J M Brickman

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Expression-independent gene trap vectors for random and targeted mutagenesis in embryonic stem cells
    Anestis Tsakiridis
    MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Nucleic Acids Res 37:e129. 2009
  2. pmc Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript
    Maurice A Canham
    Institute for Stem Cell Research, Medical Research Council Centre for Regenerative Medicine, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Biol 8:e1000379. 2010
  3. ncbi request reprint Molecular effects of novel mutations in Hesx1/HESX1 associated with human pituitary disorders
    J M Brickman
    Division of Mammalian Development, National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Development 128:5189-99. 2001
  4. ncbi request reprint Hex is a transcriptional repressor that contributes to anterior identity and suppresses Spemann organiser function
    J M Brickman
    Divisions of Mammalian Development and Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 127:2303-15. 2000
  5. ncbi request reprint An HMG-like protein that can switch a transcriptional activator to a repressor
    N Lehming
    Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138
    Nature 371:175-9. 1994
  6. ncbi request reprint Axis duplication and anterior identity in the mouse embryo
    P Thomas
    Deutsches Krebsforschungszentrum, Abteilung Angewandte Tumorvirologie, Heidelberg, Germany
    Cold Spring Harb Symp Quant Biol 62:115-25. 1997
  7. ncbi request reprint Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse
    M T Dattani
    London Centre for Paediatric Endocrinology and Metabolism, Institute of Child Health, UK
    Nat Genet 19:125-33. 1998
  8. ncbi request reprint HESX1: a novel gene implicated in a familial form of septo-optic dysplasia
    M T Dattani
    London Centre for Paediatric Endocrinology and Metabolism, Institute of Child Health, UK
    Acta Paediatr Suppl 88:49-54. 1999
  9. ncbi request reprint Heterozygous HESX1 mutations associated with isolated congenital pituitary hypoplasia and septo-optic dysplasia
    P Q Thomas
    Gene Discovery Unit, The Murdoch Children s Research Institute, Royal Children s Hospital, Flemington Road, Parkville, Melbourne, VIC 3052, Australia
    Hum Mol Genet 10:39-45. 2001

Collaborators

Detail Information

Publications9

  1. pmc Expression-independent gene trap vectors for random and targeted mutagenesis in embryonic stem cells
    Anestis Tsakiridis
    MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Nucleic Acids Res 37:e129. 2009
    ..Taken together our data indicate that these vectors are an effective tool for insertional mutagenesis that can be used for either gene trapping or gene targeting...
  2. pmc Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript
    Maurice A Canham
    Institute for Stem Cell Research, Medical Research Council Centre for Regenerative Medicine, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Biol 8:e1000379. 2010
    ..Taken together our data support a model in which ES cell culture has trapped a set of interconvertible cell states reminiscent of the early stages in blastocyst differentiation that may exist only transiently in the early embryo...
  3. ncbi request reprint Molecular effects of novel mutations in Hesx1/HESX1 associated with human pituitary disorders
    J M Brickman
    Division of Mammalian Development, National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Development 128:5189-99. 2001
    ..Our data suggest a possible molecular paradigm for the dominant inheritance observed in some pituitary disorders...
  4. ncbi request reprint Hex is a transcriptional repressor that contributes to anterior identity and suppresses Spemann organiser function
    J M Brickman
    Divisions of Mammalian Development and Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 127:2303-15. 2000
    ..Transient transfection experiments in ES cells suggest that Goosecoid is a direct target of Hex. Together, our results support a model in which Hex suppresses organiser activity and defines anterior identity...
  5. ncbi request reprint An HMG-like protein that can switch a transcriptional activator to a repressor
    N Lehming
    Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138
    Nature 371:175-9. 1994
    ..Thus, the HMG-like proteins DSP1 and HMG I(Y) can determine whether a specific regulator functions as an activator or a repressor of transcription...
  6. ncbi request reprint Axis duplication and anterior identity in the mouse embryo
    P Thomas
    Deutsches Krebsforschungszentrum, Abteilung Angewandte Tumorvirologie, Heidelberg, Germany
    Cold Spring Harb Symp Quant Biol 62:115-25. 1997
  7. ncbi request reprint Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse
    M T Dattani
    London Centre for Paediatric Endocrinology and Metabolism, Institute of Child Health, UK
    Nat Genet 19:125-33. 1998
    ..These data suggest an important role for Hesx1/HESX1 in forebrain, midline and pituitary development in mouse and human...
  8. ncbi request reprint HESX1: a novel gene implicated in a familial form of septo-optic dysplasia
    M T Dattani
    London Centre for Paediatric Endocrinology and Metabolism, Institute of Child Health, UK
    Acta Paediatr Suppl 88:49-54. 1999
    ..Hence, a vital role for Hesx1/HESX1 in forebrain and pituitary development in mice and humans is suggested...
  9. ncbi request reprint Heterozygous HESX1 mutations associated with isolated congenital pituitary hypoplasia and septo-optic dysplasia
    P Q Thomas
    Gene Discovery Unit, The Murdoch Children s Research Institute, Royal Children s Hospital, Flemington Road, Parkville, Melbourne, VIC 3052, Australia
    Hum Mol Genet 10:39-45. 2001
    ..These results demonstrate that some sporadic cases of the more common mild forms of pituitary hypoplasia have a genetic basis, resulting from heterozygous mutation of the HESX1 gene...