C Brayne

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint The elephant in the room - healthy brains in later life, epidemiology and public health
    Carol Brayne
    Department of Public Health and Primary Care, University of Cambridge, University Forvie Site, Robinson Way, Cambridge CB2 0SR, UK
    Nat Rev Neurosci 8:233-9. 2007
  2. pmc A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II
    Fiona E Matthews
    MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge University, Cambridge, UK
    Lancet 382:1405-12. 2013
  3. pmc A commentary on studies presenting projections of the future prevalence of dementia
    Sam Norton
    Institute of Public Health, University of Cambridge, Cambridge, UK
    BMC Public Health 13:1. 2013
  4. pmc Examining the influence of gender, education, social class and birth cohort on MMSE tracking over time: a population-based prospective cohort study
    Fiona Matthews
    MRC Biostatistics Unit, Cambridge, UK
    BMC Geriatr 12:45. 2012
  5. doi request reprint From molecule to clinic and community for neurodegeneration: research to bridge translational gaps
    Carol Brayne
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    J Alzheimers Dis 33:S385-96. 2013
  6. pmc The epidemiology of low vision and blindness associated with trichiasis in southern Sudan
    Jeremiah Ngondi
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
    BMC Ophthalmol 7:12. 2007
  7. pmc The reliability of assigning individuals to cognitive states using the Mini Mental-State Examination: a population-based prospective cohort study
    Riccardo E Marioni
    Department of Public Health and Primary Care, University of Cambridge, Cambridge CB20SR, UK
    BMC Med Res Methodol 11:127. 2011
  8. doi request reprint A European perspective on population studies of dementia
    Carol Brayne
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, United Kingdom
    Alzheimers Dement 7:3-9. 2011
  9. doi request reprint Neuropathological correlates of dementia in over-80-year-old brain donors from the population-based Cambridge city over-75s cohort (CC75C) study
    Carol Brayne
    Department of Public Health and Primary Care, University of Cambridge, Institute of Public Health, Robinson Way, Cambridge, CB2 0SR, UK
    J Alzheimers Dis 18:645-58. 2009
  10. ncbi request reprint Cohort profile: the Medical Research Council Cognitive Function and Ageing Study (CFAS)
    Carol Brayne
    Department of Public Health and Primary Care, Institute of Public Health, Cambridge University, Forvie Site, Robinson Way, Cambridge CB2 2SR, UK
    Int J Epidemiol 35:1140-5. 2006

Detail Information

Publications111 found, 100 shown here

  1. ncbi request reprint The elephant in the room - healthy brains in later life, epidemiology and public health
    Carol Brayne
    Department of Public Health and Primary Care, University of Cambridge, University Forvie Site, Robinson Way, Cambridge CB2 0SR, UK
    Nat Rev Neurosci 8:233-9. 2007
    ..This paper presents questions and areas which must be explored if the potential for prevention of dementia during brain ageing is to be properly understood...
  2. pmc A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II
    Fiona E Matthews
    MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge University, Cambridge, UK
    Lancet 382:1405-12. 2013
    ....
  3. pmc A commentary on studies presenting projections of the future prevalence of dementia
    Sam Norton
    Institute of Public Health, University of Cambridge, Cambridge, UK
    BMC Public Health 13:1. 2013
    ..This will affect all regions of the world, but particularly developing regions. Dementia projections have been used extensively to support policy. It is therefore important these projections are as accurate as possible...
  4. pmc Examining the influence of gender, education, social class and birth cohort on MMSE tracking over time: a population-based prospective cohort study
    Fiona Matthews
    MRC Biostatistics Unit, Cambridge, UK
    BMC Geriatr 12:45. 2012
    ..The aim of this paper was to examine whether gender, education, social class and birth cohort affect how mean population cognition changes with age...
  5. doi request reprint From molecule to clinic and community for neurodegeneration: research to bridge translational gaps
    Carol Brayne
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    J Alzheimers Dis 33:S385-96. 2013
    ..They have influenced thinking about future directions, and the cohorts on which the findings are based will continue to provide an important resource for novel areas of research and future health care planning...
  6. pmc The epidemiology of low vision and blindness associated with trichiasis in southern Sudan
    Jeremiah Ngondi
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
    BMC Ophthalmol 7:12. 2007
    ....
  7. pmc The reliability of assigning individuals to cognitive states using the Mini Mental-State Examination: a population-based prospective cohort study
    Riccardo E Marioni
    Department of Public Health and Primary Care, University of Cambridge, Cambridge CB20SR, UK
    BMC Med Res Methodol 11:127. 2011
    ..In practice, the MMSE is usually used to group individuals into cognitive states. The reliability of this grouping (state based approach) has not been fully explored...
  8. doi request reprint A European perspective on population studies of dementia
    Carol Brayne
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, United Kingdom
    Alzheimers Dement 7:3-9. 2011
    ..S. and European researchers have identified and attempted to tackle. To maximize information gained from studies across the world, better harmonization of methodology is needed, as informed from current research practice...
  9. doi request reprint Neuropathological correlates of dementia in over-80-year-old brain donors from the population-based Cambridge city over-75s cohort (CC75C) study
    Carol Brayne
    Department of Public Health and Primary Care, University of Cambridge, Institute of Public Health, Robinson Way, Cambridge, CB2 0SR, UK
    J Alzheimers Dis 18:645-58. 2009
    ..A greater burden of these pathologies, Lewy bodies, and hippocampal atrophy, are associated with a higher risk of, but do not define, clinical dementia in old age...
  10. ncbi request reprint Cohort profile: the Medical Research Council Cognitive Function and Ageing Study (CFAS)
    Carol Brayne
    Department of Public Health and Primary Care, Institute of Public Health, Cambridge University, Forvie Site, Robinson Way, Cambridge CB2 2SR, UK
    Int J Epidemiol 35:1140-5. 2006
  11. ncbi request reprint Very old drivers: findings from a population cohort of people aged 84 and over
    C Brayne
    Department of Public Health and Primary Care, Institute of Public Health, Cambridge, UK
    Int J Epidemiol 29:704-7. 2000
    ....
  12. pmc Dementia before death in ageing societies--the promise of prevention and the reality
    Carol Brayne
    Department of Public Health and Primary Care, Institute of Public Health, Cambridge University, Cambridge, United Kingdom
    PLoS Med 3:e397. 2006
    ..This can be explored by examining the effect on cumulative risk by time of death of factors found consistently to reduce risk at particular ages, such as education and social status...
  13. ncbi request reprint Health and ill-health in the older population in England and Wales. The Medical Research Council Cognitive Function and Ageing Study (MRC CFAS)
    C Brayne
    Department of Public Health and Primary Care, University of Cambridge, Institute of Public Health, UK
    Age Ageing 30:53-62. 2001
    ..to provide a profile of disorders and disabilities in the older population...
  14. pmc APOE and ACE polymorphisms and dementia risk in the older population over prolonged follow-up: 10 years of incidence in the MRC CFA Study
    H A D Keage
    Department of Public Health and Primary Care, University of Cambridge, UK
    Age Ageing 39:104-11. 2010
    ..We concentrate on incident dementia risk over 10 years...
  15. ncbi request reprint Risk factors for incident dementia in England and Wales: The Medical Research Council Cognitive Function and Ageing Study. A population-based nested case-control study
    Agustin G Yip
    University of Cambridge, Department of Public Health and Primary Care, Cambridge, UK
    Age Ageing 35:154-60. 2006
    ..To investigate a number of prospectively collected factors (sociodemographic, medical and behavioural) and their association with incident dementia in a population-based cohort...
  16. doi request reprint The association between social stress and global cognitive function in a population-based study: the European Prospective Investigation into Cancer (EPIC)-Norfolk study
    Y Leng
    Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, UK
    Psychol Med 43:655-66. 2013
    ..We aimed to investigate the association between different measures of social stress and cognitive function in a middle- to older-aged population using data from the European Prospective Investigation into Cancer (EPIC)-Norfolk study...
  17. doi request reprint Two-year progression from mild cognitive impairment to dementia: to what extent do different definitions agree?
    Fiona E Matthews
    Medical Resarch Council Biostatistics Unit, Institute of Public Health, Cambridge, United Kindom
    J Am Geriatr Soc 56:1424-33. 2008
    ..To determine the 2-year outcome from 16 different current classifications of mild cognitive impairment (MCI) in a population-based sample...
  18. pmc The oldest old in England and Wales: a descriptive analysis based on the MRC Cognitive Function and Ageing Study
    Jing Xie
    Department of Public Health and Primary Care, Institute of Public Health, Cambridge, CB2 0SR, UK
    Age Ageing 37:396-402. 2008
    ..to describe the characteristics and survival of the oldest old in England and Wales...
  19. ncbi request reprint Cohort profile: the Cambridge City over-75s Cohort (CC75C)
    Jane Fleming
    Department of Public Health and Primary Care, University of Cambridge, UK
    Int J Epidemiol 36:40-6. 2007
  20. ncbi request reprint Using the Mini-Mental State Examination for tracking cognition in the older population based on longitudinal data
    Mark Chatfield
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
    J Am Geriatr Soc 55:1066-71. 2007
    ..To estimate population norms for use in assessment of individuals in relation to their age-matched peers using true longitudinal patterns of decline...
  21. doi request reprint Incidence of early-onset dementias in Cambridgeshire, United Kingdom
    L Mercy
    MFPH, Institute of Public Health, University of Cambridge, University Forvie Site, Robinson Way, Cambridge, UK
    Neurology 71:1496-9. 2008
    ..To estimate the incidence of early-onset dementias in a defined area of Cambridgeshire served by Addenbrooke's Hospital...
  22. ncbi request reprint Decline across different domains of cognitive function in normal ageing: results of a longitudinal population-based study using CAMCOG
    S Cullum
    Department of Community Medicine, University of Cambridge, UK
    Int J Geriatr Psychiatry 15:853-62. 2000
    ..05). Greater decline in the Perception subscale was associated with older age (p = 0.03). Decline in specific cognitive domains may indicate a reversible phase of cognitive impairment and deserves further investigation...
  23. ncbi request reprint Population norms for the MMSE in the very old: estimates based on longitudinal data. Mini-Mental State Examination
    C Dufouil
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Neurology 55:1609-13. 2000
    ..To report the percentile distribution of Mini-Mental State Examination (MMSE) scores in older people by age, sex, and education level, estimated from longitudinal data, after correcting for loss due to dropout...
  24. ncbi request reprint Local population differences and the needs of people with cognitive impairment
    D Melzer
    Institute of Public Health, University of Cambridge, UK
    Int J Geriatr Psychiatry 12:883-7. 1997
    ..As moderate and severe cognitive impairment is a major cause of need for long-term care, population-based estimates of the numbers and characteristics of this group were calculated, to explore the effects of local differences...
  25. pmc Epidemiological pathology of dementia: attributable-risks at death in the Medical Research Council Cognitive Function and Ageing Study
    Fiona E Matthews
    Medical Research Council MRC Biostatistics, University of Cambridge, Cambridge, United Kingdom
    PLoS Med 6:e1000180. 2009
    ..We report the attributable risks (ARs) for dementia at death for common age-related degenerative and vascular pathologies, and other factors, in the MRC Cognitive Function and Ageing Study (MRC CFAS)...
  26. ncbi request reprint Prevalence and symptomatology of depression in older people living in institutions in England and Wales
    F A McDougall
    Department of Public Health and Primary Care, Cambridge University Forvie Site, Robinson Way, Cambridge CB2 0SR, UK
    Age Ageing 36:562-8. 2007
    ..Epidemiological studies have shown that depression is common in institutional settings. However, the symptomatology of depression in this group has not been compared to those living in the community...
  27. doi request reprint Age, neuropathology, and dementia
    George M Savva
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
    N Engl J Med 360:2302-9. 2009
    ..Research in Alzheimer's disease is focused mainly on younger old persons, whereas studies involving very old persons report attenuated relationships between the pathological features of Alzheimer's disease and dementia...
  28. pmc The incidence of dementia in England and Wales: findings from the five identical sites of the MRC CFA Study
    Fiona Matthews
    MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge, United Kingdom
    PLoS Med 2:e193. 2005
    ..This study aims to provide robust measures of the variation of the incidence of dementia across sites within England and Wales and produce overall estimates by age and sex...
  29. doi request reprint The neuropathological profile of mild cognitive impairment (MCI): a systematic review
    B C M Stephan
    Department of Public Health and Primary Care, Institute of Public Health, Cambridge University, Cambridge, UK
    Mol Psychiatry 17:1056-76. 2012
    ..Standardization of the definition of MCI and reporting of pathology would greatly assist in building an integrated picture of the clinical and neuropathological profile of MCI...
  30. doi request reprint Risk prediction models: a framework for assessment
    T H S Dent
    PHG Foundation, University of Cambridge, Cambridge, UK
    Public Health Genomics 15:98-105. 2012
    ....
  31. doi request reprint Co-occurrence of anxiety and depression amongst older adults in low- and middle-income countries: findings from the 10/66 study
    A M Prina
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
    Psychol Med 41:2047-56. 2011
    ..We therefore investigated the co-occurrence of anxiety and depressive syndromes amongst older adults living in developing countries and measured the separate and joint effect of these two disorders on levels of associated disability...
  32. ncbi request reprint Exploring the impact of prevalence and mortality on incidence of dementia in the oldest old: the sensitivity of a deterministic approach
    M A McGee
    MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 2SR, UK
    Neuroepidemiology 20:221-4. 2001
    ..The aim of the paper is to demonstrate the use and sensitivity of a deterministic model based on the relationship between mortality, incidence and prevalence with the example of the chronic disease dementia...
  33. doi request reprint Prospective association between emotional health and clinical evidence of Parkinson's disease
    L Ishihara-Paul
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Eur J Neurol 15:1148-54. 2008
    ..We investigate the prospective association between selected measures of emotional health and incident suspected PD...
  34. ncbi request reprint Prevalence of risk factors and severity of active trachoma in southern Sudan: an ordinal analysis
    Jeremiah Ngondi
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
    Am J Trop Med Hyg 77:126-32. 2007
    ..Our study suggests that facial hygiene and environmental sanitation are priority trachoma-control interventions in southern Sudan...
  35. pmc Survival times in people with dementia: analysis from population based cohort study with 14 year follow-up
    Jing Xie
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge CB2 0SR
    BMJ 336:258-62. 2008
    ..To provide estimates of survival after onset of dementia by age, sex, self reported health, disability, and severity of cognitive impairment...
  36. doi request reprint Does depression predict adverse outcomes for older medical inpatients? A prospective cohort study of individuals screened for a trial
    Sarah Cullum
    West Suffolk Hospital and Department of Public Health and Primary Care, University of Cambridge, UK
    Age Ageing 37:690-5. 2008
    ..to examine the relationship between depressive symptoms and hospital outcomes in an unselected consecutive sample of older medical inpatients...
  37. ncbi request reprint The CAST (Childhood Asperger Syndrome Test): preliminary development of a UK screen for mainstream primary-school-age children
    Fiona J Scott
    Autism Research Centre, Department of Psychiatry, University of Cambridge, UK
    Autism 6:9-31. 2002
    ..Results suggest that compared with other tools currently available, the CAST may be useful for identifying children at risk for AS and related conditions, in a mainstream non-clinical sample. Further research is ongoing...
  38. pmc Estimated life expectancy of Parkinson's patients compared with the UK population
    Lianna S Ishihara
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    J Neurol Neurosurg Psychiatry 78:1304-9. 2007
    ..These may be of greater value to patients than standardised mortality ratios (SMRs), which are usually reported in studies on mortality in PD...
  39. pmc Lewy bodies and neuronal loss in subcortical areas and disability in non-demented older people: a population based neuropathological cohort study
    M Byford
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    BMC Geriatr 9:22. 2009
    ..The aim is to examine the clinicopathological correlates of functional disability in subcortical neuronal populations of non-demented elderly individuals...
  40. pmc Population studies of sporadic cerebral amyloid angiopathy and dementia: a systematic review
    Hannah A D Keage
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    BMC Neurol 9:3. 2009
    ..We searched the literature for prospective population-based epidemiological clinicopathological studies, free of the biases of other sampling techniques, which were used as a comparison...
  41. pmc An investigation of the population impact of variation in HbA1c levels in older people in England and Wales: from a population based multi-centre longitudinal study
    Lu Gao
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    BMC Public Health 8:54. 2008
    ..The aim of this study is to investigate the association between the level of HbA1c and mortality from all causes, incident cardiovascular disease, cognitive decline and physical disability in people aged 65 and over in England and Wales...
  42. ncbi request reprint Who will be eligible? An investigation of the dementia population eligible for cholinesterase treatment following the change in NICE guidance
    Fiona E Matthews
    MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Cambridge, UK
    Int J Geriatr Psychiatry 25:719-24. 2010
    ..Investigate the impact of the changes in eligibility within England and Wales (E&W) for prescription within the UK National Health Service for treatment of Alzheimer's disease (AD)...
  43. doi request reprint Prevalence of autism-spectrum conditions: UK school-based population study
    Simon Baron-Cohen
    University of Cambridge, Autism Research Centre, Department of Psychiatry, Douglas House, 18b Trumpington Road, Cambridge CB2 8AH, UK
    Br J Psychiatry 194:500-9. 2009
    ..Recent reports estimate the prevalence of autism-spectrum conditions in the UK to be 1%...
  44. pmc Operationalization of mild cognitive impairment: a graphical approach
    Fiona E Matthews
    Medical Research Council Biostatistics Unit, Institute of Public Health, Cambridge, United Kingdom
    PLoS Med 4:1615-9. 2007
  45. doi request reprint Time for a change in the research paradigm for Alzheimer's disease: the value of a chaotic matrix modeling approach
    Sally Hunter
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Forvie Site, Robinson Way, Cambridge, United Kingdom
    CNS Neurosci Ther 16:254-62. 2010
    ....
  46. ncbi request reprint Early cognitive change in the general population: how do different definitions work?
    Blossom C M Stephan
    Department of Public Health and Primary Care, Institute of Public Health, Cambridge, United Kingdom
    J Am Geriatr Soc 55:1534-40. 2007
    ..To explore the application of existing classifications of mild cognitive impairment (MCI) and associated states in a large population sample...
  47. ncbi request reprint Dementia risk prediction in the population: are screening models accurate?
    Blossom C M Stephan
    Department of Public Health and Primary Care, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 0SR, UK
    Nat Rev Neurol 6:318-26. 2010
    ..A parsimonious and cost-effective consensus model needs to be developed that accurately identifies individuals with a high risk of future dementia...
  48. doi request reprint The association between late-life cognitive test scores and retrospective informant interview data
    Riccardo E Marioni
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Int Psychogeriatr 23:274-9. 2011
    ..This study tested the association between last cognitive assessment before death and a retrospective informant assessment of cognition...
  49. pmc Falls in advanced old age: recalled falls and prospective follow-up of over-90-year-olds in the Cambridge City over-75s Cohort study
    Jane Fleming
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    BMC Geriatr 8:6. 2008
    ..This study set out to inform service planning by describing the epidemiology of falls in advanced old age using both retrospectively and prospectively collected falls data...
  50. doi request reprint Epidemiological studies of the effect of stroke on incident dementia: a systematic review
    George M Savva
    University of Cambridge, Institute of Public Health, Robinson Way, Cambridge CB20SR, UK
    Stroke 41:e41-6. 2010
    ..Stroke is implicated in the incidence of dementia, and the risk of poststroke dementia is well characterized, but the excess risk of dementia in those with stroke compared with those without stroke is not well known...
  51. pmc Inability to get up after falling, subsequent time on floor, and summoning help: prospective cohort study in people over 90
    Jane Fleming
    Department of Public Health and Primary Care, University of Cambridge, Institute of Public Health, Cambridge CB2 0SR
    BMJ 337:a2227. 2008
    ..To describe the incidence and extent of lying on the floor for a long time after being unable to get up from a fall among people aged over 90; to explore their use of call alarm systems in these circumstances...
  52. pmc Education differences in life expectancy with cognitive impairment
    Fiona E Matthews
    Institute of Public Health, Cambridge, UK
    J Gerontol A Biol Sci Med Sci 64:125-31. 2009
    ..Low education has an impact on life expectancy and level of cognition, but little is known on its effect on life expectancy with cognitive impairment...
  53. ncbi request reprint Prevalence, correlates and course of behavioural and psychological symptoms of dementia in the population
    George M Savva
    Department of Public Health and Primary Care, University of Cambridge, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 0SR, UK
    Br J Psychiatry 194:212-9. 2009
    ..Behavioural and psychological symptoms of dementia (BPSD) are major contributors to the burden of dementia...
  54. doi request reprint Vascular factors and prevention of dementia
    Blossom C M Stephan
    Department of Public Health and Primary Care, Institute of Public Health, Cambridge, UK
    Int Rev Psychiatry 20:344-56. 2008
    ....
  55. doi request reprint Risk factors for trachomatous trichiasis in children: cross-sectional household surveys in Southern Sudan
    Jeremiah Ngondi
    The Carter Center, Atlanta, Georgia, USA
    Trans R Soc Trop Med Hyg 103:305-14. 2009
    ....
  56. pmc What will happen if we do nothing to control trachoma: health expectancies for blinding trachoma in southern Sudan
    Jeremiah M Ngondi
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
    PLoS Negl Trop Dis 3:e396. 2009
    ..We aimed to describe more completely the burden of blinding trachoma in Southern Sudan using health expectancies...
  57. ncbi request reprint Recovery in instrumental activities of daily living (IADLs): findings from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS)
    David Seidel
    Department of Public Health and Primary Care, University of Cambridge, UK
    Age Ageing 38:663-8. 2009
    ..to provide evidence for predictors of recovery in instrumental activities of daily living (IADLs) among disabled older people living in the community...
  58. pmc A comparison of parametric models for the investigation of the shape of cognitive change in the older population
    Graciela Muniz Terrera
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, University Forvie Site, CB2 0SR, Cambridge, UK
    BMC Neurol 8:16. 2008
    ....
  59. doi request reprint One size fits all? Why we need more sophisticated analytical methods in the explanation of trajectories of cognition in older age and their potential risk factors
    Graciela Muniz Terrera
    MRC Biostatistics Unit, Institute of Public Health, University of Cambridge, Cambridge, U K
    Int Psychogeriatr 22:291-9. 2010
    ..The identification of groups of individuals with similar patterns of cognitive change over time may improve our ability to see whether the effect of risk factors is consistent across groups...
  60. doi request reprint Education and trajectories of cognitive decline over 9 years in very old people: methods and risk analysis
    Graciela Muniz-Terrera
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, University Forvie Site, Cambridge, CB2 0SR, UK
    Age Ageing 38:277-82. 2009
    ..Such considerations limit our understanding of how basic variables such as education can affect cognitive trajectories...
  61. pmc Blinding trachoma in postconflict southern Sudan
    Jeremiah Ngondi
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
    PLoS Med 3:e478. 2006
    ..We conducted this study to estimate the prevalence of trachoma, estimate targets for interventions, and establish a baseline for monitoring and evaluation...
  62. ncbi request reprint Reaching the population with dementia drugs: what are the challenges?
    Fiona E Matthews
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Int J Geriatr Psychiatry 22:627-31. 2007
    ..Since then the cost of prescription in England and Wales has risen. There has been little investigation of uptake at the population level...
  63. pmc The frequency and validity of self-reported diagnosis of Parkinson's Disease in the UK elderly: MRC CFAS cohort
    Thomas Foltynie
    Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 2PY, UK
    BMC Neurol 6:29. 2006
    ..Estimates of the incidence and prevalence of chronic diseases can be made using established cohort studies but these estimates may have lower reliability if based purely on self-reported diagnosis...
  64. ncbi request reprint Incidence of dementia in England and Wales: the MRC Cognitive Function and Ageing Study
    Carol Brayne
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Alzheimer Dis Assoc Disord 20:S47-51. 2006
  65. ncbi request reprint Challenges in the epidemiological investigation of the relationships between physical activity, obesity, diabetes, dementia and depression
    Carol Brayne
    Department of Public Health and Primary Care, Institute of Public Health, Cambridge University, Forvie Site, Robinson Way, Cambridge CB2 2SR, UK
    Neurobiol Aging 26:6-10. 2005
    ....
  66. pmc An investigation of whether factors associated with short-term attrition change or persist over ten years: data from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS)
    Fiona E Matthews
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge, CB2 2SR, UK
    BMC Public Health 6:185. 2006
    ..Factors associated with the loss of participants in long-term longitudinal studies of ageing, due to refusal or moves, have been discussed less than those with short term follow-up...
  67. ncbi request reprint What is the evidence for a premorbid parkinsonian personality: a systematic review
    Lianna Ishihara
    University of Cambridge, Department of Public Health and Primary Care, Cambridge, United Kingdom
    Mov Disord 21:1066-72. 2006
    ..Even then, the term "premorbid" is difficult to define due to the unknown latent period before onset of PD. Additional research would involve correlating personality characteristics to activities or changes in the brain...
  68. pmc Attrition and bias in the MRC cognitive function and ageing study: an epidemiological investigation
    Fiona E Matthews
    MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 2SR, UK
    BMC Public Health 4:12. 2004
    ..This paper aims to identify potential biases in the two-year follow-up interviews...
  69. ncbi request reprint Screening for autism spectrum disorders: what is the evidence?
    Jo Williams
    Department of Public Health and Primary Care, University of Cambridge, UK
    Autism 10:11-35. 2006
    ..This review supports the current policy position of the National Screening Committee, that on the basis of existing evidence, screening for autism spectrum disorders cannot be recommended...
  70. ncbi request reprint Vascular parkinsonism: a review of the precision and frequency of the diagnosis
    Thomas Foltynie
    Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK
    Neuroepidemiology 21:1-7. 2002
    ....
  71. ncbi request reprint The CAST (Childhood Asperger Syndrome Test): test accuracy
    Jo Williams
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, UK
    Autism 9:45-68. 2005
    ..There is not currently enough evidence to recommend the use of the CAST as a screening test within a public health screening programme in the general population...
  72. ncbi request reprint A genome wide linkage disequilibrium screen in Parkinson's disease
    Thomas Foltynie
    Dept of Neurology, University of Cambridge, Cambridge, CB2 2PY, UK
    J Neurol 252:597-602. 2005
    ..Subgroup analysis of the most promising marker shows some evidence that microsatellite marker D1S2886 is associated with familial forms of the disease...
  73. ncbi request reprint A systematic review of prevalence and incidence studies of dementia with Lewy bodies
    Julia Zaccai
    Department of Public Health and Primary Care, University of Cambridge, Robinson Way, Cambridge CB2 2SR, UK
    Age Ageing 34:561-6. 2005
    ..Substantial variation in the prevalence of Dementia with Lewy Bodies (DLB) has been reported with estimates ranging from 0 to 26.3% of all dementia cases, potentially making it the second most common dementia subtype...
  74. pmc Prevalence and causes of blindness and low vision in southern Sudan
    Jeremiah Ngondi
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
    PLoS Med 3:e477. 2006
    ..We aimed to estimate the prevalence of blindness and low vision, identify the main causes of blindness and low vision, and estimate targets for blindness prevention programs in Mankien payam (district), southern Sudan...
  75. ncbi request reprint Survival in a population sample is predicted by proportions of lymphocyte subsets
    Felicia A Huppert
    Department of Psychiatry, Addenbrooke s Hospital, University of Cambridge, Box 189, CB2 2QQ, Cambridge, UK
    Mech Ageing Dev 124:449-51. 2003
    ..For individual lymphocyte subsets, higher CD4 and CD19 percentages were associated with better survival, but only the CD19 percentage remained significant when adjusted for age and sex...
  76. ncbi request reprint The Q-CHAT (Quantitative CHecklist for Autism in Toddlers): a normally distributed quantitative measure of autistic traits at 18-24 months of age: preliminary report
    Carrie Allison
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge, CB2 8AH, UK
    J Autism Dev Disord 38:1414-25. 2008
    ..8 (7.7)). The intraclass correlation for test-retest reliability was 0.82 (n = 330). The distribution in the control group was close to normal. Full examination of the clinical validity of the Q-CHAT and test properties is underway...
  77. ncbi request reprint Systematic review of the depressive symptoms associated with vascular conditions
    Fiona McDougall
    Department of Public Health and Primary Care, University of Cambridge, UK
    J Affect Disord 104:25-35. 2007
    ..Numerous studies report a positive association between the presence of vascular conditions and depression; however, it is unclear whether this presents a distinct subtype of depression...
  78. ncbi request reprint Prevalence of depression in older people in England and Wales: the MRC CFA Study
    Fiona A McDougall
    Department of Public Health and Primary Care, Cambridge University, UK
    Psychol Med 37:1787-95. 2007
    ..Depression in old age is an important public health problem. The aims of this study were to report the prevalence of depression in the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS), a community-based, cohort...
  79. pmc Self-reported parkinsonian symptoms in the EPIC-Norfolk cohort
    Lianna S Ishihara
    Department of Public Health and Primary Care, University of Cambridge, Forvie Site, Cambridge CB2 2SR, UK
    BMC Neurol 5:15. 2005
    ..The objective of the study was to determine the self-reported prevalence of parkinsonian symptoms from a questionnaire, and to examine their association with age and self-reported Parkinson's disease in a large cohort...
  80. ncbi request reprint Association of depression with peripheral leukocyte counts in EPIC-Norfolk--role of sex and cigarette smoking
    Paul Surtees
    Strangeways Research Laboratory, Institute of Public Health, University of Cambridge, Worts Causeway, England, UK
    J Psychosom Res 54:303-6. 2003
    ..To investigate the associations among depression, smoking behaviour and enumerative measures of immunity in a population-based cohort study...
  81. ncbi request reprint The Childhood Asperger Syndrome Test (CAST): test-retest reliability in a high scoring sample
    Carrie Allison
    University of Cambridge, UK
    Autism 11:173-85. 2007
    ..The correlation between the two test scores was 0.67 (Spearman's rho). The CAST shows moderate test-retest reliability in a high scoring sample, further evidence that it is a relatively robust screening tool for epidemiological research...
  82. ncbi request reprint The heterogeneity of idiopathic Parkinson's disease
    Thomas Foltynie
    Cambridge Centre for Brain Repair, University of Cambridge, UK
    J Neurol 249:138-45. 2002
    ....
  83. ncbi request reprint The prevalence of frontotemporal dementia
    E Ratnavalli
    Department of Neurology, Addenbrooke s Hospital, University of Cambridge, 15 Chaucer Road, Cambridge CB2 2EF, UK
    Neurology 58:1615-21. 2002
    ..To estimate the prevalence of frontotemporal dementia (FTD) and other degenerative early-onset dementias in a geographically defined population...
  84. doi request reprint Biomarkers, dementia, and public health
    C F Wright
    PHG Foundation, Cambridge, United Kingdom
    Ann N Y Acad Sci 1180:11-9. 2009
    ..Ensuring research activity that addresses these wider perspectives is essential...
  85. pmc Apolipoprotein E4 is only a weak predictor of dementia and cognitive decline in the general population
    A G Yip
    Department of Public Health and Primary Care, University Forvie Site, Robinson Way, Cambridge CB2 2SR, UK
    J Med Genet 39:639-43. 2002
    ..It is crucial to understand how this genetic factor affects dementia risk in the general population, as well as in narrowly diagnosed, selected, patient groups...
  86. ncbi request reprint A systematic review of depression and mental illness preceding Parkinson's disease
    L Ishihara
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
    Acta Neurol Scand 113:211-20. 2006
    ..Premorbid anxiety may also be associated with PD although the evidence was not as strong. A few studies have looked at dementia as a co-morbid or sequel, but never as a predictor of PD...
  87. pmc The genetic basis of Parkinson's disease
    T Foltynie
    Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK
    J Neurol Neurosurg Psychiatry 73:363-70. 2002
    ..The identification of such susceptibility genes will eventually enable us to more accurately classify this complex disease...
  88. doi request reprint Increased fructose intake as a risk factor for dementia
    B C M Stephan
    Institute of Public Health, University of Cambridge, UK
    J Gerontol A Biol Sci Med Sci 65:809-14. 2010
    ..This article considers the association between refined sugar intake, markers of cardiovascular disease risk, and the possible promotion of the development of dementia...
  89. ncbi request reprint Alzheimer disease is not associated with polymorphisms in the angiotensinogen and renin genes
    A Taylor
    Department of Medical Genetics, Wellcome Trust Centre for Molecular Mechanisms in Disease, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge, UK
    Am J Med Genet 105:761-4. 2001
    ..Thus, these polymorphisms are unlikely to be associated with AD risk...
  90. ncbi request reprint Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease
    Yonghong Li
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Hum Mol Genet 17:759-67. 2008
    ..These data implicate NEDD9 as a novel susceptibility gene for LOAD and possibly PD...
  91. ncbi request reprint Analysis of longitudinal studies with death and drop-out: a case study
    Carole Dufouil
    INSERM Unit 360, Hopital La Salpetriere, 75651 Paris Cedex 13, France
    Stat Med 23:2215-26. 2004
    ..The problem of informative drop-out is also discussed. The methods are implemented in the 'Stata' statistical package...
  92. ncbi request reprint Prevalence of cognitive impairment: results from the MRC trial of assessment and management of older people in the community
    Greta Rait
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Age Ageing 34:242-8. 2005
    ..cognitive impairment is an important part of the diagnostic criteria for dementia. The Mini-Mental State Examination (MMSE) is recommended to test for cognitive impairment and to monitor medication response...
  93. ncbi request reprint Neutrophil counts, monocyte counts and cardiovascular disease in the elderly
    Eleanor M Pinto
    Centre for Applied Medical Statistics, University of Cambridge, Cambridge, UK
    Exp Gerontol 39:615-9. 2004
    ..We examined whether this association is sustained in an elderly population-based sample...
  94. ncbi request reprint Adverse experience in childhood as a developmental risk factor for altered immune status in adulthood
    Paul Surtees
    Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK
    Int J Behav Med 10:251-68. 2003
    ..Caution is needed in the interpretation of these findings that require replication but they may be seen to aid understanding of the mechanisms through which early environmental exposures act...
  95. ncbi request reprint A systematic review of prevalence studies of dementia in Parkinson's disease
    Dag Aarsland
    Section of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway
    Mov Disord 20:1255-63. 2005
    ..The estimated prevalence of PDD in the general population aged 65 years and over is 0.2 to 0.5%...
  96. ncbi request reprint Effect of 3 years of SAFE (surgery, antibiotics, facial cleanliness, and environmental change) strategy for trachoma control in southern Sudan: a cross-sectional study
    Jeremiah Ngondi
    Department of Public Health and Primary Care, Institute of Public Health, Cambridge, UK
    Lancet 368:589-95. 2006
    ..We did a 3-year evaluation to quantify uptake of SAFE (surgery, antibiotics, facial cleanliness, and environmental change) interventions, and to assess the prevalence of active trachoma and unclean faces...
  97. ncbi request reprint Effectiveness of liaison psychiatric nursing in older medical inpatients with depression: a randomised controlled trial
    Sarah Cullum
    Division of Psychiatry, Cotham House, Cotham Hill, Bristol BS6 6JL, UK
    Age Ageing 36:436-42. 2007
    ..To compare liaison psychiatric nursing with usual medical care in the management of older medical inpatients who screen positive for depression...
  98. ncbi request reprint The burden of diseases on disability-free life expectancy in later life
    Carol Jagger
    Department of Health Sciences, University of Leicester, Leicester, United Kingdom
    J Gerontol A Biol Sci Med Sci 62:408-14. 2007
    ..We use a longitudinal study with follow-up at 2, 6, and 10 years to assess the impact of different diseases on both total life expectancy (TLE) and disability-free life expectancy (DFLE)...
  99. pmc Blindness survey methods: response from Sudan study authors
    Jeremiah Ngondi
    PLoS Med 4:e86. 2007
  100. ncbi request reprint Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants
    Andrew Grupe
    Celera Diagnostics, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Hum Mol Genet 16:865-73. 2007
    ..This is a missense mutation in the galanin-like peptide precursor gene (P = 0.00005, OR = 1.2, false positive rate = 0.87)...
  101. ncbi request reprint Educational differences in the dynamics of disability incidence, recovery and mortality: Findings from the MRC Cognitive Function and Ageing Study (MRC CFAS)
    Carol Jagger
    Leicester Nuffield Research Unit, Department of Health Sciences, University of Leicester, Leicester, UK
    Int J Epidemiol 36:358-65. 2007
    ....