S R Bramhall

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. pmc Marimastat as maintenance therapy for patients with advanced gastric cancer: a randomised trial
    S R Bramhall
    Department of Surgery, Queen Elizabeth Hospital, Birmingham, UK
    Br J Cancer 86:1864-70. 2002
  2. ncbi request reprint Novel non-operative treatment and treatment strategies in pancreatic cancer
    S R Bramhall
    Department of Surgery, Queen Elizabeth Hospital, Birmingham, B15 2TH, UK
    Expert Opin Investig Drugs 9:1179-95. 2000
  3. pmc A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer
    S R Bramhall
    Department of Surgery, Liver Unit, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Br J Cancer 87:161-7. 2002
  4. ncbi request reprint Liver transplantation in the UK
    S R Bramhall
    Department of Surgery, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    World J Gastroenterol 7:602-11. 2001
  5. ncbi request reprint Marimastat as first-line therapy for patients with unresectable pancreatic cancer: a randomized trial
    S R Bramhall
    Liver Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom
    J Clin Oncol 19:3447-55. 2001
  6. pmc Specialist outreach service for on-table repair of iatrogenic bile duct injuries--a new kind of 'travelling surgeon'
    M A Silva
    The Liver Unit, Queen Elizabeth Hospital, Birmingham, UK
    Ann R Coll Surg Engl 90:243-6. 2008
  7. ncbi request reprint Orthotopic liver transplantation for epithelioid haemangioendothelioma
    W Zhang
    Department of Liver Surgery, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Birmingham, UK
    Eur J Surg Oncol 33:898-901. 2007
  8. ncbi request reprint Effect of preoperative chemotherapy on liver resection for colorectal liver metastases
    N N Mehta
    Hepato biliary pancreatic Surgery and Liver Transplant Unit, Nuffield House, Queen Elizabeth Hospital, Edgbaston, Birmingham B152TH, UK
    Eur J Surg Oncol 34:782-6. 2008
  9. ncbi request reprint Role of completion pancreatectomy as a damage control option for post-pancreatic surgical complications
    A Tamijmarane
    Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
    Dig Surg 23:229-34. 2006
  10. doi request reprint Cholangiocarcinoma complicating primary sclerosing cholangitis: a 24-year experience
    G Morris-Stiff
    Department of Hepatobiliary and Liver Transplant Surgery, Queen Elizabeth Hospital, Birmingham, UK
    Dig Surg 25:126-32. 2008

Collaborators

Detail Information

Publications34

  1. pmc Marimastat as maintenance therapy for patients with advanced gastric cancer: a randomised trial
    S R Bramhall
    Department of Surgery, Queen Elizabeth Hospital, Birmingham, UK
    Br J Cancer 86:1864-70. 2002
    ..The greatest benefit was observed in patients who had previously received chemotherapy. A further randomised study of marimastat in these patients is warranted...
  2. ncbi request reprint Novel non-operative treatment and treatment strategies in pancreatic cancer
    S R Bramhall
    Department of Surgery, Queen Elizabeth Hospital, Birmingham, B15 2TH, UK
    Expert Opin Investig Drugs 9:1179-95. 2000
    ..Each of these treatments and treatment regimens are discussed along with their current progress...
  3. pmc A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer
    S R Bramhall
    Department of Surgery, Liver Unit, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Br J Cancer 87:161-7. 2002
    ..The combination of marimastat with gemcitabine was well tolerated. Further studies of marimastat as a maintenance treatment following a response or stable disease on gemcitabine may be justified...
  4. ncbi request reprint Liver transplantation in the UK
    S R Bramhall
    Department of Surgery, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    World J Gastroenterol 7:602-11. 2001
    ..This paper provides a review of the practice of liver transplantation with the main emphasis on UK practice and indications for transplantation...
  5. ncbi request reprint Marimastat as first-line therapy for patients with unresectable pancreatic cancer: a randomized trial
    S R Bramhall
    Liver Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom
    J Clin Oncol 19:3447-55. 2001
    ..This, the largest randomized study in pancreatic cancer performed to date, compares marimastat, the first of a new class of agents, with gemcitabine...
  6. pmc Specialist outreach service for on-table repair of iatrogenic bile duct injuries--a new kind of 'travelling surgeon'
    M A Silva
    The Liver Unit, Queen Elizabeth Hospital, Birmingham, UK
    Ann R Coll Surg Engl 90:243-6. 2008
    ..The objective of this study was to determine the outcome of on table repair of iatrogenic bile duct injuries (IBDIs) following laparoscopic cholecystectomy, by specialist hepatobiliary surgeons as an outreach service...
  7. ncbi request reprint Orthotopic liver transplantation for epithelioid haemangioendothelioma
    W Zhang
    Department of Liver Surgery, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Birmingham, UK
    Eur J Surg Oncol 33:898-901. 2007
    ..To report seven cases of epithelioid haemangioendothelioma (EHE) of the liver, a rare, low-grade malignant neoplasm of vascular origin that have been treated in our institution...
  8. ncbi request reprint Effect of preoperative chemotherapy on liver resection for colorectal liver metastases
    N N Mehta
    Hepato biliary pancreatic Surgery and Liver Transplant Unit, Nuffield House, Queen Elizabeth Hospital, Edgbaston, Birmingham B152TH, UK
    Eur J Surg Oncol 34:782-6. 2008
    ..To compare the effects of preoperative chemotherapy on liver parenchyma morphology, as well as morbidity and mortality after liver resection for colorectal liver metastases...
  9. ncbi request reprint Role of completion pancreatectomy as a damage control option for post-pancreatic surgical complications
    A Tamijmarane
    Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
    Dig Surg 23:229-34. 2006
    ..Management of pancreatic leak and haemorrhage is complex with high mortality rates. In this study, the results of completion pancreatectomy which was performed as a last resort option were analysed...
  10. doi request reprint Cholangiocarcinoma complicating primary sclerosing cholangitis: a 24-year experience
    G Morris-Stiff
    Department of Hepatobiliary and Liver Transplant Surgery, Queen Elizabeth Hospital, Birmingham, UK
    Dig Surg 25:126-32. 2008
    ..To report the prevalence and outcome of cholangiocarcinoma arising in primary sclerosing cholangitis for a British tertiary referral centre...
  11. ncbi request reprint Neuroendocrine tumours of the pancreas: predictors of survival after surgical treatment
    N P Jarufe
    The Liver Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
    Dig Surg 22:157-62. 2005
    ..Neuroendocrine tumours of pancreatic and duodenal origin (NETP) are rare and we present a significant experience from a single centre...
  12. ncbi request reprint Surgery for hilar cholangiocarcinoma; a 10 year experience of a tertiary referral centre in the UK
    M A Silva
    The Liver Unit, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, 3rd Floor, Nuffield House, Edgbaston, Birmingham B15 2TH, UK
    Eur J Surg Oncol 31:533-9. 2005
    ..To review the outcome of patients operated for hilar cholangiocarcinoma and analyse prognostic variables...
  13. ncbi request reprint Surgical treatment of metastases to the pancreas
    N Jarufe
    The Liver and Hepatobiliary Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
    Surgeon 3:79-83. 2005
    ..Metastases to the pancreas are rare and their surgical treatment is not well reported. We present a considerable experience from a single centre analysing various prognostic factors...
  14. doi request reprint Risk factors for litigation following major transectional bile duct injury sustained at laparoscopic cholecystectomy
    M T P R Perera
    The Liver Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, UK
    World J Surg 34:2635-41. 2010
    ..The present study aimed to analyze risk factors for litigation and to quantify the subsequent medicolegal burden...
  15. doi request reprint Laparoscopic posterior sectoral bile duct injury: the emerging role of nonoperative management with improved long-term results after delayed diagnosis
    M T P R Perera
    The Liver Unit, University Hospital Birmingham, Queen Elizabeth NHS Trust, Edgbaston, Birmingham, B15 2TH, UK
    Surg Endosc 25:2684-91. 2011
    ..Paucity of data on the management of these injuries led the authors to conduct this study aimed at reviewing management strategies for laparoscopic RPSD injuries at a specialist center...
  16. ncbi request reprint The use of liver grafts from donors with bacterial meningitis
    S Satoi
    The Liver and Hepatobiliary Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    Transplantation 72:1108-13. 2001
    ..05). CONCLUSION: Liver transplantation from donors with bacterial meningitis is a safe procedure provided both donors and recipients receive adequate antimicrobial therapy...
  17. doi request reprint Liver resection for metastatic soft tissue sarcoma: an analysis of prognostic factors
    R Marudanayagam
    Department of Hepatobiliary and Transplantation Surgery, Liver Unit, Queen Elizabeth Hospital, University Hospital of Birmingham NHS Foundation Trust, Birmingham, UK
    Eur J Surg Oncol 37:87-92. 2011
    ..The aim of this retrospective study was to analyse the outcome following hepatic resection for metastatic STS and to identify factors predicting survival...
  18. ncbi request reprint Favourable prognostic factors in a large UK experience of adenocarcinoma of the head of the pancreas and periampullary region
    N P Jarufe
    The Liver Unit, Queen Elizabeth Hospital, Birmingham, UK
    Dig Surg 21:202-9. 2004
    ..To present the surgical experience in a regional unit, analysing the post-operative outcome, and determining risk factors for survival after pancreaticoduodenectomy for periampullary and pancreatic head carcinoma...
  19. pmc Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease
    S R Bramhall
    Department of Surgery, City Hospital NHS Trust Birmingham, UK
    Br J Cancer 73:972-8. 1996
    ..02) and there was an association between increased immunoreactivity for MMP2 and the degree of tumour differentiation (P < 0.01). The results implicate MMP2, MMP3 and TIMP1 in the invasive phenotype of pancreatic and ampullary cancer...
  20. pmc Liver resection for colorectal metastases
    S R Bramhall
    The Liver Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
    Ann R Coll Surg Engl 85:334-9. 2003
    ..The improved outcome suggests that more patients could benefit from resection if more was known of what criteria are predictive of a good outcome...
  21. doi request reprint Use of bioelectrical impedance analysis to assess liver steatosis
    C S Bhati
    Liver Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom
    Transplant Proc 41:1677-81. 2009
    ..Our hypothesis was that liver steatosis would result in an increased resistance to current flow, and correlate with the degree of liver steatosis...
  22. ncbi request reprint Haemorrhage following pancreaticoduodenectomy: risk factors and the importance of sentinel bleed
    I Koukoutsis
    Liver Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
    Dig Surg 23:224-8. 2006
    ..To document the prevalence and to evaluate the management strategies of haemorrhagic complications following pancreaticoduodenectomy (PD)...
  23. ncbi request reprint Treatment of hydatid disease of the liver. Evaluation of a UK experience
    M A Silva
    The Liver Unit, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Edgbaston, Birmingham, UK
    Dig Surg 21:227-33; discussion 233-4. 2004
    ..Hydatid disease of the liver though endemic in many countries, is rare in the UK. We evaluated a 16-year experience of treating hydatidosis using a management protocol combining surgery with anti-scolicidals...
  24. doi request reprint Asymptomatic transmission of Treponema pallidum (syphilis) through deceased donor liver transplantation
    L Tariciotti
    The Liver Unit, Department of Microbiology, Queen Elizabeth Hospital, Birmingham, UK
    Transpl Infect Dis 14:321-5. 2012
    ..This report supplements the existing limited evidence on safe use of infected grafts from syphilitic donors through appropriate post-exposure prophylaxis...
  25. doi request reprint An unusual case of duodenal obstruction-gangliocytic paraganglioma
    C M Mann
    West Midlands Liver Unit, Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust, Birmingham, B15 2TH, UK
    J Hepatobiliary Pancreat Surg 16:562-5. 2009
    ..We discuss the management of this unusual case and review the literature...
  26. doi request reprint Antiangiogenic therapy and surgical practice
    A R John
    Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK
    Br J Surg 95:281-93. 2008
    ..Antiangiogenic therapy has become a reality with the recent introduction of bevacizumab, a monoclonal antibody against vascular endothelial growth factor...
  27. ncbi request reprint Diabetic control after total pancreatectomy
    P Jethwa
    The Liver Unit, Queen Elizabeth Hospital, University of Birmingham, Edgbaston, Birmingham B15 2TH, United Kingdom
    Dig Liver Dis 38:415-9. 2006
    ..The aim of this study was to determine glycaemic control in patients resected for benign and malignant disease...
  28. ncbi request reprint A tale of three spilled gall stones: one liver mass and two abscesses
    C S Bhati
    Queen Elizabeth Hospital, Birmingham, UK
    Dig Surg 23:198-200. 2006
    ..We recommend that every attempt should be made to avoid gall-bladder perforation during dissection; if this happens every effort should be made to remove the spilled stones...
  29. pmc Modelling prognostic factors in advanced pancreatic cancer
    D D Stocken
    Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, UK
    Br J Cancer 99:883-93. 2008
    ..The functional form of the relationship between continuous covariates and survival should always be assessed. Our model should aid individual patient risk stratification and the design and analysis of future trials in pancreatic cancer...
  30. ncbi request reprint Imbalance of expression of matrix metalloproteinases (MMPs) and tissue inhibitors of the matrix metalloproteinases (TIMPs) in human pancreatic carcinoma
    S R Bramhall
    Department of Surgery, City Hospital NHS Trust, Birmingham, U K
    J Pathol 182:347-55. 1997
    ....
  31. ncbi request reprint A 10-year experience of complex liver trauma
    R D Brammer
    Liver Unit, Department of Surgery, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Br J Surg 89:1532-7. 2002
    ..It is likely that surgeons outside specialist centres will have limited experience in its management; therefore best practice should be identified and a specialist approach developed...
  32. pmc Endostatin expression in a pancreatic cell line is modulated by a TNFalpha-dependent elastase
    R D Brammer
    Division of Medical Sciences, University of Birmingham, Birmingham B15 2TT, UK
    Br J Cancer 93:1024-8. 2005
    ..Endostatin is however susceptible to degradation by intracellular proteases and if tissue injury accompanies inflammation, endostatin may be degraded, allowing angiogenesis to occur...
  33. pmc Endostatin expression in pancreatic tissue is modulated by elastase
    R D Brammer
    Division of Medical Sciences, University of Birmingham, Birmingham B15 2TT, UK
    Br J Cancer 92:89-93. 2005
    ..The stability of endostatin may have implications for its therapeutic use...
  34. ncbi request reprint Letter 1: Systematic review of outcome of synchronous portal-superior mesenteric vein resection during pancreatectomy for cancer (Br J Surg 2006; 93: 662-673)
    J A C Buckels
    Br J Surg 93:1303; author reply 1304. 2006