Chris Boshoff

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Integrated virus-host methylome analysis in head and neck squamous cell carcinoma
    Gareth A Wilson
    Medical Genomics UCL Cancer Institute University College London London, UK
    Epigenetics 8:953-61. 2013
  2. pmc Gene expression array profile of human osteosarcoma
    P Leonard
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London, UK
    Br J Cancer 89:2284-8. 2003
  3. pmc Predicting biomarkers for ovarian cancer using gene-expression microarrays
    T R Adib
    Cancer Research UK Viral Oncology Group, Wolfson Institute for Biomedical Research, University College London, Cruciform Building, Gower Street, London WC1E 6BT, UK
    Br J Cancer 90:686-92. 2004
  4. pmc Characterisation of the anti-apoptotic function of survivin-DeltaEx3 during TNFalpha-mediated cell death
    M H Malcles
    Cancer Research UK Viral Oncology Group, Wolfson Institute for Biomedical Research, University College, London, UK
    Br J Cancer 96:1659-66. 2007
  5. ncbi request reprint Kaposi's sarcoma biology
    Chris Boshoff
    Wolfson Institute for Biomedical Research, University College London, United Kingdom
    IUBMB Life 53:259-61. 2002
  6. pmc Unraveling virus-induced lymphomagenesis
    Chris Boshoff
    UCL Cancer Institute, University College London, London, United Kingdom
    J Clin Invest 121:838-41. 2011
  7. ncbi request reprint Kaposi's sarcoma-associated herpesvirus: a new DNA tumor virus
    C Boshoff
    The CRC Viral Oncology Group, Department of Oncology, Sir Jules Thorn Institute, University College London, London W1N 8AA, United Kingdom
    Annu Rev Med 52:453-70. 2001
  8. ncbi request reprint AIDS-related malignancies
    Chris Boshoff
    Viral Oncology Group, Wolfson Institute for Biomedical Research, University College, London, UK
    Nat Rev Cancer 2:373-82. 2002
  9. pmc Epidemiology and pathogenesis of Kaposi's sarcoma-associated herpesvirus
    C Boshoff
    Department of Oncology and Molecular Pathology, The Wolfson Institute for Biomedical Research, Cruciform Building, University College London, Gower Street, London WC1 6BT, UK
    Philos Trans R Soc Lond B Biol Sci 356:517-34. 2001
  10. pmc Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin
    Hsei Wei Wang
    The Cancer Research UK Viral Oncology Group, Wolfson Institute for Biomedical Research, Cruciform Building, University College London, London WC1E 6BT, UK
    EMBO J 21:2602-15. 2002

Detail Information

Publications65

  1. pmc Integrated virus-host methylome analysis in head and neck squamous cell carcinoma
    Gareth A Wilson
    Medical Genomics UCL Cancer Institute University College London London, UK
    Epigenetics 8:953-61. 2013
    ....
  2. pmc Gene expression array profile of human osteosarcoma
    P Leonard
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London, UK
    Br J Cancer 89:2284-8. 2003
    ..Confirmatory immunohistochemical staining using the Ezrin antibody was performed in a selection of samples...
  3. pmc Predicting biomarkers for ovarian cancer using gene-expression microarrays
    T R Adib
    Cancer Research UK Viral Oncology Group, Wolfson Institute for Biomedical Research, University College London, Cruciform Building, Gower Street, London WC1E 6BT, UK
    Br J Cancer 90:686-92. 2004
    ..We have identified a novel biomarker, mammaglobin-2 (MGB2), which is highly expressed specific to ovarian cancer. MGB2, in combination with other putative markers identified here, could have the potential for screening...
  4. pmc Characterisation of the anti-apoptotic function of survivin-DeltaEx3 during TNFalpha-mediated cell death
    M H Malcles
    Cancer Research UK Viral Oncology Group, Wolfson Institute for Biomedical Research, University College, London, UK
    Br J Cancer 96:1659-66. 2007
    ..This study suggests that targeting survivin-DeltaEx3, rather than survivin alone, could be relevant for treating human cancers...
  5. ncbi request reprint Kaposi's sarcoma biology
    Chris Boshoff
    Wolfson Institute for Biomedical Research, University College London, United Kingdom
    IUBMB Life 53:259-61. 2002
    ..Kaposi's sarcoma is a tumour of endothelium and is the most common malignancy in HIV infected individuals. AIDS-related cancers are providing critical insight into cancer immunity and viral oncogenesis...
  6. pmc Unraveling virus-induced lymphomagenesis
    Chris Boshoff
    UCL Cancer Institute, University College London, London, United Kingdom
    J Clin Invest 121:838-41. 2011
    ....
  7. ncbi request reprint Kaposi's sarcoma-associated herpesvirus: a new DNA tumor virus
    C Boshoff
    The CRC Viral Oncology Group, Department of Oncology, Sir Jules Thorn Institute, University College London, London W1N 8AA, United Kingdom
    Annu Rev Med 52:453-70. 2001
    ..The epidemiologic association of KSHV with malignancies and the coding features of its genome suggest that it is a new DNA tumor virus...
  8. ncbi request reprint AIDS-related malignancies
    Chris Boshoff
    Viral Oncology Group, Wolfson Institute for Biomedical Research, University College, London, UK
    Nat Rev Cancer 2:373-82. 2002
    ..Gaining insight into the epidemiology and mechanisms that underlie AIDS-related cancers has provided us with a better understanding of cancer immunity and viral oncogenesis...
  9. pmc Epidemiology and pathogenesis of Kaposi's sarcoma-associated herpesvirus
    C Boshoff
    Department of Oncology and Molecular Pathology, The Wolfson Institute for Biomedical Research, Cruciform Building, University College London, Gower Street, London WC1 6BT, UK
    Philos Trans R Soc Lond B Biol Sci 356:517-34. 2001
    ..The histogenesis, clonality and pathology of the tumours are described, together with the epidemiology and possible modes of transmission of the virus...
  10. pmc Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin
    Hsei Wei Wang
    The Cancer Research UK Viral Oncology Group, Wolfson Institute for Biomedical Research, Cruciform Building, University College London, London WC1E 6BT, UK
    EMBO J 21:2602-15. 2002
    ..These data also suggest that survivin-DeltaEx3 might function by a similar mechanism to that of K7. We denote K7 as vIAP (viral inhibitor-of-apoptosis protein)...
  11. pmc KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming
    Amy Hansen
    Cancer Research UK Viral Oncology Group, University College London Cancer Institute, University College London, London WC1E 6BT, United Kingdom
    Genes Dev 24:195-205. 2010
    ..These findings demonstrate that viral miRNAs could influence the differentiation status of infected cells, and thereby contribute to KSHV-induced oncogenesis...
  12. pmc KSHV manipulates Notch signaling by DLL4 and JAG1 to alter cell cycle genes in lymphatic endothelia
    Victoria Emuss
    Cancer Research UK Viral Oncology Group, UCL Cancer Institute, University College London, London, United Kingdom
    PLoS Pathog 5:e1000616. 2009
    ..In addition, differences in signaling potency between these ligands suggest a possible complementary role for JAG1 and DLL4 in the context of KS...
  13. pmc The CD8 and CD4 T-cell response against Kaposi's sarcoma-associated herpesvirus is skewed towards early and late lytic antigens
    Rebecca C Robey
    Department of Immunology, Imperial College London, London, United Kingdom
    PLoS ONE 4:e5890. 2009
    ..This knowledge will be important to future immunological investigations into KSHV and may eventually lead to the development of better immunotherapies for KSHV-related diseases...
  14. pmc Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6
    Heike Laman
    Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, University College London, London, UK
    EMBO J 24:3104-16. 2005
    ..Transformed phenotypes were dependent on cdk6, as knockdown of cdk6 reversed them. Fbxo7 was highly expressed in epithelial tumors, but not in normal tissues, suggesting that it may have a proto-oncogenic role in human cancers...
  15. pmc Toll-like receptor 4 mediates innate immunity to Kaposi sarcoma herpesvirus
    Dimitrios Lagos
    Cancer Research UK Viral Oncology Group, UCL Cancer Institute, Paul O Gorman Building, Huntley Street, University College London, London WC1E 6BT, UK
    Cell Host Microbe 4:470-83. 2008
    ..Our findings reveal a role for TLR4 in innate immunity against herpesviruses and suggest the potential use of TLR4 agonists for the treatment of KSHV-related neoplasms...
  16. doi request reprint Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets
    James M Flanagan
    Cancer Research UK Viral Oncology Group, University College London Cancer Institute, Paul O Gorman Building, 74 Huntley Street, London, United Kingdom WC1E 6BT
    Mol Cancer Ther 8:249-60. 2009
    ..These in vitro data validate PPAP2C and RNASEH2A as putative cancer targets and endorse this in silico approach for identifying novel candidates...
  17. doi request reprint The microRNA-30 family targets DLL4 to modulate endothelial cell behavior during angiogenesis
    Gemma Bridge
    Cancer Research UK Viral Oncology Group, UCL Cancer Institute, University College London, London, United Kingdom
    Blood 120:5063-72. 2012
    ..Together these results demonstrate that the highly conserved molecular targeting of DLL4 by the miR-30 family regulates angiogenesis...
  18. pmc Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients
    James M Flanagan
    CR UK Viral Oncology Group, UCL Cancer Institute, London, UK
    Hum Mol Genet 18:1332-42. 2009
    ..ACCESSION NUMBERS: The microarray data and associated .BED and .WIG files can be accessed through Gene Expression Omnibus accession number: GSE14603...
  19. doi request reprint miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator
    Dimitrios Lagos
    Cancer Research UK Viral Oncology Group, UCL Cancer Institute, University College London, London WC1E 6BT, U K
    Nat Cell Biol 12:513-9. 2010
    ..By targeting p300, rather than a transcription factor or signalling protein, miR-132 has a broad role in the regulation of antiviral immunity...
  20. ncbi request reprint Kaposi sarcoma herpesvirus-encoded vFLIP and vIRF1 regulate antigen presentation in lymphatic endothelial cells
    Dimitrios Lagos
    Cancer Research United Kingdom Viral Oncology Group, Wolfson Institute for Biomedical Research, University College London, UK
    Blood 109:1550-8. 2007
    ..We propose that regulation of MHC-I by vFLIP and vIRF1 plays a crucial role in the host-pathogen equilibrium...
  21. doi request reprint Cancer epigenome
    Matthias Lechner
    UCL Cancer Institute, University College London, London, UK
    Adv Genet 70:247-76. 2010
    ....
  22. pmc Kaposi's sarcoma-associated herpesvirus-infected primary effusion lymphoma has a plasma cell gene expression profile
    Richard G Jenner
    Wohl Virion Centre, Department of Immunology and Molecular Pathology, Windeyer Institute, University College London, London W1T 4JF, United Kingdom
    Proc Natl Acad Sci U S A 100:10399-404. 2003
    ..Similar to malignant plasma cells, all PEL samples tested express the vitamin D receptor and are sensitive to the vitamin D analogue drug EB 1089 (Seocalcitol)...
  23. ncbi request reprint The molecular pathology of Kaposi's sarcoma-associated herpesvirus
    Richard G Jenner
    Wohl Virion Centre, Windeyer Institute for Medical Research, Cleveland Street, UCL University College London, London, UK
    Biochim Biophys Acta 1602:1-22. 2002
    ..Over the last few years a wealth of data has been gained on the role of KSHV genes during infection. This review is an attempt to assemble this information into a more complete picture of how KSHV may cause disease...
  24. ncbi request reprint Short- and long-term effects of highly active antiretroviral therapy on Kaposi sarcoma-associated herpesvirus immune responses and viraemia
    Dimitra Bourboulia
    Wolfson Institute for Biomedical Research and the Department of Sexually Transmitted Diseases, University College London, London, UK
    AIDS 18:485-93. 2004
    ....
  25. ncbi request reprint Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells
    Richard J Vart
    Cancer Research U K Viral Oncology Group, Wolfson Institute for Biomedical Research, University College London, London, United Kingdom
    Cancer Res 67:4042-51. 2007
    ..These findings support the paracrine and autocrine roles of the lytic KSHV-encoded proteins, vIL6 and vGPCR, in KS pathogenesis and identify Ang2 as a potential therapeutic target for this neoplasm...
  26. ncbi request reprint Inhibiting primary effusion lymphoma by lentiviral vectors encoding short hairpin RNA
    Andrew Godfrey
    Cancer Research United Kingdom Viral Oncology Group, Wolfson Institute for Biomedical Research, UCL, Gower Street, London, United Kingdom WC1E 6BT
    Blood 105:2510-8. 2005
    ..This shows the use of lentiviral-mediated RNA interference in vivo as a potential therapeutic against a virally driven human cancer...
  27. pmc Kaposi's sarcoma-associated herpesvirus cytotoxic T lymphocytes recognize and target Darwinian positively selected autologous K1 epitopes
    Justin Stebbing
    Cancer Research U K Viral Oncology Group, The Wolfson Institute for Biomedical Research, University College London, United Kingdom
    J Virol 77:4306-14. 2003
    ..Furthermore, these epitopes are highly conserved sequences within KSHV isolates from a specific strain but are not conserved between different strains. We conclude that CTL recognition contributes to K1, and therefore to KSHV, evolution...
  28. pmc Adrenomedullin haploinsufficiency predisposes to secondary lymphedema
    Leonid L Nikitenko
    Cancer Research UK Viral Oncology Group, UCL Cancer Institute, University College London, London, UK
    J Invest Dermatol 133:1768-76. 2013
    ....
  29. ncbi request reprint Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma
    Hsei Wei Wang
    Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, Cruciform Building, Gower Street, University College London, London WC1E 6BT, UK
    Nat Genet 36:687-93. 2004
    ....
  30. pmc LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription
    Tyson V Sharp
    Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, Cruciform Building, University College London, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 101:16531-6. 2004
    ..Our data indicate that LIMD1 is a tumor-suppressor gene, the protein product of which functionally interacts with pRB and the loss of which promotes lung carcinogenesis...
  31. ncbi request reprint KSHV vFLIP binds to IKK-gamma to activate IKK
    Nigel Field
    Department of Immunology and Molecular Pathology, University College London, Windeyer Institute, 46 Cleveland St, London W1T 2AH, UK
    J Cell Sci 116:3721-8. 2003
    ..An inhibitor of Hsp90, geldanamycin, inhibited IKK's kinase activity induced by vFLIP and killed PEL cells, suggesting that vFLIP activation of IKK contributes to PEL cell survival...
  32. ncbi request reprint Small-molecule mimics of an alpha-helix for efficient transport of proteins into cells
    Masahiro Okuyama
    Biological and Medicinal Chemistry Group, Wolfson Institute for Biomedical Research, University College London, Gower Street, London, WC1E 6BT, UK
    Nat Methods 4:153-9. 2007
    ..Uptake of SMoC-geminin was inhibited at 4 degrees C and by chlorpromazine, a compound that induces misassembly of clathrin-coated pits at the cell surface. Thus the mechanism of uptake is likely to be clathrin-mediated endocytosis...
  33. ncbi request reprint Lentiviral manipulation of gene expression in human adult and embryonic stem cells
    Mark O Clements
    Wolfson Institute of Biomedical Research, University College, London, United Kingdom
    Tissue Eng 12:1741-51. 2006
    ..These vectors will enable rapid analysis of gene function in stem cells and permit the generation of knock-in / knock-out models of human disease in the rapidly developing field of gene therapy...
  34. pmc DNA methylome of familial breast cancer identifies distinct profiles defined by mutation status
    James M Flanagan
    CRUK Viral Oncology Group, UCL Cancer Institute, London WC1E 6BT, UK
    Am J Hum Genet 86:420-33. 2010
    ..Together, these data show that methylation profiles for familial breast cancers are defined by the mutation status and are distinct from the intrinsic subtypes...
  35. ncbi request reprint Kaposi sarcoma as a model of oncogenesis and cancer treatment
    Amy Hansen
    Cancer Research UK Viral Oncology Group, Wolfson Institute for Biomedical Research, UCL, London, UK
    Expert Rev Anticancer Ther 7:211-20. 2007
    ....
  36. doi request reprint In vitro transformation of mesenchymal stem cells induces gradual genomic hypomethylation
    Laurence Wild
    CRUK Viral Oncology Group, UCL Cancer Institute, University College London, 72 Huntley Street, WC1E 6BT, UK
    Carcinogenesis 31:1854-62. 2010
    ..These data support the hypothesis that DNA hypomethylation occurs via a gradual mechanism and is not a requirement for transformation...
  37. pmc Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production
    Juan M Funes
    Cancer Research U K Viral Oncology Group, University College London, London WC 1E 6BT, UK
    Proc Natl Acad Sci U S A 104:6223-8. 2007
    ..We did find, however, a reversible increase in the transcription of glycolytic enzymes in tumors generated by transformed MSC, indicating this is a secondary phenomenon resulting from adaptation of the tumor to its microenvironment...
  38. pmc Oncogenic transformation of mesenchymal stem cells decreases Nrf2 expression favoring in vivo tumor growth and poorer survival
    Juan M Funes
    UCL Cancer Institute, University College London, Paul O Gorman Building, Huntley Street, London WC1E 6BT, UK
    Mol Cancer 13:20. 2014
    ..However, activating mutations in the Nrf2 pathway have been found to promote tumorigenesis in certain models. Therefore, the role of Nrf2 in cancer remains contentious...
  39. doi request reprint Cellular origin of Kaposi's sarcoma and Kaposi's sarcoma-associated herpesvirus-induced cell reprogramming
    Laila Cancian
    UCL Cancer Institute, 72 Huntley Street, University College London, London WC1E 6BT, UK
    Trends Cell Biol 23:421-32. 2013
    ..e., prospero homeobox 1 (PROX1) and MAF] and discuss how this may contribute to viral persistence and KS sarcomagenesis...
  40. pmc KSHV G protein-coupled receptor inhibits lytic gene transcription in primary-effusion lymphoma cells via p21-mediated inhibition of Cdk2
    Mark Cannon
    Division of International Medicine and Infectious Diseases, Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
    Blood 107:277-84. 2006
    ..The ability of vGPCR to delay or abort KSHV replication may explain how despite being a lytic product, this potent signaling molecule has a vital role in tumor formation via its induction of various KS-associated cytokines...
  41. ncbi request reprint Kaposi sarcoma-associated herpesvirus infects monotypic (IgM lambda) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disorders
    M Q Du
    Department of Histopathology, Royal Free and University College Medical School, University College London, London, United Kingdom
    Blood 97:2130-6. 2001
    ..Activation of the IL-6 receptor signaling pathway may play a role in differentiation of KSHV-infected naive B cells into plasmablasts and development of lymphoproliferative lesions. (Blood. 2001;97:2130-2136)..
  42. pmc Characterization of monoclonal antibodies raised against the latent nuclear antigen of human herpesvirus 8
    P Kellam
    Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, United Kingdom
    J Virol 73:5149-55. 1999
    ..In situ immunocytochemistry of KS lesions with these antibodies show that LNA is extensively expressed in KS spindle cells...
  43. pmc A molecular map of mesenchymal tumors
    Stephen R Henderson
    Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, Gower Street, University College London, London, WC1E 6BT, UK
    Genome Biol 6:R76. 2005
    ..Histological diagnosis is challenging due to the poor or heterogenous differentiation of many tumors, resulting in uncertainty over prognosis and appropriate therapy...
  44. pmc K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function
    Tyson V Sharp
    The CRC Viral Oncology Group, Wolfson Institute for Biomedical Research, University College London, London, United Kingdom WC1E 6BT
    J Virol 76:802-16. 2002
    ..The putative functions of K15 with respect to its interaction with HAX-1 are discussed...
  45. pmc Identification of Kaposi's sarcoma-associated herpesvirus (KSHV)-specific cytotoxic T-lymphocyte epitopes and evaluation of reconstitution of KSHV-specific responses in human immunodeficiency virus type 1-Infected patients receiving highly active antiretr
    John Wilkinson
    Department of Immunology, Chelsea and Westminster Hospital, Imperial College School of Medicine, London, United Kingdom
    J Virol 76:2634-40. 2002
    ..Although these increases were modest in comparison to the number of SFC observed with the HIV-1 gag peptide SLYNTVATL, they represented a fourfold increase from the baseline, continuing an upward trend to week 52...
  46. doi request reprint Exploring the interaction between siRNA and the SMoC biomolecule transporters: implications for small molecule-mediated delivery of siRNA
    Matt Gooding
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London, UK
    Chem Biol Drug Des 79:9-21. 2012
    ..Knockdown of Cdc7 kinase, a target for cancer, is achieved...
  47. ncbi request reprint RNA interference: a potential tool against Kaposi's sarcoma-associated herpesvirus
    Andrew Godfrey
    Cancer Research UK Viral Oncology Group, Wolfson Institute for Biomedical Research, University College London, London, UK
    Curr Opin Infect Dis 16:593-600. 2003
    ..We discuss here the potential for exploiting this phenomenon to prevent or treat viral infections, in particular Kaposi's sarcoma-associated herpesvirus...
  48. ncbi request reprint Imatinib binding and cKIT inhibition is abrogated by the cKIT kinase domain I missense mutation Val654Ala
    Sean R McLean
    Cancer Research UK Viral Oncology Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, United Kingdom
    Mol Cancer Ther 4:2008-15. 2005
    ....
  49. ncbi request reprint Distinct cellular origins of primary effusion lymphoma with and without EBV infection
    Rifat Hamoudi
    Department of Histopathology, Royal Free and University College Medical School, University College London, Rockefeller Building, University Street, London WC1E 6JJ, UK
    Leuk Res 28:333-8. 2004
    ..Our results indicate that EBV positive PELs are derived from germinal centre or post-germinal centre B-cells, whereas EBV negative PELs may originate from either germinal/post-germinal centre or naïve B-cells...
  50. ncbi request reprint Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells
    C Boshoff
    Virology Laboratory, Royal Marsden Hospital, London, UK
    Nat Med 1:1274-8. 1995
    ..These findings show that KSHV/HHV-8 is present in the cell types thought to represent neoplastic cells in these lesions...
  51. ncbi request reprint Aetiology of Kaposi's sarcoma: current understanding and implications for therapy
    C Boshoff
    Institute of Cancer Research, Chester Beatty Laboratories, London, UK
    Mol Med Today 3:488-94. 1997
    ..Today, Kaposi's sarcoma is one of the most frequent neoplasms in men under 50 years old in the USA, and in some African countries it is the most common tumour overall...
  52. pmc Detection of antibodies to human herpesvirus 8 in Italian children: evidence for horizontal transmission
    D Whitby
    Institute of Cancer Research, London, UK
    Br J Cancer 82:702-4. 2000
    ..In this study we examine HHV-8 infection in children from Italy, a country with an elevated prevalence of HHV-8 in adults and high socio-economic conditions...
  53. ncbi request reprint APOBEC-Mediated Cytosine Deamination Links PIK3CA Helical Domain Mutations to Human Papillomavirus-Driven Tumor Development
    Stephen Henderson
    Department of Oncology, UCL Cancer Institute, University College London, London WC1E 6BT, UK Bill Lyons Informatics Centre, UCL Cancer Institute, University College London, London WC1E 6BT, UK
    Cell Rep 7:1833-41. 2014
    ..Our findings implicate APOBEC activity as a key driver of PIK3CA mutagenesis and HPV-induced transformation. ..
  54. pmc Internal ribosome entry site regulates translation of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein
    W Low
    Windeyer Institute of Medical Sciences, University College London, United Kingdom
    J Virol 75:2938-45. 2001
    ..Induction of apoptosis by serum withdrawal from PEL cells results in a relative increase in v-FLIP synthesis, as previously described for some cellular proteins translated from IRES...
  55. pmc Kaposi's sarcoma-associated herpesvirus latent and lytic gene expression as revealed by DNA arrays
    R G Jenner
    Wohl Virion Centre, Department of Immunology and Molecular Pathology, Windeyer Institute, University College London, London W1T 4JF, United Kingdom
    J Virol 75:891-902. 2001
    ..Furthermore, latent and lytic genes thought to be functionally related cluster into groups. The correlation between gene expression and function also infers possible roles for KSHV genes yet to be characterized...
  56. ncbi request reprint Kaposi virus scores cancer coup
    Chris Boshoff
    Nat Med 9:261-2. 2003
  57. ncbi request reprint Viral coinfections among African children infected with human immunodeficiency virus type 1
    Rana Chakraborty
    Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
    Clin Infect Dis 36:922-4. 2003
    ..A protective role for hepatitis G virus cannot be excluded but likely affects only a minority of HIV-1-infected African children...
  58. pmc KSHV LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptor
    Daniel L Di Bartolo
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA
    Blood 111:4731-40. 2008
    ....
  59. ncbi request reprint Linking Kaposi virus to cancer-associated cytokines
    Hsei Wei Wang
    Institute of Microbiology and Immunology, National Yang Ming University, No 155 Sec 2 Li Nong Street, Taipei 112, Taiwan
    Trends Mol Med 11:309-12. 2005
    ..Although the exact mechanism for p38-MK2 activation remains unclear, this study provides a new direction linking viral infection to selective mRNA turnover and cytokine biosynthesis...
  60. ncbi request reprint Genotypic analysis at multiple loci across Kaposi's sarcoma herpesvirus (KSHV) DNA molecules: clustering patterns, novel variants and chimerism
    Jianchao Zong
    Molecular Virology Laboratories, Department of Oncology, The Johns Hopkins University School of Medicine, 1650 Orleans Street, CRB 3M09, Baltimore, MD 21205, USA
    J Clin Virol 23:119-48. 2002
    ..However, chimeric genomes have also been detected, especially with regard to the presence of P versus M alleles of the ORF-K15 gene...
  61. ncbi request reprint High incidence of Kaposi sarcoma-associated herpesvirus-related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease
    Eric Oksenhendler
    Department of Immunology and Hematology, Laboratory of Hematology, Hopital Saint Louis, 1 Ave Claude Vellefaux, 75010 Paris, France
    Blood 99:2331-6. 2002
    ..In contrast, the PEL and PEL-like NHL may implicate a different original infected cell whose growth is promoted by the cytokine-rich environment of the MCD lesions...
  62. doi request reprint Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome
    Claire Bagneris
    Institute of Structural and Molecular Biology, School of Crystallography, Birkbeck College, Malet Street, London WC1E 7HX, UK
    Mol Cell 30:620-31. 2008
    ..In addition to identifying and subsequently probing the ks-vFLIP-IKKgamma interface, we have also investigated the effects of a mutation implicated in the genetic disorder anhydrotic ectodermal dysplasia with immunodeficiency (EDA-ID)...
  63. ncbi request reprint Risk factors for Kaposi's sarcoma: a case-control study of HIV-seronegative people in Uganda
    John Ziegler
    Uganda Cancer Institute and Makerere University Medical School, Kampala, Uganda
    Int J Cancer 103:233-40. 2003
    ..7; p < 0.001). The risk of Kaposi's sarcoma is clearly linked to antibody status for KSHV, but it would seem that in Uganda other factors are also important in the development of the tumour...
  64. pmc Associations between Burkitt lymphoma among children in Malawi and infection with HIV, EBV and malaria: results from a case-control study
    Nora Mutalima
    Department of Public Health, University of Oxford, Oxford, United Kingdom
    PLoS ONE 3:e2505. 2008
    ..Burkitt lymphoma, a childhood cancer common in parts of sub-Saharan Africa, has been associated with Epstein Barr Virus (EBV) and malaria, but its association with human immunodeficiency virus (HIV) is not clear...
  65. ncbi request reprint The sero-epidemiology of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in adults with cancer in Uganda
    Robert Newton
    Cancer Research UK, Epidemiology Unit, Radcliffe Infirmary, Oxford, United Kingdom
    Int J Cancer 103:226-32. 2003
    ..03). In conclusion, in this population in Uganda, where KSHV is relatively common, the prevalence of anti-KSHV antibodies increased with age but showed little association with nearly 50 other factors studied...