K C Breen

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. ncbi request reprint The generation and characterization of a rat neural cell line overexpressing the alpha2,6(N) sialyltransferase
    K C Breen
    Department of Pharmacology and Clinical Pharmacology, University of Dundee, Ninewells Hospital Medical School, Dundee, Scotland, UK
    Glycoconj J 15:199-202. 1998
  2. ncbi request reprint The role of protein glycosylation in the control of cellular N-sialyltransferase activity
    Kieran C Breen
    Department of Psychiatry, University of Dundee, Ninewells Hospital Medical School, Dundee, UK
    FEBS Lett 517:215-8. 2002
  3. ncbi request reprint The role of protein phosphorylation in alpha2,6(N)-sialyltransferase activity
    Kieran C Breen
    Department of Psychiatry, University of Dundee Medical School, Ninewells Hospital, UK
    Biochem Biophys Res Commun 309:32-5. 2003
  4. ncbi request reprint A decrease in neural sialyltransferase activity in Alzheimer's disease
    T M Maguire
    Department of Pharmacology and Clinical Pharmacology, University of Dundee, UK
    Dementia 6:185-90. 1995
  5. ncbi request reprint Modest cholinergic deafferentation fails to alter hippocampal G-proteins
    M McLaughlin
    Neuroscience Institute, Department of Pharmacology and Neuroscience, Ninewells Medical School, University of Dundee, UK
    Neurochem Int 35:59-64. 1999
  6. pmc Activation of phospholipase D by metabotropic glutamate receptor agonists in rat cerebrocortical synaptosomes
    T Shinomura
    Department of Pharmacology and Neuroscience, Ninewells Hospital Medical School, University of Dundee, Dundee, DD1 9SY
    Br J Pharmacol 131:1011-8. 2000
  7. ncbi request reprint The over-expression of the wild type or mutant forms of the presenilin-1 protein alters glycoprotein processing in a human neuroblastoma cell line
    M J Farquhar
    Department of Psychiatry, University of Dundee, Ninewells Hospital Medical School, Dundee DD1 9SY, UK
    Neurosci Lett 346:53-6. 2003
  8. ncbi request reprint The potential role of tau protein O-glycosylation in Alzheimer's disease
    Laura A Robertson
    Alzheimer s Disease Research Centre, Division of Pathology and Neuroscience, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, UK
    J Alzheimers Dis 6:489-95. 2004
  9. ncbi request reprint Axonal transport of the cellular prion protein is increased during axon regeneration
    Kenneth L Moya
    Commissariat à l Energie Atomique Centre National de Recherche Scientifique Unité de Recherche Associeé URA 2210, Service Hospitalier Frederic Joliot, DRM DSV, Orsay, France
    J Neurochem 92:1044-53. 2005
  10. ncbi request reprint Lipopolysaccharide stimulates the secretion of the amyloid precursor protein via a protein kinase C-mediated pathway
    Claire I Small
    Alzheimer s Disease Research Centre, Division of Pathology and Neurosciences, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, UK
    Neurobiol Dis 19:400-6. 2005

Collaborators

  • K Sandhoff
  • Kenneth L Moya
  • Claire I Small
  • Laura A Robertson
  • M McLaughlin
  • M J Farquhar
  • T Shinomura
  • Luigi Di Giamberardino
  • Geoffrey A Lyles
  • Hervé Volland
  • Raymonde Hassig
  • C W Gray
  • E del Rio
  • C P Downes
  • T M Maguire
  • J McCulloch
  • F M Inglis
  • B M Ross

Detail Information

Publications10

  1. ncbi request reprint The generation and characterization of a rat neural cell line overexpressing the alpha2,6(N) sialyltransferase
    K C Breen
    Department of Pharmacology and Clinical Pharmacology, University of Dundee, Ninewells Hospital Medical School, Dundee, Scotland, UK
    Glycoconj J 15:199-202. 1998
    ..These cells will provide an ideal model system with which to further investigate the effect of altered sialic acid on neural cell function...
  2. ncbi request reprint The role of protein glycosylation in the control of cellular N-sialyltransferase activity
    Kieran C Breen
    Department of Psychiatry, University of Dundee, Ninewells Hospital Medical School, Dundee, UK
    FEBS Lett 517:215-8. 2002
    ..The enzyme activity is glycosylation dependent, with the penultimate galactose residue on complex N-linked oligosaccharides playing a pivotal role. These results serve to underline the complexity of the glycosylation process...
  3. ncbi request reprint The role of protein phosphorylation in alpha2,6(N)-sialyltransferase activity
    Kieran C Breen
    Department of Psychiatry, University of Dundee Medical School, Ninewells Hospital, UK
    Biochem Biophys Res Commun 309:32-5. 2003
    ..These results provide further evidence for the role of second messenger-associated kinase enzymes in the modulation of the cell glycosylation potential...
  4. ncbi request reprint A decrease in neural sialyltransferase activity in Alzheimer's disease
    T M Maguire
    Department of Pharmacology and Clinical Pharmacology, University of Dundee, UK
    Dementia 6:185-90. 1995
    ..Therefore, it is suggested that the decrease in sialyltransferase enzyme activity may be a specific biochemical event associated with the AD-like neurodegeneration...
  5. ncbi request reprint Modest cholinergic deafferentation fails to alter hippocampal G-proteins
    M McLaughlin
    Neuroscience Institute, Department of Pharmacology and Neuroscience, Ninewells Medical School, University of Dundee, UK
    Neurochem Int 35:59-64. 1999
    ....
  6. pmc Activation of phospholipase D by metabotropic glutamate receptor agonists in rat cerebrocortical synaptosomes
    T Shinomura
    Department of Pharmacology and Neuroscience, Ninewells Hospital Medical School, University of Dundee, Dundee, DD1 9SY
    Br J Pharmacol 131:1011-8. 2000
    ..These data suggest that, in rat cerebrocortical synaptosomes, the 1S,3R-ACPD-sensitive mGluR is coupled to PLD through a mechanism that is independent of both PKC and PI-PLC...
  7. ncbi request reprint The over-expression of the wild type or mutant forms of the presenilin-1 protein alters glycoprotein processing in a human neuroblastoma cell line
    M J Farquhar
    Department of Psychiatry, University of Dundee, Ninewells Hospital Medical School, Dundee DD1 9SY, UK
    Neurosci Lett 346:53-6. 2003
    ..These results suggest that the over-expression of either the wild type or mutant PS1 disturbs glycoprotein processing within the Golgi...
  8. ncbi request reprint The potential role of tau protein O-glycosylation in Alzheimer's disease
    Laura A Robertson
    Alzheimer s Disease Research Centre, Division of Pathology and Neuroscience, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, UK
    J Alzheimers Dis 6:489-95. 2004
    ..The specificity of the changes in the phosphorylation of individual amino acid residues provides evidence for a targeted O-glycosylation of tau...
  9. ncbi request reprint Axonal transport of the cellular prion protein is increased during axon regeneration
    Kenneth L Moya
    Commissariat à l Energie Atomique Centre National de Recherche Scientifique Unité de Recherche Associeé URA 2210, Service Hospitalier Frederic Joliot, DRM DSV, Orsay, France
    J Neurochem 92:1044-53. 2005
    ..These results raise the possibility that PrPc may play a role in the growth of axons in vivo, perhaps as an adhesion molecule interacting with the extracellular environment through specialized glycosylation...
  10. ncbi request reprint Lipopolysaccharide stimulates the secretion of the amyloid precursor protein via a protein kinase C-mediated pathway
    Claire I Small
    Alzheimer s Disease Research Centre, Division of Pathology and Neurosciences, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, UK
    Neurobiol Dis 19:400-6. 2005
    ..The stimulation of APPs secretion was blocked by the protein kinase C (PKC) inhibitor GF109203x, suggesting that LPS may act via a PKC-mediated pathway to increase APPs secretion...