Affiliation: University of Oxford
Braun M, Wendt A, Karanauskaite J, Galvanovskis J, Clark A, MacDonald P, et al
. Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic beta cells. J Gen Physiol. 2007;129:221-31 pubmed
Braun M, Ramracheya R, Bengtsson M, Clark A, Walker J, Johnson P, et al
. Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells. Diabetes. 2010;59:1694-701 pubmed publisher
..The presence of GABA(A)R in non-beta-cells suggests that GABA may also be involved in the regulation of somatostatin and glucagon secretion. ..
Braun M, Ramracheya R, Amisten S, Bengtsson M, Moritoh Y, Zhang Q, et al
. Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells. Diabetologia. 2009;52:1566-78 pubmed publisher
..1/2.2 K(+) channels. Exocytosis is tightly linked to Ca(2+)-influx via P/Q-type Ca(2+) channels. Glucose stimulation of somatostatin secretion involves both K(ATP) channel-dependent and -independent processes. ..
Ramracheya R, Ward C, Shigeto M, Walker J, Amisten S, Zhang Q, et al
. Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets. Diabetes. 2010;59:2198-208 pubmed publisher
..We propose that voltage-dependent inactivation of these channels underlies the inhibition of glucagon secretion by tolbutamide and glucose. ..