Research Topics
| Angela M BorzychowskiSummaryAffiliation: University of Oxford Country: UK Publications
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Detail Information
Publications
Changes in systemic type 1 and type 2 immunity in normal pregnancy and pre-eclampsia may be mediated by natural killer cellsAngela M Borzychowski
Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, UK
Eur J Immunol 35:3054-63. 2005..001 and p <0.01, respectively) and pre-eclamptic women (p <0.05). These results confirm that immunoregulation occurs in pregnancy, but suggest a dominant role of the innate rather than the adaptive immune system...
Inflammation and pre-eclampsiaA M Borzychowski
Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford OX3 9DU, UK
Semin Fetal Neonatal Med 11:309-16. 2006..While clinical management of pre-eclampsia does not currently include anti-inflammatory agents, current research is focusing on ways to reduce inflammation and oxidative stress...
NK cells and human pregnancy--an inflammatory viewIan L Sargent
Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK, OX3 9DU
Trends Immunol 27:399-404. 2006..We suggest novel ways in which the trophoblast might stimulate the maternal systemic inflammatory response, and how dysfunctional NK-cell activation could result in the maternal syndrome of pre-eclampsia...
Immunoregulation in normal pregnancy and pre-eclampsia: an overviewIan L Sargent
Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
Reprod Biomed Online 13:680-6. 2006..There is evidence that such trophoblast debris interacts with maternal leukocytes and endothelial cells to stimulate the release of proinflammatory cytokines, which could then trigger the maternal disease...
Immunoregulation in normal pregnancy and pre-eclampsia: an overviewIan L Sargent
Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
Reprod Biomed Online 14:111-7. 2007..There is evidence that such trophoblast debris interacts with maternal leukocytes and endothelial cells to stimulate the release of proinflammatory cytokines, which could then trigger the maternal disease...
Uterine natural killer cells: a specialized differentiation regulated by ovarian hormonesB Anne Croy
Department of Anatomy and Cell Biology, Research Group in Reproduction, Development and Sexual Function, Queen s University, Kingston, ON, Canada
Immunol Rev 214:161-85. 2006..This review highlights the biology of uNK cells during successful pregnancy...
