Research Topics
Species | Matthew J BownSummaryAffiliation: University of Leicester Country: UK Publications
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Publications
Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1Matthew J Bown
Department of Cardiovascular Sciences, University of Leicester, Leicester LE2 7LX, UK
Am J Hum Genet 89:619-27. 2011..In conclusion, this study has identified a biologically plausible genetic variant associated specifically with AAA, and we suggest that this variant has a possible functional role in LRP1 expression...- Genome Wide Association Studies: identifying the genes that determine the risk of abdominal aortic aneurysmMatthew J Bown
Eur J Vasc Endovasc Surg 36:395-6. 2008 
Subintimal angioplasty: meta-analytical evidence of clinical utilityM J Bown
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
Eur J Vasc Endovasc Surg 38:323-37. 2009..The aim of this study was to determine accurate estimates of the success rate of subintimal angioplasty in terms of ability to recanalise occluded vessels, patency over time and limb salvage rates...- Association between the coronary artery disease risk locus on chromosome 9p21.3 and abdominal aortic aneurysmMatthew J Bown
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
Circ Cardiovasc Genet 1:39-42. 2008..3 and coronary artery disease. We performed a case-control study to investigate the association between this locus and abdominal aortic aneurysm (AAA)... - Quality control in systematic reviews and meta-analysesM J Bown
The University of Leicester, Department of Cardiovascular Sciences, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, United Kingdom
Eur J Vasc Endovasc Surg 40:669-77. 2010.... 
The interleukin-10-1082 'A' allele and abdominal aortic aneurysmsMatthew J Bown
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
J Vasc Surg 46:687-93. 2007..The aim of this study was to determine whether this polymorphism is associated with AAA and also examine its effect on the growth of small AAA...- A comparison of methods for determining genotypes at the tumour necrosis factor-alpha-308, interleukin (IL)-1beta+3953, IL-6 -174 and IL-10 -1082/-819/-592 polymorphic lociM J Bown
Department of Surgery, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, UK
Int J Immunogenet 32:83-90. 2005..909; IL-10 -1082, K = 0.876; IL-10 -592, K = 0.920. IHG is a valid method for the determination of genotypes at the loci examined in this study and produces comparable results to those of more traditional methods of genotyping... - Cytokine gene polymorphisms and the inflammatory response to abdominal aortic aneurysm repairM J Bown
Department of Surgery, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
Br J Surg 90:1085-92. 2003..The aim of this study was to determine whether cytokine gene polymorphisms affect cytokine production in vivo in patients undergoing abdominal aortic aneurysm (AAA) repair... - Pre-discharge duplex ultrasound scans detect endoleaks not seen on completion angiography after endovascular aneurysm repairRebecca M Sandford
Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, UK
J Endovasc Ther 17:349-53. 2010..To determine whether a pre-discharge duplex ultrasound scan detects early endoleaks that would not otherwise have been identified... - Rapid access carotid endarterectomy can be performed in the hyperacute period without a significant increase in procedural risksM K Salem
Vascular Surgery Group, Department of Cardiovascular Sciences, Robert Kilpatrick Clinical Sciences Building, University of Leicester, Leicester LE2 7LX, UK
Eur J Vasc Endovasc Surg 41:222-8. 2011.... - Endovascular abdominal aortic aneurysm repair: 5-year follow-up resultsR M Sandford
Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester, UK
Ann Vasc Surg 22:372-8. 2008..EVAR has the advantages of shorter hospital stay and reduced perioperative morbidity and mortality. Long-term follow-up remains a priority following aortic stenting in order to detect late complications such as endoleak... - A meta-analysis of 50 years of ruptured abdominal aortic aneurysm repairM J Bown
Departments of Surgery and Epidemiology and Public Health, University of Leicester, Leicester, UK
Br J Surg 89:714-30. 2002..CONCLUSION: Contrary to the conclusion of recent studies, this paper demonstrates a gradual reduction with time in the operative mortality rate of RAAA repair... - A systematic review and meta-analysis of endovascular repair (EVAR) for ruptured abdominal aortic aneurysmH S Rayt
Department of Cardiovascular Sciences, Vascular Surgery Research Group, University of Leicester, Leicester Royal Infirmary, Leicester LE2 7LX, UK
Eur J Vasc Endovasc Surg 36:536-44. 2008..The aim of this study was to estimate the mortality rate from EVAR due to ruptured abdominal aortic aneurysm (RAAA)... - Duplex ultrasound scanning is reliable in the detection of endoleak following endovascular aneurysm repairR M Sandford
Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, Level 2 RKCSB, Leicester Royal Infirmary, Leicester LE2 7LX, United Kingdom
Eur J Vasc Endovasc Surg 32:537-41. 2006..To investigate the value of duplex ultrasound scanning (DUSS) in the routine follow up of patients following EVAR... - The management of abdominal aortic aneurysms in patients with concurrent renal impairmentM J Bown
Department of Surgery, Leicester Royal Infirmary, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester LE2 7LX, UK
Eur J Vasc Endovasc Surg 30:1-11. 2005..This aim of this review was to determine the risks of surgery in this patient group and determine whether any clear management strategies exist to enhance their clinical management... - Neutrophil activation occurs in the lower-limbs of patients undergoing elective repair of abdominal aortic aneurysmM G A Norwood
Department of Vascular Surgery, University of Leicester, Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK
Eur J Vasc Endovasc Surg 29:390-4. 2005..AAA repair is associated with a systemic inflammatory response, mediated in part by neutrophils. The aim of this study was to determine where neutrophil activation occurs... - The post-operative complications of endovascular aortic aneurysm repairM J Bown
Department of Surgery, University of Leicester, Leicester, UK
J Cardiovasc Surg (Torino) 45:335-47. 2004..This paper reviews the current published data regarding the nature, incidence and implications of the complications of EVAR... - Conservative management of type 2 endoleaks is not associated with increased risk of aneurysm ruptureH S Rayt
Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester, UK
Eur J Vasc Endovasc Surg 38:718-23. 2009..Controversy exists over the management of type 2 endoleaks. This study examined the outcomes of patients with type 2 endoleaks treated conservatively to inform the ongoing management debate... - Cytokines, their genetic polymorphisms, and outcome after abdominal aortic aneurysm repairM J Bown
Department of Surgery, University of Leicester, Leicester, UK
Eur J Vasc Endovasc Surg 28:274-80. 2004..The aims of this study were to determine if cytokines or their genetic polymorphisms were related to outcome after abdominal aortic aneurysm (AAA) repair... - Repair of ruptured abdominal aortic aneurysms by endovascular techniquesMatthew J Bown
Department of Surgery, University of Leicester, Leicester Royal Infirmary, Leicester LE2 7LX, UK
Adv Surg 41:63-80. 2007..The alternative is for major centers to continue to develop their endovascular programs, to do more cases, and to compare the results with historical controls undergoing open repair... - Endovascular abdominal aortic aneurysm repairM G A Norwood
Department of Vascular Surgery, The Leicester Royal Infirmary, Leicester, UK
Postgrad Med J 83:21-7. 2007..This review aimed at providing an overview of EVAR and a discussion of the potential benefits and current limitations of the technique... - The clinical value of the systemic inflammatory response syndrome (SIRS) in abdominal aortic aneurysm repairM G Norwood
Department of Surgery, University of Leicester, Leicester, UK
Eur J Vasc Endovasc Surg 27:292-8. 2004..High SIRS scores, and the development of SIRS late in the postoperative period are associated with adverse outcome in elective patients, and can therefore be used as an indicator of potential problems... - Is infrainguinal bypass grafting successful following failed angioplasty?R M Sandford
Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, Level 2 RKCSB, Leicester Royal Infirmary, Leicester LE2 7LX, UK
Eur J Vasc Endovasc Surg 34:29-34. 2007..We aimed to evaluate the outcome of infrainguinal bypass grafting following failed attempt at angioplasty... - Changing epidemiology of abdominal aortic aneurysms in England and Wales: older and more benign?Edward Choke
Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester, United Kingdom
Circulation 125:1617-25. 2012..This finding may have important implications for screening programs. This study determined trends in AAA incidence and mortality in England and Wales... - Scoring systems do not accurately predict outcome following abdominal aortic aneurysm repairRebecca M Sandford
Department of Cardiovascular Sciences, Division of Surgery, University of Leicester, Leicester, UK
ANZ J Surg 77:275-82. 2007..Abdominal aortic aneurysm repair is associated with significant morbidity and mortality. This study aims to evaluate the efficiency of scoring systems in a group of patients undergoing abdominal aortic aneurysm repair... - The pro-inflammatory and chemotactic cytokine microenvironment of the abdominal aortic aneurysm wall: a protein array studyRachel K Middleton
Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
J Vasc Surg 45:574-80. 2007..This study aims to investigate the cytokine expression profile of the established AAA wall... - Buttock claudication and erectile dysfunction after internal iliac artery embolization in patients prior to endovascular aortic aneurysm repairH S Rayt
Division of Cardiovascular Sciences, Vascular Surgery Research Group, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester, LE2 7LX, UK
Cardiovasc Intervent Radiol 31:728-34. 2008..33). We conclude that buttock claudication and erectile dysfunction are frequent complications of IIA embolization and patients should be counseled accordingly... - The systemic inflammatory response syndrome, organ failure, and mortality after abdominal aortic aneurysm repairM J Bown
Department of Surgery, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
J Vasc Surg 37:600-6. 2003.... - Systematic review and meta-analysis of 12 years of endovascular abdominal aortic aneurysm repairS C Franks
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
Eur J Vasc Endovasc Surg 33:154-71. 2007..The aim of this study was to estimate these rates from the published data, and examine how this has changed as more patients have undergone ER... - Interleukin 6 production during abdominal aortic aneurysm repair arises from the gastrointestinal tract and not the legsM G A Norwood
Department of Surgery, University of Leicester, Leicester, UK
Br J Surg 91:1153-6. 2004..In this study the relative contributions of these areas to the inflammatory response were assessed during elective AAA repair... - Evaluation of level 1 care facilities for vascular patientsMichael G A Norwood
Department of Surgery, Leicester General Hospital, and University of Leicester, Leicester, England, UK
ANZ J Surg 74:346-9. 2004..A surgical acute care unit (SACU) was established within our hospital to specifically provide level 1 care to surgical patients. We assess the impact that this has had on outcome in vascular patients... - The ectatic aorta: no benefit in surveillanceDavid M R Gibbs
Department of Vascular Surgery, Leicester Royal Infirmary, Leicester, United Kingdom
Ann Vasc Surg 24:908-11. 2010..To determine if patients presenting with an infrarenal aorta of 25-30 mm in diameter benefit from continued ultrasound surveillance, and if so to identify the frequency required... - The post-operative mortality of ruptured abdominal aortic aneurysm repairM J Bown
Department of Surgery, Leicester Royal Infirmary, University of Leicester, UK
Eur J Vasc Endovasc Surg 27:65-74. 2004..DISCUSSION: Factors associated with delayed peri-operative death after RAAA are not the same as those previously found to be associated with overall peri-operative mortality after RAAA repair... - Abdominal aortic aneurysm repair in patients with chronic renal diseaseM G A Norwood
Department of Surgery, University of Leicester, Leicester, UK
Eur J Vasc Endovasc Surg 27:287-91. 2004..CONCLUSIONS: AAA repair in RF patients is associated with increased postoperative morbidity and mortality. Previously non-dialysis-dependent patients have a high risk of subsequent long-term dialysis... - Is there an association between angiotensin converting enzyme (ACE) genotypes and abdominal aortic aneurysm?B Obukofe
Department of Cardiovascular Sciences, University of Leicester, UK
Eur J Vasc Endovasc Surg 40:457-60. 2010..This study aimed to investigate the possible association between the ACE insertion/deletion polymorphism and abdominal aortic aneurysm (AAA) in order to replicate the findings of other authors... - Ischaemia-reperfusion injury and regional inflammatory responses in abdominal aortic aneurysm repairM G A Norwood
Department of Vascular Surgery, University of Leicester, Leicester, UK
Eur J Vasc Endovasc Surg 28:234-45. 2004.... - Cytokines and inflammatory pathways in the pathogenesis of multiple organ failure following abdominal aortic aneurysm repairM J Bown
Department of Surgery, University of Leicester, Leicester, UK
Eur J Vasc Endovasc Surg 22:485-95. 2001..The combination of these individual changes in organ function is the multiple-organ dysfunction syndrome, which may progress to multiple organ failure... - The genetic basis of abdominal aortic aneurysms: a reviewR M Sandford
Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester, UK
Eur J Vasc Endovasc Surg 33:381-90. 2007..This paper reviews the evidence for a genetic predisposition to aneurysm formation including familial and segregation studies in addition to experimental evidence investigating specific candidate genes... - Low atmospheric pressure is associated with rupture of abdominal aortic aneurysmsM J Bown
Department of Surgery, University of Leicester, Leicester, UK
Eur J Vasc Endovasc Surg 25:68-71. 2003..CONCLUSIONS: low atmospheric pressure is associated with increased rate of AAA rupture. The method by which this change in pressure precipitates rupture cannot be determined from this study... - Short leukocyte telomere length is associated with abdominal aortic aneurysm (AAA)G Atturu
Department of Cardiovascular Sciences, Robert Kilpatrick Building, Leicester Royal Infirmary, University of Leicester, Leicester LE2 7LX, United Kingdom
Eur J Vasc Endovasc Surg 39:559-64. 2010..The aim of this study was to determine the relationship between abdominal aortic aneurysm (AAA) and white cell telomere length... - Characterisation of Interleukin-8 and monocyte chemoattractant protein-1 expression within the abdominal aortic aneurysm and their association with mural inflammationR K Middleton
Department of Cardiovascular Sciences, Vascular Surgery Group, University of Leicester, Leicester, UK
Eur J Vasc Endovasc Surg 37:46-55. 2009..This study investigated the expression of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) within the AAA, and their relationship with mural inflammation...