Jerome Boudeau

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. pmc MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm
    Jerome Boudeau
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    EMBO J 22:5102-14. 2003
  2. pmc LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
    Jose M Lizcano
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, UK
    EMBO J 23:833-43. 2004
  3. ncbi Analysis of the LKB1-STRAD-MO25 complex
    Jerome Boudeau
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland
    J Cell Sci 117:6365-75. 2004
  4. pmc Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress
    Anna Zagorska
    Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, Medical Sciences Institute Wellcome Trust Biocentre Complex, University of Dundee, Dundee DD1 5EH, Scotland, UK
    J Cell Biol 176:89-100. 2007
  5. pmc Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
    Simon A Hawley
    Division of Molecular Physiology, University of Dundee, Dundee DD1 5EH, UK
    J Biol 2:28. 2003
  6. ncbi LKB1, a protein kinase regulating cell proliferation and polarity
    Jerome Boudeau
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    FEBS Lett 546:159-65. 2003
  7. ncbi Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor
    Christine C Milburn
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Nat Struct Mol Biol 11:193-200. 2004
  8. pmc Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability
    Jerome Boudeau
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 370:849-57. 2003
  9. pmc Identification of Protor as a novel Rictor-binding component of mTOR complex-2
    Laura R Pearce
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 405:513-22. 2007
  10. ncbi Emerging roles of pseudokinases
    Jerome Boudeau
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Trends Cell Biol 16:443-52. 2006

Detail Information

Publications12

  1. pmc MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm
    Jerome Boudeau
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    EMBO J 22:5102-14. 2003
    ..Our results indicate that MO25 may function as a scaffolding component of the LKB1-STRAD complex and plays a crucial role in regulating LKB1 activity and cellular localization...
  2. pmc LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
    Jose M Lizcano
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, UK
    EMBO J 23:833-43. 2004
    ..Between them, these kinases may mediate the physiological effects of LKB1, including its tumour suppressor function...
  3. ncbi Analysis of the LKB1-STRAD-MO25 complex
    Jerome Boudeau
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland
    J Cell Sci 117:6365-75. 2004
    ..Taken together, our findings reinforce the functional importance of the binding of LKB1 to STRAD, and provide a greater understanding of the mechanism by which LKB1 is regulated and activated through its interaction with STRAD and MO25...
  4. pmc Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress
    Anna Zagorska
    Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, Medical Sciences Institute Wellcome Trust Biocentre Complex, University of Dundee, Dundee DD1 5EH, Scotland, UK
    J Cell Biol 176:89-100. 2007
    ..Mutational analysis suggests that the WNK1 C-terminal noncatalytic domain mediates vesicle localization. Our observations shed light on the mechanism by which WNK1 is regulated by hyperosmotic stress...
  5. pmc Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
    Simon A Hawley
    Division of Molecular Physiology, University of Dundee, Dundee DD1 5EH, UK
    J Biol 2:28. 2003
    ..We recently showed that LKB1 exists as a complex with two accessory subunits, STRAD alpha/beta and MO25 alpha/beta...
  6. ncbi LKB1, a protein kinase regulating cell proliferation and polarity
    Jerome Boudeau
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    FEBS Lett 546:159-65. 2003
    ..We also outline the current understanding of the molecular mechanisms by which LKB1 is regulated in vivo, through interaction with other proteins as well as by protein phosphorylation and prenylation...
  7. ncbi Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor
    Christine C Milburn
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Nat Struct Mol Biol 11:193-200. 2004
    ....
  8. pmc Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability
    Jerome Boudeau
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 370:849-57. 2003
    ..Hsp90 inhibitors are being considered as potential anti-cancer agents. However, our observations indicate that prolonged usage of these drugs could possibly lead to tumour development by decreasing cellular levels of LKB1...
  9. pmc Identification of Protor as a novel Rictor-binding component of mTOR complex-2
    Laura R Pearce
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 405:513-22. 2007
    ..Protor-1 is a novel Rictor-binding subunit of mTORC2, but further work is required to establish its role...
  10. ncbi Emerging roles of pseudokinases
    Jerome Boudeau
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Trends Cell Biol 16:443-52. 2006
    ..We also discuss the emerging functions of other pseudokinases, including HER3 (also called ErbB3), EphB6, CCK4 (also called PTK7), KSR, Trb3, GCN2, TRRAP, ILK and CASK...
  11. pmc Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome
    Gopal P Sapkota
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 362:481-90. 2002
    ....
  12. ncbi The N-terminal region of ABC50 interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2
    Sonia Paytubi
    Division of Molecular Physiology, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
    Biochem J 409:223-31. 2008
    ..Expression of a mutant of ABC50 in which both sites are mutated to alanine markedly decreased the association of eIF2 with 80S ribosomal and polysomal fractions...