N Bown

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint Gain of chromosome arm 17q and adverse outcome in patients with neuroblastoma
    N Bown
    Department of Human Genetics, University of Newcastle upon Tyne, United Kingdom
    N Engl J Med 340:1954-61. 1999
  2. ncbi request reprint 17q gain in neuroblastoma predicts adverse clinical outcome. U.K. Cancer Cytogenetics Group and the U.K. Children's Cancer Study Group
    N Bown
    Department of Human Genetics, University of Newcastle upon Tyne, United Kingdom
    Med Pediatr Oncol 36:14-9. 2001
  3. ncbi request reprint Comprehensive genetic and histopathologic study reveals three types of neuroblastoma tumors
    M Lastowska
    Human Genetics Unit, School of Biochemistry and Genetics, University of Newcastle upon Tyne, United Kingdom
    J Clin Oncol 19:3080-90. 2001
  4. ncbi request reprint Molecular cytogenetic definition of 17q translocation breakpoints in neuroblastoma
    M Lastowska
    Department of Human Genetics, University of Newcastle upon Tyne, United Kingdom
    Med Pediatr Oncol 36:20-3. 2001
  5. ncbi request reprint Jumping translocation at 11q23 with MLL gene rearrangement and interstitial telomeric sequences
    G Cuthbert
    Department of Human Genetics, University of Newcastle upon Tyne, England
    Genes Chromosomes Cancer 24:295-8. 1999
  6. ncbi request reprint Sensitivity of FISH in detection of MLL translocations
    G Cuthbert
    School of Biochemistry and Genetics, University of Newcastle upon Tyne, United Kingdom
    Genes Chromosomes Cancer 29:180-5. 2000
  7. pmc Acute lymphoblastic leukaemia of the L3 subtype in adults in the Northern health region of England 1983-99
    M R Velangi
    Department of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    J Clin Pathol 55:591-5. 2002
  8. ncbi request reprint Donor lymphocyte infusions for post-transplant relapse of refractory anemia with excess blasts and monosomy 7
    R Skinner
    Department of Paediatric and Adolescent Oncology, and Children s BMT Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom
    Pediatr Blood Cancer 50:670-2. 2008
  9. pmc Erythroleukaemia in the north of England: a population based study
    A W Wells
    Department of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    J Clin Pathol 54:608-12. 2001

Detail Information

Publications9

  1. ncbi request reprint Gain of chromosome arm 17q and adverse outcome in patients with neuroblastoma
    N Bown
    Department of Human Genetics, University of Newcastle upon Tyne, United Kingdom
    N Engl J Med 340:1954-61. 1999
    ..We investigated these associations and evaluated the prognostic importance of the status of chromosome 17...
  2. ncbi request reprint 17q gain in neuroblastoma predicts adverse clinical outcome. U.K. Cancer Cytogenetics Group and the U.K. Children's Cancer Study Group
    N Bown
    Department of Human Genetics, University of Newcastle upon Tyne, United Kingdom
    Med Pediatr Oncol 36:14-9. 2001
    ..We sought to further investigate the clinical and prognostic associations of chromosome 17 status in relation to other well-established predictive factors...
  3. ncbi request reprint Comprehensive genetic and histopathologic study reveals three types of neuroblastoma tumors
    M Lastowska
    Human Genetics Unit, School of Biochemistry and Genetics, University of Newcastle upon Tyne, United Kingdom
    J Clin Oncol 19:3080-90. 2001
    ..To determine the relationship between multiple genetic features, tumor morphology, and prognosis in neuroblastoma...
  4. ncbi request reprint Molecular cytogenetic definition of 17q translocation breakpoints in neuroblastoma
    M Lastowska
    Department of Human Genetics, University of Newcastle upon Tyne, United Kingdom
    Med Pediatr Oncol 36:20-3. 2001
    ..CONCLUSION: These results suggest that the dosage of a gene, or genes, in 17q22-qter is responsible for the clinical effects of 17q gain, rather than the disruption of a specific gene...
  5. ncbi request reprint Jumping translocation at 11q23 with MLL gene rearrangement and interstitial telomeric sequences
    G Cuthbert
    Department of Human Genetics, University of Newcastle upon Tyne, England
    Genes Chromosomes Cancer 24:295-8. 1999
    ..Southern blot analysis of the MLL breakpoint cluster region showed the presence of an MLL gene rearrangement. Jumping translocation with MLL gene rearrangement is a previously unreported phenomenon in leukemia cytogenetics...
  6. ncbi request reprint Sensitivity of FISH in detection of MLL translocations
    G Cuthbert
    School of Biochemistry and Genetics, University of Newcastle upon Tyne, United Kingdom
    Genes Chromosomes Cancer 29:180-5. 2000
    ..Therefore, we conclude that the Oncor MLL FISH probe has a 9.1% false negative rate, i.e., 90.9% sensitivity in detection of classic MLL translocations. Vysis MLL FISH detected the rearrangement in all 33 cases...
  7. pmc Acute lymphoblastic leukaemia of the L3 subtype in adults in the Northern health region of England 1983-99
    M R Velangi
    Department of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    J Clin Pathol 55:591-5. 2002
    ..This paper describes a series from a population based study of 24 patients with L3 ALL presenting over 17 years...
  8. ncbi request reprint Donor lymphocyte infusions for post-transplant relapse of refractory anemia with excess blasts and monosomy 7
    R Skinner
    Department of Paediatric and Adolescent Oncology, and Children s BMT Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom
    Pediatr Blood Cancer 50:670-2. 2008
    ..This case suggests that DLI and graft-versus-myelodysplasia (GVMDS) may be beneficial in post-transplant relapse of pediatric myelodysplasia...
  9. pmc Erythroleukaemia in the north of England: a population based study
    A W Wells
    Department of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    J Clin Pathol 54:608-12. 2001
    ..005). CONCLUSION: This study demonstrates a worse survival for patients with erythroleukaemia than that reported in some published trials of selected patients...