C S Bond

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. pmc Conformational flexibility revealed by the crystal structure of a crenarchaeal RadA
    Antonio Ariza
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee Dow St, Dundee, DD1 5EH, UK
    Nucleic Acids Res 33:1465-73. 2005
  2. pmc Structure of Hjc, a Holliday junction resolvase, from Sulfolobus solfataricus
    C S Bond
    Wellcome Trust Biocentre, University of Dundee, Dundee, Tayside DD1 5EH, United Kingdom
    Proc Natl Acad Sci U S A 98:5509-14. 2001
  3. ncbi TopDraw: a sketchpad for protein structure topology cartoons
    Charles S Bond
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, Scotland
    Bioinformatics 19:311-2. 2003
  4. ncbi Structure and reactivity in the non-mevalonate pathway of isoprenoid biosynthesis
    W N Hunter
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem Soc Trans 31:537-42. 2003
  5. ncbi Targeting metabolic pathways in microbial pathogens: oxidative stress and anti-folate drug resistance in trypanosomatids
    W N Hunter
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem Soc Trans 31:607-10. 2003
  6. ncbi High resolution structure of the phosphohistidine-activated form of Escherichia coli cofactor-dependent phosphoglycerate mutase
    C S Bond
    Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Biol Chem 276:3247-53. 2001
  7. ncbi Structure of the macrocycle thiostrepton solved using the anomalous dispersion contribution of sulfur
    C S Bond
    The Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Acta Crystallogr D Biol Crystallogr 57:755-8. 2001
  8. ncbi Crystallization and preliminary X-ray diffraction studies of recombinant Escherichia coli 4-diphosphocytidyl-2-C-methyl-D-erythritol synthetase
    L E Kemp
    The Wellcome Trust Biocentre, University of Dundee, Dundee, DD1 5EH, Scotland
    Acta Crystallogr D Biol Crystallogr 57:1189-91. 2001
  9. ncbi The structure of reduced tryparedoxin peroxidase reveals a decamer and insight into reactivity of 2Cys-peroxiredoxins
    M S Alphey
    Department of Biochemistry, The Wellcome Trust Biocentre, University of Dundee, Dundee, DD1 5EH, UK
    J Mol Biol 300:903-16. 2000
  10. ncbi The identification of isoprenoids that bind in the intersubunit cavity of Escherichia coli 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase by complementary biophysical methods
    Lauris E Kemp
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr D Biol Crystallogr 61:45-52. 2005

Collaborators

  • W N Hunter
  • M F White
  • A H Fairlamb
  • D Richard
  • R B Ravelli
  • Antonio Ariza
  • Lauris E Kemp
  • Claire L Middleton
  • Mads Gabrielsen
  • Magnus S Alphey
  • Felix Rohdich
  • Adelbert Bacher
  • Wolfgang Eisenreich
  • Archa H Fox
  • Stephen C Graham
  • Joanne L Parker
  • Gordon A Leonard
  • Mamuka Kvaratskhelia
  • David R Hall
  • L E Kemp
  • M S Alphey
  • Ian M Eggleston
  • Mark J Dixon
  • Kirsten A Armour
  • Tim J Vickers
  • Ralf Laupitz
  • Johannes Kaiser
  • Neil Greig
  • Angus I Lamond
  • Michael A J Ferguson
  • Hans C Freeman
  • J Mitchell Guss
  • Stefan Hecht
  • Sean M McSweeney
  • Emmanuel Tetaud
  • Elena Micossi
  • C Ian Watt
  • David M J Lilley
  • Alan Berry
  • Jonathan M Fogg
  • Benjamin N Wardleworth
  • E Tetaud

Detail Information

Publications21

  1. pmc Conformational flexibility revealed by the crystal structure of a crenarchaeal RadA
    Antonio Ariza
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee Dow St, Dundee, DD1 5EH, UK
    Nucleic Acids Res 33:1465-73. 2005
    ..Additional analysis reveals that the interaction specificity of the five human Rad51 paralogues can be predicted using a simple model based on the RadA structure...
  2. pmc Structure of Hjc, a Holliday junction resolvase, from Sulfolobus solfataricus
    C S Bond
    Wellcome Trust Biocentre, University of Dundee, Dundee, Tayside DD1 5EH, United Kingdom
    Proc Natl Acad Sci U S A 98:5509-14. 2001
    ..A model of the Hjc-Holliday junction complex is proposed, based on the available functional and structural data...
  3. ncbi TopDraw: a sketchpad for protein structure topology cartoons
    Charles S Bond
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, Scotland
    Bioinformatics 19:311-2. 2003
    ..TopDraw is a simple, freely available TCL/Tk based drawing program designed specifically for the production of publication quality topology cartoons in a style commonly presented by structural biologists...
  4. ncbi Structure and reactivity in the non-mevalonate pathway of isoprenoid biosynthesis
    W N Hunter
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem Soc Trans 31:537-42. 2003
    ..Since both enzymes are validated drug targets, the models provide templates for structure-based design of anti-microbial agents targeting a number of serious human diseases...
  5. ncbi Targeting metabolic pathways in microbial pathogens: oxidative stress and anti-folate drug resistance in trypanosomatids
    W N Hunter
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem Soc Trans 31:607-10. 2003
    ....
  6. ncbi High resolution structure of the phosphohistidine-activated form of Escherichia coli cofactor-dependent phosphoglycerate mutase
    C S Bond
    Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Biol Chem 276:3247-53. 2001
    ..E. coli dPGM, like the mammalian dPGMs, is a dimer, whereas previous structural work has concentrated on monomeric and tetrameric yeast forms. We can now analyze the sequence differences that cause this variation of quaternary structure...
  7. ncbi Structure of the macrocycle thiostrepton solved using the anomalous dispersion contribution of sulfur
    C S Bond
    The Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Acta Crystallogr D Biol Crystallogr 57:755-8. 2001
    ..33 A resolution at the Cu Kalpha wavelength. Data measured to 1.02 A resolution with a synchrotron source were used for refinement. Details of the molecular structure, intramolecular and intermolecular interactions are given...
  8. ncbi Crystallization and preliminary X-ray diffraction studies of recombinant Escherichia coli 4-diphosphocytidyl-2-C-methyl-D-erythritol synthetase
    L E Kemp
    The Wellcome Trust Biocentre, University of Dundee, Dundee, DD1 5EH, Scotland
    Acta Crystallogr D Biol Crystallogr 57:1189-91. 2001
    ..60, c = 175.56 A. Diffraction data have been recorded to 2.4 A resolution using synchrotron radiation...
  9. ncbi The structure of reduced tryparedoxin peroxidase reveals a decamer and insight into reactivity of 2Cys-peroxiredoxins
    M S Alphey
    Department of Biochemistry, The Wellcome Trust Biocentre, University of Dundee, Dundee, DD1 5EH, UK
    J Mol Biol 300:903-16. 2000
    ....
  10. ncbi The identification of isoprenoids that bind in the intersubunit cavity of Escherichia coli 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase by complementary biophysical methods
    Lauris E Kemp
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr D Biol Crystallogr 61:45-52. 2005
    ..The observation that MECP synthase binds three metabolites that are produced by enzymes two, three and four stages downstream in isoprenoid biosynthesis suggests that feedback regulation of the non-mevalonate pathway is possible...
  11. ncbi Specificity of the trypanothione-dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme
    Antonio Ariza
    Division of Biological Chemistry and Molecular Microbiology, Wellcome Trust Biocentre, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Mol Microbiol 59:1239-48. 2006
    ..These differences correlate with the differential binding of glutathione and trypanothione-based substrates, and thus offer a route to the rational design of L. major-specific GLO1 inhibitors...
  12. ncbi Tryparedoxins from Crithidia fasciculata and Trypanosoma brucei: photoreduction of the redox disulfide using synchrotron radiation and evidence for a conformational switch implicated in function
    Magnus S Alphey
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    J Biol Chem 278:25919-25. 2003
    ..Comparisons with chloroplast TrX and its substrate fructose 1,6-bisphosphate phosphatase suggest that this movement may represent a general feature of redox regulation in the trypanothione and thioredoxin peroxidase pathways...
  13. ncbi Structure of a tetragonal crystal form of Escherichia coli 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
    Lauris E Kemp
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr D Biol Crystallogr 59:607-10. 2003
    ..2001), Nature Struct. Biol. 8, 641-647]...
  14. ncbi Structure of tagatose-1,6-bisphosphate aldolase. Insight into chiral discrimination, mechanism, and specificity of class II aldolases
    David R Hall
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Biol Chem 277:22018-24. 2002
    ..The availability of more space and a wider range of aldehyde partners used by TBPA together with the highly specific nature of FBPA suggest that TBPA might be a preferred enzyme to modify for use in biotransformation chemistry...
  15. ncbi Mechanistic implications for Escherichia coli cofactor-dependent phosphoglycerate mutase based on the high-resolution crystal structure of a vanadate complex
    Charles S Bond
    Division of Biological Chemistry and Molecular Microbiology, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, Scotland, UK
    J Mol Biol 316:1071-81. 2002
    ..The sequence similarity of E.coli and human dPGMs allows us to correlate structure with clinical pathology...
  16. ncbi The crystal structure of a plant 2C-methyl-D-erythritol 4-phosphate cytidylyltransferase exhibits a distinct quaternary structure compared to bacterial homologues and a possible role in feedback regulation for cytidine monophosphate
    Mads Gabrielsen
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, UK
    FEBS J 273:1065-73. 2006
    ....
  17. ncbi Crystallization and preliminary X-ray diffraction studies of Hje, a HolliDay junction resolving enzyme from Sulfolobus solfataricus
    Claire L Middleton
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr D Biol Crystallogr 59:171-3. 2003
    ....
  18. pmc Substrate recognition and catalysis by the Holliday junction resolving enzyme Hje
    Claire L Middleton
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
    Nucleic Acids Res 32:5442-51. 2004
    ..The loop may act as a conformational switch, ensuring that the active site is completed only on binding a four-way junction, thus explaining the exquisite specificity of these enzymes...
  19. pmc P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner
    Archa H Fox
    Division of Gene Regulation and Expression, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, United Kingdom
    Mol Biol Cell 16:5304-15. 2005
    ..Thus paraspeckles are the sites where a subset of the total cellular pool of p54nrb is targeted in a RNA Polymerase II-dependent manner...
  20. ncbi Structural and functional implications of metal ion selection in aminopeptidase P, a metalloprotease with a dinuclear metal center
    Stephen C Graham
    School of Molecular and Microbial Biosciences, University of Sydney, NSW 2006, Australia
    Biochemistry 44:13820-36. 2005
    ..A Zn atom bound at such a site would stabilize product binding and enhance inhibition...
  21. ncbi Holliday junction resolution is modulated by archaeal chromatin components in vitro
    Mamuka Kvaratskhelia
    Centre for Biomolecular Science, University of Saint Andrews, North Haugh, Saint Andrews, KY16 9ST, United Kingdom
    J Biol Chem 277:2992-6. 2002
    ..Analysis of crystal packing interactions in the crystal structure of Hjc suggests a molecular basis for this autoinhibition. The wider implications of these findings for the quantitative study of DNA-protein interactions is discussed...