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Genomes and Genes | Chris BoshoffSummaryAffiliation: University College London Country: UK Publications
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Publications
Kaposi's sarcoma-associated herpesvirus: a new DNA tumor virusC Boshoff
The CRC Viral Oncology Group, Department of Oncology, Sir Jules Thorn Institute, University College London, London W1N 8AA, United Kingdom
Annu Rev Med 52:453-70. 2001..The epidemiologic association of KSHV with malignancies and the coding features of its genome suggest that it is a new DNA tumor virus...
Unraveling virus-induced lymphomagenesisChris Boshoff
UCL Cancer Institute, University College London, London, United Kingdom
J Clin Invest 121:838-41. 2011....- Kaposi's sarcoma biologyChris Boshoff
Wolfson Institute for Biomedical Research, University College London, United Kingdom
IUBMB Life 53:259-61. 2002..Kaposi's sarcoma is a tumour of endothelium and is the most common malignancy in HIV infected individuals. AIDS-related cancers are providing critical insight into cancer immunity and viral oncogenesis... - AIDS-related malignanciesChris Boshoff
Viral Oncology Group, Wolfson Institute for Biomedical Research, University College, London, UK
Nat Rev Cancer 2:373-82. 2002..Gaining insight into the epidemiology and mechanisms that underlie AIDS-related cancers has provided us with a better understanding of cancer immunity and viral oncogenesis... - Epidemiology and pathogenesis of Kaposi's sarcoma-associated herpesvirusC Boshoff
Department of Oncology and Molecular Pathology, The Wolfson Institute for Biomedical Research, Cruciform Building, University College London, Gower Street, London WC1 6BT, UK
Philos Trans R Soc Lond B Biol Sci 356:517-34. 2001..The histogenesis, clonality and pathology of the tumours are described, together with the epidemiology and possible modes of transmission of the virus... - KSHV-encoded miRNAs target MAF to induce endothelial cell reprogrammingAmy Hansen
Cancer Research UK Viral Oncology Group, University College London Cancer Institute, University College London, London WC1E 6BT, United Kingdom
Genes Dev 24:195-205. 2010..These findings demonstrate that viral miRNAs could influence the differentiation status of infected cells, and thereby contribute to KSHV-induced oncogenesis... - KSHV manipulates Notch signaling by DLL4 and JAG1 to alter cell cycle genes in lymphatic endotheliaVictoria Emuss
Cancer Research UK Viral Oncology Group, UCL Cancer Institute, University College London, London, United Kingdom
PLoS Pathog 5:e1000616. 2009..In addition, differences in signaling potency between these ligands suggest a possible complementary role for JAG1 and DLL4 in the context of KS... - Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivinHsei-Wei Wang
The Cancer Research UK Viral Oncology Group, Wolfson Institute for Biomedical Research, Cruciform Building, University College London, London WC1E 6BT, UK
EMBO J 21:2602-15. 2002..These data also suggest that survivin-DeltaEx3 might function by a similar mechanism to that of K7. We denote K7 as vIAP (viral inhibitor-of-apoptosis protein)... - Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6Heike Laman
Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, University College London, London, UK
EMBO J 24:3104-16. 2005..Transformed phenotypes were dependent on cdk6, as knockdown of cdk6 reversed them. Fbxo7 was highly expressed in epithelial tumors, but not in normal tissues, suggesting that it may have a proto-oncogenic role in human cancers... - Toll-like receptor 4 mediates innate immunity to Kaposi sarcoma herpesvirusDimitrios Lagos
Cancer Research UK Viral Oncology Group, UCL Cancer Institute, Paul O Gorman Building, Huntley Street, University College London, London WC1E 6BT, UK
Cell Host Microbe 4:470-83. 2008..Our findings reveal a role for TLR4 in innate immunity against herpesviruses and suggest the potential use of TLR4 agonists for the treatment of KSHV-related neoplasms... - The CD8 and CD4 T-cell response against Kaposi's sarcoma-associated herpesvirus is skewed towards early and late lytic antigensRebecca C Robey
Department of Immunology, Imperial College London, London, United Kingdom
PLoS ONE 4:e5890. 2009..This knowledge will be important to future immunological investigations into KSHV and may eventually lead to the development of better immunotherapies for KSHV-related diseases... 
The microRNA-30 family targets DLL4 to modulate endothelial cell behavior during angiogenesisGemma Bridge
Cancer Research UK Viral Oncology Group, UCL Cancer Institute, University College London, London, United Kingdom
Blood 120:5063-72. 2012..Together these results demonstrate that the highly conserved molecular targeting of DLL4 by the miR-30 family regulates angiogenesis...- Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patientsJames M Flanagan
CR UK Viral Oncology Group, UCL Cancer Institute, London, UK
Hum Mol Genet 18:1332-42. 2009..ACCESSION NUMBERS: The microarray data and associated .BED and .WIG files can be accessed through Gene Expression Omnibus accession number: GSE14603... - Kaposi sarcoma herpesvirus-encoded vFLIP and vIRF1 regulate antigen presentation in lymphatic endothelial cellsDimitrios Lagos
Cancer Research United Kingdom Viral Oncology Group, Wolfson Institute for Biomedical Research, University College London, UK
Blood 109:1550-8. 2007..We propose that regulation of MHC-I by vFLIP and vIRF1 plays a crucial role in the host-pathogen equilibrium... - miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activatorDimitrios Lagos
Cancer Research UK Viral Oncology Group, UCL Cancer Institute, University College London, London WC1E 6BT, U K
Nat Cell Biol 12:513-9. 2010..By targeting p300, rather than a transcription factor or signalling protein, miR-132 has a broad role in the regulation of antiviral immunity... - Short- and long-term effects of highly active antiretroviral therapy on Kaposi sarcoma-associated herpesvirus immune responses and viraemiaDimitra Bourboulia
Wolfson Institute for Biomedical Research and the Department of Sexually Transmitted Diseases, University College London, London, UK
AIDS 18:485-93. 2004..These immune responses could contribute to the decreased incidence of KS during HAART, but it is unlikely to be a complete explanation for the often rapid resolution of KS when HAART is started... - Inhibiting primary effusion lymphoma by lentiviral vectors encoding short hairpin RNAAndrew Godfrey
Cancer Research United Kingdom Viral Oncology Group, Wolfson Institute for Biomedical Research, UCL, Gower Street, London, United Kingdom WC1E 6BT
Blood 105:2510-8. 2005..This shows the use of lentiviral-mediated RNA interference in vivo as a potential therapeutic against a virally driven human cancer... - Kaposi's sarcoma-associated herpesvirus cytotoxic T lymphocytes recognize and target Darwinian positively selected autologous K1 epitopesJustin Stebbing
Cancer Research U.K. Viral Oncology Group, The Wolfson Institute for Biomedical Research, University College London, United Kingdom
J Virol 77:4306-14. 2003..Furthermore, these epitopes are highly conserved sequences within KSHV isolates from a specific strain but are not conserved between different strains. We conclude that CTL recognition contributes to K1, and therefore to KSHV, evolution... - Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cellsRichard J Vart
Cancer Research U K Viral Oncology Group, Wolfson Institute for Biomedical Research, University College London, London, United Kingdom
Cancer Res 67:4042-51. 2007..These findings support the paracrine and autocrine roles of the lytic KSHV-encoded proteins, vIL6 and vGPCR, in KS pathogenesis and identify Ang2 as a potential therapeutic target for this neoplasm... - Kaposi sarcoma as a model of oncogenesis and cancer treatmentAmy Hansen
Cancer Research UK Viral Oncology Group, Wolfson Institute for Biomedical Research, UCL, London, UK
Expert Rev Anticancer Ther 7:211-20. 2007.... - Cancer epigenomeMatthias Lechner
UCL Cancer Institute, University College London, London, UK
Adv Genet 70:247-76. 2010.... - DNA methylome of familial breast cancer identifies distinct profiles defined by mutation statusJames M Flanagan
CRUK Viral Oncology Group, UCL Cancer Institute, London WC1E 6BT, UK
Am J Hum Genet 86:420-33. 2010..Together, these data show that methylation profiles for familial breast cancers are defined by the mutation status and are distinct from the intrinsic subtypes... - The molecular pathology of Kaposi's sarcoma-associated herpesvirusRichard G Jenner
Wohl Virion Centre, Windeyer Institute for Medical Research, Cleveland Street, UCL University College London, London, UK
Biochim Biophys Acta 1602:1-22. 2002..Over the last few years a wealth of data has been gained on the role of KSHV genes during infection. This review is an attempt to assemble this information into a more complete picture of how KSHV may cause disease... - Kaposi's sarcoma-associated herpesvirus-infected primary effusion lymphoma has a plasma cell gene expression profileRichard G Jenner
Wohl Virion Centre, Department of Immunology and Molecular Pathology, Windeyer Institute, University College London, London W1T 4JF, United Kingdom
Proc Natl Acad Sci U S A 100:10399-404. 2003..Similar to malignant plasma cells, all PEL samples tested express the vitamin D receptor and are sensitive to the vitamin D analogue drug EB 1089 (Seocalcitol)... - Lentiviral manipulation of gene expression in human adult and embryonic stem cellsMark O Clements
Wolfson Institute of Biomedical Research, University College, London, United Kingdom
Tissue Eng 12:1741-51. 2006..These vectors will enable rapid analysis of gene function in stem cells and permit the generation of knock-in / knock-out models of human disease in the rapidly developing field of gene therapy... - Small-molecule mimics of an alpha-helix for efficient transport of proteins into cellsMasahiro Okuyama
Biological and Medicinal Chemistry Group, Wolfson Institute for Biomedical Research, University College London, Gower Street, London, WC1E 6BT, UK
Nat Methods 4:153-9. 2007..Uptake of SMoC-geminin was inhibited at 4 degrees C and by chlorpromazine, a compound that induces misassembly of clathrin-coated pits at the cell surface. Thus the mechanism of uptake is likely to be clathrin-mediated endocytosis... - Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy productionJuan M Funes
Cancer Research U K Viral Oncology Group, University College London, London WC 1E 6BT, UK
Proc Natl Acad Sci U S A 104:6223-8. 2007..We did find, however, a reversible increase in the transcription of glycolytic enzymes in tumors generated by transformed MSC, indicating this is a secondary phenomenon resulting from adaptation of the tumor to its microenvironment... - LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcriptionTyson V Sharp
Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, Cruciform Building, University College London, London WC1E 6BT, United Kingdom
Proc Natl Acad Sci U S A 101:16531-6. 2004..Our data indicate that LIMD1 is a tumor-suppressor gene, the protein product of which functionally interacts with pRB and the loss of which promotes lung carcinogenesis... - Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcomaHsei-Wei Wang
Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, Cruciform Building, Gower Street, University College London, London WC1E 6BT, UK
Nat Genet 36:687-93. 2004.... - In vitro transformation of mesenchymal stem cells induces gradual genomic hypomethylationLaurence Wild
CRUK Viral Oncology Group, UCL Cancer Institute, University College London, 72 Huntley Street, WC1E 6BT, UK
Carcinogenesis 31:1854-62. 2010..These data support the hypothesis that DNA hypomethylation occurs via a gradual mechanism and is not a requirement for transformation... - KSHV vFLIP binds to IKK-gamma to activate IKKNigel Field
Department of Immunology and Molecular Pathology, University College London, Windeyer Institute, 46 Cleveland St, London W1T 2AH, UK
J Cell Sci 116:3721-8. 2003..An inhibitor of Hsp90, geldanamycin, inhibited IKK's kinase activity induced by vFLIP and killed PEL cells, suggesting that vFLIP activation of IKK contributes to PEL cell survival... - Identification of Kaposi's sarcoma-associated herpesvirus (KSHV)-specific cytotoxic T-lymphocyte epitopes and evaluation of reconstitution of KSHV-specific responses in human immunodeficiency virus type 1-Infected patients receiving highly active antiretrJohn Wilkinson
Department of Immunology, Chelsea and Westminster Hospital, Imperial College School of Medicine, London, United Kingdom
J Virol 76:2634-40. 2002..Although these increases were modest in comparison to the number of SFC observed with the HIV-1 gag peptide SLYNTVATL, they represented a fourfold increase from the baseline, continuing an upward trend to week 52... - Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targetsJames M Flanagan
Cancer Research UK Viral Oncology Group, University College London Cancer Institute, Paul O Gorman Building, 74 Huntley Street, London, United Kingdom WC1E 6BT
Mol Cancer Ther 8:249-60. 2009..These in vitro data validate PPAP2C and RNASEH2A as putative cancer targets and endorse this in silico approach for identifying novel candidates... - KSHV G protein-coupled receptor inhibits lytic gene transcription in primary-effusion lymphoma cells via p21-mediated inhibition of Cdk2Mark Cannon
Division of International Medicine and Infectious Diseases, Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
Blood 107:277-84. 2006..The ability of vGPCR to delay or abort KSHV replication may explain how despite being a lytic product, this potent signaling molecule has a vital role in tumor formation via its induction of various KS-associated cytokines... - Kaposi sarcoma-associated herpesvirus infects monotypic (IgM lambda) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disordersM Q Du
Department of Histopathology, Royal Free and University College Medical School, University College London, London, United Kingdom
Blood 97:2130-6. 2001..Activation of the IL-6 receptor signaling pathway may play a role in differentiation of KSHV-infected naive B cells into plasmablasts and development of lymphoproliferative lesions. (Blood. 2001;97:2130-2136).. - Characterization of monoclonal antibodies raised against the latent nuclear antigen of human herpesvirus 8P Kellam
Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, United Kingdom
J Virol 73:5149-55. 1999..In situ immunocytochemistry of KS lesions with these antibodies show that LNA is extensively expressed in KS spindle cells... - Exploring the interaction between siRNA and the SMoC biomolecule transporters: implications for small molecule-mediated delivery of siRNAMatt Gooding
Wolfson Institute for Biomedical Research, University College London, Gower Street, London, UK
Chem Biol Drug Des 79:9-21. 2012..Knockdown of Cdc7 kinase, a target for cancer, is achieved... - Imatinib binding and cKIT inhibition is abrogated by the cKIT kinase domain I missense mutation Val654AlaSean R McLean
Cancer Research UK Viral Oncology Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, United Kingdom
Mol Cancer Ther 4:2008-15. 2005.... - Distinct cellular origins of primary effusion lymphoma with and without EBV infectionRifat Hamoudi
Department of Histopathology, Royal Free and University College Medical School, University College London, Rockefeller Building, University Street, London WC1E 6JJ, UK
Leuk Res 28:333-8. 2004..Our results indicate that EBV positive PELs are derived from germinal centre or post-germinal centre B-cells, whereas EBV negative PELs may originate from either germinal/post-germinal centre or naïve B-cells... - RNA interference: a potential tool against Kaposi's sarcoma-associated herpesvirusAndrew Godfrey
Cancer Research UK Viral Oncology Group, Wolfson Institute for Biomedical Research, University College London, London, UK
Curr Opin Infect Dis 16:593-600. 2003..New delivery techniques should be developed to allow the process to be used as a therapeutic tool against viruses and malignancies in humans... - A molecular map of mesenchymal tumorsStephen R Henderson
Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, Gower Street, University College London, London, WC1E 6BT, UK
Genome Biol 6:R76. 2005..Histological diagnosis is challenging due to the poor or heterogenous differentiation of many tumors, resulting in uncertainty over prognosis and appropriate therapy... - Aetiology of Kaposi's sarcoma: current understanding and implications for therapyC Boshoff
Institute of Cancer Research, Chester Beatty Laboratories, London, UK
Mol Med Today 3:488-94. 1997..Today, Kaposi's sarcoma is one of the most frequent neoplasms in men under 50 years old in the USA, and in some African countries it is the most common tumour overall... - Detection of antibodies to human herpesvirus 8 in Italian children: evidence for horizontal transmissionD Whitby
Institute of Cancer Research, London, UK
Br J Cancer 82:702-4. 2000..In this study we examine HHV-8 infection in children from Italy, a country with an elevated prevalence of HHV-8 in adults and high socio-economic conditions... - Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cellsC Boshoff
Virology Laboratory, Royal Marsden Hospital, London, UK
Nat Med 1:1274-8. 1995..These findings show that KSHV/HHV-8 is present in the cell types thought to represent neoplastic cells in these lesions... - K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic functionTyson V Sharp
The CRC Viral Oncology Group, Wolfson Institute for Biomedical Research, University College London, London, United Kingdom WC1E 6BT
J Virol 76:802-16. 2002..The putative functions of K15 with respect to its interaction with HAX-1 are discussed... - Internal ribosome entry site regulates translation of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory proteinW Low
Windeyer Institute of Medical Sciences, University College London, United Kingdom
J Virol 75:2938-45. 2001..Induction of apoptosis by serum withdrawal from PEL cells results in a relative increase in v-FLIP synthesis, as previously described for some cellular proteins translated from IRES... - Kaposi's sarcoma-associated herpesvirus latent and lytic gene expression as revealed by DNA arraysR G Jenner
Wohl Virion Centre, Department of Immunology and Molecular Pathology, Windeyer Institute, University College London, London W1T 4JF, United Kingdom
J Virol 75:891-902. 2001..Furthermore, latent and lytic genes thought to be functionally related cluster into groups. The correlation between gene expression and function also infers possible roles for KSHV genes yet to be characterized... - Genotypic analysis at multiple loci across Kaposi's sarcoma herpesvirus (KSHV) DNA molecules: clustering patterns, novel variants and chimerismJianchao Zong
Molecular Virology Laboratories, Department of Oncology, The Johns Hopkins University School of Medicine, 1650 Orleans Street, CRB 3M09, Baltimore, MD 21205, USA
J Clin Virol 23:119-48. 2002.... - High incidence of Kaposi sarcoma-associated herpesvirus-related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman diseaseEric Oksenhendler
Department of Immunology and Hematology, Laboratory of Hematology, Hopital Saint Louis, 1 Ave Claude Vellefaux, 75010 Paris, France
Blood 99:2331-6. 2002..In contrast, the PEL and PEL-like NHL may implicate a different original infected cell whose growth is promoted by the cytokine-rich environment of the MCD lesions... - KSHV LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptorDaniel L Di Bartolo
Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA
Blood 111:4731-40. 2008.... - Kaposi virus scores cancer coupChris Boshoff
Nat Med 9:261-2. 2003 - Viral coinfections among African children infected with human immunodeficiency virus type 1Rana Chakraborty
Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
Clin Infect Dis 36:922-4. 2003..A protective role for hepatitis G virus cannot be excluded but likely affects only a minority of HIV-1-infected African children... - Linking Kaposi virus to cancer-associated cytokinesHsei Wei Wang
Institute of Microbiology and Immunology, National Yang Ming University, No 155 Sec 2 Li Nong Street, Taipei 112, Taiwan
Trends Mol Med 11:309-12. 2005..Although the exact mechanism for p38-MK2 activation remains unclear, this study provides a new direction linking viral infection to selective mRNA turnover and cytokine biosynthesis... - Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosomeClaire Bagneris
Institute of Structural and Molecular Biology, School of Crystallography, Birkbeck College, Malet Street, London WC1E 7HX, UK
Mol Cell 30:620-31. 2008..In addition to identifying and subsequently probing the ks-vFLIP-IKKgamma interface, we have also investigated the effects of a mutation implicated in the genetic disorder anhydrotic ectodermal dysplasia with immunodeficiency (EDA-ID)... - Associations between Burkitt lymphoma among children in Malawi and infection with HIV, EBV and malaria: results from a case-control studyNora Mutalima
Department of Public Health, University of Oxford, Oxford, United Kingdom
PLoS ONE 3:e2505. 2008..Burkitt lymphoma, a childhood cancer common in parts of sub-Saharan Africa, has been associated with Epstein Barr Virus (EBV) and malaria, but its association with human immunodeficiency virus (HIV) is not clear... - The sero-epidemiology of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in adults with cancer in UgandaRobert Newton
Cancer Research UK, Epidemiology Unit, Radcliffe Infirmary, Oxford, United Kingdom
Int J Cancer 103:226-32. 2003..03). In conclusion, in this population in Uganda, where KSHV is relatively common, the prevalence of anti-KSHV antibodies increased with age but showed little association with nearly 50 other factors studied... - Risk factors for Kaposi's sarcoma: a case-control study of HIV-seronegative people in UgandaJohn Ziegler
Uganda Cancer Institute and Makerere University Medical School, Kampala, Uganda
Int J Cancer 103:233-40. 2003..7; p < 0.001). The risk of Kaposi's sarcoma is clearly linked to antibody status for KSHV, but it would seem that in Uganda other factors are also important in the development of the tumour...