M D Brand

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Regulation analysis of energy metabolism
    M D Brand
    Department of Biochemistry, University of Cambridge, UK
    J Exp Biol 200:193-202. 1997
  2. pmc Treatment of rats with glucagon or mannoheptulose increases mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase activity and decreases succinyl-CoA content in liver
    P A Quant
    Department of Biochemistry, University of Cambridge, U K
    Biochem J 262:159-64. 1989
  3. ncbi request reprint The sum of flux control coefficients in the electron-transport chain of mitochondria
    M D Brand
    Department of Biochemistry, University of Cambridge, England
    Eur J Biochem 226:819-29. 1994
  4. pmc The effect of chloroform on mitochondrial energy transduction
    L F Chien
    Department of Biochemistry, University of Cambridge, U K
    Biochem J 320:837-45. 1996
  5. ncbi request reprint Effects of the mitogen concanavalin A on pathways of thymocyte energy metabolism
    S Krauss
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK
    Biochim Biophys Acta 1412:129-38. 1999
  6. ncbi request reprint Stimulation of the electron transport chain in mitochondria isolated from rats treated with mannoheptulose or glucagon
    M D Brand
    Department of Biochemistry, University of Cambridge, England
    Arch Biochem Biophys 283:278-84. 1990
  7. ncbi request reprint The effect of metabolic depression on proton leak rate in mitochondria from hibernating frogs
    J St-Pierre
    Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK
    J Exp Biol 203:1469-76. 2000
  8. ncbi request reprint The significance and mechanism of mitochondrial proton conductance
    M D Brand
    Department of Biochemistry, University of Cambridge, UK
    Int J Obes Relat Metab Disord 23:S4-11. 1999
  9. ncbi request reprint Glucagon activates mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in vivo by decreasing the extent of succinylation of the enzyme
    P A Quant
    Department of Biochemistry, University of Cambridge, England
    Eur J Biochem 187:169-74. 1990
  10. ncbi request reprint The proton permeability of the inner membrane of liver mitochondria from ectothermic and endothermic vertebrates and from obese rats: correlations with standard metabolic rate and phospholipid fatty acid composition
    P S Brookes
    Department of Biochemistry, University of Cambridge, UK
    Comp Biochem Physiol B Biochem Mol Biol 119:325-34. 1998

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Regulation analysis of energy metabolism
    M D Brand
    Department of Biochemistry, University of Cambridge, UK
    J Exp Biol 200:193-202. 1997
    ....
  2. pmc Treatment of rats with glucagon or mannoheptulose increases mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase activity and decreases succinyl-CoA content in liver
    P A Quant
    Department of Biochemistry, University of Cambridge, U K
    Biochem J 262:159-64. 1989
    ..They support the hypothesis that the formation of ketone bodies from acetyl-CoA may be regulated by the extent of succinylation of mitochondrial HMG-CoA synthase...
  3. ncbi request reprint The sum of flux control coefficients in the electron-transport chain of mitochondria
    M D Brand
    Department of Biochemistry, University of Cambridge, England
    Eur J Biochem 226:819-29. 1994
    ..Both definitions are valid, but they give different information. It is important to be aware of which definition is being used when analysing control coefficients in electron-transport chains and other group-transfer systems...
  4. pmc The effect of chloroform on mitochondrial energy transduction
    L F Chien
    Department of Biochemistry, University of Cambridge, U K
    Biochem J 320:837-45. 1996
    ..We conclude that chloroform changes the measured H+/O as an artifact by causing mitochondrial breakage and does not cause measurable redox slip, whereas TMPD genuinely lowers H+/O...
  5. ncbi request reprint Effects of the mitogen concanavalin A on pathways of thymocyte energy metabolism
    S Krauss
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK
    Biochim Biophys Acta 1412:129-38. 1999
    ....
  6. ncbi request reprint Stimulation of the electron transport chain in mitochondria isolated from rats treated with mannoheptulose or glucagon
    M D Brand
    Department of Biochemistry, University of Cambridge, England
    Arch Biochem Biophys 283:278-84. 1990
    ..The kinetics of electron transport through the cytochrome bc1 complex were not affected. Effects on cytochrome c oxidase were small or nonexistent...
  7. ncbi request reprint The effect of metabolic depression on proton leak rate in mitochondria from hibernating frogs
    J St-Pierre
    Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK
    J Exp Biol 203:1469-76. 2000
    ....
  8. ncbi request reprint The significance and mechanism of mitochondrial proton conductance
    M D Brand
    Department of Biochemistry, University of Cambridge, UK
    Int J Obes Relat Metab Disord 23:S4-11. 1999
    ..UCP1 catalyses a regulated inducible proton conductance in brown adipose tissue and the possibility remains open that UCP2 and UCP3 have a similar role in other tissues, although this has yet to be demonstrated...
  9. ncbi request reprint Glucagon activates mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in vivo by decreasing the extent of succinylation of the enzyme
    P A Quant
    Department of Biochemistry, University of Cambridge, England
    Eur J Biochem 187:169-74. 1990
    ..This may be an important control mechanism in ketogenesis...
  10. ncbi request reprint The proton permeability of the inner membrane of liver mitochondria from ectothermic and endothermic vertebrates and from obese rats: correlations with standard metabolic rate and phospholipid fatty acid composition
    P S Brookes
    Department of Biochemistry, University of Cambridge, UK
    Comp Biochem Physiol B Biochem Mol Biol 119:325-34. 1998
    ....
  11. ncbi request reprint The responses of rat hepatocytes to glucagon and adrenaline. Application of quantified elasticity analysis
    E K Ainscow
    Department of Biochemistry, University of Cambridge, UK
    Eur J Biochem 265:1043-55. 1999
    ..Conversely, it could be seen that the failure of adrenaline to maintain a constant glucose 6-phosphate concentration was due to the stimulation of glycogen breakdown and inhibition of glucose release...
  12. ncbi request reprint Mitochondrial matrix reactive oxygen species production is very sensitive to mild uncoupling
    S Miwa
    MRC Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, U K
    Biochem Soc Trans 31:1300-1. 2003
    ..Thus mild uncoupling may be particularly significant for ROS production from complex I on the matrix side of the mitochondrial inner membrane...
  13. ncbi request reprint Extracting meaning from microarray data
    R K Curtis
    MRC Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, U K
    Biochem Soc Trans 31:1474-5. 2003
    ..The application of modular control analysis to microarray data in order to partition and quantify the importance of mRNA clusters in mediating responses is described...
  14. ncbi request reprint Quantitation of signal transduction
    S Krauss
    Department of Biochemistry, University of Cambridge, Cambridge, UK
    FASEB J 14:2581-8. 2000
    ..The approach allows a quantitative description of the relative importance of signal transduction pathways and the routes by which they activate a specific cellular process. It should be widely applicable...
  15. ncbi request reprint Processes contributing to metabolic depression in hepatopancreas cells from the snail Helix aspersa
    T Bishop
    MRC Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    J Exp Biol 203:3603-12. 2000
    ..Thus, the fraction of cellular respiration devoted to different processes remained constant and the cellular energy balance was preserved in the hypometabolic state...
  16. ncbi request reprint Uncoupling to survive? The role of mitochondrial inefficiency in ageing
    M D Brand
    MRC Dunn Human Nutrition Unit, Hills Road, CB2 2XY, Cambridge, UK
    Exp Gerontol 35:811-20. 2000
    ..However, to date there is no direct evidence in cells or organisms that mitochondrial proton cycling lowers ROS production or oxidative damage or that it increases lifespan...
  17. ncbi request reprint The efficiency and plasticity of mitochondrial energy transduction
    M D Brand
    MRC Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    Biochem Soc Trans 33:897-904. 2005
    ..UCPs may also integrate inputs from different fuels in pancreatic beta-cells and modulate insulin secretion. They are exciting potential targets for treatment of obesity, cachexia, aging and diabetes...
  18. pmc Mitochondria as ATP consumers: cellular treason in anoxia
    J St-Pierre
    Department of Zoology, University of Cambridge, Cambridge, England CB2 3EJ
    Proc Natl Acad Sci U S A 97:8670-4. 2000
    ..However, ATP use by the F(1)F(0)-ATPase is limited in anoxia by a profound inhibition of the enzyme. Even so, ATP use by the F(1)F(0)-ATPase might account for approximately 9% of the ATP turnover in anoxic frog skeletal muscle...
  19. ncbi request reprint Uncoupling protein 2 from carp and zebrafish, ectothermic vertebrates
    J A Stuart
    Department of Biochemistry, University of Cambridge, UK
    Biochim Biophys Acta 1413:50-4. 1999
    ..Carp and zebrafish are ectotherms--they do not raise their body temperatures above ambient by producing excess heat. The presence of UCP2 in these fish thus suggests the protein may have function(s) not related to thermogenesis...
  20. pmc AMP decreases the efficiency of skeletal-muscle mitochondria
    S Cadenas
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK
    Biochem J 351:307-11. 2000
    ..AMP activation of ANT could be important for physiological regulation of metabolic rate...
  21. ncbi request reprint Intrinsic metabolic depression in cells isolated from the hepatopancreas of estivating snails
    M Guppy
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK
    FASEB J 14:999-1004. 2000
    ..This suggests that pH and state change affect metabolic depression by similar mechanisms but that the metabolic depression by hypoxia involves a separate mechanism...
  22. ncbi request reprint Top down metabolic control analysis
    M D Brand
    Department of Biochemistry, University of Cambridge, U K
    J Theor Biol 182:351-60. 1996
    ..It discusses the ways the approach has been used in organelles and cells to identify the sites of action of effectors, to measure the distribution of control by blocks of reactions, and to measure regulation by effectors...
  23. ncbi request reprint Respiration rate of hepatocytes varies with body mass in birds
    Paul L Else
    Department of Biomedical Science, Metabolic Research Centre, University of Wollongong, Wollongong, NSW 2522, Australia
    J Exp Biol 207:2305-11. 2004
    ..These results are discussed in the context of competing theories to explain the metabolism-body size allometry, and are found to support the 'allometric cascade' model...
  24. ncbi request reprint Proton leak in hepatocytes and liver mitochondria from archosaurs (crocodiles) and allometric relationships for ectotherms
    A J Hulbert
    Metabolic Research Centre and Department of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia
    J Comp Physiol B 172:387-97. 2002
    ..2, similar to the exponent in mammalian hepatocytes. However, unlike mammals, liver mitochondrial proton conductance in ectotherms showed no allometric relationship with body size...
  25. ncbi request reprint Mitochondrial uncoupling as a target for drug development for the treatment of obesity
    J A Harper
    MRC Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    Obes Rev 2:255-65. 2001
    ..Specific uncoupling of muscle or brown adipocyte mitochondria remains an attractive target for the development of antiobesity drugs...
  26. ncbi request reprint Structure and function of mitochondria in hepatopancreas cells from metabolically depressed snails
    T Bishop
    Medical Research Council, Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, United Kingdom
    Physiol Biochem Zool 75:134-44. 2002
    ..Thus the lower mitochondrial respiration rate in hepatopancreas cells from aestivating snails was not caused by differences in mitochondrial volume or surface density but was associated with intrinsic changes in the mitochondria...
  27. ncbi request reprint Coenzyme Q induces GDP-sensitive proton conductance in kidney mitochondria
    K S Echtay
    MRC Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    Biochem Soc Trans 29:763-8. 2001
    ..We conclude that CoQ acted in mitochondria through production of superoxide, which mediated uncoupling, probably by acting through uncoupling protein 2...
  28. ncbi request reprint Physiological levels of mammalian uncoupling protein 2 do not uncouple yeast mitochondria
    J A Stuart
    Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, United Kingdom
    J Biol Chem 276:18633-9. 2001
    ..These observations suggest that uncoupling of yeast mitochondria by UCP2 is an overexpression artifact leading to compromised mitochondrial integrity...
  29. ncbi request reprint Mitochondrial proton leak and the uncoupling protein 1 homologues
    J A Stuart
    MRC Dunn Human Nutrition Unit, Cambridge, UK
    Biochim Biophys Acta 1504:144-58. 2001
    ..The physiological role of the proton leak, and of the uncoupling protein 1 homologues, remains similarly unclear...
  30. ncbi request reprint Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
    J C Clapham
    Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK
    Nature 406:415-8. 2000
    ..This provides evidence that skeletal muscle UCP-3 has the potential to influence metabolic rate and glucose homeostasis in the whole animal...