R P Boot Handford

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi request reprint A novel and highly conserved collagen (pro(alpha)1(XXVII)) with a unique expression pattern and unusual molecular characteristics establishes a new clade within the vertebrate fibrillar collagen family
    Raymond P Boot-Handford
    Wellcome Trust Centre for Cell Matrix Research, School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Biol Chem 278:31067-77. 2003
  2. ncbi request reprint Fibrillar collagen: the key to vertebrate evolution? A tale of molecular incest
    Raymond P Boot-Handford
    The Wellcome Trust Centre for Cell Matrix Research, School of Biological Sciences, University of Manchester, UK
    Bioessays 25:142-51. 2003
  3. pmc The bcl-2 knockout mouse exhibits marked changes in osteoblast phenotype and collagen deposition in bone as well as a mild growth plate phenotype
    R P Boot-Handford
    Wellcome Trust Centre of Cell Matrix Research, School of Biological Sciences, University of Manchester, UK
    Int J Exp Pathol 79:329-35. 1998
  4. ncbi request reprint Role of pericytes in vascular calcification: a review
    A E Canfield
    Wellcome Trust Centre for Cell Matrix Research, Schools of Medicine, Manchester, UK
    Z Kardiol 89:20-7. 2000
  5. ncbi request reprint Matrix Gla protein is differentially expressed during the deposition of a calcified matrix by vascular pericytes
    A E Canfield
    Wellcome Trust Centre for Cell Matrix Research, School of Medicine, University of Manchester, Manchester, UK
    FEBS Lett 487:267-71. 2000
  6. ncbi request reprint The involvement of matrix glycoproteins in vascular calcification and fibrosis: an immunohistochemical study
    A E Canfield
    Wellcome Trust Centre for Cell Matrix Research, 2 205, Stopford Building, The University of Manchester, Manchester, UK
    J Pathol 196:228-34. 2002
  7. pmc Isolation of cDNAs encoding the complete sequence of bovine type X collagen. Evidence for the condensed nature of mammalian type X collagen genes
    J T Thomas
    Department of Biochemistry and Molecular Biology, School of Biological Sciences, University of Manchester, U K
    Biochem J 273:141-8. 1991
  8. ncbi request reprint The ribosomal protein QM is expressed differentially during vertebrate endochondral bone development
    H Green
    The Wellcome Trust Centre for Cell Matrix Research, School of Biological Sciences, University of Manchester, UK
    J Bone Miner Res 15:1066-75. 2000
  9. doi request reprint The biology of the circadian Ck1epsilon tau mutation in mice and Syrian hamsters: a tale of two species
    A S I Loudon
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    Cold Spring Harb Symp Quant Biol 72:261-71. 2007
  10. pmc Amino acid substitutions of conserved residues in the carboxyl-terminal domain of the alpha 1(X) chain of type X collagen occur in two unrelated families with metaphyseal chondrodysplasia type Schmid
    G A Wallis
    School of Biological Sciences, University of Manchester, UK
    Am J Hum Genet 54:169-78. 1994

Collaborators

  • A E Canfield
  • E S Maywood
  • J A Hoyland
  • A J Freemont
  • A Zambelli
  • M H Hastings
  • B Newman
  • A Paul Mould
  • Karl Kadler
  • Julie Huxley-Jones
  • M J Humphries
  • O Makitie
  • Michael Briggs
  • C Baldock
  • S L Dallas
  • S S Apte
  • M P Sarras
  • Raymond P Boot-Handford
  • Xin Wang
  • R P Boot-Handford
  • Darren A Plumb
  • G A Wallis
  • Kristen D Hadfield
  • Qing Jun Meng
  • A S I Loudon
  • Matthew S P Ho
  • Xiaoming Zhang
  • David J Thornton
  • Katarzyna A Piróg-Garcia
  • David L Robertson
  • Cathy Tournier
  • Claire Farrington Rock
  • M E Grant
  • Richard Ewan
  • Richard Poulsom
  • Georgina Collett
  • Danny S Tuckwell
  • H Green
  • Andrei S Semikhodskii
  • Joseph S Takahashi
  • Gillian A Wallis
  • Hugh D Piggins
  • Andrew S I Loudon
  • Martin Sladek
  • David A Bechtold
  • Laure Sudre
  • Larisa Logunova
  • Monica Gallego
  • Jake Lebiecki
  • Colette A Inkson
  • David M Virshup
  • Timothy M Brown
  • Seung Hee Yoo
  • Nicholas R J Glossop
  • Johanna E Chesham
  • M C Hillarby
  • Gary Gibson
  • Tori W Y Chan
  • Dick Heinegard
  • William G Cole
  • Matthews Athiyal
  • Andrew C Robinson
  • Federico Dajas-Bailador
  • Bagirathy Nadarajah
  • Danny Chan
  • Barry W McColl
  • Laila Ferrara
  • D A Bechtold
  • Q J Meng
  • Jia Wei Jin
  • Kwok Yeung Tsang
  • Kenneth M C Cheung
  • Lynette Knowles
  • Vivek Dhir
  • David O Sillence
  • Lorna N Forse
  • Rebecca L K Lo
  • - Lili
  • Kathryn S E Cheah
  • Roger S Meadows
  • Aleksandr Mironov
  • Miki Susic
  • Vivian C W Ng
  • Ulrike Mayer
  • Jill Dixon
  • Chun Guo
  • Emmanouil S Papadakis
  • Midori Kayahara
  • Jan Seyfried
  • Anita J Merritt

Detail Information

Publications28

  1. ncbi request reprint A novel and highly conserved collagen (pro(alpha)1(XXVII)) with a unique expression pattern and unusual molecular characteristics establishes a new clade within the vertebrate fibrillar collagen family
    Raymond P Boot-Handford
    Wellcome Trust Centre for Cell Matrix Research, School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Biol Chem 278:31067-77. 2003
    ..Furthermore, the exon structure of the type XXVII collagen gene is similar to, but distinct from, those of the genes coding for the type A or B clade pro(alpha) chains...
  2. ncbi request reprint Fibrillar collagen: the key to vertebrate evolution? A tale of molecular incest
    Raymond P Boot-Handford
    The Wellcome Trust Centre for Cell Matrix Research, School of Biological Sciences, University of Manchester, UK
    Bioessays 25:142-51. 2003
    ....
  3. pmc The bcl-2 knockout mouse exhibits marked changes in osteoblast phenotype and collagen deposition in bone as well as a mild growth plate phenotype
    R P Boot-Handford
    Wellcome Trust Centre of Cell Matrix Research, School of Biological Sciences, University of Manchester, UK
    Int J Exp Pathol 79:329-35. 1998
    ..The results suggest an important role for Bcl-2 in controlling osteoblast phenotype and bone deposition in vivo...
  4. ncbi request reprint Role of pericytes in vascular calcification: a review
    A E Canfield
    Wellcome Trust Centre for Cell Matrix Research, Schools of Medicine, Manchester, UK
    Z Kardiol 89:20-7. 2000
    ....
  5. ncbi request reprint Matrix Gla protein is differentially expressed during the deposition of a calcified matrix by vascular pericytes
    A E Canfield
    Wellcome Trust Centre for Cell Matrix Research, School of Medicine, University of Manchester, Manchester, UK
    FEBS Lett 487:267-71. 2000
    ..Antibodies to MGP inhibited the deposition of a calcified matrix by pericytes, suggesting that MGP regulates both cell differentiation and calcification...
  6. ncbi request reprint The involvement of matrix glycoproteins in vascular calcification and fibrosis: an immunohistochemical study
    A E Canfield
    Wellcome Trust Centre for Cell Matrix Research, 2 205, Stopford Building, The University of Manchester, Manchester, UK
    J Pathol 196:228-34. 2002
    ..Modulation of their production and activity may offer a novel approach to the therapy of a number of vascular diseases...
  7. pmc Isolation of cDNAs encoding the complete sequence of bovine type X collagen. Evidence for the condensed nature of mammalian type X collagen genes
    J T Thomas
    Department of Biochemistry and Molecular Biology, School of Biological Sciences, University of Manchester, U K
    Biochem J 273:141-8. 1991
    ..3 kb of the coding sequence being contained within one exon...
  8. ncbi request reprint The ribosomal protein QM is expressed differentially during vertebrate endochondral bone development
    H Green
    The Wellcome Trust Centre for Cell Matrix Research, School of Biological Sciences, University of Manchester, UK
    J Bone Miner Res 15:1066-75. 2000
    ..The in vivo and in vitro expression pattern of QM suggests that this protein may have a role in cell differentiation before mineralization...
  9. doi request reprint The biology of the circadian Ck1epsilon tau mutation in mice and Syrian hamsters: a tale of two species
    A S I Loudon
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    Cold Spring Harb Symp Quant Biol 72:261-71. 2007
    ..tau has consistent effects in both hamsters and mice on the circadian organization of behavior and metabolism, highlighting the global impact of this mutation on mammalian clockwork in brain and periphery...
  10. pmc Amino acid substitutions of conserved residues in the carboxyl-terminal domain of the alpha 1(X) chain of type X collagen occur in two unrelated families with metaphyseal chondrodysplasia type Schmid
    G A Wallis
    School of Biological Sciences, University of Manchester, UK
    Am J Hum Genet 54:169-78. 1994
    ....
  11. pmc The human collagen X gene. Complete primary translated sequence and chromosomal localization
    J T Thomas
    Department of Biochemistry and Molecular Biology, School of Biological Sciences, University of Manchester, U K
    Biochem J 280:617-23. 1991
    ..3200 bp. By a combination of somatic cell hybrid screening and hybridization in situ the human collagen X gene (COL10A1) has been assigned to the distal end of the long arm of chromosome 6 at the locus 6q21-6q22.3...
  12. ncbi request reprint Transcription factor XBP-1 is expressed during osteoblast differentiation and is transcriptionally regulated by parathyroid hormone (PTH)
    A Zambelli
    Wellcome Trust Centre for Cell Matrix Research, 2 205 Stopford Building, School of Biological Sciences, University of Manchester, UK
    Cell Biol Int 29:647-53. 2005
    ..In addition, xbp-1 is transcriptionally upregulated by parathyroid hormone within 2.5 h of treatment and decreases thereafter...
  13. pmc Mutations within the gene encoding the alpha 1 (X) chain of type X collagen (COL10A1) cause metaphyseal chondrodysplasia type Schmid but not several other forms of metaphyseal chondrodysplasia
    G A Wallis
    School of Biological Sciences, University of Manchester, UK
    J Med Genet 33:450-7. 1996
    ....
  14. pmc Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP
    Katarzyna A Piróg-Garcia
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, UK
    Hum Mol Genet 16:2072-88. 2007
    ..This ultimately affects the morphology and proliferation of growth plate chondrocytes, eventually leading to chondrodysplasia and reduced long bone growth...
  15. pmc Collagen XXVII is developmentally regulated and forms thin fibrillar structures distinct from those of classical vertebrate fibrillar collagens
    Darren A Plumb
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Biol Chem 282:12791-5. 2007
    ..The transient nature of its expression and unusual fibrillar structure suggest that collagen XXVII plays a developmental role distinct from those of the classical fibrillar collagens...
  16. ncbi request reprint The characterisation of six ADAMTS proteases in the basal chordate Ciona intestinalis provides new insights into the vertebrate ADAMTS family
    Julie Huxley-Jones
    Wellcome Trust Centre for Cell Matrix Research, Michael Smith Building, Faculty of Life Sciences, University of Manchester, UK
    Int J Biochem Cell Biol 37:1838-45. 2005
    ..The expansion and sub-specialization of the ADAMTS family is a component of the increased complexity of extracellular matrix that is associated with the evolution of vertebrates...
  17. ncbi request reprint On the origins of the extracellular matrix in vertebrates
    Julie Huxley-Jones
    Wellcome Trust Centre for Cell Matrix Research, University of Manchester, Manchester, UK
    Matrix Biol 26:2-11. 2007
    ..Extracellular matrix genes and their processing enzymes appear to be over-represented in the vertebrate genome suggesting that these genes played an active role enabling and underpinning the evolution of vertebrates...
  18. pmc Identification of multiple integrin beta1 homologs in zebrafish (Danio rerio)
    A Paul Mould
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    BMC Cell Biol 7:24. 2006
    ....
  19. pmc The integrins of the urochordate Ciona intestinalis provide novel insights into the molecular evolution of the vertebrate integrin family
    Richard Ewan
    Plant Molecular Science Group, University of Glasgow, Bower Building, G12 8QQ, UK
    BMC Evol Biol 5:31. 2005
    ..The publication of the genome of a basal chordate, Ciona intestinalis, provides a unique opportunity to gain further insight into how and when the expanded integrin supergene family found in vertebrates evolved...
  20. pmc Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins
    Qing Jun Meng
    Faculty of Life Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Neuron 58:78-88. 2008
    ....
  21. ncbi request reprint HtrA1 inhibits mineral deposition by osteoblasts: requirement for the protease and PDZ domains
    Kristen D Hadfield
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Biol Chem 283:5928-38. 2008
    ..These results suggest that HtrA1 may regulate matrix calcification via the inhibition of BMP-2 signaling, modulating osteoblast gene expression, and/or via the degradation of specific matrix proteins...
  22. pmc Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death
    Xin Wang
    Faculty of Life Sciences, Wellcome Trust Center for Cell Matrix Research, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Mol Cell Biol 27:7935-46. 2007
    ..Together, our data demonstrate for the first time that MKK4 is an essential activator of JNK required for the normal development of the brain...
  23. ncbi request reprint Receptor tyrosine kinase Axl modulates the osteogenic differentiation of pericytes
    Georgina Collett
    Wellcome Trust Centre for Cell Matrix Research, University of Manchester, 2 205, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Circ Res 92:1123-9. 2003
    ..These effects were inhibited by coincubation of pericytes with Axl-ECD and recombinant Gas6. Together these results demonstrate that activation of Axl inhibits the osteogenic differentiation of vascular pericytes...
  24. ncbi request reprint Collagens at a glance
    Karl E Kadler
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    J Cell Sci 120:1955-8. 2007
  25. pmc The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio
    Julie Huxley-Jones
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, UK
    BMC Evol Biol 7:63. 2007
    ..Here we present a comprehensive analysis of vertebrate metzincins using genes from both Ciona intestinalis and Danio rerio to provide new insights into the complex evolution of this gene superfamily...
  26. ncbi request reprint COL10A1 nonsense and frame-shift mutations have a gain-of-function effect on the growth plate in human and mouse metaphyseal chondrodysplasia type Schmid
    Matthew S P Ho
    Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong, China
    Hum Mol Genet 16:1201-15. 2007
    ..Our findings provide strong in vivo evidence for a gain-of-function effect that is linked to the activation of endoplasmic reticulum-stress response and altered chondrocyte differentiation, as a possible molecular pathogenesis for MCDS...
  27. pmc Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway
    Xin Wang
    University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Mol Cell Biol 25:336-45. 2005
    ..Overall, this is the first study to rigorously establish the role of MEK5 in vivo as an activator of ERK5 and as an essential regulator of cell survival that is required for normal embryonic development...
  28. ncbi request reprint The collagens of hydra provide insight into the evolution of metazoan extracellular matrices
    Xiaoming Zhang
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Biol Chem 282:6792-802. 2007
    ....