David J Boocock

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. pmc Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography
    David J Boocock
    Department of Cancer Studies and Molecular Medicine, Cancer Biomarkers and Prevention Group, 5th Floor RKCSB, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    J Chromatogr B Analyt Technol Biomed Life Sci 848:182-7. 2007
  2. ncbi request reprint Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent
    David J Boocock
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, Leicester Royal Infirmary, Leicester University, Leicester LE2 7LX, United Kingdom
    Cancer Epidemiol Biomarkers Prev 16:1246-52. 2007
  3. ncbi request reprint Quantitation of silibinin, a putative cancer chemopreventive agent derived from milk thistle (Silybum marianum), in human plasma by high-performance liquid chromatography and identification of possible metabolites
    Carmen S L Hoh
    Cancer Biomarkers and Chemoprevention Group, Department of Cancer Studies and Molecular Medicine, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX, United Kingdom
    J Agric Food Chem 55:2532-5. 2007
  4. ncbi request reprint Tissue distribution in mice and metabolism in murine and human liver of apigenin and tricin, flavones with putative cancer chemopreventive properties
    Hong Cai
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK
    Cancer Chemother Pharmacol 60:257-66. 2007
  5. ncbi request reprint Development of analyses by high-performance liquid chromatography and liquid chromatography/tandem mass spectrometry of bilberry (Vaccinium myrtilus) anthocyanins in human plasma and urine
    Darren N Cooke
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, United Kingdom
    J Agric Food Chem 54:7009-13. 2006
  6. ncbi request reprint Tamoxifen forms DNA adducts in human colon after administration of a single [14C]-labeled therapeutic dose
    Karen Brown
    Cancer Biomarkers and Prevention Group, Reproductive Sciences, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, United Kingdom
    Cancer Res 67:6995-7002. 2007
  7. ncbi request reprint Identification of human CYP forms involved in the activation of tamoxifen and irreversible binding to DNA
    David J Boocock
    MRC Molecular Endocrinology Group, Department of Obstetrics and Gynaecology, Robert Kilpatrick Building, University of Leicester, Leicester LE2 7LX, UK
    Carcinogenesis 23:1897-901. 2002
  8. ncbi request reprint Tamoxifen DNA damage detected in human endometrium using accelerator mass spectrometry
    Elizabeth A Martin
    Cancer Biomarkers and Prevention Group, University of Leicester, Leicester, United Kingdom
    Cancer Res 63:8461-5. 2003
  9. ncbi request reprint Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine
    Christopher R Ireson
    Medical Research Council Toxicology Unit, University of Leicester, Leicester LE1 9HN, United Kingdom
    Cancer Epidemiol Biomarkers Prev 11:105-11. 2002

Collaborators

Detail Information

Publications9

  1. pmc Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography
    David J Boocock
    Department of Cancer Studies and Molecular Medicine, Cancer Biomarkers and Prevention Group, 5th Floor RKCSB, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    J Chromatogr B Analyt Technol Biomed Life Sci 848:182-7. 2007
    ..The data presented in this report demonstrate a rapid, sensitive and accurate method for the analysis of resveratrol and its metabolites in human plasma and urine for pharmacokinetic studies...
  2. ncbi request reprint Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent
    David J Boocock
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, Leicester Royal Infirmary, Leicester University, Leicester LE2 7LX, United Kingdom
    Cancer Epidemiol Biomarkers Prev 16:1246-52. 2007
    ..However, the high systemic levels of resveratrol conjugate metabolites suggest that their cancer chemopreventive properties warrant investigation...
  3. ncbi request reprint Quantitation of silibinin, a putative cancer chemopreventive agent derived from milk thistle (Silybum marianum), in human plasma by high-performance liquid chromatography and identification of possible metabolites
    Carmen S L Hoh
    Cancer Biomarkers and Chemoprevention Group, Department of Cancer Studies and Molecular Medicine, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX, United Kingdom
    J Agric Food Chem 55:2532-5. 2007
    ..This method was utilized to detect silibinin in plasma of colorectal patients after 7 days of treatment with silipide (silibinin formulated with phosphatidyl choline)...
  4. ncbi request reprint Tissue distribution in mice and metabolism in murine and human liver of apigenin and tricin, flavones with putative cancer chemopreventive properties
    Hong Cai
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK
    Cancer Chemother Pharmacol 60:257-66. 2007
    ..Their pharmacology is only poorly understood. We compared their tissue levels in mice in vivo and their metabolism in liver fractions in vitro...
  5. ncbi request reprint Development of analyses by high-performance liquid chromatography and liquid chromatography/tandem mass spectrometry of bilberry (Vaccinium myrtilus) anthocyanins in human plasma and urine
    Darren N Cooke
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, United Kingdom
    J Agric Food Chem 54:7009-13. 2006
    ..Mass spectrometric analysis employing multiple reaction monitoring suggests the presence of unchanged anthocyanins and anthocyanidin glucuronide metabolites...
  6. ncbi request reprint Tamoxifen forms DNA adducts in human colon after administration of a single [14C]-labeled therapeutic dose
    Karen Brown
    Cancer Biomarkers and Prevention Group, Reproductive Sciences, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, United Kingdom
    Cancer Res 67:6995-7002. 2007
    ..These findings provide a mechanistic basis through which tamoxifen could increase the incidence of colon cancers in women...
  7. ncbi request reprint Identification of human CYP forms involved in the activation of tamoxifen and irreversible binding to DNA
    David J Boocock
    MRC Molecular Endocrinology Group, Department of Obstetrics and Gynaecology, Robert Kilpatrick Building, University of Leicester, Leicester LE2 7LX, UK
    Carcinogenesis 23:1897-901. 2002
    ..It is concluded that CYP3A4 is the only P450 of those tested that converts tamoxifen to alpha-hydroxytamoxifen and the only one that results in appreciable levels of irreversible binding of tamoxifen to DNA...
  8. ncbi request reprint Tamoxifen DNA damage detected in human endometrium using accelerator mass spectrometry
    Elizabeth A Martin
    Cancer Biomarkers and Prevention Group, University of Leicester, Leicester, United Kingdom
    Cancer Res 63:8461-5. 2003
    ..Our findings support the hypothesis that the low level of DNA adducts in human uterus is unlikely to be involved with endometrial cancer development...
  9. ncbi request reprint Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine
    Christopher R Ireson
    Medical Research Council Toxicology Unit, University of Leicester, Leicester LE1 9HN, United Kingdom
    Cancer Epidemiol Biomarkers Prev 11:105-11. 2002
    ..The pharmacological implications of the intestinal metabolism of curcumin should be taken into account in the design of future chemoprevention trials of this dietary constituent...