Research Topics
Species | N BownSummaryAffiliation: University of Newcastle Country: UK Publications
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Detail Information
Publications
Cytogenetic abnormalities and clinical outcome in Wilms tumor: a study by the U.K. cancer cytogenetics group and the U.K. Children's Cancer Study GroupNick Bown
School of Biochemistry and Genetics, University of Newcastle upon Tyne, United Kingdom
Med Pediatr Oncol 38:11-21. 2002..Identification of markers associated with elevated risk of relapse and fatal outcome could allow more effective treatment stratification at presentation...
Neuroblastoma tumour genetics: clinical and biological aspectsN Bown
School of Biochemistry and Genetics, University of Newcastle upon Tyne Northern Genetics Service, Royal Victoria Infirmary, 19 20 Claremont Place, Newcastle upon Tyne NE2 4AA, UK
J Clin Pathol 54:897-910. 2001..Reliable detection of these molecular cytogenetic features should be regarded as mandatory for all new cases at presentation...- Comprehensive genetic and histopathologic study reveals three types of neuroblastoma tumorsM Lastowska
Human Genetics Unit, School of Biochemistry and Genetics, University of Newcastle upon Tyne, United Kingdom
J Clin Oncol 19:3080-90. 2001..To determine the relationship between multiple genetic features, tumor morphology, and prognosis in neuroblastoma... - Gain of chromosome arm 17q and adverse outcome in patients with neuroblastomaN Bown
Department of Human Genetics, University of Newcastle upon Tyne, United Kingdom
N Engl J Med 340:1954-61. 1999..We investigated these associations and evaluated the prognostic importance of the status of chromosome 17... - 17q gain in neuroblastoma predicts adverse clinical outcome. U.K. Cancer Cytogenetics Group and the U.K. Children's Cancer Study GroupN Bown
Department of Human Genetics, University of Newcastle upon Tyne, United Kingdom
Med Pediatr Oncol 36:14-9. 2001..We sought to further investigate the clinical and prognostic associations of chromosome 17 status in relation to other well-established predictive factors... - Sensitivity of FISH in detection of MLL translocationsG Cuthbert
School of Biochemistry and Genetics, University of Newcastle upon Tyne, United Kingdom
Genes Chromosomes Cancer 29:180-5. 2000..Therefore, we conclude that the Oncor MLL FISH probe has a 9.1% false negative rate, i.e., 90.9% sensitivity in detection of classic MLL translocations. Vysis MLL FISH detected the rearrangement in all 33 cases... - Jumping translocation at 11q23 with MLL gene rearrangement and interstitial telomeric sequencesG Cuthbert
Department of Human Genetics, University of Newcastle upon Tyne, England
Genes Chromosomes Cancer 24:295-8. 1999..Southern blot analysis of the MLL breakpoint cluster region showed the presence of an MLL gene rearrangement. Jumping translocation with MLL gene rearrangement is a previously unreported phenomenon in leukemia cytogenetics... - Donor lymphocyte infusions for post-transplant relapse of refractory anemia with excess blasts and monosomy 7R Skinner
Department of Paediatric and Adolescent Oncology, and Children s BMT Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom
Pediatr Blood Cancer 50:670-2. 2008..This case suggests that DLI and graft-versus-myelodysplasia (GVMDS) may be beneficial in post-transplant relapse of pediatric myelodysplasia... - Acute lymphoblastic leukaemia of the L3 subtype in adults in the Northern health region of England 1983-99M R Velangi
Department of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
J Clin Pathol 55:591-5. 2002..This paper describes a series from a population based study of 24 patients with L3 ALL presenting over 17 years... - Molecular cytogenetic definition of 17q translocation breakpoints in neuroblastomaM Lastowska
Department of Human Genetics, University of Newcastle upon Tyne, United Kingdom
Med Pediatr Oncol 36:20-3. 2001..CONCLUSION: These results suggest that the dosage of a gene, or genes, in 17q22-qter is responsible for the clinical effects of 17q gain, rather than the disruption of a specific gene... - Erythroleukaemia in the north of England: a population based studyA W Wells
Department of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
J Clin Pathol 54:608-12. 2001..005). CONCLUSION: This study demonstrates a worse survival for patients with erythroleukaemia than that reported in some published trials of selected patients... - Unequivocal delineation of clinicogenetic subgroups and development of a new model for improved outcome prediction in neuroblastomaJo Vandesompele
Center for Medical Genetics Ghent CMGG, Ghent University Hospital, MRB, De Pintelaan 185, B 9000 Ghent, Belgium
J Clin Oncol 23:2280-99. 2005..In this study, we aimed for comprehensive genetic subgroup discovery and assessment of independent prognostic markers based on genome-wide aberrations detected by comparative genomic hybridization (CGH)... - Abnormal constitutional karyotypes in patients with neuroblastoma: a report of four new cases and review of 47 others in the literatureDaniel Satgé
Laboratory of Pathology, Centre Hospitalier, 19000 Tulle, France
Cancer Genet Cytogenet 147:89-98. 2003..A search for genes implicated in neuroblastoma biology should use these data... - Imatinib improves but may not fully reverse the poor prognosis of patients with CML with derivative chromosome 9 deletionsBrian J P Huntly
Bone Marrow Transplantation/Leukemia, Oregon Health and Science University, Portland, OR
Blood 102:2205-12. 2003..04), for major cytogenetic response (P =.008) in chronic phase, and for hematologic response in advanced phases (P =.007) of CML. This finding suggests that differences in survival may become apparent with longer follow-up... - Breakpoint position on 17q identifies the most aggressive neuroblastoma tumorsMaria Łastowska
Institute of Human Genetics, International Centre for Life, University of Newcastle upon Tyne, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
Genes Chromosomes Cancer 34:428-36. 2002..1 and 17qter acting to promote tumor progression... - Transient response to imatinib mesylate (STI571) in a patient with the ETV6-ABL t(9;12) translocationStephen G O'Brien
School of Clinical and Laboratory Sciences and the School of Biochemistry and Genetics, University of Newcastle, United Kingdom
Blood 99:3465-7. 2002..This case has implications for the design of future studies using STI571 in leukemias involving ABL-encoded fusion proteins other than BCR-ABL... - Late-appearing MLL rearrangement arising as a secondary change in adult acute myeloid leukemiaDavid Rowe
Institute of Human Genetics, University of Newcastle upon Tyne, England
Genes Chromosomes Cancer 34:126-8. 2002..To date, this is the first report of an MLL rearrangement evolving as a secondary abnormality within a preexisting leukemic clone... - Combined genome-wide allelotyping and copy number analysis identify frequent genetic losses without copy number reduction in medulloblastomaJacqueline A Langdon
Northern Institute for Cancer Research, University of Newcastle, Newcastle-upon-Tyne, UK
Genes Chromosomes Cancer 45:47-60. 2006.... 
Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemiaMarian Case
Northern Institute for Cancer Research, Newcastle upon Tyne, Tyne and Wear, United Kingdom
Cancer Res 68:6803-9. 2008..Inhibitors of the pathway, which are currently undergoing clinical trial, may be a novel therapeutic option for cALL, particularly at relapse...