K C Breen
Affiliation: University of Dundee
- The generation and characterization of a rat neural cell line overexpressing the alpha2,6(N) sialyltransferaseK C Breen
Department of Pharmacology and Clinical Pharmacology, University of Dundee, Ninewells Hospital Medical School, Dundee, Scotland, UK
Glycoconj J 15:199-202. 1998..These cells will provide an ideal model system with which to further investigate the effect of altered sialic acid on neural cell function...
- The role of protein glycosylation in the control of cellular N-sialyltransferase activityKieran C Breen
Department of Psychiatry, University of Dundee, Ninewells Hospital Medical School, Dundee, UK
FEBS Lett 517:215-8. 2002..The enzyme activity is glycosylation dependent, with the penultimate galactose residue on complex N-linked oligosaccharides playing a pivotal role. These results serve to underline the complexity of the glycosylation process...
- The role of protein phosphorylation in alpha2,6(N)-sialyltransferase activityKieran C Breen
Department of Psychiatry, University of Dundee Medical School, Ninewells Hospital, UK
Biochem Biophys Res Commun 309:32-5. 2003..These results provide further evidence for the role of second messenger-associated kinase enzymes in the modulation of the cell glycosylation potential...
- A decrease in neural sialyltransferase activity in Alzheimer's diseaseT M Maguire
Department of Pharmacology and Clinical Pharmacology, University of Dundee, UK
Dementia 6:185-90. 1995..Therefore, it is suggested that the decrease in sialyltransferase enzyme activity may be a specific biochemical event associated with the AD-like neurodegeneration...
- Modest cholinergic deafferentation fails to alter hippocampal G-proteinsM McLaughlin
Neuroscience Institute, Department of Pharmacology and Neuroscience, Ninewells Medical School, University of Dundee, UK
Neurochem Int 35:59-64. 1999....
- Activation of phospholipase D by metabotropic glutamate receptor agonists in rat cerebrocortical synaptosomesT Shinomura
Department of Pharmacology and Neuroscience, Ninewells Hospital Medical School, University of Dundee, Dundee, DD1 9SY
Br J Pharmacol 131:1011-8. 2000..These data suggest that, in rat cerebrocortical synaptosomes, the 1S,3R-ACPD-sensitive mGluR is coupled to PLD through a mechanism that is independent of both PKC and PI-PLC...
- The over-expression of the wild type or mutant forms of the presenilin-1 protein alters glycoprotein processing in a human neuroblastoma cell lineM J Farquhar
Department of Psychiatry, University of Dundee, Ninewells Hospital Medical School, Dundee DD1 9SY, UK
Neurosci Lett 346:53-6. 2003..These results suggest that the over-expression of either the wild type or mutant PS1 disturbs glycoprotein processing within the Golgi...
- The potential role of tau protein O-glycosylation in Alzheimer's diseaseLaura A Robertson
Alzheimer s Disease Research Centre, Division of Pathology and Neuroscience, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, UK
J Alzheimers Dis 6:489-95. 2004..The specificity of the changes in the phosphorylation of individual amino acid residues provides evidence for a targeted O-glycosylation of tau...
- Axonal transport of the cellular prion protein is increased during axon regenerationKenneth L Moya
Commissariat à l Energie Atomique Centre National de Recherche Scientifique Unité de Recherche Associeé URA 2210, Service Hospitalier Frederic Joliot, DRM DSV, Orsay, France
J Neurochem 92:1044-53. 2005..These results raise the possibility that PrPc may play a role in the growth of axons in vivo, perhaps as an adhesion molecule interacting with the extracellular environment through specialized glycosylation...
- Lipopolysaccharide stimulates the secretion of the amyloid precursor protein via a protein kinase C-mediated pathwayClaire I Small
Alzheimer s Disease Research Centre, Division of Pathology and Neurosciences, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, UK
Neurobiol Dis 19:400-6. 2005..The stimulation of APPs secretion was blocked by the protein kinase C (PKC) inhibitor GF109203x, suggesting that LPS may act via a PKC-mediated pathway to increase APPs secretion...