M Booth

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi Carriage of DRB1*13 is associated with increased posttreatment IgE levels against Schistosoma mansoni antigens and lower long-term reinfection levels
    Mark Booth
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Immunol 176:7112-8. 2006
  2. ncbi The role of residential location in apparent helminth and malaria associations
    Mark Booth
    Department of Pathology, Tennis Court Road, Cambridge, CB5 8QU, UK
    Trends Parasitol 22:359-62. 2006
  3. pmc Age-adjusted Plasmodium falciparum antibody levels in school-aged children are a stable marker of microgeographical variations in exposure to Plasmodium infection
    Shona Wilson
    Department of Pathology, University of Cambridge, Cambridge, UK
    BMC Infect Dis 7:67. 2007
  4. ncbi Spatial awareness in parasite immuno-epidemiology
    Mark Booth
    University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, UK
    Parasite Immunol 26:499-507. 2004
  5. pmc Exposure to malaria affects the regression of hepatosplenomegaly after treatment for Schistosoma mansoni infection in Kenyan children
    Mark Booth
    Division of Microbiology and Parasitology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    BMC Med 2:36. 2004
  6. pmc Micro-geographical variation in exposure to Schistosoma mansoni and malaria, and exacerbation of splenomegaly in Kenyan school-aged children
    Mark Booth
    Division of Microbiology and Parasitology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    BMC Infect Dis 4:13. 2004
  7. ncbi Hepatosplenic morbidity in two neighbouring communities in Uganda with high levels of Schistosoma mansoni infection but very different durations of residence
    M Booth
    Dept of Pathology, University of Cambridge, Tennis Court Rd, Cambridge CB2 1QP, UK
    Trans R Soc Trop Med Hyg 98:125-36. 2004
  8. ncbi Periportal fibrosis in human Schistosoma mansoni infection is associated with low IL-10, low IFN-gamma, high TNF-alpha, or low RANTES, depending on age and gender
    Mark Booth
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    J Immunol 172:1295-303. 2004
  9. ncbi The influence of sampling effort and the performance of the Kato-Katz technique in diagnosing Schistosoma mansoni and hookworm co-infections in rural Côte d'Ivoire
    M Booth
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Parasitology 127:525-31. 2003
  10. ncbi The relationship between age, sex, egg-count and specific antibody responses against Schistosoma mansoni antigens in a Ugandan fishing community
    Cynthia W A Naus
    Division of Microbiology and Parasitology, Department of Pathology, University of Cambridge, UK
    Trop Med Int Health 8:561-8. 2003

Collaborators

Detail Information

Publications23

  1. ncbi Carriage of DRB1*13 is associated with increased posttreatment IgE levels against Schistosoma mansoni antigens and lower long-term reinfection levels
    Mark Booth
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Immunol 176:7112-8. 2006
    ..These results indicate that genetic background has a prominent influence on the posttreatment Th2 immune response to S. mansoni Ags, as well as a downstream association with long-term reinfection levels...
  2. ncbi The role of residential location in apparent helminth and malaria associations
    Mark Booth
    Department of Pathology, Tennis Court Road, Cambridge, CB5 8QU, UK
    Trends Parasitol 22:359-62. 2006
    ..Here, it is argued that a variety of factors have led to this confusion but that many problems might be helped by more deliberate consideration of residential location and spatial aspects of exposure in parasitological surveys...
  3. pmc Age-adjusted Plasmodium falciparum antibody levels in school-aged children are a stable marker of microgeographical variations in exposure to Plasmodium infection
    Shona Wilson
    Department of Pathology, University of Cambridge, Cambridge, UK
    BMC Infect Dis 7:67. 2007
    ....
  4. ncbi Spatial awareness in parasite immuno-epidemiology
    Mark Booth
    University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, UK
    Parasite Immunol 26:499-507. 2004
  5. pmc Exposure to malaria affects the regression of hepatosplenomegaly after treatment for Schistosoma mansoni infection in Kenyan children
    Mark Booth
    Division of Microbiology and Parasitology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    BMC Med 2:36. 2004
    ..The present analysis focused on the possibility that exposure to malaria infection may have limited the resolution of hepatosplenomegaly in a cohort of Kenyan schoolchildren...
  6. pmc Micro-geographical variation in exposure to Schistosoma mansoni and malaria, and exacerbation of splenomegaly in Kenyan school-aged children
    Mark Booth
    Division of Microbiology and Parasitology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    BMC Infect Dis 4:13. 2004
    ..Here, we have investigated whether relatively high exposure to both infections has a clinically measurable effect on this condition...
  7. ncbi Hepatosplenic morbidity in two neighbouring communities in Uganda with high levels of Schistosoma mansoni infection but very different durations of residence
    M Booth
    Dept of Pathology, University of Cambridge, Tennis Court Rd, Cambridge CB2 1QP, UK
    Trans R Soc Trop Med Hyg 98:125-36. 2004
    ..This parameter should therefore be a routine measurement during epidemiological surveys of S. mansoni...
  8. ncbi Periportal fibrosis in human Schistosoma mansoni infection is associated with low IL-10, low IFN-gamma, high TNF-alpha, or low RANTES, depending on age and gender
    Mark Booth
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    J Immunol 172:1295-303. 2004
    ..These results demonstrate that periportal fibrosis is associated with cytokine production profiles that vary with both age and gender...
  9. ncbi The influence of sampling effort and the performance of the Kato-Katz technique in diagnosing Schistosoma mansoni and hookworm co-infections in rural Côte d'Ivoire
    M Booth
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Parasitology 127:525-31. 2003
    ..If confirmed in other settings, these findings have implications for estimating the prevalence of multiple species helminth infections, and hence the design and implementation of efficacious and cost-effective control programmes...
  10. ncbi The relationship between age, sex, egg-count and specific antibody responses against Schistosoma mansoni antigens in a Ugandan fishing community
    Cynthia W A Naus
    Division of Microbiology and Parasitology, Department of Pathology, University of Cambridge, UK
    Trop Med Int Health 8:561-8. 2003
    ..IgG4-SEA and IgG4-SWA were both strongly correlated with egg count. Patterns of IgE-SWA responses were qualitatively different to IgG4 responses, suggesting independent pathways of regulation...
  11. pmc Hepatosplenomegaly associated with chronic malaria exposure: evidence for a pro-inflammatory mechanism exacerbated by schistosomiasis
    S Wilson
    Department of Pathology, University of Cambridge, Cambridge, UK
    Parasite Immunol 31:64-71. 2009
    ..mansoni infected children, compared to those without detectable S. mansoni and malarial infections, but exposed to malaria, suggest that S. mansoni infection may augment the underlying inflammatory reaction...
  12. pmc Hepatosplenomegaly is associated with low regulatory and Th2 responses to schistosome antigens in childhood schistosomiasis and malaria coinfection
    Shona Wilson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, United Kingdom
    Infect Immun 76:2212-8. 2008
    ....
  13. ncbi Hepatosplenomegaly in Kenyan schoolchildren: exacerbation by concurrent chronic exposure to malaria and Schistosoma mansoni infection
    Shona Wilson
    Department of Pathology, University of Cambridge, Cambridge, UK
    Trop Med Int Health 12:1442-9. 2007
    ..We investigated the role of chronic malaria in childhood hepatosplenomegaly in the presence and absence of concurrent S. mansoni infection...
  14. ncbi Microgeographical and tribal variations in water contact and Schistosoma mansoni exposure within a Ugandan fishing community
    Angela Pinot de Moira
    Department of Pathology, University of Cambridge, Cambridge, UK
    Trop Med Int Health 12:724-35. 2007
    ..To explore patterns of water contact and Schistosoma mansoni exposure by age, sex, tribe and space within a single village...
  15. pmc Health implications of chronic hepatosplenomegaly in Kenyan school-aged children chronically exposed to malarial infections and Schistosoma mansoni
    Shona Wilson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Trans R Soc Trop Med Hyg 104:110-6. 2010
    ..This study shows that hepatosplenomegaly associated with chronic exposure to malaria and schistosomiasis is not a benign symptom amongst school-aged children but has potential long-term health consequences...
  16. ncbi Applied and basic research on the epidemiology, morbidity, and immunology of schistosomiasis in fishing communities on Lake Albert, Uganda
    David W Dunne
    Division of Microbiology and Parasitology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Trans R Soc Trop Med Hyg 100:216-23. 2006
    ..Such information and operational capacity are needed to facilitate much needed schistosomiasis control programmes, such as the Schistosomiasis Control Initiative that was launched in Uganda in 2003...
  17. pmc Cytokine production in whole blood cultures from a fishing community in an area of high endemicity for Schistosoma mansoni in Uganda: the differential effect of parasite worm and egg antigens
    Sarah Joseph
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom
    Infect Immun 72:728-34. 2004
    ..mansoni and during acute human infections, chronic intense exposure to and infection with S. mansoni in this cohort resulted in very low levels of response to SEA in vitro in the presence of a vigorous and mixed Th1-Th2 response to SWA...
  18. pmc Eosinophil activity in Schistosoma mansoni infections in vivo and in vitro in relation to plasma cytokine profile pre- and posttreatment with praziquantel
    Claus M Reimert
    DBL, Institute for Health Research and Development, Jaegersborg Alle 1 D, 2720 Charlottenlund, Denmark
    Clin Vaccine Immunol 13:584-93. 2006
    ..Moreover, it is possible that infection intensity-dependent levels of plasma IL-10 may be involved in the prevention of treatment-induced anaphylactic reactions...
  19. ncbi Regression of hepatosplenomegaly in Kenyan school-aged children after praziquantel treatment and three years of greatly reduced exposure to Schistosoma mansoni
    Birgitte J Vennervald
    Danish Bilharziasis Laboratory, Charlottenlund, Denmark
    Trans R Soc Trop Med Hyg 99:150-60. 2005
    ..mansoni, even with continuing exposure to malaria. The lack of complete resolution of hepatosplenomegaly in most children suggests, among other things, a residual organomegaly attributable to malaria...
  20. ncbi Detailed clinical and ultrasound examination of children and adolescents in a Schistosoma mansoni endemic area in Kenya: hepatosplenic disease in the absence of portal fibrosis
    Birgitte J Vennervald
    Danish Bilharziasis Laboratory, Charlottenlund, Denmark
    Trop Med Int Health 9:461-70. 2004
    ..These results indicate that hepatosplenic disease in school-aged children attributable to S. mansoni infection, involving hepatosplenomegaly and increased portal vein diameter, can occur in the absence of peri-portal fibrosis...
  21. pmc Plasmodium falciparum and helminth coinfection in a semi urban population of pregnant women in Uganda
    Stephen D Hillier
    The University of Birmingham Medical School, Birmingham, United Kingdom
    J Infect Dis 198:920-7. 2008
    ..Recent studies suggest helminth infections may increase susceptibility to Plasmodium falciparum infection. If confirmed, this increased susceptibility could be particularly important during pregnancy-induced immunosuppression...
  22. ncbi Reduction in the prevalence and intensity of hookworm infections after praziquantel treatment for schistosomiasis infection
    Jurg Utzinger
    Office of Population Research, Princeton University, Princeton, NJ 08544, USA
    Int J Parasitol 32:759-65. 2002
    ..In areas where both schistosome and hookworm coexist, and praziquantel is being recommended for schistosomiasis control, large-scale application of this drug might also reduce the burden of hookworms...
  23. doi Parasitic co-infections: challenges and solutions
    Mark Booth
    Parasitology 135:749. 2008