eagerly awaited...
  32. ncbi request reprint Eosinophilic airway inflammation and exacerbations of COPD: a randomised controlled trial
    R Siva
    Institute for Lung Health, Glenfield Hospital, Groby Road, Leicester, LE3 9PQ, UK
    Eur Respir J 29:906-13. 2007
    ..A management strategy that aims to minimise eosinophilic airway inflammation, as well as symptoms, is associated with a reduction in severe exacerbations of chronic obstructive pulmonary disease...
  33. ncbi request reprint Comparison of asthma treatment given in addition to inhaled corticosteroids on airway inflammation and responsiveness
    R H Green
    Institute for Lung Health, Dept of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Groby Road, Leicester LE3 9PQ, UK
    Eur Respir J 27:1144-51. 2006
    ..In conclusion, treatment given in addition to low-dose inhaled corticosteroids results in modest benefits. Formoterol and high-dose budesonide have contrasting effects on eosinophilic airway inflammation...
  34. doi request reprint Induced sputum and bronchial mucosal expression of interleukin-13 is not increased in chronic obstructive pulmonary disease
    S Saha
    Institute of Lung Health, Leicester, UK
    Allergy 63:1239-43. 2008
    ..We sought to examine IL-13 expression in COPD subjects in induced sputum and bronchus specimens. We hypothesized that inflammatory cells expressing IL-13 localize to the airway smooth muscle bundle and bronchial glands...
  35. ncbi request reprint Observational study of the natural history of eosinophilic bronchitis
    M A Berry
    Institute of Lung Health, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Clin Exp Allergy 35:598-601. 2005
    ..Eosinophilic bronchitis is an important cause of chronic cough. Treatment with inhaled corticosteroids is associated with a short-term improvement in cough and reduced sputum eosinophil count but the long-term outcome is uncertain...
  36. pmc Mast cell migration to Th2 stimulated airway smooth muscle from asthmatics
    A Sutcliffe
    Institute for Lung Health, Department of Infection, University of Leicester, Leicester, UK
    Thorax 61:657-62. 2006
    ..Mast cell microlocalisation within the airway smooth muscle (ASM) bundle is an important determinant of the asthmatic phenotype. We hypothesised that mast cells migrate towards ASM in response to ASM derived chemokines...
  37. ncbi request reprint Sputum eosinophilia in idiopathic pulmonary fibrosis
    S S Birring
    Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester, LE3 9QP, United Kingdom
    Inflamm Res 54:51-6. 2005
    ..We tested the hypothesis that the cough and increased cough reflex sensitivity seen in patients with idiopathic pulmonary fibrosis may be due to airway inflammation in a prospective, cross-sectional study...
  38. pmc Sputum IL-5 concentration is associated with a sputum eosinophilia and attenuated by corticosteroid therapy in COPD
    M Bafadhel
    Institute for Lung Health, Leicester, UK
    Respiration 78:256-62. 2009
    ..Whether these inflammatory phenotypes have differential cytokine and chemokine expression is unknown...
  39. ncbi request reprint Interleukin-4 and -13 expression is co-localized to mast cells within the airway smooth muscle in asthma
    C E Brightling
    Institute for Lung Health, Leicester Warwick Medical School and University Hospitals of Leicester, Leicester, UK
    Clin Exp Allergy 33:1711-6. 2003
    ..In asthma, Th2 cytokines have been implicated as playing a critical role in the development of airway inflammation and hyper-responsiveness. Whether inflammatory cells within the airway smooth muscle release these cytokines is unknown...
  40. pmc CRTH2 expression on T cells in asthma
    K Mutalithas
    Institute for Lung Health, Department of Infection Immunity and Inflammation, University Hospitals of Leicester, Leicester, UK
    Clin Exp Immunol 161:34-40. 2010
    ..However, given their small numbers they are unlikely to have a significant involvement in the pathogenesis of asthma. CRTH2 antagonism may not diminish T cell accumulation in the asthmatic lung...
  41. ncbi request reprint The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma
    M A Berry
    Institute for Lung Health, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Clin Exp Allergy 35:1175-9. 2005
    ..Nitric oxide (NO) has potential advantages as a tool to monitor airway inflammation although little is known about the relationship between NO and eosinophilic airway inflammation and the factors which influence it...
  42. pmc Comparison of airway immunopathology of eosinophilic bronchitis and asthma
    C E Brightling
    Institute for Lung Health, University of Leicester, Division of Respiratory Medicine, Leicester UK
    Thorax 58:528-32. 2003
    ....
  43. pmc Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids
    R H Green
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Groby Road, Leicester LE3 9PQ, UK
    Thorax 57:875-9. 2002
    ....
  44. ncbi request reprint Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial
    C E Brightling
    Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK
    Lancet 356:1480-5. 2000
    ..Whether these patients have different airway pathology from other COPD patients is unclear. We tested the hypothesis that response to prednisolone is related to the presence of eosinophilic airway inflammation...
  45. pmc Granulocyte-macrophage colony-stimulating factor expression in induced sputum and bronchial mucosa in asthma and COPD
    S Saha
    Institute for Lung Health, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Groby Road, Leicester, UK
    Thorax 64:671-6. 2009
    ..However, the expression of GM-CSF and its receptor in airway samples in asthma and COPD across disease severity needs to be further defined...
  46. ncbi request reprint Activation of human lung mast cells by monomeric immunoglobulin E
    G Cruse
    Institute for Lung Health, Dept of Infection, Immunity and Inflammation, University of Leicester, UK
    Eur Respir J 25:858-63. 2005
    ..These findings support the hypothesis that immunoglobulin E loading of mast cells within the asthmatic airway contributes to the disordered airway physiology of this disease...
  47. ncbi request reprint Induced sputum inflammatory mediator concentrations in eosinophilic bronchitis and asthma
    C E Brightling
    Glenfield Hospital, Leicester, United Kingdom and Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Respir Crit Care Med 162:878-82. 2000
    ..64 ng/ml [0.36 to 0.90] and 11-fold [3.3 to 36]), respectively. In conclusion, eosinophilic bronchitis is associated with active airway inflammation with increased release of vasoactive and bronchoconstrictor mediators...
  48. ncbi request reprint Mast cells express IL-13R alpha 1: IL-13 promotes human lung mast cell proliferation and Fc epsilon RI expression
    D Kaur
    Department of Infection, Institute for Lung Health, Inflammation and Immunity, University of Leicester, Leicester, UK
    Allergy 61:1047-53. 2006
    ..The IL-13 receptor, IL-13Ralpha1, is expressed on most leukocytes, except T-cells. Evidence to support IL-13Ralpha1 expression on mast cells is limited...
  49. pmc Functional KCa3.1 K+ channels are required for human lung mast cell migration
    G Cruse
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Thorax 61:880-5. 2006
    ..A study was undertaken to test the hypothesis that blockade of K(Ca)3.1 would attenuate HLMC proliferation and migration...
  50. ncbi request reprint New insights into the relationship between airway inflammation and asthma
    A J Wardlaw
    Department of Respiratory Medicine, Institute for Lung Health, Leicester Warwick Medical School, Glenfield Hospital, Groby Road, Leicester LE3 9QP, U K
    Clin Sci (Lond) 103:201-11. 2002
    ....
  51. ncbi request reprint Multiple inflammatory hits and the pathogenesis of severe airway disease
    I D Pavord
    Institute for Lung Health, Dept of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester, LE3 9QP, UK
    Eur Respir J 27:884-8. 2006
    ....
  52. pmc Idiopathic chronic cough: association with organ specific autoimmune disease and bronchoalveolar lymphocytosis
    S S Birring
    Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK
    Thorax 58:1066-70. 2003
    ..An immunopathological study was undertaken to test the hypothesis that idiopathic chronic cough is associated with lymphocytic airway inflammation...
  53. ncbi request reprint Induced sputum and other outcome measures in chronic obstructive pulmonary disease: safety and repeatability
    C E Brightling
    Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK
    Respir Med 95:999-1002. 2001
    ..96. In conclusion, sputum induction is safe and the cell and fluid phase mediators repeatable in the investigation of airway inflammation in patients with COPD. VAS symptom scores and the CRQ are reproducible outcome measures in COPD...
  54. ncbi request reprint New insights into the role of the mast cell in asthma
    C E Brightling
    University of Leicester and Warwick Medical School, Leicester, UK
    Clin Exp Allergy 33:550-6. 2003
  55. doi request reprint Increased sputum and bronchial biopsy IL-13 expression in severe asthma
    Shironjit K Saha
    Institute for Lung Health, Clinical Sciences Wing, University Hospitals of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 121:685-91. 2008
    ..The importance of IL-13 in the asthma paradigm is supported by increased expression in human subjects, particularly in patients with mild-to-moderate asthma. However, the role of IL-13 in severe asthma needs to be further defined...
  56. ncbi request reprint A comparison of the validity of different diagnostic tests in adults with asthma
    Cameron J Hunter
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester, UK
    Chest 121:1051-7. 2002
    ..We set out to compare the sensitivity and specificity of different tests in this setting...
  57. pmc Isolation of filamentous fungi from sputum in asthma is associated with reduced post-bronchodilator FEV1
    J Agbetile
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, UK
    Clin Exp Allergy 42:782-91. 2012
    ..Fungal sensitization is common in severe asthma, but the clinical relevance of this and the relationship with airway colonization by fungi remain unclear. The range of fungi that may colonize the airways in asthma is unknown...
  58. pmc Management of asthma in adults: current therapy and future directions
    R H Green
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester, UK
    Postgrad Med J 79:259-67. 2003
    ....
  59. pmc Expression of CCR8 is increased in asthma
    K Mutalithas
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, UK
    Clin Exp Allergy 40:1175-85. 2010
    ..Chemokines and their receptors could play key roles in the recruitment of T cells to the asthmatic lung. CCR8 is preferentially expressed on T-helper type 2 cells, and is thought to play a role in the pathogenesis of human asthma...
  60. ncbi request reprint Mast-cell infiltration of airway smooth muscle in asthma
    Christopher E Brightling
    Division of Respiratory Medicine, Institute for Lung Health, Leicester Warwick Medical School and University Hospitals of Leicester, Leicester, United Kingdom
    N Engl J Med 346:1699-705. 2002
    ..We tested the hypothesis that there were differences between the two conditions in the microlocalization of mast cells within the airway smooth muscle...
  61. ncbi request reprint Chemokine concentrations and mast cell chemotactic activity in BAL fluid in patients with eosinophilic bronchitis and asthma, and in normal control subjects
    Lucy Woodman
    Insitute for Lung Health, University of Leicester, Glenfield Hospital, UK
    Chest 130:371-8. 2006
    ..The mast cell chemotactic activity of airway secretions has not been assessed in patients with eosinophilic bronchitis...
  62. ncbi request reprint Co-cultivation of mast cells and Fc epsilon RI alpha+ dendritic-like cells from human hip bone marrow
    D Kaur
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester and Warwick Medical School, University Hospitals of Leicester, Glenfield General Hospital, Leicester, UK
    Clin Exp Allergy 35:226-33. 2005
    ..Hip bone marrow could provide a more convenient less invasive source of mast cell progenitors...
  63. ncbi request reprint Inflammatory cell microlocalisation and airway dysfunction: cause and effect?
    S Siddiqui
    Dept of Respiratory Medicine, University Hospitals of Leicester, Groby Road, Leicester, LE3 9QP, UK
    Eur Respir J 30:1043-56. 2007
    ....
  64. ncbi request reprint Cough and asthma
    M A Berry
    Department of Respiratory Medicine, Institute for Lung Health, Glenfield Hospital, Groby Road, Leicester, UK
    Clin Exp Allergy 33:1481-3. 2003
  65. pmc A case of cough, lymphocytic bronchoalveolitis and coeliac disease with improvement following a gluten free diet
    C E Brightling
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, University Hospitals of Leicester, Leicester LE3 9QP, UK
    Thorax 57:91-2. 2002
    ..All features improved markedly on a gluten free diet, suggesting a causal relationship between coeliac disease, cough, and lymphocytic bronchoalveolitis...
  66. doi request reprint Mepolizumab and exacerbations of refractory eosinophilic asthma
    Pranabashis Haldar
    Institute for Lung Health, Glenfield Hospital, University Hospitals of Leicester National Health Service Trust, Leicester, United Kingdom
    N Engl J Med 360:973-84. 2009
    ..Preventing exacerbations remains an important goal of therapy. There is evidence that eosinophilic inflammation of the airway is associated with the risk of exacerbations...
  67. ncbi request reprint Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis
    Mike A Berry
    Institute for Lung Health, University Hospitals of Leicester, Groby Road, Leicester LE3 9QP, UK
    J Allergy Clin Immunol 114:1106-9. 2004
    ..In asthma, the T H 2-type cytokine IL-13 has been implicated in the development of airway inflammation and hyperresponsiveness. Whether the expression of IL-13 is different between these 2 conditions is unknown...
  68. ncbi request reprint Eosinophilic bronchitis: an important cause of prolonged cough
    C E Brightling
    Department of Respiratory Medicine and Thoracic Surgery, Institute of Lung Health, Leicester, UK
    Ann Med 32:446-51. 2000
    ..Further study of this interesting condition may shed light on the relationship between airway inflammation and airway responsiveness, leading to a greater understanding of both eosinophilic bronchitis and asthma...
  69. doi request reprint Pre-eclampsia is associated with airway hyperresponsiveness
    S Siddiqui
    Institute of Lung Health, University of Leicester, Leicester, UK
    BJOG 115:520-2. 2008
    ..038) in matched controls. Therefore, AHR was increased in women who have had pre-eclampsia. This association and its possible mechanisms warrant further investigation...
  70. ncbi request reprint Evidence of a role of tumor necrosis factor alpha in refractory asthma
    Mike A Berry
    Institute for Lung Health, University Hospital of Leicester National Health Service Trust, Glenfield Hospital, Leicester, United Kingdom
    N Engl J Med 354:697-708. 2006
    ..The development of tumor necrosis factor alpha (TNF-alpha) antagonists has made it feasible to investigate the role of this cytokine in refractory asthma...
  71. pmc Qualitative analysis of high-resolution CT scans in severe asthma
    Sumit Gupta
    Institute for Lung Health, University of Leicester, Leicester, UK
    Chest 136:1521-8. 2009
    ..We sought to describe the HRCT scan abnormalities of a large severe asthma cohort and to determine the utility of clinical features to direct the use of HRCT scanning in this group of patients...
  72. ncbi request reprint Airway smooth muscle and mast cell-derived CC chemokine ligand 19 mediate airway smooth muscle migration in asthma
    Davinder Kaur
    Institute for Lung Health, and Department of Infection, Inflammation and Immunity, University of Leicester, Leicester, United Kingdom
    Am J Respir Crit Care Med 174:1179-88. 2006
    ..We hypothesized that this results from migration of ASM or progenitors in response to chemokines derived from ASM or mast cells within the ASM bundle...
  73. ncbi request reprint Expression of chemokine receptors by lung T cells from normal and asthmatic subjects
    J J Campbell
    Institute for Lung Health and Division of Respiratory Medicine, Leicester University School of Medicine, Leicester, United Kingdom
    J Immunol 166:2842-8. 2001
    ....
  74. ncbi request reprint Eosinophilic bronchitis: clinical features, management and pathogenesis
    Surinder S Birring
    Department of Respiratory Medicine, Institute for Lung Health, Glenfield Hospital, Leicester, UK
    Am J Respir Med 2:169-73. 2003
    ..Further study of this interesting condition will increase our understanding of airway inflammation and airway responsiveness, leading to novel targets for therapeutics for both eosinophilic bronchitis and asthma...
  75. ncbi request reprint Idiopathic chronic cough and organ-specific autoimmune diseases: a case-control study
    Surinder S Birring
    Department of Respiratory Medicine, Institute for Lung Health, University Hospitals of Leicester NHS Trust, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Respir Med 98:242-6. 2004
    ..001). Organ-specific autoantibodies were present in a significantly higher proportion of cases than controls (40% vs. 13%; P = 0.047). These findings suggest a relationship between idiopathic chronic cough and organ-specific autoimmunity...
  76. doi request reprint Eosinophil protein in airway macrophages: a novel biomarker of eosinophilic inflammation in patients with asthma
    Neeta S Kulkarni
    Institute for Lung Health, Glenfield Hospital, Groby Road, Leicester LE3 9QP, United Kingdom
    J Allergy Clin Immunol 126:61-9.e3. 2010
    ....
  77. ncbi request reprint Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial
    Ruth H Green
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, LE3 9PQ, Leicester, UK
    Lancet 360:1715-21. 2002
    ..We aimed to assess whether a management strategy that minimises eosinophilic inflammation reduces asthma exacerbations compared with a standard management strategy...
  78. ncbi request reprint Human lung mast cells adhere to human airway smooth muscle, in part, via tumor suppressor in lung cancer-1
    Weidong Yang
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester Medical School, Leicester, United Kingdom
    J Immunol 176:1238-43. 2006
    ..This supports the hypothesis that adhesion is important in the recruitment and retention of HLMC by the ASM in asthma, and for the functional interaction of these cells...
  79. ncbi request reprint Induced sputum inflammatory mediator concentrations in chronic cough
    Surinder S Birring
    Department of Respiratory Medicine, Institute for Lung Health, Glenfield Hospital, Leicester, United Kingdom
    Am J Respir Crit Care Med 169:15-9. 2004
    ..Our findings support the view that there is release of inflammatory and tussive mediators in patients with chronic cough and suggest that there might be similarities in the mechanism of cough in a diverse range of conditions...
  80. ncbi request reprint TH2 cytokine expression in bronchoalveolar lavage fluid T lymphocytes and bronchial submucosa is a feature of asthma and eosinophilic bronchitis
    Christopher E Brightling
    Division of Respiratory Medicine, Institute for Lung Health, Leicester Warwick Medical School and University Hospitals of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 110:899-905. 2002
    ..Eosinophilic bronchitis has similar immunopathology to asthma but without disordered airway physiology. Whether eosinophilic bronchitis is associated with increased expression of T(H)2 cytokines is unknown...
  81. ncbi request reprint Clinical, radiologic, and induced sputum features of chronic obstructive pulmonary disease in nonsmokers: a descriptive study
    Surinder S Birring
    Department of Respiratory Medicine, Radiology, and Respiratory Physiology, and Leicester Children s Asthma Centre, Institute for Lung Health, Glenfield Hospital, Leicester, United Kingdom
    Am J Respir Crit Care Med 166:1078-83. 2002
    ..Further investigation of this group may disclose novel mechanisms of fixed airflow obstruction...
  82. ncbi request reprint Association between neutrophilic airway inflammation and airflow limitation in adults with asthma
    Dominick E Shaw
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester LE3 9QP, UK
    Chest 132:1871-5. 2007
    ..Chronic inflammation is assumed to be important, although there is limited and contradictory information about the relationship between airway inflammation and postbronchodilator FEV1...
  83. doi request reprint Cluster analysis and clinical asthma phenotypes
    Pranab Haldar
    Institute for Lung Health, Glenfield Hospital, Leicester LE39QP, UK
    Am J Respir Crit Care Med 178:218-24. 2008
    ..Heterogeneity in asthma expression is multidimensional, including variability in clinical, physiologic, and pathologic parameters. Classification requires consideration of these disparate domains in a unified model...
  84. pmc IgE sensitization to Aspergillus fumigatus is associated with reduced lung function in asthma
    Abbie Fairs
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Glenfield Hospital, UK
    Am J Respir Crit Care Med 182:1362-8. 2010
    ..The importance of Aspergillus fumigatus sensitization and colonization of the airways in patients with asthma is unclear. Objectives: To define the relationship between the clinical and laboratory features of A. fumigatus-associated asthma...
  85. doi request reprint Fibrocyte localization to the airway smooth muscle is a feature of asthma
    Ruth Saunders
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 123:376-84. 2009
    ..Airway smooth muscle (ASM) hyperplasia is a hallmark of asthma that is associated with disease severity and persistent airflow obstruction...
  86. doi request reprint Clinical significance of small airway obstruction markers in patients with asthma
    S Gonem
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, UK
    Clin Exp Allergy 44:499-507. 2014
    ..The role of small airway obstruction in the clinical expression of asthma is incompletely understood...
  87. ncbi request reprint Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6
    Fay Hollins
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester Medical School, United Kingdom
    J Immunol 181:2772-80. 2008
    ..Targeting these interactions in asthma might offer a new strategy for the treatment of this common disease...
  88. doi request reprint Ciliary dysfunction and ultrastructural abnormalities are features of severe asthma
    Biju Thomas
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 126:722-729.e2. 2010
    ..Epithelial dysfunction has been implicated in asthma pathophysiology, but no studies have directly assessed ciliary function in asthma...
  89. pmc Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor
    S Mark Duffy
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, and Glenfield Hospital, Leicester, UK
    Eur J Immunol 37:1653-62. 2007
    ..1, providing a clearly defined mechanism by which adenosine inhibits HLMC migration and degranulation. A2A receptor agonists with channel-modulating function may be useful for the treatment of mast cell-mediated disease...
  90. ncbi request reprint Improving the sampling technique of arterialized capillary samples to obtain more accurate PaO2 measurements
    S Wimpress
    Respiratory Physiology Department, University Hospitals of Leicester, UK
    Chron Respir Dis 2:47-50. 2005
    ..We conclude that the addition of simultaneous pulse oximetry with ELCS will identify rogue measurements in about 8% of cases highlighting the need for repeat samples and thus increasing the accuracy of the measurement of PaO2 by ELCS...
  91. ncbi request reprint Severe asthma in adults: what are the important questions?
    Pascal Chanez
    INSERM U454 and Clinique des Maladies Respiratoires, Montpellier, France
    J Allergy Clin Immunol 119:1337-48. 2007
    ..Inhaled corticosteroids and bronchodilators are the mainstay of treatment, but patients with SRA remain uncontrolled, indicating a need for new therapies...
  92. ncbi request reprint Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease
    Elizabeth Gamble
    Department of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
    Am J Respir Crit Care Med 168:976-82. 2003
    ..Phosphodiesterase-4 inhibitors represent a promising new class of substances for use in antiinflammatory treatment of this disease...
  93. ncbi request reprint Sputum induction in asthma: a research technique or a clinical tool?
    Christopher E Brightling
    Chest 129:503-4. 2006
  94. ncbi request reprint Eosinophils in asthma and airway hyperresponsiveness
    Christopher E Brightling
    Am J Respir Crit Care Med 169:131-2; author reply 132-3. 2004
  95. ncbi request reprint An empiric integrative approach to the management of cough: ACCP evidence-based clinical practice guidelines
    Melvin R Pratter
    the Robert Wood Johnson School of Medicine at Camden, Suite 312, 3 Cooper Plaza, Camden, NJ 08103, USA
    Chest 129:222S-231S. 2006
    ..Review the literature to provide a comprehensive approach, including algorithms for the clinician to follow in evaluating and treating the patient with acute, subacute, and chronic cough...
  96. ncbi request reprint Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses
    Gavin E Morris
    Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield, Sheffield, S10 2JF, UK
    FASEB J 20:2153-5. 2006
    ..Thus, inflammatory responses to pathogens are regulated by networks in which patterns of TLR expression and colocalization of tissue cells and leukocytes are critical...
  97. pmc Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines
    Richard S Irwin
    University of Massachusetts Medical School, Room S6 842, 55 Lake Ave North, Worcester, MA 01655, USA
    Chest 129:1S-23S. 2006