N Bown

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint Cytogenetic abnormalities and clinical outcome in Wilms tumor: a study by the U.K. cancer cytogenetics group and the U.K. Children's Cancer Study Group
    Nick Bown
    School of Biochemistry and Genetics, University of Newcastle upon Tyne, United Kingdom
    Med Pediatr Oncol 38:11-21. 2002
  2. pmc Neuroblastoma tumour genetics: clinical and biological aspects
    N Bown
    School of Biochemistry and Genetics, University of Newcastle upon Tyne Northern Genetics Service, Royal Victoria Infirmary, 19 20 Claremont Place, Newcastle upon Tyne NE2 4AA, UK
    J Clin Pathol 54:897-910. 2001
  3. ncbi request reprint Comprehensive genetic and histopathologic study reveals three types of neuroblastoma tumors
    M Lastowska
    Human Genetics Unit, School of Biochemistry and Genetics, University of Newcastle upon Tyne, United Kingdom
    J Clin Oncol 19:3080-90. 2001
  4. ncbi request reprint Gain of chromosome arm 17q and adverse outcome in patients with neuroblastoma
    N Bown
    Department of Human Genetics, University of Newcastle upon Tyne, United Kingdom
    N Engl J Med 340:1954-61. 1999
  5. ncbi request reprint 17q gain in neuroblastoma predicts adverse clinical outcome. U.K. Cancer Cytogenetics Group and the U.K. Children's Cancer Study Group
    N Bown
    Department of Human Genetics, University of Newcastle upon Tyne, United Kingdom
    Med Pediatr Oncol 36:14-9. 2001
  6. ncbi request reprint Sensitivity of FISH in detection of MLL translocations
    G Cuthbert
    School of Biochemistry and Genetics, University of Newcastle upon Tyne, United Kingdom
    Genes Chromosomes Cancer 29:180-5. 2000
  7. ncbi request reprint Jumping translocation at 11q23 with MLL gene rearrangement and interstitial telomeric sequences
    G Cuthbert
    Department of Human Genetics, University of Newcastle upon Tyne, England
    Genes Chromosomes Cancer 24:295-8. 1999
  8. ncbi request reprint Donor lymphocyte infusions for post-transplant relapse of refractory anemia with excess blasts and monosomy 7
    R Skinner
    Department of Paediatric and Adolescent Oncology, and Children s BMT Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom
    Pediatr Blood Cancer 50:670-2. 2008
  9. pmc Acute lymphoblastic leukaemia of the L3 subtype in adults in the Northern health region of England 1983-99
    M R Velangi
    Department of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    J Clin Pathol 55:591-5. 2002
  10. ncbi request reprint Molecular cytogenetic definition of 17q translocation breakpoints in neuroblastoma
    M Lastowska
    Department of Human Genetics, University of Newcastle upon Tyne, United Kingdom
    Med Pediatr Oncol 36:20-3. 2001

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Cytogenetic abnormalities and clinical outcome in Wilms tumor: a study by the U.K. cancer cytogenetics group and the U.K. Children's Cancer Study Group
    Nick Bown
    School of Biochemistry and Genetics, University of Newcastle upon Tyne, United Kingdom
    Med Pediatr Oncol 38:11-21. 2002
    ..Identification of markers associated with elevated risk of relapse and fatal outcome could allow more effective treatment stratification at presentation...
  2. pmc Neuroblastoma tumour genetics: clinical and biological aspects
    N Bown
    School of Biochemistry and Genetics, University of Newcastle upon Tyne Northern Genetics Service, Royal Victoria Infirmary, 19 20 Claremont Place, Newcastle upon Tyne NE2 4AA, UK
    J Clin Pathol 54:897-910. 2001
    ..Reliable detection of these molecular cytogenetic features should be regarded as mandatory for all new cases at presentation...
  3. ncbi request reprint Comprehensive genetic and histopathologic study reveals three types of neuroblastoma tumors
    M Lastowska
    Human Genetics Unit, School of Biochemistry and Genetics, University of Newcastle upon Tyne, United Kingdom
    J Clin Oncol 19:3080-90. 2001
    ..To determine the relationship between multiple genetic features, tumor morphology, and prognosis in neuroblastoma...
  4. ncbi request reprint Gain of chromosome arm 17q and adverse outcome in patients with neuroblastoma
    N Bown
    Department of Human Genetics, University of Newcastle upon Tyne, United Kingdom
    N Engl J Med 340:1954-61. 1999
    ..We investigated these associations and evaluated the prognostic importance of the status of chromosome 17...
  5. ncbi request reprint 17q gain in neuroblastoma predicts adverse clinical outcome. U.K. Cancer Cytogenetics Group and the U.K. Children's Cancer Study Group
    N Bown
    Department of Human Genetics, University of Newcastle upon Tyne, United Kingdom
    Med Pediatr Oncol 36:14-9. 2001
    ..We sought to further investigate the clinical and prognostic associations of chromosome 17 status in relation to other well-established predictive factors...
  6. ncbi request reprint Sensitivity of FISH in detection of MLL translocations
    G Cuthbert
    School of Biochemistry and Genetics, University of Newcastle upon Tyne, United Kingdom
    Genes Chromosomes Cancer 29:180-5. 2000
    ..Therefore, we conclude that the Oncor MLL FISH probe has a 9.1% false negative rate, i.e., 90.9% sensitivity in detection of classic MLL translocations. Vysis MLL FISH detected the rearrangement in all 33 cases...
  7. ncbi request reprint Jumping translocation at 11q23 with MLL gene rearrangement and interstitial telomeric sequences
    G Cuthbert
    Department of Human Genetics, University of Newcastle upon Tyne, England
    Genes Chromosomes Cancer 24:295-8. 1999
    ..Southern blot analysis of the MLL breakpoint cluster region showed the presence of an MLL gene rearrangement. Jumping translocation with MLL gene rearrangement is a previously unreported phenomenon in leukemia cytogenetics...
  8. ncbi request reprint Donor lymphocyte infusions for post-transplant relapse of refractory anemia with excess blasts and monosomy 7
    R Skinner
    Department of Paediatric and Adolescent Oncology, and Children s BMT Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom
    Pediatr Blood Cancer 50:670-2. 2008
    ..This case suggests that DLI and graft-versus-myelodysplasia (GVMDS) may be beneficial in post-transplant relapse of pediatric myelodysplasia...
  9. pmc Acute lymphoblastic leukaemia of the L3 subtype in adults in the Northern health region of England 1983-99
    M R Velangi
    Department of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    J Clin Pathol 55:591-5. 2002
    ..This paper describes a series from a population based study of 24 patients with L3 ALL presenting over 17 years...
  10. ncbi request reprint Molecular cytogenetic definition of 17q translocation breakpoints in neuroblastoma
    M Lastowska
    Department of Human Genetics, University of Newcastle upon Tyne, United Kingdom
    Med Pediatr Oncol 36:20-3. 2001
    ..CONCLUSION: These results suggest that the dosage of a gene, or genes, in 17q22-qter is responsible for the clinical effects of 17q gain, rather than the disruption of a specific gene...
  11. pmc Erythroleukaemia in the north of England: a population based study
    A W Wells
    Department of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    J Clin Pathol 54:608-12. 2001
    ..005). CONCLUSION: This study demonstrates a worse survival for patients with erythroleukaemia than that reported in some published trials of selected patients...
  12. ncbi request reprint Unequivocal delineation of clinicogenetic subgroups and development of a new model for improved outcome prediction in neuroblastoma
    Jo Vandesompele
    Center for Medical Genetics Ghent CMGG, Ghent University Hospital, MRB, De Pintelaan 185, B 9000 Ghent, Belgium
    J Clin Oncol 23:2280-99. 2005
    ..In this study, we aimed for comprehensive genetic subgroup discovery and assessment of independent prognostic markers based on genome-wide aberrations detected by comparative genomic hybridization (CGH)...
  13. ncbi request reprint Abnormal constitutional karyotypes in patients with neuroblastoma: a report of four new cases and review of 47 others in the literature
    Daniel Satgé
    Laboratory of Pathology, Centre Hospitalier, 19000 Tulle, France
    Cancer Genet Cytogenet 147:89-98. 2003
    ..A search for genes implicated in neuroblastoma biology should use these data...
  14. ncbi request reprint Imatinib improves but may not fully reverse the poor prognosis of patients with CML with derivative chromosome 9 deletions
    Brian J P Huntly
    Bone Marrow Transplantation Leukemia, Oregon Health and Science University, Portland, OR
    Blood 102:2205-12. 2003
    ..04), for major cytogenetic response (P =.008) in chronic phase, and for hematologic response in advanced phases (P =.007) of CML. This finding suggests that differences in survival may become apparent with longer follow-up...
  15. ncbi request reprint Breakpoint position on 17q identifies the most aggressive neuroblastoma tumors
    Maria Łastowska
    Institute of Human Genetics, International Centre for Life, University of Newcastle upon Tyne, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
    Genes Chromosomes Cancer 34:428-36. 2002
    ..1 and 17qter acting to promote tumor progression...
  16. ncbi request reprint Transient response to imatinib mesylate (STI571) in a patient with the ETV6-ABL t(9;12) translocation
    Stephen G O'Brien
    School of Clinical and Laboratory Sciences and the School of Biochemistry and Genetics, University of Newcastle, United Kingdom
    Blood 99:3465-7. 2002
    ..This case has implications for the design of future studies using STI571 in leukemias involving ABL-encoded fusion proteins other than BCR-ABL...
  17. ncbi request reprint Late-appearing MLL rearrangement arising as a secondary change in adult acute myeloid leukemia
    David Rowe
    Institute of Human Genetics, University of Newcastle upon Tyne, England
    Genes Chromosomes Cancer 34:126-8. 2002
    ..To date, this is the first report of an MLL rearrangement evolving as a secondary abnormality within a preexisting leukemic clone...
  18. ncbi request reprint Combined genome-wide allelotyping and copy number analysis identify frequent genetic losses without copy number reduction in medulloblastoma
    Jacqueline A Langdon
    Northern Institute for Cancer Research, University of Newcastle, Newcastle upon Tyne, UK
    Genes Chromosomes Cancer 45:47-60. 2006
    ....
  19. doi request reprint Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia
    Marian Case
    Northern Institute for Cancer Research, Newcastle upon Tyne, Tyne and Wear, United Kingdom
    Cancer Res 68:6803-9. 2008
    ..Inhibitors of the pathway, which are currently undergoing clinical trial, may be a novel therapeutic option for cALL, particularly at relapse...