Matthew J Bown

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. pmc Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1
    Matthew J Bown
    Department of Cardiovascular Sciences, University of Leicester, Leicester LE2 7LX, UK
    Am J Hum Genet 89:619-27. 2011
  2. doi request reprint Subintimal angioplasty: meta-analytical evidence of clinical utility
    M J Bown
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Eur J Vasc Endovasc Surg 38:323-37. 2009
  3. doi request reprint Association between the coronary artery disease risk locus on chromosome 9p21.3 and abdominal aortic aneurysm
    Matthew J Bown
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Circ Cardiovasc Genet 1:39-42. 2008
  4. doi request reprint Quality control in systematic reviews and meta-analyses
    M J Bown
    The University of Leicester, Department of Cardiovascular Sciences, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, United Kingdom
    Eur J Vasc Endovasc Surg 40:669-77. 2010
  5. ncbi request reprint The interleukin-10-1082 'A' allele and abdominal aortic aneurysms
    Matthew J Bown
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    J Vasc Surg 46:687-93. 2007
  6. ncbi request reprint A comparison of methods for determining genotypes at the tumour necrosis factor-alpha-308, interleukin (IL)-1beta+3953, IL-6 -174 and IL-10 -1082/-819/-592 polymorphic loci
    M J Bown
    Department of Surgery, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, UK
    Int J Immunogenet 32:83-90. 2005
  7. ncbi request reprint Cytokine gene polymorphisms and the inflammatory response to abdominal aortic aneurysm repair
    M J Bown
    Department of Surgery, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
    Br J Surg 90:1085-92. 2003
  8. doi request reprint Differential microRNA expression profiles in peripheral arterial disease
    Philip W Stather
    Department of Cardiovascular Sciences and Department of Genetics and the NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester, Leicester, United Kingdom
    Circ Cardiovasc Genet 6:490-7. 2013
  9. doi request reprint Pre-discharge duplex ultrasound scans detect endoleaks not seen on completion angiography after endovascular aneurysm repair
    Rebecca M Sandford
    Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, UK
    J Endovasc Ther 17:349-53. 2010
  10. doi request reprint A systematic review and meta-analysis of endovascular repair (EVAR) for ruptured abdominal aortic aneurysm
    H S Rayt
    Department of Cardiovascular Sciences, Vascular Surgery Research Group, University of Leicester, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Eur J Vasc Endovasc Surg 36:536-44. 2008

Detail Information

Publications45

  1. pmc Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1
    Matthew J Bown
    Department of Cardiovascular Sciences, University of Leicester, Leicester LE2 7LX, UK
    Am J Hum Genet 89:619-27. 2011
    ..In conclusion, this study has identified a biologically plausible genetic variant associated specifically with AAA, and we suggest that this variant has a possible functional role in LRP1 expression...
  2. doi request reprint Subintimal angioplasty: meta-analytical evidence of clinical utility
    M J Bown
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Eur J Vasc Endovasc Surg 38:323-37. 2009
    ..The aim of this study was to determine accurate estimates of the success rate of subintimal angioplasty in terms of ability to recanalise occluded vessels, patency over time and limb salvage rates...
  3. doi request reprint Association between the coronary artery disease risk locus on chromosome 9p21.3 and abdominal aortic aneurysm
    Matthew J Bown
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Circ Cardiovasc Genet 1:39-42. 2008
    ..3 and coronary artery disease. We performed a case-control study to investigate the association between this locus and abdominal aortic aneurysm (AAA)...
  4. doi request reprint Quality control in systematic reviews and meta-analyses
    M J Bown
    The University of Leicester, Department of Cardiovascular Sciences, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, United Kingdom
    Eur J Vasc Endovasc Surg 40:669-77. 2010
    ....
  5. ncbi request reprint The interleukin-10-1082 'A' allele and abdominal aortic aneurysms
    Matthew J Bown
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    J Vasc Surg 46:687-93. 2007
    ..The aim of this study was to determine whether this polymorphism is associated with AAA and also examine its effect on the growth of small AAA...
  6. ncbi request reprint A comparison of methods for determining genotypes at the tumour necrosis factor-alpha-308, interleukin (IL)-1beta+3953, IL-6 -174 and IL-10 -1082/-819/-592 polymorphic loci
    M J Bown
    Department of Surgery, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, UK
    Int J Immunogenet 32:83-90. 2005
    ..909; IL-10 -1082, K = 0.876; IL-10 -592, K = 0.920. IHG is a valid method for the determination of genotypes at the loci examined in this study and produces comparable results to those of more traditional methods of genotyping...
  7. ncbi request reprint Cytokine gene polymorphisms and the inflammatory response to abdominal aortic aneurysm repair
    M J Bown
    Department of Surgery, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
    Br J Surg 90:1085-92. 2003
    ..The aim of this study was to determine whether cytokine gene polymorphisms affect cytokine production in vivo in patients undergoing abdominal aortic aneurysm (AAA) repair...
  8. doi request reprint Differential microRNA expression profiles in peripheral arterial disease
    Philip W Stather
    Department of Cardiovascular Sciences and Department of Genetics and the NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester, Leicester, United Kingdom
    Circ Cardiovasc Genet 6:490-7. 2013
    ..Recently, microRNAs (miRNAs), a class of short noncoding RNA controlling gene expression, have emerged as major regulators of multiple biological processes...
  9. doi request reprint Pre-discharge duplex ultrasound scans detect endoleaks not seen on completion angiography after endovascular aneurysm repair
    Rebecca M Sandford
    Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, UK
    J Endovasc Ther 17:349-53. 2010
    ..To determine whether a pre-discharge duplex ultrasound scan detects early endoleaks that would not otherwise have been identified...
  10. doi request reprint A systematic review and meta-analysis of endovascular repair (EVAR) for ruptured abdominal aortic aneurysm
    H S Rayt
    Department of Cardiovascular Sciences, Vascular Surgery Research Group, University of Leicester, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Eur J Vasc Endovasc Surg 36:536-44. 2008
    ..The aim of this study was to estimate the mortality rate from EVAR due to ruptured abdominal aortic aneurysm (RAAA)...
  11. ncbi request reprint Duplex ultrasound scanning is reliable in the detection of endoleak following endovascular aneurysm repair
    R M Sandford
    Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, Level 2 RKCSB, Leicester Royal Infirmary, Leicester LE2 7LX, United Kingdom
    Eur J Vasc Endovasc Surg 32:537-41. 2006
    ..To investigate the value of duplex ultrasound scanning (DUSS) in the routine follow up of patients following EVAR...
  12. ncbi request reprint The management of abdominal aortic aneurysms in patients with concurrent renal impairment
    M J Bown
    Department of Surgery, Leicester Royal Infirmary, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester LE2 7LX, UK
    Eur J Vasc Endovasc Surg 30:1-11. 2005
    ..This aim of this review was to determine the risks of surgery in this patient group and determine whether any clear management strategies exist to enhance their clinical management...
  13. doi request reprint Endovascular abdominal aortic aneurysm repair: 5-year follow-up results
    R M Sandford
    Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester, UK
    Ann Vasc Surg 22:372-8. 2008
    ..EVAR has the advantages of shorter hospital stay and reduced perioperative morbidity and mortality. Long-term follow-up remains a priority following aortic stenting in order to detect late complications such as endoleak...
  14. ncbi request reprint Neutrophil activation occurs in the lower-limbs of patients undergoing elective repair of abdominal aortic aneurysm
    M G A Norwood
    Department of Vascular Surgery, University of Leicester, Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Eur J Vasc Endovasc Surg 29:390-4. 2005
    ..AAA repair is associated with a systemic inflammatory response, mediated in part by neutrophils. The aim of this study was to determine where neutrophil activation occurs...
  15. ncbi request reprint The post-operative complications of endovascular aortic aneurysm repair
    M J Bown
    Department of Surgery, University of Leicester, Leicester, UK
    J Cardiovasc Surg (Torino) 45:335-47. 2004
    ..This paper reviews the current published data regarding the nature, incidence and implications of the complications of EVAR...
  16. doi request reprint Conservative management of type 2 endoleaks is not associated with increased risk of aneurysm rupture
    H S Rayt
    Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester, UK
    Eur J Vasc Endovasc Surg 38:718-23. 2009
    ..Controversy exists over the management of type 2 endoleaks. This study examined the outcomes of patients with type 2 endoleaks treated conservatively to inform the ongoing management debate...
  17. doi request reprint Rapid access carotid endarterectomy can be performed in the hyperacute period without a significant increase in procedural risks
    M K Salem
    Vascular Surgery Group, Department of Cardiovascular Sciences, Robert Kilpatrick Clinical Sciences Building, University of Leicester, Leicester LE2 7LX, UK
    Eur J Vasc Endovasc Surg 41:222-8. 2011
    ....
  18. ncbi request reprint A meta-analysis of 50 years of ruptured abdominal aortic aneurysm repair
    M J Bown
    Departments of Surgery and Epidemiology and Public Health, University of Leicester, Leicester, UK
    Br J Surg 89:714-30. 2002
    ..The aim of this study was to estimate the operative mortality of RAAA repair and determine how it has changed over time...
  19. ncbi request reprint Cytokines, their genetic polymorphisms, and outcome after abdominal aortic aneurysm repair
    M J Bown
    Department of Surgery, University of Leicester, Leicester, UK
    Eur J Vasc Endovasc Surg 28:274-80. 2004
    ..The aims of this study were to determine if cytokines or their genetic polymorphisms were related to outcome after abdominal aortic aneurysm (AAA) repair...
  20. doi request reprint A systematic review and meta-analysis of the association between markers of hemostasis and abdominal aortic aneurysm presence and size
    David A Sidloff
    Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom Electronic address
    J Vasc Surg 59:528-535.e4. 2014
    ..The purpose of this study was to summarize the current evidence of the association between markers of hemostasis and both the presence and size of abdominal aortic aneurysms (AAAs)...
  21. ncbi request reprint Repair of ruptured abdominal aortic aneurysms by endovascular techniques
    Matthew J Bown
    Department of Surgery, University of Leicester, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Adv Surg 41:63-80. 2007
    ..The alternative is for major centers to continue to develop their endovascular programs, to do more cases, and to compare the results with historical controls undergoing open repair...
  22. ncbi request reprint Is infrainguinal bypass grafting successful following failed angioplasty?
    R M Sandford
    Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, Level 2 RKCSB, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Eur J Vasc Endovasc Surg 34:29-34. 2007
    ..We aimed to evaluate the outcome of infrainguinal bypass grafting following failed attempt at angioplasty...
  23. ncbi request reprint The clinical value of the systemic inflammatory response syndrome (SIRS) in abdominal aortic aneurysm repair
    M G Norwood
    Department of Surgery, University of Leicester, Leicester, UK
    Eur J Vasc Endovasc Surg 27:292-8. 2004
    ..The systemic inflammatory response syndrome (SIRS) is common after major surgery. We examine the dynamics of SIRS in AAA patients, and assess the impact of the number of SIRS criteria on patient outcome...
  24. pmc Endovascular abdominal aortic aneurysm repair
    M G A Norwood
    Department of Vascular Surgery, The Leicester Royal Infirmary, Leicester, UK
    Postgrad Med J 83:21-7. 2007
    ..This review aimed at providing an overview of EVAR and a discussion of the potential benefits and current limitations of the technique...
  25. doi request reprint Endovascular aortic aneurysm repair in patients with hostile neck anatomy
    Philip W Stather
    Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, UK
    J Endovasc Ther 20:623-37. 2013
    ..To report a systematic review and meta-analysis of outcomes following endovascular aneurysm repair (EVAR) in patients with hostile neck anatomy (HNA) vs. those with favorable neck anatomy (FNA)...
  26. doi request reprint Changing epidemiology of abdominal aortic aneurysms in England and Wales: older and more benign?
    Edward Choke
    Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester, United Kingdom
    Circulation 125:1617-25. 2012
    ..This finding may have important implications for screening programs. This study determined trends in AAA incidence and mortality in England and Wales...
  27. ncbi request reprint The pro-inflammatory and chemotactic cytokine microenvironment of the abdominal aortic aneurysm wall: a protein array study
    Rachel K Middleton
    Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    J Vasc Surg 45:574-80. 2007
    ..This study aims to investigate the cytokine expression profile of the established AAA wall...
  28. ncbi request reprint Scoring systems do not accurately predict outcome following abdominal aortic aneurysm repair
    Rebecca M Sandford
    Department of Cardiovascular Sciences, Division of Surgery, University of Leicester, Leicester, UK
    ANZ J Surg 77:275-82. 2007
    ..Abdominal aortic aneurysm repair is associated with significant morbidity and mortality. This study aims to evaluate the efficiency of scoring systems in a group of patients undergoing abdominal aortic aneurysm repair...
  29. doi request reprint Buttock claudication and erectile dysfunction after internal iliac artery embolization in patients prior to endovascular aortic aneurysm repair
    H S Rayt
    Division of Cardiovascular Sciences, Vascular Surgery Research Group, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester, LE2 7LX, UK
    Cardiovasc Intervent Radiol 31:728-34. 2008
    ..33). We conclude that buttock claudication and erectile dysfunction are frequent complications of IIA embolization and patients should be counseled accordingly...
  30. ncbi request reprint Systematic review and meta-analysis of 12 years of endovascular abdominal aortic aneurysm repair
    S C Franks
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Eur J Vasc Endovasc Surg 33:154-71. 2007
    ..The aim of this study was to estimate these rates from the published data, and examine how this has changed as more patients have undergone ER...
  31. ncbi request reprint Interleukin 6 production during abdominal aortic aneurysm repair arises from the gastrointestinal tract and not the legs
    M G A Norwood
    Department of Surgery, University of Leicester, Leicester, UK
    Br J Surg 91:1153-6. 2004
    ..In this study the relative contributions of these areas to the inflammatory response were assessed during elective AAA repair...
  32. ncbi request reprint The systemic inflammatory response syndrome, organ failure, and mortality after abdominal aortic aneurysm repair
    M J Bown
    Department of Surgery, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
    J Vasc Surg 37:600-6. 2003
    ....
  33. doi request reprint Sexual dimorphism of abdominal aortic aneurysms: a striking example of "male disadvantage" in cardiovascular disease
    Lisa D S Bloomer
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK Electronic address
    Atherosclerosis 225:22-8. 2012
    ..Future research should focus on the major biological differences between the sexes identifying why men are at more risk of AAA than women...
  34. ncbi request reprint Evaluation of level 1 care facilities for vascular patients
    Michael G A Norwood
    Department of Surgery, Leicester General Hospital, and University of Leicester, Leicester, England, UK
    ANZ J Surg 74:346-9. 2004
    ..A surgical acute care unit (SACU) was established within our hospital to specifically provide level 1 care to surgical patients. We assess the impact that this has had on outcome in vascular patients...
  35. doi request reprint The ectatic aorta: no benefit in surveillance
    David M R Gibbs
    Department of Vascular Surgery, Leicester Royal Infirmary, Leicester, United Kingdom
    Ann Vasc Surg 24:908-11. 2010
    ..To determine if patients presenting with an infrarenal aorta of 25-30 mm in diameter benefit from continued ultrasound surveillance, and if so to identify the frequency required...
  36. ncbi request reprint Abdominal aortic aneurysm repair in patients with chronic renal disease
    M G A Norwood
    Department of Surgery, University of Leicester, Leicester, UK
    Eur J Vasc Endovasc Surg 27:287-91. 2004
    ..To assess the outcome of AAA repair in patients with established renal failure (RF), including patients on dialysis...
  37. ncbi request reprint The post-operative mortality of ruptured abdominal aortic aneurysm repair
    M J Bown
    Department of Surgery, Leicester Royal Infirmary, University of Leicester, UK
    Eur J Vasc Endovasc Surg 27:65-74. 2004
    ..Late peri-operative death after ruptured abdominal aortic aneurysm (RAAA) repair is usually due to multiple-organ failure. The aim of this study was to identify any factors that are associated with mortality in this group of patients...
  38. ncbi request reprint Low atmospheric pressure is associated with rupture of abdominal aortic aneurysms
    M J Bown
    Department of Surgery, University of Leicester, Leicester, UK
    Eur J Vasc Endovasc Surg 25:68-71. 2003
    ..One of the main meterological changes between the seasons is a change in atmospheric pressure. The aim of this study was to investigate whether there was any relationship between atmospheric pressure and the incidence of AAA rupture...
  39. ncbi request reprint The genetic basis of abdominal aortic aneurysms: a review
    R M Sandford
    Vascular Surgery Group, Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester, UK
    Eur J Vasc Endovasc Surg 33:381-90. 2007
    ..This paper reviews the evidence for a genetic predisposition to aneurysm formation including familial and segregation studies in addition to experimental evidence investigating specific candidate genes...
  40. ncbi request reprint Cytokines and inflammatory pathways in the pathogenesis of multiple organ failure following abdominal aortic aneurysm repair
    M J Bown
    Department of Surgery, University of Leicester, Leicester, UK
    Eur J Vasc Endovasc Surg 22:485-95. 2001
    ..The combination of these individual changes in organ function is the multiple-organ dysfunction syndrome, which may progress to multiple organ failure...
  41. ncbi request reprint Ischaemia-reperfusion injury and regional inflammatory responses in abdominal aortic aneurysm repair
    M G A Norwood
    Department of Vascular Surgery, University of Leicester, Leicester, UK
    Eur J Vasc Endovasc Surg 28:234-45. 2004
    ....
  42. doi request reprint Is there an association between angiotensin converting enzyme (ACE) genotypes and abdominal aortic aneurysm?
    B Obukofe
    Department of Cardiovascular Sciences, University of Leicester, UK
    Eur J Vasc Endovasc Surg 40:457-60. 2010
    ..This study aimed to investigate the possible association between the ACE insertion/deletion polymorphism and abdominal aortic aneurysm (AAA) in order to replicate the findings of other authors...
  43. doi request reprint Characterisation of Interleukin-8 and monocyte chemoattractant protein-1 expression within the abdominal aortic aneurysm and their association with mural inflammation
    R K Middleton
    Department of Cardiovascular Sciences, Vascular Surgery Group, University of Leicester, Leicester, UK
    Eur J Vasc Endovasc Surg 37:46-55. 2009
    ..This study investigated the expression of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) within the AAA, and their relationship with mural inflammation...
  44. doi request reprint Short leukocyte telomere length is associated with abdominal aortic aneurysm (AAA)
    G Atturu
    Department of Cardiovascular Sciences, Robert Kilpatrick Building, Leicester Royal Infirmary, University of Leicester, Leicester LE2 7LX, United Kingdom
    Eur J Vasc Endovasc Surg 39:559-64. 2010
    ..The aim of this study was to determine the relationship between abdominal aortic aneurysm (AAA) and white cell telomere length...